DZNE research center
@dzne.science
Dedicated to advancing the scientific understanding of neurodegenerative diseases - from mechanisms to diagnosis, therapy, and prevention (such as AD, PD or ALS).
🔗 Imprint: https://dzne.de/en/imprint
🔗 Data Protection: https://dzne.de/en/data-protection/
🔗 Imprint: https://dzne.de/en/imprint
🔗 Data Protection: https://dzne.de/en/data-protection/
New paper out: Advanced Molecular Tweezers Effectively Target Membranes Lacking Choline Headgroups for Broad-Spectrum Antiviral Efficacy.: Weil, Tatjana; Lawrenz, Jan; Taghuo Kaptouom, Estelle; et al.
Journal of the American Chemical Society Vol. 148, no. 3, p.… | Thanks for sharing #dzne #papers
Journal of the American Chemical Society Vol. 148, no. 3, p.… | Thanks for sharing #dzne #papers
Advanced Molecular Tweezers Effectively Target Membranes Lacking Choline Headgroups for Broad-Spectrum Antiviral Efficacy.
Weil, Tatjana; Lawrenz, Jan; Taghuo Kaptouom, Estelle; et al.
Journal of the American Chemical Society Vol. 148, no. 3, p. 3626 - 3637
dlvr.it
February 14, 2026 at 6:13 PM
New paper out: Patterns and Trajectories of Behavioral and Neuropsychiatric Symptoms in Frontotemporal Dementia and Primary Progressive Aphasia.: Marth, Lena; Martinez-Murcia, Francisco J; Górriz-Sáez, Juan-Manuel; et al.
Neurology Vol. 106, no. 4, p. e214510 | Thanks for sharing #dzne #papers
Neurology Vol. 106, no. 4, p. e214510 | Thanks for sharing #dzne #papers
Patterns and Trajectories of Behavioral and Neuropsychiatric Symptoms in Frontotemporal Dementia and Primary Progressive Aphasia.
Marth, Lena; Martinez-Murcia, Francisco J; Górriz-Sáez, Juan-Manuel; et al.
Neurology Vol. 106, no. 4, p. e214510
dlvr.it
February 14, 2026 at 1:53 PM
New paper out: Kupffer cells control neonatal hepatic metabolism via Igf1 signaling.: Makdissi, Nikola; Hirschmann, Daria J; Frolov, Aleksej; et al.
Development Vol. 153, no. 2, p. dev204962 | Thanks for sharing #dzne #papers
Development Vol. 153, no. 2, p. dev204962 | Thanks for sharing #dzne #papers
Kupffer cells control neonatal hepatic metabolism via Igf1 signaling.
Makdissi, Nikola; Hirschmann, Daria J; Frolov, Aleksej; et al.
Development Vol. 153, no. 2, p. dev204962
dlvr.it
February 14, 2026 at 10:53 AM
New paper out: Airborne Radioiodine: A Comparative View of Chemical Forms in Medicine, Nuclear Industry, and Fallout Scenarios.: Schomäcker, Klaus; Sudbrock, Ferdinand; Fischer, Thomas; et al.
International journal of molecular sciences Vol. 27, no. 2, p. 590 - | Thanks for sharing #dzne #papers
International journal of molecular sciences Vol. 27, no. 2, p. 590 - | Thanks for sharing #dzne #papers
Airborne Radioiodine: A Comparative View of Chemical Forms in Medicine, Nuclear Industry, and Fallout Scenarios.
Schomäcker, Klaus; Sudbrock, Ferdinand; Fischer, Thomas; et al.
International journal of molecular sciences Vol. 27, no. 2, p. 590 -
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February 13, 2026 at 6:13 PM
New paper out: Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpression.: Xie, Kan; Ryan, Devon; Schröder, Susanne; et al.
Journal of neuroinflammation Vol. 23, no. 1, p. 39 | Thanks for sharing #dzne #papers
Journal of neuroinflammation Vol. 23, no. 1, p. 39 | Thanks for sharing #dzne #papers
Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpression.
Xie, Kan; Ryan, Devon; Schröder, Susanne; et al.
Journal of neuroinflammation Vol. 23, no. 1, p. 39
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February 13, 2026 at 1:53 PM
New paper out: MicroRNA-29a-5p contributes to neuroinflammation through TLR7.: McGurran, Hugo; Graceffo, Eugenio; Kumbol, Victor; et al.
Journal of neuroinflammation Vol. 23, no. 1, p. 38 | Thanks for sharing #dzne #papers
Journal of neuroinflammation Vol. 23, no. 1, p. 38 | Thanks for sharing #dzne #papers
MicroRNA-29a-5p contributes to neuroinflammation through TLR7.
McGurran, Hugo; Graceffo, Eugenio; Kumbol, Victor; et al.
Journal of neuroinflammation Vol. 23, no. 1, p. 38
dlvr.it
February 13, 2026 at 10:54 AM
New paper out: Retrospective analysis of neurofilament-light chain in patients with inflammatory bowel disease – A pilot study: Wolff, Andreas; Feneberg, Emily; Shakhtour, Julius; et al.
PLOS ONE Vol. 21, no. 1, p. e0340182 - | Thanks for sharing #dzne #papers
PLOS ONE Vol. 21, no. 1, p. e0340182 - | Thanks for sharing #dzne #papers
Retrospective analysis of neurofilament-light chain in patients with inflammatory bowel disease – A pilot study
Wolff, Andreas; Feneberg, Emily; Shakhtour, Julius; et al.
PLOS ONE Vol. 21, no. 1, p. e0340182 -
dlvr.it
February 12, 2026 at 6:14 PM
New paper out: Non-hematopoietic erythropoietin splice variant is produced in the diseased human brain and confers neuroprotection.: Hartung, Theresa; Freyer, Dorette; Zemella, Anne; et al.
Frontiers in cellular neuroscience Vol. 19, p. 1677505 | Thanks for sharing #dzne #papers
Frontiers in cellular neuroscience Vol. 19, p. 1677505 | Thanks for sharing #dzne #papers
Non-hematopoietic erythropoietin splice variant is produced in the diseased human brain and confers neuroprotection.
Hartung, Theresa; Freyer, Dorette; Zemella, Anne; et al.
Frontiers in cellular neuroscience Vol. 19, p. 1677505
dlvr.it
February 12, 2026 at 1:53 PM
New paper out: Cerebellar Resistance to Amyloid Plaque Deposition and Elevated Microglial ECM Proteoglycan Uptake in 5xFAD Mice.: Cangalaya, Carla; Düsedau, Henning Peter; Dunay, Ildiko Rita; et al.
Cells Vol. 15, no. 2, p. 182 - | Thanks for sharing #dzne #papers
Cells Vol. 15, no. 2, p. 182 - | Thanks for sharing #dzne #papers
Cerebellar Resistance to Amyloid Plaque Deposition and Elevated Microglial ECM Proteoglycan Uptake in 5xFAD Mice.
Cangalaya, Carla; Düsedau, Henning Peter; Dunay, Ildiko Rita; et al.
Cells Vol. 15, no. 2, p. 182 -
dlvr.it
February 12, 2026 at 10:53 AM
New paper out: Care preferences of older migrants and minority ethnic groups with various care needs: A scoping review.: Peters-Nehrenheim, Viktoria; Rommerskirch-Manietta, Mike; Tezcan-Güntekin, Hürrem; et al.
PLOS ONE Vol. 21, no. 1, p. e0341147 - | Thanks for sharing #dzne #papers
PLOS ONE Vol. 21, no. 1, p. e0341147 - | Thanks for sharing #dzne #papers
Care preferences of older migrants and minority ethnic groups with various care needs: A scoping review.
Peters-Nehrenheim, Viktoria; Rommerskirch-Manietta, Mike; Tezcan-Güntekin, Hürrem; et al.
PLOS ONE Vol. 21, no. 1, p. e0341147 -
dlvr.it
February 11, 2026 at 6:13 PM
New paper out: Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.: Bräuer, Stefan; Sondermann, Verena; Schniewind, Inaki; et al.
Alzheimer's and dementia Vol. 22, no. 1, p. e71167 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 22, no. 1, p. e71167 | Thanks for sharing #dzne #papers
Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.
Bräuer, Stefan; Sondermann, Verena; Schniewind, Inaki; et al.
Alzheimer's and dementia Vol. 22, no. 1, p. e71167
dlvr.it
February 11, 2026 at 1:53 PM
New paper out: From cigarettes to symptoms: the association between smoking and depression in the German National Cohort (NAKO).: Völker, Maja P; Callies, Carolin M; Frank, Josef; et al.
BMC public health Vol. 26, no. 1, p. 301 | Thanks for sharing #dzne #papers
BMC public health Vol. 26, no. 1, p. 301 | Thanks for sharing #dzne #papers
From cigarettes to symptoms: the association between smoking and depression in the German National Cohort (NAKO).
Völker, Maja P; Callies, Carolin M; Frank, Josef; et al.
BMC public health Vol. 26, no. 1, p. 301
dlvr.it
February 11, 2026 at 10:53 AM
New paper out: Intranasal blood-brain barrier bypass enables sequential mitochondria-targeted bioengineered nanolamellar system for ischemic stroke therapy.: Yin, Yue; Li, Zixuan; Shu, Weijie; et al.
Nature Communications Vol. 17, no. 1, p. 760 | Thanks for sharing #dzne #papers
Nature Communications Vol. 17, no. 1, p. 760 | Thanks for sharing #dzne #papers
Intranasal blood-brain barrier bypass enables sequential mitochondria-targeted bioengineered nanolamellar system for ischemic stroke therapy.
Yin, Yue; Li, Zixuan; Shu, Weijie; et al.
Nature Communications Vol. 17, no. 1, p. 760
dlvr.it
February 5, 2026 at 1:53 PM
New paper out: Secondary obsessive-compulsive syndromes: a systematic literature review resulting in 228 suspected cases.: Runge, Kimon; Feige, Bernd; Schiele, Miriam A; et al.
Molecular psychiatry Vol. 31, no. 2, p. 1121 - 1131 | Thanks for sharing #dzne #papers
Molecular psychiatry Vol. 31, no. 2, p. 1121 - 1131 | Thanks for sharing #dzne #papers
Secondary obsessive-compulsive syndromes: a systematic literature review resulting in 228 suspected cases.
Runge, Kimon; Feige, Bernd; Schiele, Miriam A; et al.
Molecular psychiatry Vol. 31, no. 2, p. 1121 - 1131
dlvr.it
February 5, 2026 at 10:53 AM
Reposted by DZNE research center
📢 Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism - Nature Communications
TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficac...
www.nature.com
February 4, 2026 at 3:41 PM
📢 Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...
New paper out: Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease.: Kennedy, James T; Wisch, Julie K; Boerwinkle, Anna H; et al.
Alzheimer's and dementia Vol. 22, no. 1, p. e71103 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 22, no. 1, p. e71103 | Thanks for sharing #dzne #papers
Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease.
Kennedy, James T; Wisch, Julie K; Boerwinkle, Anna H; et al.
Alzheimer's and dementia Vol. 22, no. 1, p. e71103
dlvr.it
February 4, 2026 at 6:14 PM
New paper out: Integrin-dependence of extramedullary erythropoiesis in the spleen of Jak2-V617F positive myeloproliferative neoplasm in mice.: Baldauf, Conny K; Poschmann, Linda; Edelmann-Stephan, Bärbel; et al.
Experimental hematology Vol. 154, p. 105340 - | Thanks for sharing #dzne #papers
Experimental hematology Vol. 154, p. 105340 - | Thanks for sharing #dzne #papers
Integrin-dependence of extramedullary erythropoiesis in the spleen of Jak2-V617F positive myeloproliferative neoplasm in mice.
Baldauf, Conny K; Poschmann, Linda; Edelmann-Stephan, Bärbel; et al.
Experimental hematology Vol. 154, p. 105340 -
dlvr.it
February 4, 2026 at 1:53 PM
New paper out: [18F]FDG-PET/CT Imaging for Response Characterisation of Experimental Melanomas to Anti-PD-L1/Anti-CTLA-4 Immunotherapy.: Antons, Melissa J; Kloiber-Langhorst, Sandra; Hirner-Eppeneder, Heidrun; et al.
Molecular imaging & biology Vol. 27, no. 6, p.… | Thanks for sharing #dzne #papers
Molecular imaging & biology Vol. 27, no. 6, p.… | Thanks for sharing #dzne #papers
[18F]FDG-PET/CT Imaging for Response Characterisation of Experimental Melanomas to Anti-PD-L1/Anti-CTLA-4 Immunotherapy.
Antons, Melissa J; Kloiber-Langhorst, Sandra; Hirner-Eppeneder, Heidrun; et al.
Molecular imaging & biology Vol. 27, no. 6, p. 1006 - 1014
dlvr.it
February 4, 2026 at 10:54 AM
New paper out: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.: Shen, Xueyi; Toenders, Yara J; Han, Laura K M; et al.
Molecular psychiatry Vol. 31, no. 2, p. 611 - 621 | Thanks for sharing #dzne #papers
Molecular psychiatry Vol. 31, no. 2, p. 611 - 621 | Thanks for sharing #dzne #papers
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.
Shen, Xueyi; Toenders, Yara J; Han, Laura K M; et al.
Molecular psychiatry Vol. 31, no. 2, p. 611 - 621
dlvr.it
February 3, 2026 at 6:14 PM
New paper out: Genetisch informierte Therapie in der Psychiatrie: neue Dynamik durch APOE und Antikörpertherapie der Alzheimer-Krankheit | Genetically informed treatment in psychiatry: new dynamics through APOE and antibody treatment of Alzheimer's disease:… | Thanks for sharing #dzne #papers
Genetisch informierte Therapie in der Psychiatrie: neue Dynamik durch APOE und Antikörpertherapie der Alzheimer-Krankheit | Genetically informed treatment in psychiatry: new dynamics through APOE and antibody treatment of Alzheimer's disease
Müller, Daniel J; Freitag, Christine M; Heilbronner, Urs; et al.
Der Nervenarzt Vol. 97, no. 1, p. 82 - 85
dlvr.it
February 3, 2026 at 1:53 PM
New paper out: Clinical and Genotypic Spectrum of Twinkle-Related Disorders: Insights From a Multinational Cohort Study.: Lopriore, Piervito; Ünlütürk, Zeynep; Klopstock, Thomas; et al.
Neurology Vol. 106, no. 3, p. e214401 | Thanks for sharing #dzne #papers
Neurology Vol. 106, no. 3, p. e214401 | Thanks for sharing #dzne #papers
Clinical and Genotypic Spectrum of Twinkle-Related Disorders: Insights From a Multinational Cohort Study.
Lopriore, Piervito; Ünlütürk, Zeynep; Klopstock, Thomas; et al.
Neurology Vol. 106, no. 3, p. e214401
dlvr.it
February 3, 2026 at 10:53 AM
New paper out: Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults.: Küppers, Vincent; Bi, Hanwen; Nicolaisen-Sobesky, Eliana; et al.
Scientific reports Vol. 16, no. 1, p.… | Thanks for sharing #dzne #papers
Scientific reports Vol. 16, no. 1, p.… | Thanks for sharing #dzne #papers
Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults.
Küppers, Vincent; Bi, Hanwen; Nicolaisen-Sobesky, Eliana; et al.
Scientific reports Vol. 16, no. 1, p. 1318
dlvr.it
February 1, 2026 at 10:53 AM
New paper out: High‐Throughput 3D Glioblastoma Model in Glycosaminoglycan Hydrogels for Personalized Therapeutic Screening: Trautmann, Rajvinder Kaur; Dennison, Nicholas; McCortney, Kathleen; et al.
Macromolecular bioscience Vol. 26, no. 1, p. e00394 | Thanks for sharing #dzne #papers
Macromolecular bioscience Vol. 26, no. 1, p. e00394 | Thanks for sharing #dzne #papers
High‐Throughput 3D Glioblastoma Model in Glycosaminoglycan Hydrogels for Personalized Therapeutic Screening
Trautmann, Rajvinder Kaur; Dennison, Nicholas; McCortney, Kathleen; et al.
Macromolecular bioscience Vol. 26, no. 1, p. e00394
dlvr.it
January 31, 2026 at 6:14 PM
New paper out: Abnormal Amplitude-Integrated Electroencephalography and Acidosis as Key Criteria Initiating Therapeutic Hypothermia in Asphyxiated Newborns - Data From the German Hypothermia Registry.: Demir, Sebiha; Groteklaes, Anne; Dresbach, Till; et al.
Acta… | Thanks for sharing #dzne #papers
Acta… | Thanks for sharing #dzne #papers
Abnormal Amplitude-Integrated Electroencephalography and Acidosis as Key Criteria Initiating Therapeutic Hypothermia in Asphyxiated Newborns - Data From the German Hypothermia Registry.
Demir, Sebiha; Groteklaes, Anne; Dresbach, Till; et al.
Acta paediatrica Vol. 115, no. 2, p. 482 - 490
dlvr.it
January 31, 2026 at 1:53 PM