DZNE research center
@dzne.science
Dedicated to advancing the scientific understanding of neurodegenerative diseases - from mechanisms to diagnosis, therapy, and prevention (such as AD, PD or ALS).
🔗 Imprint: https://dzne.de/en/imprint
🔗 Data Protection: https://dzne.de/en/data-protection/
🔗 Imprint: https://dzne.de/en/imprint
🔗 Data Protection: https://dzne.de/en/data-protection/
New paper out: AI Superresolution: Converting T1‐weighted MRI from 3T to 7T resolution toward enhanced imaging biomarkers for Alzheimer’s disease: Gicquel, Malo; Flood, Gabrielle; Zhao, Ruoyi; et al.
Alzheimer's and dementia Vol. 21 Suppl 8, no. Suppl 8, p. e109817 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 21 Suppl 8, no. Suppl 8, p. e109817 | Thanks for sharing #dzne #papers
AI Superresolution: Converting T1‐weighted MRI from 3T to 7T resolution toward enhanced imaging biomarkers for Alzheimer’s disease
Gicquel, Malo; Flood, Gabrielle; Zhao, Ruoyi; et al.
Alzheimer's and dementia Vol. 21 Suppl 8, no. Suppl 8, p. e109817
dlvr.it
December 31, 2025 at 6:13 PM
New paper out: Connector Hubs Accelerate the Spread of Tau Pathology in Alzheimer's Disease: Hirsch, Fabian; Frontzkowski, Lukas; Roemer-Cassiano, Sebastian; et al.
Alzheimer's and dementia Vol. 21 Suppl 8, no. Suppl 8, p. e109933 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 21 Suppl 8, no. Suppl 8, p. e109933 | Thanks for sharing #dzne #papers
Connector Hubs Accelerate the Spread of Tau Pathology in Alzheimer's Disease
Hirsch, Fabian; Frontzkowski, Lukas; Roemer-Cassiano, Sebastian; et al.
Alzheimer's and dementia Vol. 21 Suppl 8, no. Suppl 8, p. e109933
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December 31, 2025 at 1:53 PM
New paper out: Lifestyle and health signatures of brain pathological and cognitive aging: Behrenbruch, Niklas; Schwarck, Svenja; Schumann-Werner, Beate; et al.
Alzheimer's and dementia Vol. 21 Suppl 8, no. Suppl 8, p. e109741 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 21 Suppl 8, no. Suppl 8, p. e109741 | Thanks for sharing #dzne #papers
Lifestyle and health signatures of brain pathological and cognitive aging
Behrenbruch, Niklas; Schwarck, Svenja; Schumann-Werner, Beate; et al.
Alzheimer's and dementia Vol. 21 Suppl 8, no. Suppl 8, p. e109741
dlvr.it
December 31, 2025 at 10:54 AM
New paper out: TMEM106B modulates disease severity in genetic frontotemporal dementia phenoconverters: Pasternak, Maurice; Mirza, Saira S; Paterson, Andrew D; et al.
Alzheimer's and dementia Vol. 21 Suppl 2, no. Suppl 2, p. e103532 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 21 Suppl 2, no. Suppl 2, p. e103532 | Thanks for sharing #dzne #papers
TMEM106B modulates disease severity in genetic frontotemporal dementia phenoconverters
Pasternak, Maurice; Mirza, Saira S; Paterson, Andrew D; et al.
Alzheimer's and dementia Vol. 21 Suppl 2, no. Suppl 2, p. e103532
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December 30, 2025 at 6:14 PM
New paper out: Social Support Predicts Depressive Symptoms in Dementia – A Four‐Year Longitudinal Study: Jeran, Lina Charlotte; Blecha, Nadia; Rodriguez, Francisca S; et al.
Alzheimer's and dementia Vol. 21 Suppl 4, no. Suppl 4, p. e102810 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 21 Suppl 4, no. Suppl 4, p. e102810 | Thanks for sharing #dzne #papers
Social Support Predicts Depressive Symptoms in Dementia – A Four‐Year Longitudinal Study
Jeran, Lina Charlotte; Blecha, Nadia; Rodriguez, Francisca S; et al.
Alzheimer's and dementia Vol. 21 Suppl 4, no. Suppl 4, p. e102810
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December 30, 2025 at 1:53 PM
New paper out: Structure‐function decoupling in genetic frontotemporal dementia: Tsvetanov, Kamen A; Jones, P Simon; Malpetti, Maura; et al.
Alzheimer's and dementia Vol. 21 Suppl 2, no. Suppl 2, p. e100438 | Thanks for sharing #dzne #papers
Alzheimer's and dementia Vol. 21 Suppl 2, no. Suppl 2, p. e100438 | Thanks for sharing #dzne #papers
Structure‐function decoupling in genetic frontotemporal dementia
Tsvetanov, Kamen A; Jones, P Simon; Malpetti, Maura; et al.
Alzheimer's and dementia Vol. 21 Suppl 2, no. Suppl 2, p. e100438
dlvr.it
December 30, 2025 at 10:53 AM
Paper alert: How do learning and memory emerge in the brain? DZNE's @jangrundemann.bsky.social and colleagues have observed a key mechanism of neuronal adaptability in the living brain for the 1st time. Published in @natneuro.nature.com, the study reveals dynamic regulation of nerve cell signaling.
December 23, 2025 at 10:29 AM
Paper alert: How do learning and memory emerge in the brain? DZNE's @jangrundemann.bsky.social and colleagues have observed a key mechanism of neuronal adaptability in the living brain for the 1st time. Published in @natneuro.nature.com, the study reveals dynamic regulation of nerve cell signaling.
New paper out: Dataset: MCI Data set: Garthe, Alexander; Pricop-Jeckstadt, Mihaela
| Thanks for sharing #dzne #papers
| Thanks for sharing #dzne #papers
Dataset: MCI Data set
Garthe, Alexander; Pricop-Jeckstadt, Mihaela
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December 21, 2025 at 10:53 AM
New paper out: The essential integration of sex and gender in immunological research.: Altfeld, Marcus; Consiglio, Camila; Duffy, Darragh; et al.
Immunology letters Vol. 277, p. 107097 - | Thanks for sharing #dzne #papers
Immunology letters Vol. 277, p. 107097 - | Thanks for sharing #dzne #papers
The essential integration of sex and gender in immunological research.
Altfeld, Marcus; Consiglio, Camila; Duffy, Darragh; et al.
Immunology letters Vol. 277, p. 107097 -
dlvr.it
December 20, 2025 at 6:14 PM
New paper out: β-Blocker effects in huntington's disease: A caution on clinical interpretation.: Aziz, N. Ahmad; Claassen, Daniel; Petersén, Åsa; et al.
Journal of Huntington's disease p. 18796397251401745 | Thanks for sharing #dzne #papers
Journal of Huntington's disease p. 18796397251401745 | Thanks for sharing #dzne #papers
β-Blocker effects in huntington's disease: A caution on clinical interpretation.
Aziz, N. Ahmad; Claassen, Daniel; Petersén, Åsa; et al.
Journal of Huntington's disease p. 18796397251401745
dlvr.it
December 20, 2025 at 1:53 PM
New paper out: Dataset: Chronic Aducanumab-mediated clearance of amyloid plaques decreases microglial activation and induces a unique microglial phenotype associated with antigen presentation: deWeerd, Lis; Sandmann, T.; Ha, C.; et al.
| Thanks for sharing #dzne #papers
| Thanks for sharing #dzne #papers
Dataset: Chronic Aducanumab-mediated clearance of amyloid plaques decreases microglial activation and induces a unique microglial phenotype associated with antigen presentation
deWeerd, Lis; Sandmann, T.; Ha, C.; et al.
dlvr.it
December 20, 2025 at 10:53 AM
New paper out: Cryo-em structure of the Nup98 fibril polymorph 1 (EMD-13851): Ibanez de Opakua, Alain; Geraets, JA
| Thanks for sharing #dzne #papers
| Thanks for sharing #dzne #papers
Cryo-em structure of the Nup98 fibril polymorph 1 (EMD-13851)
Ibanez de Opakua, Alain; Geraets, JA
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December 20, 2025 at 6:41 AM
New paper out: Cryo-em structure of the Nup98 fibril polymorph 2 (EMD-13852): Ibanez de Opakua, Alain; Geraets, JA
| Thanks for sharing #dzne #papers
| Thanks for sharing #dzne #papers
Cryo-em structure of the Nup98 fibril polymorph 2 (EMD-13852)
Ibanez de Opakua, Alain; Geraets, JA
dlvr.it
December 19, 2025 at 6:13 PM
New paper out: Cryo-em structure of the Nup98 fibril polymorph 4 (EMD-13854): Ibanez de Opakua, Alain; Geraets, JA
| Thanks for sharing #dzne #papers
| Thanks for sharing #dzne #papers
Cryo-em structure of the Nup98 fibril polymorph 4 (EMD-13854)
Ibanez de Opakua, Alain; Geraets, JA
dlvr.it
December 19, 2025 at 1:54 PM
Dataset: LTBio Pipelines GUI, v1
Saraiva, Joao
dlvr.it
December 19, 2025 at 6:42 AM
New paper out: Dataset: RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics, v1: Rayan, Bader; Barnea, Eilon; Indig, Rinat; et al.
| Thanks for sharing #dzne #papers
| Thanks for sharing #dzne #papers
Dataset: RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics, v1
Rayan, Bader; Barnea, Eilon; Indig, Rinat; et al.
dlvr.it
December 18, 2025 at 6:13 PM
New paper out: Dataset: RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics, v2: Rayan, Bader; Barnea, Eilon; Indig, Rinat; et al.
| Thanks for sharing #dzne #papers
| Thanks for sharing #dzne #papers
Dataset: RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics, v2
Rayan, Bader; Barnea, Eilon; Indig, Rinat; et al.
dlvr.it
December 18, 2025 at 1:54 PM
Woohoo! Triple recognition for Martin Reuter (DZNE Bonn): @helmholtz.de funding secures the open-source brain MRI software FastSurfer, also awarded with the Helmholtz Software Sustainability Prize. In addition, DZNE Foundation bridge funding advances AI biomarkers for neurodegenerative diseases.
December 17, 2025 at 12:48 PM
Woohoo! Triple recognition for Martin Reuter (DZNE Bonn): @helmholtz.de funding secures the open-source brain MRI software FastSurfer, also awarded with the Helmholtz Software Sustainability Prize. In addition, DZNE Foundation bridge funding advances AI biomarkers for neurodegenerative diseases.
Congrats dear Lucas Ribeiro! Lucas has taken up a prestigious position in his home country of Brazil. Alongside his work at DZNE Bonn, the immunologist and bioinformatician is now a Visiting Research Fellow at his alma mater, the Federal University of Minas Gerais.
December 17, 2025 at 11:19 AM
Congrats dear Lucas Ribeiro! Lucas has taken up a prestigious position in his home country of Brazil. Alongside his work at DZNE Bonn, the immunologist and bioinformatician is now a Visiting Research Fellow at his alma mater, the Federal University of Minas Gerais.
Congrats! Frank Bradke received the “Drs. Ayeez and Shelena Lalji & Family ALS Endowed Award for Innovative Healing”, funded with US$ 40k. The award honors his research on the growth of nerve connections. It's presented by the Sean M. Healey and AMG Center for ALS at Massachusetts General Hospital.
December 16, 2025 at 3:34 PM
Congrats! Frank Bradke received the “Drs. Ayeez and Shelena Lalji & Family ALS Endowed Award for Innovative Healing”, funded with US$ 40k. The award honors his research on the growth of nerve connections. It's presented by the Sean M. Healey and AMG Center for ALS at Massachusetts General Hospital.
Baseline results from the international PROFA study highlight the patient-reported, psychosocial, and health-economic burden of Friedreich’s ataxia. 🧠 For details, read the paper in The Lancet Regional Health – Europe.
📸: vita555 - stock.adobe.com
📸: vita555 - stock.adobe.com
December 16, 2025 at 2:40 PM
Baseline results from the international PROFA study highlight the patient-reported, psychosocial, and health-economic burden of Friedreich’s ataxia. 🧠 For details, read the paper in The Lancet Regional Health – Europe.
📸: vita555 - stock.adobe.com
📸: vita555 - stock.adobe.com
🧠New study by scientists from DZNE and Harvard Medical School shows: More than one third of dementia cases in Germany could be prevented
👉 www.dzne.de/en/news/pres...
📸: DZNE
👉 www.dzne.de/en/news/pres...
📸: DZNE
December 10, 2025 at 2:32 PM
🧠New study by scientists from DZNE and Harvard Medical School shows: More than one third of dementia cases in Germany could be prevented
👉 www.dzne.de/en/news/pres...
📸: DZNE
👉 www.dzne.de/en/news/pres...
📸: DZNE
New paper out: Synphilin-1 modulates alpha-synuclein assembly, release and uptake.: Lázaro, Diana F; Amen, Triana; Gerhardt, Ellen; et al.
npj Parkinson's Disease Vol. 11, no. 1, p. 326 | Thanks for sharing #dzne #papers
npj Parkinson's Disease Vol. 11, no. 1, p. 326 | Thanks for sharing #dzne #papers
Synphilin-1 modulates alpha-synuclein assembly, release and uptake.
Lázaro, Diana F; Amen, Triana; Gerhardt, Ellen; et al.
npj Parkinson's Disease Vol. 11, no. 1, p. 326
dlvr.it
December 4, 2025 at 1:54 PM
New paper out: Digital Outcomes of Upper Limb Ataxia Capture Meaningful Longitudinal Change and Treatment Response: Hermle, Dominik; Schubert, Robin; Barallon, Pascal; et al.
Movement disorders Vol. 40, no. 11, p. 2486 - 2496 | Thanks for sharing #dzne #papers
Movement disorders Vol. 40, no. 11, p. 2486 - 2496 | Thanks for sharing #dzne #papers
Digital Outcomes of Upper Limb Ataxia Capture Meaningful Longitudinal Change and Treatment Response
Hermle, Dominik; Schubert, Robin; Barallon, Pascal; et al.
Movement disorders Vol. 40, no. 11, p. 2486 - 2496
dlvr.it
December 4, 2025 at 6:42 AM
New paper out: Probabilistic Mapping of Magnetic Resonance‐Guided Focused Ultrasound ( MRgFUS) Thalamotomy Targets in Essential Tremor and Tremor‐Dominant Parkinson's Disease: Insights from a German Cohort: Krauss, Jonas; Upadhyay, Neeraj; Purrer, Veronika; et… | Thanks for sharing #dzne #papers
Probabilistic Mapping of Magnetic Resonance‐Guided Focused Ultrasound ( MRgFUS) Thalamotomy Targets in Essential Tremor and Tremor‐Dominant Parkinson's Disease: Insights from a German Cohort
Krauss, Jonas; Upadhyay, Neeraj; Purrer, Veronika; et al.
Movement disorders Vol. 40, no. 11, p. 2540 - 2542
dlvr.it
December 3, 2025 at 6:13 PM