Max Schelski
@maxschelski.bsky.social
Neuroscientist. Developing mathematical models of cell biology underlying synaptic plasticity. Coding Python.
PhD done @ Bradke lab #NeuroDev #Microtubules
PostDoc in Tchumatchenko group. #SynapticPlasticity #Dendrites
https://github.com/maxschelski/
PhD done @ Bradke lab #NeuroDev #Microtubules
PostDoc in Tchumatchenko group. #SynapticPlasticity #Dendrites
https://github.com/maxschelski/
Pinned
Are axon and dendrite development indeed driven by separate mechanisms? By building a data-integrated biophysical model across developmental stages, we identified slowdown of microtubule retrograde flow (MT-RF) as unifying mechanism for both axon and dendrite development doi.org/10.64898/202... 🧪 🧠📈
Reposted by Max Schelski
While much of machine learning is retrospective (learn the past distribution) learning in biology is prospective (learn for the future) - here we discuss some implications for neuroscience (with @tdverstynen.bsky.social, Josh Vogelstein, Pratik Chaudhari): www.cell.com/neuron/abstr...
Toward a science of prospective learning
In a constantly changing world, effective intelligence means anticipating future changes.
Kording et al. argue that organisms adapt prospectively, modeling how environments
and capabilities of the org...
www.cell.com
December 22, 2025 at 8:47 PM
While much of machine learning is retrospective (learn the past distribution) learning in biology is prospective (learn for the future) - here we discuss some implications for neuroscience (with @tdverstynen.bsky.social, Josh Vogelstein, Pratik Chaudhari): www.cell.com/neuron/abstr...
Reposted by Max Schelski
I am excited to share our new paper, where we developed and used a new approach that allows us to dynamically monitor autophagy in the intact mouse brain! biorxiv.org/cgi/content/...
Fluorescence lifetime-based biosensor for monitoring compartmentalized autophagy dynamics in the intact mammalian brain
Synaptic architecture underlies neuronal computation, with autophagy serving as a key regulator of synaptic plasticity, function and local metabolism. Yet, autophagy dynamics and regulation within int...
biorxiv.org
December 26, 2025 at 4:57 AM
I am excited to share our new paper, where we developed and used a new approach that allows us to dynamically monitor autophagy in the intact mouse brain! biorxiv.org/cgi/content/...
Reposted by Max Schelski
Finally got the job ad—looking for 2 PhD students to start spring next year:
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
December 3, 2025 at 9:37 AM
Finally got the job ad—looking for 2 PhD students to start spring next year:
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
Reposted by Max Schelski
Glad to see this out 😊 Thanks to @joss-openjournals.bsky.social for the smooth review process 🙏
Just published in JOSS: 'MotilA – A Python pipeline for the analysis of microglial fine process motility in 3D time-lapse multiphoton microscopy data' https://doi.org/10.21105/joss.09267
December 23, 2025 at 6:54 PM
Glad to see this out 😊 Thanks to @joss-openjournals.bsky.social for the smooth review process 🙏
Reposted by Max Schelski
Happy to share that our #JOSS paper on MotilA is now published 😊
#OpenSource #Python pipeline for reproducible, batch-scale analysis of #microglia fine-process motility in 3D/4D in vivo multiphoton imaging:
📄 doi.org/10.21105/jos...
💻 github.com/FabrizioMusa...
#Neuroscience 🧪 #OpenScience
#OpenSource #Python pipeline for reproducible, batch-scale analysis of #microglia fine-process motility in 3D/4D in vivo multiphoton imaging:
📄 doi.org/10.21105/jos...
💻 github.com/FabrizioMusa...
#Neuroscience 🧪 #OpenScience
MotilA – A Python pipeline for the analysis of microglial fine process motility in 3D time-lapse multiphoton microscopy data
Musacchio et al., (2025). MotilA – A Python pipeline for the analysis of microglial fine process motility in 3D time-lapse multiphoton microscopy data. Journal of Open Source Software, 10(116), 9267, ...
doi.org
December 23, 2025 at 6:58 PM
Happy to share that our #JOSS paper on MotilA is now published 😊
#OpenSource #Python pipeline for reproducible, batch-scale analysis of #microglia fine-process motility in 3D/4D in vivo multiphoton imaging:
📄 doi.org/10.21105/jos...
💻 github.com/FabrizioMusa...
#Neuroscience 🧪 #OpenScience
#OpenSource #Python pipeline for reproducible, batch-scale analysis of #microglia fine-process motility in 3D/4D in vivo multiphoton imaging:
📄 doi.org/10.21105/jos...
💻 github.com/FabrizioMusa...
#Neuroscience 🧪 #OpenScience
Reposted by Max Schelski
🔬📊 PhD (100%) – Statistics & ML for self-driving microscopy
Joint PhD with David Ginsbourger (Stats) & Pertz Lab (Cell Biology).
Gaussian Processes, Bayesian design, active learning on live-cell experiments.
ohws.prospective.ch/public/v1/jo...
#PhD #Statistics #MachineLearning #Bayesian
Joint PhD with David Ginsbourger (Stats) & Pertz Lab (Cell Biology).
Gaussian Processes, Bayesian design, active learning on live-cell experiments.
ohws.prospective.ch/public/v1/jo...
#PhD #Statistics #MachineLearning #Bayesian
Uni Bern: PhD Position in Statistics with a focus on Statistical Machine Learning for Self-Driving Microscopy
ohws.prospective.ch
December 21, 2025 at 2:48 PM
🔬📊 PhD (100%) – Statistics & ML for self-driving microscopy
Joint PhD with David Ginsbourger (Stats) & Pertz Lab (Cell Biology).
Gaussian Processes, Bayesian design, active learning on live-cell experiments.
ohws.prospective.ch/public/v1/jo...
#PhD #Statistics #MachineLearning #Bayesian
Joint PhD with David Ginsbourger (Stats) & Pertz Lab (Cell Biology).
Gaussian Processes, Bayesian design, active learning on live-cell experiments.
ohws.prospective.ch/public/v1/jo...
#PhD #Statistics #MachineLearning #Bayesian
Reposted by Max Schelski
Our paper is featured in Neuroscience News @neurosciencenews.bsky.social !
neurosciencenews.com/olfaction-do...
neurosciencenews.com/olfaction-do...
Two Dopamine Neuron Subtypes Process Smell in Different Ways - Neuroscience News
Closely related dopamine-releasing neurons in the olfactory bulb behave in fundamentally different ways depending on their physical structure.
neurosciencenews.com
December 19, 2025 at 9:53 AM
Our paper is featured in Neuroscience News @neurosciencenews.bsky.social !
neurosciencenews.com/olfaction-do...
neurosciencenews.com/olfaction-do...
Reposted by Max Schelski
How does the axonal sub-membrane periodic cytoskeleton develop? Nick & Rohan from our lab found that building blocks are delivered in packets and co-assemble locally with actin for final structure. Fun collaboration with imaging Guru @christlet.bsky.social and his team.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
December 19, 2025 at 6:36 PM
How does the axonal sub-membrane periodic cytoskeleton develop? Nick & Rohan from our lab found that building blocks are delivered in packets and co-assemble locally with actin for final structure. Fun collaboration with imaging Guru @christlet.bsky.social and his team.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Max Schelski
Slowdown of microtubule retrograde flow enables axon and dendrite development and maintenance https://www.biorxiv.org/content/10.64898/2025.12.18.694605v1
December 19, 2025 at 7:15 AM
Slowdown of microtubule retrograde flow enables axon and dendrite development and maintenance https://www.biorxiv.org/content/10.64898/2025.12.18.694605v1
Are axon and dendrite development indeed driven by separate mechanisms? By building a data-integrated biophysical model across developmental stages, we identified slowdown of microtubule retrograde flow (MT-RF) as unifying mechanism for both axon and dendrite development doi.org/10.64898/202... 🧪 🧠📈
December 19, 2025 at 4:25 PM
Are axon and dendrite development indeed driven by separate mechanisms? By building a data-integrated biophysical model across developmental stages, we identified slowdown of microtubule retrograde flow (MT-RF) as unifying mechanism for both axon and dendrite development doi.org/10.64898/202... 🧪 🧠📈
Reposted by Max Schelski
🚨Big news!🚨
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
🧠🎼 What does it take to restore movement? Neuroscientist and engineer, @juangallego.bsky.social, joins the new Centre for Restorative Neurotechnology at the Champalimaud Foundation.
🔗 Find out more in this interview: www.fchampalimaud.org/news/juan-al...
🔗 Find out more in this interview: www.fchampalimaud.org/news/juan-al...
October 7, 2025 at 4:37 PM
🚨Big news!🚨
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
Reposted by Max Schelski
Maybe check out the associated website. icg-explorer.org. I know I know, it's not fully integrated with ICG1, but these things are difficult.
October 7, 2025 at 10:12 PM
Maybe check out the associated website. icg-explorer.org. I know I know, it's not fully integrated with ICG1, but these things are difficult.
Reposted by Max Schelski
“Mapping ion channel function” doi.org/10.7554/eLif... isn’t exactly a citation slayer, but it’s still one of my favourites (& my first independent project). Today we push pt 2, where we trace code origin & unite almost all channel models in a common expression. Boom! www.biorxiv.org/content/10.1...
An ion channel omnimodel for standardized biophysical neuron modelling
Biophysical neuron modeling is an indispensable tool in neuroscience research, with the combination of diverse ion channel kinetics and morphologies being used to explain various single-neuron propert...
www.biorxiv.org
October 6, 2025 at 6:25 PM
“Mapping ion channel function” doi.org/10.7554/eLif... isn’t exactly a citation slayer, but it’s still one of my favourites (& my first independent project). Today we push pt 2, where we trace code origin & unite almost all channel models in a common expression. Boom! www.biorxiv.org/content/10.1...
Reposted by Max Schelski
Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
Assembly-based computations through contextual dendritic gating of plasticity
Neuronal assemblies — groups of strongly connected neurons — are considered the basic building blocks of perception and memory in the brain by encoding representations of specific concepts. Despite re...
www.biorxiv.org
July 25, 2025 at 10:53 AM
Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
Reposted by Max Schelski
Very happy to share this preprint from the lab led by @cmiehl.bsky.social, Sebastian and Maurycy on how to flexibly learn with nonlinear dendrites and inhibitory context-dependent gating, putting biological detail in ANNs. Check out Christoph's post below for a preview or the paper for more details!
Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
Assembly-based computations through contextual dendritic gating of plasticity
Neuronal assemblies — groups of strongly connected neurons — are considered the basic building blocks of perception and memory in the brain by encoding representations of specific concepts. Despite re...
www.biorxiv.org
July 25, 2025 at 1:21 PM
Very happy to share this preprint from the lab led by @cmiehl.bsky.social, Sebastian and Maurycy on how to flexibly learn with nonlinear dendrites and inhibitory context-dependent gating, putting biological detail in ANNs. Check out Christoph's post below for a preview or the paper for more details!
Reposted by Max Schelski
Very happy our cautionary tale of GECI expression in the hippocampus is out in @eLife.
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print https://x.com/tonykellyEU/status/1723654794626154891. 1/3
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print https://x.com/tonykellyEU/status/1723654794626154891. 1/3
August 30, 2025 at 8:14 PM
Very happy our cautionary tale of GECI expression in the hippocampus is out in @eLife.
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print https://x.com/tonykellyEU/status/1723654794626154891. 1/3
https://elifesciences.org/articles/93804
We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression.
Also a tweet print https://x.com/tonykellyEU/status/1723654794626154891. 1/3
Reposted by Max Schelski
Dendrites have been under the microscope, since 1888. We took it further and put dendrites under 3 different microscopes (ExM, STED, EM) and reconstructed entire branches to reveal fine nanoscale details. #SuperResolution #ElectronMicroscopy #Morphology
https://doi.org/10.1101/2025.07.18.664460
https://doi.org/10.1101/2025.07.18.664460
August 30, 2025 at 8:14 PM
Dendrites have been under the microscope, since 1888. We took it further and put dendrites under 3 different microscopes (ExM, STED, EM) and reconstructed entire branches to reveal fine nanoscale details. #SuperResolution #ElectronMicroscopy #Morphology
https://doi.org/10.1101/2025.07.18.664460
https://doi.org/10.1101/2025.07.18.664460
Reposted by Max Schelski
Recently I referred to how dendritic compartmentalisation increases computation.
What is a computational unit. How has the view evolved from point neuron (basis for ANNs). How a neuroscience view may increase AI efficiency.
buff.ly/zoF1rJz
preprint on compartmentalisation buff.ly/TAsJuVr
What is a computational unit. How has the view evolved from point neuron (basis for ANNs). How a neuroscience view may increase AI efficiency.
buff.ly/zoF1rJz
preprint on compartmentalisation buff.ly/TAsJuVr
September 2, 2025 at 3:33 PM
Recently I referred to how dendritic compartmentalisation increases computation.
What is a computational unit. How has the view evolved from point neuron (basis for ANNs). How a neuroscience view may increase AI efficiency.
buff.ly/zoF1rJz
preprint on compartmentalisation buff.ly/TAsJuVr
What is a computational unit. How has the view evolved from point neuron (basis for ANNs). How a neuroscience view may increase AI efficiency.
buff.ly/zoF1rJz
preprint on compartmentalisation buff.ly/TAsJuVr
Reposted by Max Schelski
New group leader position in computational neuroscience @ Neurocentre Magendie, INSERM, Bordeaux! More info here: www.bordeaux-neurocampus.fr/group-leader...
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
Group leader tenured-track position in Computational Neuroscience - Bordeaux Neurocampus
Neurocentre Magendie
www.bordeaux-neurocampus.fr
July 4, 2025 at 12:26 PM
New group leader position in computational neuroscience @ Neurocentre Magendie, INSERM, Bordeaux! More info here: www.bordeaux-neurocampus.fr/group-leader...
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
Reposted by Max Schelski
We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...
Memory by a thousand rules: Automated discovery of functional multi-type plasticity rules reveals variety & degeneracy at the heart of learning
Synaptic plasticity is the basis of learning and memory, but the link between synaptic changes and neural function remains elusive. Here, we used automated search algorithms to obtain thousands of str...
www.biorxiv.org
June 2, 2025 at 6:50 PM
We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...
Reposted by Max Schelski
Here is your last reminder that the application deadline for Imbizo.Africa is nearing quickly, the 1st of July, in fact tomorrow. Still the place where diversity is at its best in the world! Tell all who need to hear. #africa #neuro
#Imbizo - Simons Computational Neuroscience Imbizo - #Imbizo
Simons Computational Neuroscience Imbizo summer school in Cape Town, South Africa
Imbizo.Africa
June 30, 2025 at 7:53 PM
Here is your last reminder that the application deadline for Imbizo.Africa is nearing quickly, the 1st of July, in fact tomorrow. Still the place where diversity is at its best in the world! Tell all who need to hear. #africa #neuro
Reposted by Max Schelski
First Bluesky post! I'm excited to share a preprint from my postdoctoral work where we 1) define the developmental mechanisms guiding formation of a vagal gut-brain circuit and 2) discover that this circuit regulates much more than just appetite. www.biorxiv.org/content/10.1...
Ontogeny of the vagal gut-brain axis
Gut-brain communication is a key component of homeostasis which regulates behaviors such as appetite and reward. Intestinal entero-endocrine cells (EECs) translate nutrient intake into signals which a...
www.biorxiv.org
May 8, 2025 at 8:18 PM
First Bluesky post! I'm excited to share a preprint from my postdoctoral work where we 1) define the developmental mechanisms guiding formation of a vagal gut-brain circuit and 2) discover that this circuit regulates much more than just appetite. www.biorxiv.org/content/10.1...
Reposted by Max Schelski
PhD/Postdoc position in Computational Neuroscience at the Institute of Neuroinformatics (UZH and ETH Zürich): we are investigating the neural circuits underlying perception and learning in uncertain environments: www.ini.uzh.ch/en/research/... #PhD #ComputationalNeuroscience #UZHZurich #ETHZurich
Open positions
www.ini.uzh.ch
June 11, 2025 at 8:54 AM
PhD/Postdoc position in Computational Neuroscience at the Institute of Neuroinformatics (UZH and ETH Zürich): we are investigating the neural circuits underlying perception and learning in uncertain environments: www.ini.uzh.ch/en/research/... #PhD #ComputationalNeuroscience #UZHZurich #ETHZurich
Reposted by Max Schelski
Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...
June 11, 2025 at 3:18 PM
Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...
Reposted by Max Schelski
My latest Aronov lab paper is now published @Nature!
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
June 11, 2025 at 10:24 PM
My latest Aronov lab paper is now published @Nature!
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum