Maxim Igaev
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maxotubule.bsky.social
Maxim Igaev
@maxotubule.bsky.social
370 followers 1.2K following 10 posts
Computational Biophysicist and Royal Society University Research Fellow at the School of Life Sciences, University of Dundee 🇬🇧

Studying kinetochore-microtubule magic 🪄

Views are my own.

https://www.dundee.ac.uk/people/maxim-igaev
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maxotubule.bsky.social
Maxim Igaev @maxotubule.bsky.social · Jun 3
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
Reposted by Maxim Igaev
jjimenezluna.bsky.social
BioEmu is now on @science.org ! The revised version includes an upgraded model and makes a lot of MD simulation data internally generated at MSR available to the public. This took a lot of firepower from us in the last two years.
www.science.org/doi/10.1126/...
Scalable emulation of protein equilibrium ensembles with generative deep learning
Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that...
www.science.org
July 10, 2025 at 6:09 PM
Reposted by Maxim Igaev
mhko.bsky.social
New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring.

www.sciencedirect.com/science/arti...
A scheme of chemico-biological evolution of protein-RNA interactions. It started about 4.5 billion years ago with prebiotic monomers, went through peptides, oligonucleotides, and simple complexes, reaching proteins and RNA at about 4-3.7 billion years ago.
July 9, 2025 at 8:59 AM
Reposted by Maxim Igaev
compbiophys.bsky.social
📌Carter @carterjwilson.bsky.social‬ is presenting (P-2.44) "A Tale of Two #Aquaporins: Structural Mechanisms of Gating and Inhibition in Aqp3 and Aqp7" and + 📌Florian will explain (P-2.196) "How Loop #Dynamics Control Activity and Selectivity of a Short Chain #Reductase" Happy discussions! 👥
July 2, 2025 at 7:32 AM
Reposted by Maxim Igaev
compbiophys.bsky.social
Have a great D2@ #EBSA2025 in Rome🫠! Here are the posters of today's session: 📌Maksim @maksimkalutskii.bsky.social is presenting (P-2.195) his project addressing #Microtubule Dynamics Are Defined by Conformations and Stability of Clustered #Protofilaments 📜🔗 www.pnas.org/doi/10.1073/...
Microtubule dynamics are defined by conformations and stability of clustered protofilaments | PNAS
Microtubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at their ends. Microtubule growth, shortening, and transitions betw...
www.pnas.org
July 2, 2025 at 7:32 AM
Reposted by Maxim Igaev
deriverylab.bsky.social
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs
A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie
June 23, 2025 at 1:00 PM
Reposted by Maxim Igaev
manuelthery.bsky.social
the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours.
Alone you go faster, together we go further.
June 4, 2025 at 10:50 AM
Reposted by Maxim Igaev
vladimirvolkov.bsky.social
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
June 3, 2025 at 11:14 AM
Reposted by Maxim Igaev
hoxinsocks.bsky.social
( #TubulinTuesday! )
maxotubule.bsky.social Maxim Igaev @maxotubule.bsky.social · Jun 3
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 10, 2025 at 11:29 PM
Reposted by Maxim Igaev
vladimirvolkov.bsky.social
UK immigration policy is destabilising international academics’ careers. The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabu et al
www.timeshighereducation.com/opinion/uk-i...
UK immigration policy is destabilising international academics’ careers
The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabi, Fleura Bardhi and Laetitia Mimoun
www.timeshighereducation.com
June 8, 2025 at 5:49 PM
Reposted by Maxim Igaev
compbiophys.bsky.social
📜 Great work by Maksim and Co-authors! Congratulations to this latest #microtubule #publication in @pnas.org 🍾 @maxotubule.bsky.social @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social
maxotubule.bsky.social Maxim Igaev @maxotubule.bsky.social · Jun 3
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 5, 2025 at 8:56 AM
Reposted by Maxim Igaev
maxotubule.bsky.social
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 3, 2025 at 9:08 AM
Reposted by Maxim Igaev
matthchavent.bsky.social
Our joint paper with Wonpil Im lab is now available as a preprint:
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"

www.biorxiv.org/content/10.1...
May 27, 2025 at 1:06 PM
maxotubule.bsky.social
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 3, 2025 at 9:08 AM
Reposted by Maxim Igaev
rcbernardi.bsky.social
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...
February 17, 2025 at 6:56 AM
Reposted by Maxim Igaev
irobcross.bsky.social
Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
February 12, 2025 at 4:22 PM
Reposted by Maxim Igaev
compbiophys.bsky.social
The regular registration for on-site participation has been closed. However, it is still possible to join our workshop online! You find the link to the according registration on our workshop website 🔗https://www.mpinat.mpg.de/workshop/huenfeld #TheoryHünfeld2025 #biophysics
compbiophys.bsky.social CompBioPhys @compbiophys.bsky.social · Dec 4
📢 It's our great pleasure to invite you all to our upcoming #Workshop on "Computer Simulation and #Theory of Macromolecules" in #Hünfeld on March 7-8, 2025 in #hybrid format! See you online or on-site! More details are provided here: www.mpinat.mpg.de/workshop/hue... #TheoryHünfeld2025 #biophysics
January 7, 2025 at 9:55 AM
Reposted by Maxim Igaev
mhko.bsky.social
We have a PhD position in Molecular chemical physics at UCT Prague, Czechia. It is closely related to our research of the evolution of #protein-RNA interactions. A pre-PhD #internship available from January 2025. Apply directly by email to positions@mhko.science.
December 14, 2024 at 1:04 PM
Reposted by Maxim Igaev
martinvoegele.bsky.social
The inside of a cell is incredibly crowded! With advancing computing power and smart algorithms, this complex world is becoming more accessible through simulations.

This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...

#CompChem
Recent Progress in Modeling and Simulation of Biomolecular Crowding and Condensation Inside Cells
Macromolecular crowding in the cellular cytoplasm can potentially impact diffusion rates of proteins, their intrinsic structural stability, binding of proteins to their corresponding partners as well ...
pubs.acs.org
December 13, 2024 at 4:47 PM
Reposted by Maxim Igaev
ewaldlab.org
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉

We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.

I am beginning the search for two postdocs now - stay tuned for more details!

ewaldlab.org
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
ewaldlab.org
December 13, 2024 at 2:12 PM
Reposted by Maxim Igaev
mpibp.bsky.social
Do not miss our latest #cryoET work! 🕵️ Xing et al. present the dynamic architecture of TRiC in human cells! The study of this protein-folding chaperonin opens the door to understanding its dysfunction in diseases like cancer and neurodegeneration 🧠🧪 #teamTOMO @becklab.bsky.social
Chaperonin TRiC within human cells. The left panel displays a representative 3D map from a tomogram illustrating the spatial distribution of open and closed TRiC complexes in human cells. The top right panel highlights the interaction of PDCD5 with the CCT3-1-4 subunits of the open TRiC complex. The bottom right panel shows the closed TRiC complex forming clusters of two particles.
December 12, 2024 at 9:16 AM
Reposted by Maxim Igaev
jorgeferreira.bsky.social
Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you.
go.bsky.app/G5cQqYT
November 13, 2024 at 1:59 PM
Reposted by Maxim Igaev
micromotility.bsky.social
Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN
November 13, 2024 at 8:28 PM
Reposted by Maxim Igaev
sarahrauscher.bsky.social
In this work, we use all-atom MD simulations to elucidate why human and rhesus macaque TRIM5α differ in their ability to restrict HIV. See our manuscript by Liam Haas-Neill, Deniz Meneksedag-Erol & Ibraheem Andeejani --
December 11, 2024 at 7:51 PM
Reposted by Maxim Igaev
tetherin.bsky.social
Extended until the 17th of Dec
tetherin.bsky.social Stuart Neil @tetherin.bsky.social · Nov 27
I am looking for 2 postdoctoral researchers to join my lab to work on the role of HIV-1 accessory proteins in the pathogenesis of HIV/AIDS and viral latency.

Please contact me informally or ‘re-sky’ to anyone you think may be interested. Closing Dec 10th

www.jobs.ac.uk/job/DKV639/p...
Postdoctoral Research Associate at King's College London
Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
www.jobs.ac.uk
December 11, 2024 at 7:12 AM
Reposted by Maxim Igaev
chenxinli2.bsky.social
Friends don't let friends make bad graphs repo has been updated!

Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you?

#DataVisualization

github.com/cxli233/Frie...
A figure comparing box plot and showing all data points. Group1: normally distributed data. Group2: bimodal data. Group3: Data with 3 modes.
December 10, 2024 at 4:35 PM