Maxim Igaev
@maxotubule.bsky.social
Computational Biophysicist and Royal Society University Research Fellow at the School of Life Sciences, University of Dundee 🇬🇧
Studying kinetochore-microtubule magic 🪄
Views are my own.
https://www.dundee.ac.uk/people/maxim-igaev
Studying kinetochore-microtubule magic 🪄
Views are my own.
https://www.dundee.ac.uk/people/maxim-igaev
Pinned
Maxim Igaev
@maxotubule.bsky.social
· Jun 3
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
Reposted by Maxim Igaev
BioEmu is now on @science.org ! The revised version includes an upgraded model and makes a lot of MD simulation data internally generated at MSR available to the public. This took a lot of firepower from us in the last two years.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Scalable emulation of protein equilibrium ensembles with generative deep learning
Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that...
www.science.org
July 10, 2025 at 6:09 PM
BioEmu is now on @science.org ! The revised version includes an upgraded model and makes a lot of MD simulation data internally generated at MSR available to the public. This took a lot of firepower from us in the last two years.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Maxim Igaev
New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
July 9, 2025 at 8:59 AM
New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Maxim Igaev
📌Carter @carterjwilson.bsky.social is presenting (P-2.44) "A Tale of Two #Aquaporins: Structural Mechanisms of Gating and Inhibition in Aqp3 and Aqp7" and + 📌Florian will explain (P-2.196) "How Loop #Dynamics Control Activity and Selectivity of a Short Chain #Reductase" Happy discussions! 👥
July 2, 2025 at 7:32 AM
📌Carter @carterjwilson.bsky.social is presenting (P-2.44) "A Tale of Two #Aquaporins: Structural Mechanisms of Gating and Inhibition in Aqp3 and Aqp7" and + 📌Florian will explain (P-2.196) "How Loop #Dynamics Control Activity and Selectivity of a Short Chain #Reductase" Happy discussions! 👥
Reposted by Maxim Igaev
Have a great D2@ #EBSA2025 in Rome🫠! Here are the posters of today's session: 📌Maksim @maksimkalutskii.bsky.social is presenting (P-2.195) his project addressing #Microtubule Dynamics Are Defined by Conformations and Stability of Clustered #Protofilaments 📜🔗 www.pnas.org/doi/10.1073/...
Microtubule dynamics are defined by conformations and stability of clustered protofilaments | PNAS
Microtubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at
their ends. Microtubule growth, shortening, and transitions betw...
www.pnas.org
July 2, 2025 at 7:32 AM
Have a great D2@ #EBSA2025 in Rome🫠! Here are the posters of today's session: 📌Maksim @maksimkalutskii.bsky.social is presenting (P-2.195) his project addressing #Microtubule Dynamics Are Defined by Conformations and Stability of Clustered #Protofilaments 📜🔗 www.pnas.org/doi/10.1073/...
Reposted by Maxim Igaev
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
June 23, 2025 at 1:00 PM
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
Reposted by Maxim Igaev
the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours.
Alone you go faster, together we go further.
Alone you go faster, together we go further.
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
June 4, 2025 at 10:50 AM
the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours.
Alone you go faster, together we go further.
Alone you go faster, together we go further.
Reposted by Maxim Igaev
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
June 3, 2025 at 11:14 AM
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Reposted by Maxim Igaev
( #TubulinTuesday! )
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 10, 2025 at 11:29 PM
( #TubulinTuesday! )
Reposted by Maxim Igaev
UK immigration policy is destabilising international academics’ careers. The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabu et al
www.timeshighereducation.com/opinion/uk-i...
www.timeshighereducation.com/opinion/uk-i...
UK immigration policy is destabilising international academics’ careers
The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabi, Fleura Bardhi and Laetitia Mimoun
www.timeshighereducation.com
June 8, 2025 at 5:49 PM
UK immigration policy is destabilising international academics’ careers. The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabu et al
www.timeshighereducation.com/opinion/uk-i...
www.timeshighereducation.com/opinion/uk-i...
Reposted by Maxim Igaev
📜 Great work by Maksim and Co-authors! Congratulations to this latest #microtubule #publication in @pnas.org 🍾 @maxotubule.bsky.social @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 5, 2025 at 8:56 AM
📜 Great work by Maksim and Co-authors! Congratulations to this latest #microtubule #publication in @pnas.org 🍾 @maxotubule.bsky.social @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social
Reposted by Maxim Igaev
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 3, 2025 at 9:08 AM
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
Reposted by Maxim Igaev
Our joint paper with Wonpil Im lab is now available as a preprint:
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"
www.biorxiv.org/content/10.1...
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"
www.biorxiv.org/content/10.1...
May 27, 2025 at 1:06 PM
Our joint paper with Wonpil Im lab is now available as a preprint:
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"
www.biorxiv.org/content/10.1...
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"
www.biorxiv.org/content/10.1...
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 3, 2025 at 9:08 AM
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
Reposted by Maxim Igaev
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...
www.ks.uiuc.edu/Research/vmd...
February 17, 2025 at 6:56 AM
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...
www.ks.uiuc.edu/Research/vmd...
Reposted by Maxim Igaev
Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
February 12, 2025 at 4:22 PM
Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
Reposted by Maxim Igaev
The regular registration for on-site participation has been closed. However, it is still possible to join our workshop online! You find the link to the according registration on our workshop website 🔗https://www.mpinat.mpg.de/workshop/huenfeld #TheoryHünfeld2025 #biophysics
📢 It's our great pleasure to invite you all to our upcoming #Workshop on "Computer Simulation and #Theory of Macromolecules" in #Hünfeld on March 7-8, 2025 in #hybrid format! See you online or on-site! More details are provided here: www.mpinat.mpg.de/workshop/hue... #TheoryHünfeld2025 #biophysics
January 7, 2025 at 9:55 AM
The regular registration for on-site participation has been closed. However, it is still possible to join our workshop online! You find the link to the according registration on our workshop website 🔗https://www.mpinat.mpg.de/workshop/huenfeld #TheoryHünfeld2025 #biophysics
Reposted by Maxim Igaev
We have a PhD position in Molecular chemical physics at UCT Prague, Czechia. It is closely related to our research of the evolution of #protein-RNA interactions. A pre-PhD #internship available from January 2025. Apply directly by email to positions@mhko.science.
December 14, 2024 at 1:04 PM
We have a PhD position in Molecular chemical physics at UCT Prague, Czechia. It is closely related to our research of the evolution of #protein-RNA interactions. A pre-PhD #internship available from January 2025. Apply directly by email to positions@mhko.science.
Reposted by Maxim Igaev
The inside of a cell is incredibly crowded! With advancing computing power and smart algorithms, this complex world is becoming more accessible through simulations.
This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...
#CompChem
This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...
#CompChem
Recent Progress in Modeling and Simulation of Biomolecular Crowding and Condensation Inside Cells
Macromolecular crowding in the cellular cytoplasm can potentially impact diffusion rates of proteins, their intrinsic structural stability, binding of proteins to their corresponding partners as well ...
pubs.acs.org
December 13, 2024 at 4:47 PM
The inside of a cell is incredibly crowded! With advancing computing power and smart algorithms, this complex world is becoming more accessible through simulations.
This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...
#CompChem
This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...
#CompChem
Reposted by Maxim Igaev
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
ewaldlab.org
December 13, 2024 at 2:12 PM
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
Reposted by Maxim Igaev
Do not miss our latest #cryoET work! 🕵️ Xing et al. present the dynamic architecture of TRiC in human cells! The study of this protein-folding chaperonin opens the door to understanding its dysfunction in diseases like cancer and neurodegeneration 🧠🧪 #teamTOMO @becklab.bsky.social
December 12, 2024 at 9:16 AM
Do not miss our latest #cryoET work! 🕵️ Xing et al. present the dynamic architecture of TRiC in human cells! The study of this protein-folding chaperonin opens the door to understanding its dysfunction in diseases like cancer and neurodegeneration 🧠🧪 #teamTOMO @becklab.bsky.social
Reposted by Maxim Igaev
Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you.
go.bsky.app/G5cQqYT
go.bsky.app/G5cQqYT
November 13, 2024 at 1:59 PM
Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you.
go.bsky.app/G5cQqYT
go.bsky.app/G5cQqYT
Reposted by Maxim Igaev
Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN
November 13, 2024 at 8:28 PM
Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN
Reposted by Maxim Igaev
In this work, we use all-atom MD simulations to elucidate why human and rhesus macaque TRIM5α differ in their ability to restrict HIV. See our manuscript by Liam Haas-Neill, Deniz Meneksedag-Erol & Ibraheem Andeejani --
December 11, 2024 at 7:51 PM
In this work, we use all-atom MD simulations to elucidate why human and rhesus macaque TRIM5α differ in their ability to restrict HIV. See our manuscript by Liam Haas-Neill, Deniz Meneksedag-Erol & Ibraheem Andeejani --
Reposted by Maxim Igaev
Extended until the 17th of Dec
I am looking for 2 postdoctoral researchers to join my lab to work on the role of HIV-1 accessory proteins in the pathogenesis of HIV/AIDS and viral latency.
Please contact me informally or ‘re-sky’ to anyone you think may be interested. Closing Dec 10th
www.jobs.ac.uk/job/DKV639/p...
Please contact me informally or ‘re-sky’ to anyone you think may be interested. Closing Dec 10th
www.jobs.ac.uk/job/DKV639/p...
Postdoctoral Research Associate at King's College London
Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
www.jobs.ac.uk
December 11, 2024 at 7:12 AM
Extended until the 17th of Dec
Reposted by Maxim Igaev
Friends don't let friends make bad graphs repo has been updated!
Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you?
#DataVisualization
github.com/cxli233/Frie...
Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you?
#DataVisualization
github.com/cxli233/Frie...
December 10, 2024 at 4:35 PM
Friends don't let friends make bad graphs repo has been updated!
Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you?
#DataVisualization
github.com/cxli233/Frie...
Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you?
#DataVisualization
github.com/cxli233/Frie...