Max Mahe
@maxmmahe.bsky.social
Scientist 👨🔬 - organoid developer 🧫 - fascinated by gut development/physiology - developing regenerative medicine strategies 💊
Pinned
Max Mahe
@maxmmahe.bsky.social
· Apr 28
🚀 Ouverture des pré-inscriptions ! 🚀
Rejoignez-nous à Nantes pour l’École Thématique Organoïdes 2025 🧬 Découvrez notre pré-programme complet !
⚠️ Places limitées – La pré-inscription est indispensable pour participer.
📋 Plus d’infos et pré-inscription ici : organoides.sciencesconf.org
Rejoignez-nous à Nantes pour l’École Thématique Organoïdes 2025 🧬 Découvrez notre pré-programme complet !
⚠️ Places limitées – La pré-inscription est indispensable pour participer.
📋 Plus d’infos et pré-inscription ici : organoides.sciencesconf.org
Reposted by Max Mahe
Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis https://www.biorxiv.org/content/10.1101/2025.10.31.685661v1
November 1, 2025 at 7:30 AM
Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis https://www.biorxiv.org/content/10.1101/2025.10.31.685661v1
Reposted by Max Mahe
Morphogen gradients applied basally to human embryonic stem cells to control and dissect tissue patterning https://www.biorxiv.org/content/10.1101/2025.10.30.682158v1
October 31, 2025 at 11:34 AM
Morphogen gradients applied basally to human embryonic stem cells to control and dissect tissue patterning https://www.biorxiv.org/content/10.1101/2025.10.30.682158v1
Reposted by Max Mahe
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
October 23, 2025 at 12:49 PM
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
Reposted by Max Mahe
We use CODA to map human endometrial tissue at single-cell resolution, a map that then serves as a blueprint to design a multi-compartment multicellular assembloid of the endometrium.
Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...
Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...
October 18, 2025 at 3:41 PM
We use CODA to map human endometrial tissue at single-cell resolution, a map that then serves as a blueprint to design a multi-compartment multicellular assembloid of the endometrium.
Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...
Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...
Reposted by Max Mahe
Katia took the initiative to start a Xenopus project in the lab a few years ago —and now her work is highlighted by Development! Huge congrats, Katia!
Explant elongation initiates in the epithelium
A Research Highlight showcasing new work from @katiabarrett.bsky.social, Shalabh Anand, Virginie Thome, Laurent Kodjabachian, @merkellab.bsky.social, @pflenne.bsky.social
journals.biologists.com/dev/article/...
A Research Highlight showcasing new work from @katiabarrett.bsky.social, Shalabh Anand, Virginie Thome, Laurent Kodjabachian, @merkellab.bsky.social, @pflenne.bsky.social
journals.biologists.com/dev/article/...
July 31, 2025 at 10:39 AM
Katia took the initiative to start a Xenopus project in the lab a few years ago —and now her work is highlighted by Development! Huge congrats, Katia!
Reposted by Max Mahe
The human proteome and organ age clocks across the lifespan, a tour de force report @cellpress.bsky.social
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures
A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling,
proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying
circulating senoproteins co...
www.cell.com
July 25, 2025 at 2:51 PM
The human proteome and organ age clocks across the lifespan, a tour de force report @cellpress.bsky.social
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Max Mahe
🚨 After 7 years in the making, my PhD thesis work is finally published in @science.org 🧬✨
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11
July 24, 2025 at 12:49 PM
🚨 After 7 years in the making, my PhD thesis work is finally published in @science.org 🧬✨
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves
Reposted by Max Mahe
Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11
July 24, 2025 at 12:36 PM
Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11
Reposted by Max Mahe
The gut's 'sixth sense' microbiome regulating eating behavior in real time, another new path for the gut-brain axis, "neurobiotic," in the mouse model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 23, 2025 at 4:46 PM
The gut's 'sixth sense' microbiome regulating eating behavior in real time, another new path for the gut-brain axis, "neurobiotic," in the mouse model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Max Mahe
🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9
July 23, 2025 at 7:09 PM
🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9
Elegant and insightful study on gut evolution and development - congratulations 🎊@graycamplab.bsky.social @umut-kilik.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Recent evolution of the developing human intestine affects metabolic and barrier functions
Diet, microbiota, and other exposures place the intestinal epithelium as a nexus for evolutionary change; however, little is known about genomic changes associated with adaptation to a uniquely human ...
www.science.org
July 19, 2025 at 8:41 PM
Elegant and insightful study on gut evolution and development - congratulations 🎊@graycamplab.bsky.social @umut-kilik.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Max Mahe
Recent evolution of the developing human intestine affects metabolic and barrier functions @science.org @graycamplab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
July 17, 2025 at 7:23 PM
Recent evolution of the developing human intestine affects metabolic and barrier functions @science.org @graycamplab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Max Mahe
My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...
July 12, 2025 at 10:11 PM
My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...
Reposted by Max Mahe
Pathology-oriented multiplexing enables integrative disease mapping @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 18, 2025 at 3:20 PM
Pathology-oriented multiplexing enables integrative disease mapping @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Max Mahe
Pooled #CRISPR screens are a staple of functional genomics in mammalian cells. Yet somehow in the best genetic model™ no equivalent system was available. Until now! The @perrimonlab.bsky.social lab now presents efficient pooled CRISPR screening in #Drosophila cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) - Nature Communications
Genome-wide CRISPR screens map how genes support survival and contribute to diverse biological functions. Here, the authors use antiCRISPR to enhance genome-wide CRISPR screening in Drosophila and gen...
www.nature.com
July 17, 2025 at 6:04 PM
Pooled #CRISPR screens are a staple of functional genomics in mammalian cells. Yet somehow in the best genetic model™ no equivalent system was available. Until now! The @perrimonlab.bsky.social lab now presents efficient pooled CRISPR screening in #Drosophila cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Max Mahe
New OpenProblems paper out! 📝
Led by Malte Lücken with Smita Krishnaswamy, we present openproblems.bio – a community-driven platform benchmarking single-cell analysis methods.
Excited about transparent, evolving best practices for the field!
🔗 www.nature.com/articles/s41...
Led by Malte Lücken with Smita Krishnaswamy, we present openproblems.bio – a community-driven platform benchmarking single-cell analysis methods.
Excited about transparent, evolving best practices for the field!
🔗 www.nature.com/articles/s41...
Defining and benchmarking open problems in single-cell analysis - Nature Biotechnology
Nature Biotechnology - Defining and benchmarking open problems in single-cell analysis
www.nature.com
July 3, 2025 at 6:35 AM
New OpenProblems paper out! 📝
Led by Malte Lücken with Smita Krishnaswamy, we present openproblems.bio – a community-driven platform benchmarking single-cell analysis methods.
Excited about transparent, evolving best practices for the field!
🔗 www.nature.com/articles/s41...
Led by Malte Lücken with Smita Krishnaswamy, we present openproblems.bio – a community-driven platform benchmarking single-cell analysis methods.
Excited about transparent, evolving best practices for the field!
🔗 www.nature.com/articles/s41...
Reposted by Max Mahe
We are very excited to close this years meeting with a keynote talk by Prof Jason Spence from @umich.edu. Understanding human lung development with bud tip, airway and Alveolar type2 (AT2)organoids. Unexpected transcriptional heterogeneity found in early postnatal AT2 cells occupying distinct niches
June 25, 2025 at 2:38 PM
We are very excited to close this years meeting with a keynote talk by Prof Jason Spence from @umich.edu. Understanding human lung development with bud tip, airway and Alveolar type2 (AT2)organoids. Unexpected transcriptional heterogeneity found in early postnatal AT2 cells occupying distinct niches
Reposted by Max Mahe
Episode 2️⃣ Comment la souris est devenue le modèle par excellence ? Les souris représentent près de 70 % des animaux utilisés en laboratoire. Comment expliquer ce choix ? S'est-il imposé dès le début de l'expérimentation animale ? Quelles sont les limites d’un tel modèle ?
Avec Jean-Gaël Barbara 🐁
Avec Jean-Gaël Barbara 🐁
June 24, 2025 at 5:30 AM
Episode 2️⃣ Comment la souris est devenue le modèle par excellence ? Les souris représentent près de 70 % des animaux utilisés en laboratoire. Comment expliquer ce choix ? S'est-il imposé dès le début de l'expérimentation animale ? Quelles sont les limites d’un tel modèle ?
Avec Jean-Gaël Barbara 🐁
Avec Jean-Gaël Barbara 🐁
Reposted by Max Mahe
Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...
June 24, 2025 at 4:04 PM
Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...
Reposted by Max Mahe
@bacell3d.bsky.social 2025 has begun with a bang! Time for a start selfie!
June 23, 2025 at 11:25 AM
@bacell3d.bsky.social 2025 has begun with a bang! Time for a start selfie!
Reposted by Max Mahe
We’re all set!
With 400 participants, 200 posters, and a stellar scientific program featuring both renowned experts and emerging researchers, BaCell3D 2025 is shaping up to be another unforgettable event—happening June 23–25 at the ZLF Hall, University of Basel.
With 400 participants, 200 posters, and a stellar scientific program featuring both renowned experts and emerging researchers, BaCell3D 2025 is shaping up to be another unforgettable event—happening June 23–25 at the ZLF Hall, University of Basel.
June 21, 2025 at 9:40 PM
We’re all set!
With 400 participants, 200 posters, and a stellar scientific program featuring both renowned experts and emerging researchers, BaCell3D 2025 is shaping up to be another unforgettable event—happening June 23–25 at the ZLF Hall, University of Basel.
With 400 participants, 200 posters, and a stellar scientific program featuring both renowned experts and emerging researchers, BaCell3D 2025 is shaping up to be another unforgettable event—happening June 23–25 at the ZLF Hall, University of Basel.
Reposted by Max Mahe
How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
June 18, 2025 at 5:11 PM
How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Max Mahe
The long-term goal is to grow human organs that can be harvested for transplantation
https://go.nature.com/3ST2BN7
https://go.nature.com/3ST2BN7
Mice with human cells developed using ‘game-changing’ technique
Human cells injected into amniotic fluid find their way into fetal mouse organs.
go.nature.com
June 16, 2025 at 12:56 PM
The long-term goal is to grow human organs that can be harvested for transplantation
https://go.nature.com/3ST2BN7
https://go.nature.com/3ST2BN7
Reposted by Max Mahe
New work on dynamics of morphogen signaling:
Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input
Morphogen signalling dynamics + GRN for tissue patterning
www.biorxiv.org/content/10.1...
Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input
Morphogen signalling dynamics + GRN for tissue patterning
www.biorxiv.org/content/10.1...
Rapid transcriptional response to a dynamic morphogen by time integration
During development, cells must interpret extracellular signals with speed and accuracy. While morphogen gradients pattern tissues, how cells respond to dynamic morphogens remains unclear. Here, we inv...
www.biorxiv.org
June 10, 2025 at 8:07 AM
New work on dynamics of morphogen signaling:
Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input
Morphogen signalling dynamics + GRN for tissue patterning
www.biorxiv.org/content/10.1...
Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input
Morphogen signalling dynamics + GRN for tissue patterning
www.biorxiv.org/content/10.1...
Reposted by Max Mahe
3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation
3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation
Yu and his colleagues present a 3D spatial transcriptomic map of a CS9 human embryo, investigating several key developmental events during this critical stage of body patterning.
dlvr.it
June 9, 2025 at 2:11 PM
3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation