Matt Whelan / Mathúin Ó Faoláin
@mattvxwhelan.bsky.social
Wellcome Trust Early Career Investigator allied with Jolly and Henriques labs based in QMUL #Cellular #Microbiologist doing #LIVE/#SR #Microscopy of #HIV, #NuclearPores #Tcells and all things #Trafficking and #Host #Cell ?manipulation by #Pathogens!
Reposted by Matt Whelan / Mathúin Ó Faoláin
📢 Join us next week for our mini-symposium with the membrane trafficking webinar series
Featuring talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and a keynote lecture from Gillian Griffiths @griffithslab.bsky.social.
Featuring talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and a keynote lecture from Gillian Griffiths @griffithslab.bsky.social.
FocalPlane features... membrane trafficking - FocalPlane
FocalPlane features... membrane trafficking - News
focalplane.biologists.com
September 18, 2025 at 2:01 PM
📢 Join us next week for our mini-symposium with the membrane trafficking webinar series
Featuring talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and a keynote lecture from Gillian Griffiths @griffithslab.bsky.social.
Featuring talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and a keynote lecture from Gillian Griffiths @griffithslab.bsky.social.
Great to see this in the wild!
Excited to share the preprint for our work on cyclosporine-based lentiviral transduction enhancer, BG147, which degrades innate immune barrier IFITM3, increasing gene delivery in gene therapy.
Huge thanks to everyone involved! @towerslab.bsky.social
www.biorxiv.org/content/10.1...
Huge thanks to everyone involved! @towerslab.bsky.social
www.biorxiv.org/content/10.1...
A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3
Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A analogue, optimised vi...
www.biorxiv.org
September 8, 2025 at 4:18 PM
Great to see this in the wild!
Reposted by Matt Whelan / Mathúin Ó Faoláin
Call for papers: Cell Biology of the Nucleus
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
July 16, 2025 at 12:53 PM
Call for papers: Cell Biology of the Nucleus
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social.
journals.biologists.com/jcs/pages/nu...
I'll be there!
1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
July 23, 2025 at 11:47 PM
I'll be there!
Really excited to be back in my home away from home, Berlin, for my first conference in Germany:
"Life at the Edge: The nuclear envelope in nucleocytoplasmic transport and genome organisation"
Really looking forward to it!
"Life at the Edge: The nuclear envelope in nucleocytoplasmic transport and genome organisation"
Really looking forward to it!
July 23, 2025 at 3:23 PM
Really excited to be back in my home away from home, Berlin, for my first conference in Germany:
"Life at the Edge: The nuclear envelope in nucleocytoplasmic transport and genome organisation"
Really looking forward to it!
"Life at the Edge: The nuclear envelope in nucleocytoplasmic transport and genome organisation"
Really looking forward to it!
Reposted by Matt Whelan / Mathúin Ó Faoláin
Come work at Nature Methods! A dream job. I know from experience 😄
Nature Methods is hiring!
We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model.
Apply by August 3!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model.
Apply by August 3!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
a yellow sign that says we 're hiring
ALT: a yellow sign that says we 're hiring
media.tenor.com
July 10, 2025 at 12:35 PM
Come work at Nature Methods! A dream job. I know from experience 😄
Hyped to be moving to the Blizard Institute @qmul.bsky.social in the Autumn.
As part of an exciting new development in infection research within the Blizard, I’ll be a Group Leader, Academic Lead of the Blizard Advanced Light Microscopy (BALM) Facility and soon take up a Senior Lectureship.
As part of an exciting new development in infection research within the Blizard, I’ll be a Group Leader, Academic Lead of the Blizard Advanced Light Microscopy (BALM) Facility and soon take up a Senior Lectureship.
We are delighted to be joining the Blizard Institute in Autumn. The Blizard Institute is an amazing place for discovery science and we're looking forward to more transformative research and collaborations.
www.qmul.ac.uk/blizard/abou...
www.qmul.ac.uk/blizard/abou...
Blizard Institute welcomes world-leading team of virologists
www.qmul.ac.uk
July 10, 2025 at 3:02 PM
Hyped to be moving to the Blizard Institute @qmul.bsky.social in the Autumn.
As part of an exciting new development in infection research within the Blizard, I’ll be a Group Leader, Academic Lead of the Blizard Advanced Light Microscopy (BALM) Facility and soon take up a Senior Lectureship.
As part of an exciting new development in infection research within the Blizard, I’ll be a Group Leader, Academic Lead of the Blizard Advanced Light Microscopy (BALM) Facility and soon take up a Senior Lectureship.
Hugely excited to work with this!
It's here! ✨
The #ExSRRF protocol paper is out 😍. Full details for merging Expansion Microscopy with our eSRRF analysis. From cells to tissue. A partnership with @puellesv.bsky.social's lab. Lead by Dominik Kylies and @hannah-superres.bsky.social + colleagues. #ExM #eSRRF
➡️ Open link: rdcu.be/euvEw
The #ExSRRF protocol paper is out 😍. Full details for merging Expansion Microscopy with our eSRRF analysis. From cells to tissue. A partnership with @puellesv.bsky.social's lab. Lead by Dominik Kylies and @hannah-superres.bsky.social + colleagues. #ExM #eSRRF
➡️ Open link: rdcu.be/euvEw
July 3, 2025 at 5:38 PM
Hugely excited to work with this!
This was a lot of fun!
Great to be back in my Alma Mater.
Great to be back in my Alma Mater.
🧪Great talk by @mattvxwhelan.bsky.social in the @ucddublin.bsky.social Conway CLASS lecture.
Amazing images of HIV / Nuclear interactions
Amazing images of HIV / Nuclear interactions
June 11, 2025 at 8:34 AM
This was a lot of fun!
Great to be back in my Alma Mater.
Great to be back in my Alma Mater.
Great to see this out! And very fitting the last publication from my PhD is in a @microbiologysociety.org journal. Who played a significant role in supporting my EARLY early career!
New paper from @mattvxwhelan.bsky.social from his PhD looking at Campylobacter invasion of intestinal spheroids and
published in Microbiology. Remember supporting our society's journals ensures they can continue to support us!!
@microbiologysociety.org www.microbiologyresearch.org/content/jour...
published in Microbiology. Remember supporting our society's journals ensures they can continue to support us!!
@microbiologysociety.org www.microbiologyresearch.org/content/jour...
An invasive phenotype induced by relaxation of DNA supercoiling in Campylobacter jejuni triggers disruption of tight junctions of intestinal spheroids
The relaxation of DNA supercoiling in Campylobacter jejuni leads to increased protein secretion and a more invasive phenotype, but little is known about the specific mechanisms involved. The aim of th...
www.microbiologyresearch.org
June 6, 2025 at 8:56 PM
Great to see this out! And very fitting the last publication from my PhD is in a @microbiologysociety.org journal. Who played a significant role in supporting my EARLY early career!
Reposted by Matt Whelan / Mathúin Ó Faoláin
I cannot believe I didn't post about dark sectioning! I can only blame my crazy travel schedule. Check out this amazing tool for background removal in fluorescence microscopy. An important new concept, not 'just another' denoising algorithm.
Our groundbreaking Dark Sectioning technique is now published in Nature Methods! 🎉 It supercharges existing imaging systems:
🔬 Widefield → Confocal
🔬 Single-photon → Multiphoton
🔬 2D-SIM → 3D-SIM
Now integrated in Airy PolarSIM and #FlexSIM!
doi.org/10.1038/s415...
#Microscopy #Fluorescence
🔬 Widefield → Confocal
🔬 Single-photon → Multiphoton
🔬 2D-SIM → 3D-SIM
Now integrated in Airy PolarSIM and #FlexSIM!
doi.org/10.1038/s415...
#Microscopy #Fluorescence
May 29, 2025 at 1:57 AM
I cannot believe I didn't post about dark sectioning! I can only blame my crazy travel schedule. Check out this amazing tool for background removal in fluorescence microscopy. An important new concept, not 'just another' denoising algorithm.
May 23, 2025 at 4:16 PM
Reposted by Matt Whelan / Mathúin Ó Faoláin
Yesterday, @mattvxwhelan.bsky.social gave a fantastic talk! Thanks for all the engaging questions and all the great science chat afterwards! #cshretro
May 21, 2025 at 6:45 AM
Yesterday, @mattvxwhelan.bsky.social gave a fantastic talk! Thanks for all the engaging questions and all the great science chat afterwards! #cshretro
It was a huge honour to speak today in the beautiful locale of Cold Spring Harbor, Long Island, NY. At an epic post entry events session on the 50th anniversary of #CSH #Retroviruses
May 20, 2025 at 11:41 PM
It was a huge honour to speak today in the beautiful locale of Cold Spring Harbor, Long Island, NY. At an epic post entry events session on the 50th anniversary of #CSH #Retroviruses
Can't wait for this!
After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti.
To register your interest: www.biologists.com/meetings/jcs...
To register your interest: www.biologists.com/meetings/jcs...
May 20, 2025 at 10:04 AM
Can't wait for this!
Reposted by Matt Whelan / Mathúin Ó Faoláin
Our latest preprint list is now up on FocalPlane. Our list this week is focusses on research using 🔬microscopy tools to answer questions in biology.
As always, please let us know if there are other preprints that you’d like to see included.
focalplane.biologists.com/2025/05/16/m...
As always, please let us know if there are other preprints that you’d like to see included.
focalplane.biologists.com/2025/05/16/m...
Microscopy preprints - applications in biology - FocalPlane
Microscopy preprints - applications in biology - News
focalplane.biologists.com
May 16, 2025 at 3:36 PM
Our latest preprint list is now up on FocalPlane. Our list this week is focusses on research using 🔬microscopy tools to answer questions in biology.
As always, please let us know if there are other preprints that you’d like to see included.
focalplane.biologists.com/2025/05/16/m...
As always, please let us know if there are other preprints that you’d like to see included.
focalplane.biologists.com/2025/05/16/m...
Join us at Virtual Virology for an afternoon of excellent science!
Virtual Virology is back - our first ever phage session. Do join us...
May 12, 2025 at 12:39 PM
Join us at Virtual Virology for an afternoon of excellent science!
Reposted by Matt Whelan / Mathúin Ó Faoláin
🖱️ Picking out individual cells in distorted microscopy images is now as easy as clicking a button, thanks to Cellpose3: www.janelia.org/news/newest-...
Newest version of Cellpose can spot cell boundaries even in cloudy conditions
Picking out individual cells in distorted microscopy images is now as easy as clicking a button. A new version of Cellpose – the popular tool that maps the boundaries of diverse cells in microscopy
www.janelia.org
May 9, 2025 at 1:22 PM
🖱️ Picking out individual cells in distorted microscopy images is now as easy as clicking a button, thanks to Cellpose3: www.janelia.org/news/newest-...
Reposted by Matt Whelan / Mathúin Ó Faoláin
A computational framework links transcriptomic analyses with mechanical signatures to study the interplay between cell mechanical forces and gene expression.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 17, 2025 at 4:51 PM
A computational framework links transcriptomic analyses with mechanical signatures to study the interplay between cell mechanical forces and gene expression.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Matt Whelan / Mathúin Ó Faoláin
We are #hiring!
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
March 19, 2025 at 11:50 AM
We are #hiring!
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
Reposted by Matt Whelan / Mathúin Ó Faoláin
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
February 27, 2025 at 8:13 PM
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Reposted by Matt Whelan / Mathúin Ó Faoláin
[Phys.Org]A completely new type of microscopy based on quantum sensors - Phys.org Researchers at the Technical University of Munich (TUM) have invented an entirely new field of microscopy called nuclear spin microscopy. The team can visualize magnetic signals of nuclear magnetic resonance with a...
February 27, 2025 at 8:30 PM
[Phys.Org]A completely new type of microscopy based on quantum sensors - Phys.org Researchers at the Technical University of Munich (TUM) have invented an entirely new field of microscopy called nuclear spin microscopy. The team can visualize magnetic signals of nuclear magnetic resonance with a...
Reposted by Matt Whelan / Mathúin Ó Faoláin
We wrote a protocol to quantify plasma membrane fluidity using a confocal microscope 🔬
Hopefully those interested in measuring membrane biophysical properties in live cells find it useful.
We also provide an ImageJ/Fiji tool to make the analysis as easy as possible.
www.nature.com/articles/s41...
Hopefully those interested in measuring membrane biophysical properties in live cells find it useful.
We also provide an ImageJ/Fiji tool to make the analysis as easy as possible.
www.nature.com/articles/s41...
Measuring plasma membrane fluidity using confocal microscopy - Nature Protocols
Membrane fluidity is a crucial feature in understanding cellular physiology. This protocol describes a robust pipeline for measuring plasma membrane fluidity using confocal imaging and new environment...
www.nature.com
February 19, 2025 at 4:54 PM
We wrote a protocol to quantify plasma membrane fluidity using a confocal microscope 🔬
Hopefully those interested in measuring membrane biophysical properties in live cells find it useful.
We also provide an ImageJ/Fiji tool to make the analysis as easy as possible.
www.nature.com/articles/s41...
Hopefully those interested in measuring membrane biophysical properties in live cells find it useful.
We also provide an ImageJ/Fiji tool to make the analysis as easy as possible.
www.nature.com/articles/s41...
Reposted by Matt Whelan / Mathúin Ó Faoláin
Bring your samples into focus! A new version of the #Cellpose cell boundary mapping tool, developed at @hhmijanelia.bsky.social by @computingnature.bsky.social and @marius10p.bsky.social, now works on less-than-perfect microscopy images that are noisy, blurry, or undersampled.
Newest version of Cellpose can spot cell boundaries even in cloudy conditions
Picking out individual cells in distorted microscopy images is now as easy as clicking a button. A new version of Cellpose – the popular tool that maps the boundaries of diverse cells in microscopy
buff.ly
February 17, 2025 at 1:42 PM
Bring your samples into focus! A new version of the #Cellpose cell boundary mapping tool, developed at @hhmijanelia.bsky.social by @computingnature.bsky.social and @marius10p.bsky.social, now works on less-than-perfect microscopy images that are noisy, blurry, or undersampled.
Reposted by Matt Whelan / Mathúin Ó Faoláin
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2
February 4, 2025 at 9:22 AM
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2