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matthew-batisio.bsky.social
Matthew Clark
@matthew-batisio.bsky.social
1.2K followers 750 following 15 posts
Cellular Structural Biology Wellcome DPhil Student at The University of Oxford.

Currently working in Peijun Zhang’s lab at The Oxford Division of Structural Biology.

Passionate about biomedical animation and science communication: Batisio.co.uk
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matthew-batisio.bsky.social
Matthew Clark @matthew-batisio.bsky.social · Nov 25
I am excited to share this animation of the budding yeast inner kinetochore. Created for David Barford's lab @mrclmb.bsky.social

This DNA-binding protein complex acts as an anchor for the spindles that pull chromosomes apart during mitosis.
www.science.org/doi/10.1126/...

#blender #animation #b3d
Reposted by Matthew Clark
mrclmb.bsky.social
Missed the 2025 Next Generation Biophysics Symposium?
Great news – you can now watch the fantastic talks on our YouTube channel!
www.youtube.com/playlist?lis...

Don't miss these great discussions on how new and emerging technologies may be able to address challenging biological questions.
Next Generation Biophysics Symposium 2025 - YouTube
The Next Generation Biophysics Symposium is an annual event, organised by MRC LMB, AstraZeneca, Imperial College London and MRC LMS examining the application...
www.youtube.com
November 5, 2025 at 3:37 PM
Reposted by Matthew Clark
maxewilkinson.bsky.social
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social

🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
Wilkinson Lab
We discover and study reverse transcriptases
wilkinsonlab.bio
October 31, 2025 at 7:00 PM
Reposted by Matthew Clark
lowlab.bsky.social
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...
October 29, 2025 at 5:11 PM
Reposted by Matthew Clark
dodonova-sveta.bsky.social
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Reposted by Matthew Clark
eth-dbiol.bsky.social
The centriole is crucial for cilia formation, but its molecular architecture is not known. Research from the @Wieczorek Group at ETH Zurich reports structures of the centriole’s A-C linker, revealing how it crosslinks neighboring microtubule triplets. More: biol.ethz.ch/en/news-and-...
October 20, 2025 at 2:57 PM
Reposted by Matthew Clark
robklose.bsky.social
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
Reposted by Matthew Clark
cppape.bsky.social
Are you studying synapses in electron microscopy? Tired of annotating vesicles? We have the tool for you! SynapseNet implements automatic segmentation and analysis of vesicles and other synaptic structures and has now been published:
www.molbiolcell.org/doi/full/10....
SynapseNet is a deep learning based software tool that automates the segmentation of vesicles, mitochondria, synaptic compartments, and the active zone. This is visualized in three panels. On the left, a section of an electron tomogram with a synaptic compartment densely filled with vesicles, which appear as round structures with dark boundary and light body in the image, is shwon. The top right panel shows the segmentation result of vesicles, visualized by masks with an individual color per vesicle and outlines for the segmented compartment (red) and active zone (blue). The bottom right panels shows a 3D rendering of the segmentation with vesicles shown as yellow spheres.
October 17, 2025 at 11:09 AM
Reposted by Matthew Clark
mike-wieczorek.bsky.social
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles
Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.
www.science.org
October 10, 2025 at 1:14 PM
Reposted by Matthew Clark
dyneinassembly.bsky.social
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary
September 29, 2025 at 7:09 PM
Reposted by Matthew Clark
natsmb.nature.com
New online: Molecular basis for the activation of outer dynein arms in cilia
Molecular basis for the activation of outer dynein arms in cilia
Nature Structural & Molecular Biology, Published online: 29 September 2025; doi:10.1038/s41594-025-01680-9Issa et al. show that the ciliary small guanosine triphosphatase Arl3 displaces the inhibitory regulator Shulin/DNAAF9 from the outer dynein arm, leading to motor activation.
go.nature.com
September 29, 2025 at 3:15 PM
Reposted by Matthew Clark
lapassmore.bsky.social
We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM
September 27, 2025 at 11:07 AM
Reposted by Matthew Clark
matthiaswilmanns.bsky.social
We are excited to share our latest work, where we unravel the structural and functional secrets of the once-mysterious protein Pex8 revealing how it controls the peroxisomal cargo import receptor Pex5.

Read more here: www.biorxiv.org/content/10.1101/2025.08.30.673231v1
Ensemble model of the full length Pex5 receptor (different blue color) in complex with Pex8 (green colors). Key Findings: Pex8 binds to a novel site on the mostly unfolded N-terminal region of the Pex5 receptor. This interaction is essential for peroxisomal protein import. Computational modelling reveals the formation of an assembly with the trimeric peroxisomal E3-ubiquitin ligase. We propose that this action positions the Pex5 receptor for its recycling, a step essential for the entire protein import process. Why this matters: Peroxisomes rely entirely on the import of folded proteins to function. Impaired peroxisome function is linked to severe disorders, and recent data show their crucial roles in carcinogenesis and the immune response. Our work elevates Pex8 from an enigma to a central player in this critical biological process. Read the full story and see the structures here: https://www.biorxiv.org/content/10.1101/2025.08.30.673231v1 #CellBiology #StructuralBiology #Peroxisome #ProteinImport #bioRxiv #Biochemistry
September 3, 2025 at 10:28 AM
Reposted by Matthew Clark
amunts.bsky.social
Stunning cryo-ET from Peijun Zhang lab: Direct visualization of HIV-1 nuclear import!
Hundreds of viral cores captured entering the nucleus. The NPC dilates to let the capsid through. A masterclass in correlative microscopy that makes it quantitative. A leap for structural virology! @emboreports.org
August 29, 2025 at 1:42 PM
Reposted by Matthew Clark
martinpacesa.bsky.social
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...
August 27, 2025 at 4:14 PM
Reposted by Matthew Clark
gautamdey.bsky.social
Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
August 7, 2025 at 6:12 PM
Reposted by Matthew Clark
watchclockwork.com
🕒 NEW VIDEO 🕒

How can a cell know the time? Let's explore the beautiful 24-hour cycle produced by #KaiC proteins in the cyanobacteria S. Elongatus. Rendered in #blender3d with @bradyajohnston.bsky.social's brilliant Molecular Nodes add-on. #biology
August 5, 2025 at 4:00 PM
Reposted by Matthew Clark
rezamehdipour.bsky.social
We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!!
www.biorxiv.org/content/10.1...
August 5, 2025 at 12:41 PM
Reposted by Matthew Clark
carter-lab.bsky.social
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
August 5, 2025 at 10:43 AM
Reposted by Matthew Clark
jordanraff.bsky.social
The Dunn School is a really great environment for taking up a Career Development Fellowship, and we are looking for candidates! Please spread the word.
dunnschool.bsky.social The Dunn School, Oxford @dunnschool.bsky.social · Jul 30
📣 Applications now open 📣

We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!

Please share!

www.path.ox.ac.uk/work-with-us...
July 31, 2025 at 7:59 AM
Reposted by Matthew Clark
dr-downes.bsky.social
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!

Make my day and check it out!
www.biorxiv.org/content/10.1...

#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
July 30, 2025 at 3:28 PM
Reposted by Matthew Clark
kattoropova.bsky.social
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
July 29, 2025 at 9:04 AM
Reposted by Matthew Clark
costalaboratory.bsky.social
Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...
Postdoctoral Fellow - Costa Lab
Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...
crick.wd3.myworkdayjobs.com
July 21, 2025 at 2:57 PM
Reposted by Matthew Clark
parasitematt.bsky.social
Delighted to share the final version of Richard Zhou's study on how the CD163 scavenger receptor cleans up after toxic haemoglobin spills out from our blood cells. An amazing grabber mechanism!
rdcu.be/ewPA2
July 18, 2025 at 1:39 PM
Reposted by Matthew Clark
dannybhgold.bsky.social
🎉 Excited to share my first paper as 2nd author! From the Barr & Gruneberg labs, this work explores the structure of the Chromosome Passenger Complex (CPC) and suggests a ‘pivot–tether’ model for how it binds H3pT3-phosphorylated nucleosomes
@oxfordbiochemistry.bsky.social @dunnschool.bsky.social
July 15, 2025 at 8:29 PM
matthew-batisio.bsky.social
IFT trains are really cool - and what better way to communicate their structure than baking a cake?

Created for my 1st year PhD project with Anthony Roberts and @kattoropova.bsky.social

IFT-A 🟡 IFT-B 🟢 Dynein-2 🔵
Matthew Clark holding a tray with a layered rectangular cake, showing the periodic repeating structure of IFT-A and IFT-B. Gingerbread cookies cut in the shape of dynein-2 ride on top. A close up photo of the cake on a table, showing the periodic repeating structure of IFT-A and IFT-B. Gingerbread cookies cut in the shape of dynein-2 ride on top.
July 17, 2025 at 10:21 AM