Mark Goldberg 🧠
@markgoldbergmd.bsky.social
Professor of Neurology, UT Health San Antonio. Vascular neurology | Neuroscience | Research: stroke recovery, AI, long covid | Cat family | He, him
Thrilled to be at #sfn25 with some of the best #NeurorepairLab science ever!
First up: a method to trace sparsely labeled, long distance neuronal projections across entire mouse spinal cords and brains.
Sunday afternoon (today, board NN12).
Cajal would be proud!
eppro02.ativ.me/appinfo.php?...
First up: a method to trace sparsely labeled, long distance neuronal projections across entire mouse spinal cords and brains.
Sunday afternoon (today, board NN12).
Cajal would be proud!
eppro02.ativ.me/appinfo.php?...
EventPilot
eppro02.ativ.me
November 16, 2025 at 7:09 PM
Thrilled to be at #sfn25 with some of the best #NeurorepairLab science ever!
First up: a method to trace sparsely labeled, long distance neuronal projections across entire mouse spinal cords and brains.
Sunday afternoon (today, board NN12).
Cajal would be proud!
eppro02.ativ.me/appinfo.php?...
First up: a method to trace sparsely labeled, long distance neuronal projections across entire mouse spinal cords and brains.
Sunday afternoon (today, board NN12).
Cajal would be proud!
eppro02.ativ.me/appinfo.php?...
#NIH proposals due soon? Have you seen this? All upcoming deadlines will be extended. (Mine was … tomorrow.)
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
November 15, 2025 at 9:13 PM
#NIH proposals due soon? Have you seen this? All upcoming deadlines will be extended. (Mine was … tomorrow.)
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Am I the only one who sees a field of myelinated axons?
Day 5 of #inktober - the prompt is deer
#inksketch #sketch #sketchbook #deer #inktober2025 #inktober2025deer
#drawdaily #drawchallenge
#inksketch #sketch #sketchbook #deer #inktober2025 #inktober2025deer
#drawdaily #drawchallenge
October 6, 2025 at 7:21 AM
Am I the only one who sees a field of myelinated axons?
Incredible story of genius, art, and neuroscience.
September 9, 2025 at 6:42 AM
Incredible story of genius, art, and neuroscience.
Reposted by Mark Goldberg 🧠
New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com!
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
September 8, 2025 at 8:58 PM
New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com!
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
Reposted by Mark Goldberg 🧠
Dallas and New Hampshire researchers tested 128 long COVID patients with suspected dysautonomia.
Despite heavy symptoms, most showed normal results.
Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon.
www.sciencedirect.com/science/arti...
Despite heavy symptoms, most showed normal results.
Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon.
www.sciencedirect.com/science/arti...
Minimal Objective Autonomic Dysfunction in Long COVID
www.sciencedirect.com
September 4, 2025 at 2:23 PM
Dallas and New Hampshire researchers tested 128 long COVID patients with suspected dysautonomia.
Despite heavy symptoms, most showed normal results.
Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon.
www.sciencedirect.com/science/arti...
Despite heavy symptoms, most showed normal results.
Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon.
www.sciencedirect.com/science/arti...
US stroke neurologist here. Who can explain the new AI tool that tripled good outcomes and reduced treatment times by one hour, according to this article?
From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?
From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?
Stroke centres in England given AI tool that will help 50% of patients recover
Stroke centres in England given AI tool that will help 50% of patients recover
NHS equips all centres with life-saving software that will increase number of patients avoiding serious disability
Half of all people who experience a stroke in England will now recover thanks to a revolutionary AI scanning system that increases the number of patients avoiding serious disability.
The NHS has equipped every stroke centre in England with life-saving software that quickly tells doctors if they need to perform emergency surgery and can triple the rate of recovery. Continue reading...
www.theguardian.com
September 3, 2025 at 8:16 AM
US stroke neurologist here. Who can explain the new AI tool that tripled good outcomes and reduced treatment times by one hour, according to this article?
From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?
From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?
That’s what happened to Google search? Proof that one person really can change the world!
I can hear Ed Zitron chanting the name of Prabhakar Raghavan over and over again
www.wheresyoured.at/the-men-who-...
www.wheresyoured.at/the-men-who-...
The Man Who Killed Google Search
Wanna listen to this story instead? Check out this week's Better Offline podcast, "The Man That Destroyed Google Search," available on Apple Podcasts, Spotify, and anywhere else you get your podcasts....
www.wheresyoured.at
August 23, 2025 at 10:56 PM
That’s what happened to Google search? Proof that one person really can change the world!
Greatly appreciate this review of epigenetic mechanisms underlying regeneration competency only in young animals. Especially timely perspective for those of us puzzling over CNS repair.
Excited to share our recent viewpoint with @storerlab.bsky.social led by Kirsten Sadler, on epigenetic mechanisms of regenerative resilience.
Ageing versus developmental silencing: Answers from the epigenome - Sadler - The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/...
Ageing versus developmental silencing: Answers from the epigenome - Sadler - The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
It is easier for young animals to regenerate damaged or missing tissues. In this Viewpoint, we propose that this is, in part, attributed to epigenetic changes, with chromatin becoming more closed and....
febs.onlinelibrary.wiley.com
August 22, 2025 at 10:52 PM
Greatly appreciate this review of epigenetic mechanisms underlying regeneration competency only in young animals. Especially timely perspective for those of us puzzling over CNS repair.
Happy Birthday, new Parkland Hospital!
Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*!
While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care.
www.parklandhealth.org/news-and-upd...
Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*!
While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care.
www.parklandhealth.org/news-and-upd...
News & Updates | Parkland Health
www.parklandhealth.org
August 20, 2025 at 9:22 PM
Happy Birthday, new Parkland Hospital!
Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*!
While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care.
www.parklandhealth.org/news-and-upd...
Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*!
While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care.
www.parklandhealth.org/news-and-upd...
As owner of the stroke service “black cloud” it’s good to see the ED is well prepared for our kind of day.
August 10, 2025 at 5:14 PM
As owner of the stroke service “black cloud” it’s good to see the ED is well prepared for our kind of day.
Reposted by Mark Goldberg 🧠
Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary
Spatial transcriptomics reveals human cortical layer and area specification - Nature
Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially res...
www.nature.com
August 8, 2025 at 8:13 AM
Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary
Reposted by Mark Goldberg 🧠
Multi-omic underpinnings of Alzheimer's disease promote inflammation (particularly via T cells)whereas those for stroke relate to vascular integrity @cp-neuron.bsky.social
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Human brain vascular multi-omics elucidates disease-risk associations
Reid et al. develop MultiVINE-seq to map thousands of non-coding disease variants
to genes in human brain vascular cells. Cerebrovascular disease variants compromise
vessel integrity, whereas Alzheime...
www.cell.com
July 28, 2025 at 3:04 PM
Multi-omic underpinnings of Alzheimer's disease promote inflammation (particularly via T cells)whereas those for stroke relate to vascular integrity @cp-neuron.bsky.social
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Reposted by Mark Goldberg 🧠
Post-stroke fatigue can be long-lasting and disabling in patients recovering from a #stroke. New research identified a machine learning-based model that effectively predicted early post-stroke fatigue. Knowing who is at greatest risk can inform treatment. 🧪 🧠🔄 🧠📈
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...
July 28, 2025 at 4:09 PM
Post-stroke fatigue can be long-lasting and disabling in patients recovering from a #stroke. New research identified a machine learning-based model that effectively predicted early post-stroke fatigue. Knowing who is at greatest risk can inform treatment. 🧪 🧠🔄 🧠📈
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...
Spectacular view from the 2025 Gordon Research Conference on CNS Injury & Repair near Barga, Italy. Terrific science happening here.
Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.
Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.
July 10, 2025 at 4:07 PM
Spectacular view from the 2025 Gordon Research Conference on CNS Injury & Repair near Barga, Italy. Terrific science happening here.
Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.
Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.
Reposted by Mark Goldberg 🧠
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution - Nature
A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promise...
www.nature.com
July 2, 2025 at 4:27 PM
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Thanks for posting this terrific paper from @erichorvitz.bsky.social and team!
Neurologists will be on board as we traditionally embrace *sequential diagnosis* where each finding generates a new differential, leading hopefully to the best next steps. 1/2
Preprint:
arxiv.org/abs/2506.22405
Neurologists will be on board as we traditionally embrace *sequential diagnosis* where each finding generates a new differential, leading hopefully to the best next steps. 1/2
Preprint:
arxiv.org/abs/2506.22405
July 1, 2025 at 9:16 PM
Thanks for posting this terrific paper from @erichorvitz.bsky.social and team!
Neurologists will be on board as we traditionally embrace *sequential diagnosis* where each finding generates a new differential, leading hopefully to the best next steps. 1/2
Preprint:
arxiv.org/abs/2506.22405
Neurologists will be on board as we traditionally embrace *sequential diagnosis* where each finding generates a new differential, leading hopefully to the best next steps. 1/2
Preprint:
arxiv.org/abs/2506.22405
Reposted by Mark Goldberg 🧠
Calling all researchers!
Learn the basics of reviewing a paper, structuring feedback, and some lesser-known benefits of reviewing in this upcoming webinar.
Register and submit your questions today:
vist.ly/3n8a4dx
Learn the basics of reviewing a paper, structuring feedback, and some lesser-known benefits of reviewing in this upcoming webinar.
Register and submit your questions today:
vist.ly/3n8a4dx
July 1, 2025 at 4:14 PM
Calling all researchers!
Learn the basics of reviewing a paper, structuring feedback, and some lesser-known benefits of reviewing in this upcoming webinar.
Register and submit your questions today:
vist.ly/3n8a4dx
Learn the basics of reviewing a paper, structuring feedback, and some lesser-known benefits of reviewing in this upcoming webinar.
Register and submit your questions today:
vist.ly/3n8a4dx
Reposted by Mark Goldberg 🧠
Tenecteplace (TNK) is now FDA approved for acute stroke treatment!
Brought to you by the letter “k”, here’s a great thread from bsky #stroke expert @befast.bsky.social.
Brought to you by the letter “k”, here’s a great thread from bsky #stroke expert @befast.bsky.social.
It's official. For acute stroke treatment, Alteplase (tPA) is out, and Tenecteplase (TNK) is in.
But why? And more importantly, why is it called TNK when there’s no “K” in Tenecteplase?? 🧵
But why? And more importantly, why is it called TNK when there’s no “K” in Tenecteplase?? 🧵
June 23, 2025 at 11:14 PM
Tenecteplace (TNK) is now FDA approved for acute stroke treatment!
Brought to you by the letter “k”, here’s a great thread from bsky #stroke expert @befast.bsky.social.
Brought to you by the letter “k”, here’s a great thread from bsky #stroke expert @befast.bsky.social.
Reposted by Mark Goldberg 🧠
It's official. For acute stroke treatment, Alteplase (tPA) is out, and Tenecteplase (TNK) is in.
But why? And more importantly, why is it called TNK when there’s no “K” in Tenecteplase?? 🧵
But why? And more importantly, why is it called TNK when there’s no “K” in Tenecteplase?? 🧵
June 23, 2025 at 9:52 PM
It's official. For acute stroke treatment, Alteplase (tPA) is out, and Tenecteplase (TNK) is in.
But why? And more importantly, why is it called TNK when there’s no “K” in Tenecteplase?? 🧵
But why? And more importantly, why is it called TNK when there’s no “K” in Tenecteplase?? 🧵
Reposted by Mark Goldberg 🧠
BOOM! I think this paper fills a big gap in understanding how motor cortex stim works for pain... like so many things, it all seems to boil down to the ventral-lateral periaqueductal grey (vlPAG) www.cell.com/neuron/fullt...
A sensory-motor-sensory circuit underlies antinociception ignited by primary motor cortex in mice
Wang et al. unravel the fundamental reason why activation of the primary motor cortex
produces analgesia in mice from the angle of sensory-motor interaction and elucidate
it from a descending M1-LH in...
www.cell.com
June 18, 2025 at 5:11 PM
BOOM! I think this paper fills a big gap in understanding how motor cortex stim works for pain... like so many things, it all seems to boil down to the ventral-lateral periaqueductal grey (vlPAG) www.cell.com/neuron/fullt...
Reposted by Mark Goldberg 🧠
A new precision genetic toolkit allows scientists to access and study nearly 1,000 cells in the brain and spinal cord with unprecedented accuracy. Two of the lead scientists share on the NIH BRAIN Blog how it was made and impacts how we study disease: braininitiative.nih.gov/news-events/...
🧠📈
🧠📈
June 13, 2025 at 5:42 PM
A new precision genetic toolkit allows scientists to access and study nearly 1,000 cells in the brain and spinal cord with unprecedented accuracy. Two of the lead scientists share on the NIH BRAIN Blog how it was made and impacts how we study disease: braininitiative.nih.gov/news-events/...
🧠📈
🧠📈
Appreciate this up to date review. Zebrafish and neonatal mice can do it!
Great to see our first lab review 🔗 link.springer.com/article/10.1... included in the yearly Stem Cell & Developmental Biology Nature Portfolio Collection, “From aging to regeneration”: www.biomedcentral.com/collections/...
Many thanks to the reviewers & @BMCBiology for supporting our work!
Many thanks to the reviewers & @BMCBiology for supporting our work!
Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice - BMC Biology
In adult mammals, including humans, neurons and axons in the brain and spinal cord are inherently incapable of regenerating after injury. Studies of animals with innate capacity for regeneration are p...
link.springer.com
June 8, 2025 at 1:52 AM
Appreciate this up to date review. Zebrafish and neonatal mice can do it!
Congratulation to the Lone Star Stroke Consortium, ready to begin our 13th year with research that improves clinical care and implementation for stroke patients across Texas! Grateful to our research sites and the Texas Legislature for the continuing vote of confidence.
@lonestarstroke.bsky.social
@lonestarstroke.bsky.social
June 4, 2025 at 5:40 PM
Congratulation to the Lone Star Stroke Consortium, ready to begin our 13th year with research that improves clinical care and implementation for stroke patients across Texas! Grateful to our research sites and the Texas Legislature for the continuing vote of confidence.
@lonestarstroke.bsky.social
@lonestarstroke.bsky.social