Bertoglio lab (FMC/UFSC)
LightNews LightNews
banner
bertogliolab.bsky.social
Bertoglio lab (FMC/UFSC)
@bertogliolab.bsky.social
400 followers 260 following 1.7K posts
Catch the latest updates on aversive learning & memory, anxiety, fear, stress, and effects of psychedelics and cannabinoids from our rodent lab in Florianopolis, Brazil, and others!
Posts Replies Media Videos
Pinned
bertogliolab.bsky.social
Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · Jun 4
Excited to contribute to this piece on CBD effects on anxiety and fear memory, together with Marina Portes, @isabel-werle.bsky.social, Luciane Soares and Fernanda Guterres
revistafitos.far.fiocruz.br/index.php/re...
Canabidiol, ansiedade e memórias aversivas: uma revisão das evidências pré-clínicas | Revista Fitos
revistafitos.far.fiocruz.br
bertogliolab.bsky.social
Psilocybin Outside the ClinicPublic Health Challenges of Increasing Publicity, Accessibility, and Use
jamanetwork.com/journals/jam...
jamanetwork.com
November 11, 2025 at 6:08 PM
bertogliolab.bsky.social
A software platform for real-time and adaptive neuroscience experiments
www.nature.com/articles/s41...
A software platform for real-time and adaptive neuroscience experiments - Nature Communications
An optimal model-experiment integration for testing many complex hypotheses is still lacking. Here authors introduce improv, a modular software platform enabling real-time adaptive neuroscience experi...
www.nature.com
November 11, 2025 at 4:22 PM
bertogliolab.bsky.social
Heterogeneous plasticity of amygdala interneurons in associative learning and extinction
www.nature.com/articles/s41...
Heterogeneous plasticity of amygdala interneurons in associative learning and extinction - Nature Communications
In this study, the authors uncover how diverse inhibitory interneurons in the amygdala flexibly contribute to fear and safety learning, revealing a key role for inhibition in emotional memory and adap...
www.nature.com
November 11, 2025 at 4:21 PM
bertogliolab.bsky.social
Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping
www.nature.com/articles/s41...
Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping - Nature Communications
Stability and flexibility are important, if antagonistic, features of memory. Here the authors show that a class of inhibitory neurons regulate plasticity and therefore the stability of memory represe...
www.nature.com
November 11, 2025 at 4:20 PM
bertogliolab.bsky.social
Extended fear learning enhances excitatory and inhibitory synaptic transmission onto amygdala engram cells
www.nature.com/articles/s41...
Extended fear learning enhances excitatory and inhibitory synaptic transmission onto amygdala engram cells - Nature Communications
Neural mechanisms underlying long-lasting traumatic memories are not fully understood. Here authors show that only crucial fear engram, induced by intense fear conditioning, will be amplified. Further...
www.nature.com
November 11, 2025 at 4:19 PM
bertogliolab.bsky.social
Recent innovations in cannabinoid chemistry, biology, and biosynthesis

doi.org/10.1016/j.co...
Redirecting
doi.org
November 11, 2025 at 10:13 AM
bertogliolab.bsky.social
Psilocin suppresses activity of central amygdala CRF receptor 1 neurons and decreases ethanol drinking in female mice
doi.org/10.1523/jneu...
The psychedelic psilocin suppresses activity of central amygdala corticotropin releasing factor receptor 1 neurons and decreases ethanol drinking in female mice
Alcohol use disorder (AUD) is a highly prevalent disorder with limited therapeutic options. The central amygdala (CeA) is a critical brain region as dysregulation within the CeA and the corticotropin-...
doi.org
November 11, 2025 at 10:11 AM
bertogliolab.bsky.social
Dorsal hippocampus mediates light-tone associations in male mice
elifesciences.org/reviewed-pre...
Dorsal hippocampus mediates light-tone associations in male mice
elifesciences.org
November 11, 2025 at 10:03 AM
bertogliolab.bsky.social
Age modulates the link between stress-related neural activity and mortality
www.nature.com/articles/s41...
Age modulates the link between stress-related neural activity and mortality - Nature Communications
Psychological stress is linked to poor cardiovascular outcomes, but its risk impact may vary with age. Here, the authors show that stress-related brain activity predicts mortality, especially in young...
www.nature.com
November 10, 2025 at 9:59 AM
bertogliolab.bsky.social
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com/articles/s41...
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry
Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com
November 10, 2025 at 9:58 AM
bertogliolab.bsky.social
A Comparison of Positive and Negative Allosteric Modulators of Alpha5-Containing GABAARs in the Treatment of Affective Disease

www.biologicalpsychiatryjournal.com/article/S000...
A Comparison of Positive and Negative Allosteric Modulators of Alpha5-Containing GABAARs in the Treatment of Affective Disease
Major depressive disorder (MDD) is a common psychiatric disease that significantly impairs quality of life and productivity. Unfortunately, standard monoamine-based therapies are marred by poor effica...
www.biologicalpsychiatryjournal.com
November 10, 2025 at 9:57 AM
bertogliolab.bsky.social
Large sharp-wave ripples promote hippocampo-cortical memory reactivation and consolidation during sleep
www.cell.com/neuron/fullt...
Large sharp-wave ripples promote hippocampo-cortical memory reactivation and consolidation during sleep
Robinson et al. found that the reactivation of experience-related neural ensemble patterns in hippocampus and cortex during sleep is specifically associated with a subset of large SWRs. Closed-loop op...
www.cell.com
November 10, 2025 at 9:55 AM
bertogliolab.bsky.social
Accelerated long-term forgetting across neuropsychiatric disorders: A review of mechanisms and a neurobiological perspective of forgetting
www.sciencedirect.com/science/arti...
Accelerated long-term forgetting across neuropsychiatric disorders: A review of mechanisms and a neurobiological perspective of forgetting
Accelerated long-term forgetting (ALF) is the rapid loss of newly-learnt information, typically noticeable after ~30minutes, and observed across diver…
www.sciencedirect.com
November 10, 2025 at 9:51 AM
bertogliolab.bsky.social
Adolescent male and female rats show enhanced latent inhibition of conditioned fear compared to adult rats
doi.org/10.3389/fnbe...
Frontiers | Adolescent male and female rats show enhanced latent inhibition of conditioned fear compared to adult rats
IntroductionLatent inhibition is diminished associative memory because of pre-exposure to the conditioned stimulus without any consequences. Latent inhibitio...
doi.org
November 8, 2025 at 5:37 PM
bertogliolab.bsky.social
Optogenetic stimulation of the infralimbic cortex prior to fear extinction learning rescues deficits in a preclinical model of comorbid PTSD and AUD
link.springer.com/article/10.1...
Optogenetic stimulation of the infralimbic cortex prior to fear extinction learning rescues deficits in a preclinical model of comorbid PTSD and AUD - Psychopharmacology
Rationale Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) frequently co-occur, leading to significant impairments in learning and memory. Despite the prevalence of these disorders...
link.springer.com
November 8, 2025 at 5:17 PM
bertogliolab.bsky.social
www.nature.com/articles/d41...
Pressure to publish is rising as research time shrinks, finds survey of scientists
Researchers feel that pressures to publish are increasing, but the time and resources available to do research are decreasing, according to a survey by Elsevier.
www.nature.com
November 7, 2025 at 3:20 PM
bertogliolab.bsky.social
Cannabis vaping and mental health: The association of THC and CBD with anxiety and depressive symptoms
doi.org/10.1111/add....
Cannabis vaping and mental health: The association of Δ‐9‐tetrahydrocannabinol and cannabidiol with anxiety and depressive symptoms—Findings from the United States National Youth Tobacco Survey (2021–2023)
Background and aim Cannabis use is associated with psychiatric comorbidities, and the use of elta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) produces different neurophysiological and pharmac...
doi.org
November 7, 2025 at 9:33 AM
bertogliolab.bsky.social
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults
doi.org/10.1038/s415...
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults - Scientific Reports
Scientific Reports - Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults
doi.org
November 7, 2025 at 9:32 AM
bertogliolab.bsky.social
Acute DOI treatment evokes dose and species-dependent locomotor effects on the elevated plus maze
www.sciencedirect.com/science/arti...
Acute DOI treatment evokes dose and species-dependent locomotor effects on the elevated plus maze
Recent evidence suggests that psychedelics hold promise in treating a range of neuropsychiatric disorders, highlighting the need to better understand …
www.sciencedirect.com
November 7, 2025 at 9:28 AM
bertogliolab.bsky.social
Neurobiological mechanisms and recent advances in drug-based therapeutics in depression
www.sciencedirect.com/science/arti...
www.sciencedirect.com
November 7, 2025 at 9:27 AM
bertogliolab.bsky.social
Amygdala arginine vasopressin receptor 1a mediates susceptibility to chronic social isolation in female mice
doi.org/10.1038/s414...
Amygdala AVPR1A mediates susceptibility to chronic social isolation in female mice - Nature Communications
Females are more sensitive to social exclusion and loneliness, risk factors for anxiety and stressrelated disorders. Here, the authors identified molecular signals in the amygdala that make females mo...
doi.org
November 5, 2025 at 10:06 AM
bertogliolab.bsky.social
Ketamine Assisted EMDR Therapy™ for PTSD: investigating the synergistic effects of pharmacotherapy and psychotherapy
doi.org/10.1080/2000...
Ketamine Assisted EMDR Therapy™ for PTSD: investigating the synergistic effects of pharmacotherapy and psychotherapy
Background: Posttraumatic stress disorder (PTSD) is associated with maladaptive memory reconsolidation and overgeneralized fear responses. EMDR therapy promotes trauma reprocessing by activating th...
doi.org
November 5, 2025 at 10:03 AM
bertogliolab.bsky.social
Pharmacological Management of PTSD; A Qualitative Analysis of ClinicalTrials.gov
doi.org/10.2147/dddt...
ClinicalTrials.gov
ClinicalTrials.gov
November 5, 2025 at 10:00 AM
bertogliolab.bsky.social
Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats
www.jneurosci.org/content/earl...
Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats
Impaired GABAergic inhibition, so-called neural disinhibition, in the prefrontal cortex and hippocampus has been linked to cognitive deficits. The novel object recognition (NOR) task has been used wid...
www.jneurosci.org
November 5, 2025 at 9:52 AM
bertogliolab.bsky.social
LSD microdosing in major depressive disorder: results from an open-label trial
www.sciencedirect.com/science/arti...
LSD microdosing in major depressive disorder: results from an open-label trial
Major depressive disorder (MDD) affects approximately 5% of the global population. Classic psychedelics have shown promise in treating various mental …
www.sciencedirect.com
November 5, 2025 at 9:43 AM