Bertoglio lab (FMC/UFSC)
@bertogliolab.bsky.social
Catch the latest updates on aversive learning & memory, anxiety, fear, stress, and effects of psychedelics and cannabinoids from our rodent lab in Florianopolis, Brazil, and others!
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🆕Lab study shows that ayahuasca enhances fear extinction, including under stress-induced deficits, and reduces fear generalization; cortical BDNF-TrkB receptor signaling contributes to these effects @isabel-werle.bsky.social @ecnp.eu
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A common network of emotional processing recovery across four psychiatric disorders
www.biologicalpsychiatryjournal.com/article/S000...
www.biologicalpsychiatryjournal.com/article/S000...
A common network of emotional processing recovery across four psychiatric disorders
Abnormal emotional processing serves as a common deficit across psychiatric disorders
and a primary target of pharmacotherapy. However, the neuroimaging findings underlying
emotion processing recovery...
www.biologicalpsychiatryjournal.com
February 12, 2026 at 2:21 PM
A common network of emotional processing recovery across four psychiatric disorders
www.biologicalpsychiatryjournal.com/article/S000...
www.biologicalpsychiatryjournal.com/article/S000...
Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity - Neuropsychopharmacology
Neuropsychopharmacology - Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity
www.nature.com
February 12, 2026 at 2:15 PM
Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coordinated activity and plasticity of infralimbic cortex GABAergic interneurons are critical for fear extinction encoding
doi.org/10.64898/202...
doi.org/10.64898/202...
doi.org
February 12, 2026 at 12:33 PM
Coordinated activity and plasticity of infralimbic cortex GABAergic interneurons are critical for fear extinction encoding
doi.org/10.64898/202...
doi.org/10.64898/202...
Serotonin-endocannabinoid crosstalk selectively regulates inhibitory GABAergic inputs in the medial prefrontal cortex www.nature.com/articles/s41...
Serotonin-endocannabinoid crosstalk selectively regulates inhibitory GABAergic inputs in the medial prefrontal cortex - Neuropsychopharmacology
Neuropsychopharmacology - Serotonin-endocannabinoid crosstalk selectively regulates inhibitory GABAergic inputs in the medial prefrontal cortex
www.nature.com
February 11, 2026 at 6:28 PM
Serotonin-endocannabinoid crosstalk selectively regulates inhibitory GABAergic inputs in the medial prefrontal cortex www.nature.com/articles/s41...
Astrocytes enable amygdala neural representations supporting memory
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Astrocytes enable amygdala neural representations supporting memory - Nature
Astrocytes in the basolateral amygdala dynamically track fear state and support fear memory retrieval and extinction.
www.nature.com
February 11, 2026 at 6:20 PM
Astrocytes enable amygdala neural representations supporting memory
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Conformational diversity and fully opening mechanism of native NMDA receptor
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Conformational diversity and fully opening mechanism of native NMDA receptor - Nature
Analyses of heterogeneous assemblies of native NMDA receptors from whole-brain tissue of mice reveal new characteristics of conformational diversity and channel opening.
www.nature.com
February 11, 2026 at 6:19 PM
Conformational diversity and fully opening mechanism of native NMDA receptor
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Causal links between serotonin dynamics and cued fear learning: evidence from experimental studies
doi.org/10.3389/fnco...
doi.org/10.3389/fnco...
Frontiers | Causal links between serotonin dynamics and cued fear learning: evidence from experimental studies
Serotonin is thought to regulate emotional learning and memory, but there remains much to be explored regarding its causal role in cued fear conditioning and...
doi.org
February 11, 2026 at 1:03 PM
Causal links between serotonin dynamics and cued fear learning: evidence from experimental studies
doi.org/10.3389/fnco...
doi.org/10.3389/fnco...
Psychedelics in functional disorders: A scoping review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com
February 11, 2026 at 12:52 PM
Psychedelics in functional disorders: A scoping review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Cognitive rejuvenation through partial reprogramming of engram cells
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Cognitive rejuvenation through partial reprogramming of engram cells
Berdugo-Vega et al. combine partial reprogramming and engram technologies to achieve
molecular rejuvenation of learning-associated neuronal ensembles. Engram reprogramming
counteracts molecular, cellu...
www.cell.com
February 11, 2026 at 12:36 PM
Cognitive rejuvenation through partial reprogramming of engram cells
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
@psypost.bsky.social We greatly appreciate your dissemination of our most recent work on ayahuasca (DMT) as a fear extinction facilitator @isabel-werle.bsky.social
www.psypost.org/scientists-i...
www.psypost.org/scientists-i...
www.psypost.org
February 11, 2026 at 11:56 AM
@psypost.bsky.social We greatly appreciate your dissemination of our most recent work on ayahuasca (DMT) as a fear extinction facilitator @isabel-werle.bsky.social
www.psypost.org/scientists-i...
www.psypost.org/scientists-i...
Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation - Molecular Psychiatry
Molecular Psychiatry - Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation
www.nature.com
February 10, 2026 at 12:38 PM
Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain
Mammalian brain may contain an endogenous pool of the psychedelic substance N,N-dimethyltryptamine (DMT), which may act as a co-transmitter with serot…
www.sciencedirect.com
February 10, 2026 at 12:03 PM
N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Preliminary effects of ayahuasca on mental and physical health: A systematic review of prospective studies
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Preliminary effects of ayahuasca on mental and physical health: A systematic review of prospective studies
Ayahuasca is a psychedelic plant brew that has been used in Central and South America for centuries. Recently, there has been an increase in “drug tou…
www.sciencedirect.com
February 9, 2026 at 12:14 PM
Preliminary effects of ayahuasca on mental and physical health: A systematic review of prospective studies
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo - Molecular Psychiatry
Molecular Psychiatry - Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo
www.nature.com
February 9, 2026 at 12:11 PM
Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice - Nature Communications
How microglia regulate adult hippocampal neurogenesis and cognitive and affective behavior remains poorly understood. Here, the authors show that TGF-β-deficient microglia increase adult neurogenesis ...
www.nature.com
February 9, 2026 at 12:10 PM
Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Effects of post-stress corticosterone on hippocampal excitability and behavior involving HCN1 function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Effects of post-stress corticosterone on hippocampal excitability and behavior involving hyperpolarization-activated cation channel 1 function - Translational Psychiatry
Translational Psychiatry - Effects of post-stress corticosterone on hippocampal excitability and behavior involving hyperpolarization-activated cation channel 1 function
www.nature.com
February 9, 2026 at 12:07 PM
Effects of post-stress corticosterone on hippocampal excitability and behavior involving HCN1 function
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The role of lipids in neuromodulation for psychiatric disorders: A narrative review
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The role of lipids in neuromodulation for psychiatric disorders: A narrative review - Translational Psychiatry
Translational Psychiatry - The role of lipids in neuromodulation for psychiatric disorders: A narrative review
www.nature.com
February 9, 2026 at 12:05 PM
The role of lipids in neuromodulation for psychiatric disorders: A narrative review
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Efficacy and safety of adjunctive treatment with the FAAH inhibitor JNJ-42165279 in participants with major depressive disorder with anxious distress
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Efficacy and safety of adjunctive treatment with the fatty acid amide hydrolase inhibitor JNJ-42165279 in participants with major depressive disorder with anxious distress: A double-blind, placebo-con...
JNJ-42165279 is a potent, selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for degradation of the endocannabinoid N-ar…
www.sciencedirect.com
February 9, 2026 at 11:51 AM
Efficacy and safety of adjunctive treatment with the FAAH inhibitor JNJ-42165279 in participants with major depressive disorder with anxious distress
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Effectiveness of ketamine-assisted psychotherapy as a treatment for treatment-resistant depression: a systematic review
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Effectiveness of ketamine-assisted psychotherapy as a treatment for treatment-resistant depression: a systematic review - Psychopharmacology
Background Major Depressive Disorder (MDD) is a common and debilitating condition. Current treatments fail to provide adequate relief in roughly one-third of individuals, resulting in treatment-resist...
link.springer.com
February 9, 2026 at 11:46 AM
Effectiveness of ketamine-assisted psychotherapy as a treatment for treatment-resistant depression: a systematic review
link.springer.com/article/10.1...
link.springer.com/article/10.1...
A novel finding on sex-dependent diverse behavioral responses to the anticipation of a threat in a rat model of fear conditioning with the involvement of BDNF in the prefrontal cortex
doi.org/10.3758/s134...
doi.org/10.3758/s134...
A novel finding on sex-dependent diverse behavioral responses to the anticipation of a threat in a rat model of fear conditioning with the involvement of brain-derived neurotrophic factor (BDNF) in th...
Evidence has shown significant sex differences in freezing and darting behaviors in a rat model of aversive learning using fear conditioning. The present study explored sex differences in a rat model ...
doi.org
February 7, 2026 at 12:46 PM
A novel finding on sex-dependent diverse behavioral responses to the anticipation of a threat in a rat model of fear conditioning with the involvement of BDNF in the prefrontal cortex
doi.org/10.3758/s134...
doi.org/10.3758/s134...
The science of psychedelic medicine
doi.org/10.1038/s415...
doi.org/10.1038/s415...
The science of psychedelic medicine - Nature Medicine
This Review outlines the science behind psychedelic medicine and integrates mechanistic knowledge with clinical evidence across neuropsychiatric indications, highlighting challenges, controversies and...
doi.org
February 7, 2026 at 12:33 PM
The science of psychedelic medicine
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Design, synthesis, and biological profiling of fluorinated CBD and CBG derivatives as promising therapeutic agents
doi.org/10.1186/s422...
doi.org/10.1186/s422...
Design, synthesis, and biological profiling of fluorinated cannabidiol and cannabigerol derivatives as promising therapeutic agents - Journal of Cannabis Research
Background Cannabidiol (CBD) and cannabigerol (CBG) are non-psychotropic phytocannabinoids that have significant, broad-spectrum therapeutic potential in a variety of pharmacological areas, but their ...
doi.org
February 6, 2026 at 6:37 PM
Design, synthesis, and biological profiling of fluorinated CBD and CBG derivatives as promising therapeutic agents
doi.org/10.1186/s422...
doi.org/10.1186/s422...
Gut-Mind Interactions in Psychedelic Healing
doi.org/10.14200/jrm...
doi.org/10.14200/jrm...
Gut–Mind Interactions in Psychedelic Healing | Effects of Huachuma and Ayahuasca
Ayahuasca and Huachuma ceremonies show microbiome changes and reduced depression in a case study, hinting at a gut–brain connection.
doi.org
February 6, 2026 at 6:36 PM
Gut-Mind Interactions in Psychedelic Healing
doi.org/10.14200/jrm...
doi.org/10.14200/jrm...
Neuroscience in pictures: Neuroscience of fear
doi.org/10.1016/j.aj...
doi.org/10.1016/j.aj...
Redirecting
doi.org
February 6, 2026 at 6:33 PM
Neuroscience in pictures: Neuroscience of fear
doi.org/10.1016/j.aj...
doi.org/10.1016/j.aj...
A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions - Molecular Psychiatry
Molecular Psychiatry - A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions
www.nature.com
February 6, 2026 at 6:28 PM
A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions
www.nature.com/articles/s41...
www.nature.com/articles/s41...