Bertoglio lab (FMC/UFSC)
@bertogliolab.bsky.social
Catch the latest updates on aversive learning & memory, anxiety, fear, stress, and effects of psychedelics and cannabinoids from our rodent lab in Florianopolis, Brazil, and others!
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🆕Lab study shows that ayahuasca enhances fear extinction, including under stress-induced deficits, and reduces fear generalization; cortical BDNF-TrkB receptor signaling contributes to these effects @isabel-werle.bsky.social @ecnp.eu
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Psychedelic research must be grounded in pharmacology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Psychedelic research must be grounded in pharmacology - Nature Neuroscience
Psychedelic science is growing rapidly and offers great promise for exciting new therapies, but this rapid growth has brought growing pains. These include a lack of appreciation of the history of the ...
www.nature.com
December 25, 2025 at 7:49 PM
Psychedelic research must be grounded in pharmacology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bertoglio lab (FMC/UFSC)
New paper from @ykneurores.bsky.social in our lab 📢
We show body size predicts defensive behavioral strategy; smaller animals adopt active avoidance, larger ones favor freezing, while sex and age don’t drive the effect. A clear demonstration that traits matter.
www.sciencedirect.com/science/arti...
We show body size predicts defensive behavioral strategy; smaller animals adopt active avoidance, larger ones favor freezing, while sex and age don’t drive the effect. A clear demonstration that traits matter.
www.sciencedirect.com/science/arti...
Body size predicts the selection of defensive behavioral strategies
Survival depends on the ability to respond appropriately to threats, yet the selection of defensive behaviors varies among individuals with distinct b…
www.sciencedirect.com
December 24, 2025 at 12:32 AM
New paper from @ykneurores.bsky.social in our lab 📢
We show body size predicts defensive behavioral strategy; smaller animals adopt active avoidance, larger ones favor freezing, while sex and age don’t drive the effect. A clear demonstration that traits matter.
www.sciencedirect.com/science/arti...
We show body size predicts defensive behavioral strategy; smaller animals adopt active avoidance, larger ones favor freezing, while sex and age don’t drive the effect. A clear demonstration that traits matter.
www.sciencedirect.com/science/arti...
Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampus - Nature Communications
Repeated stress triggers habituation, an important stress coping response. Here, authors chart the dynamic gene expression changes that underlie stress habituation in the mouse brain and reveal two di...
www.nature.com
December 22, 2025 at 9:59 AM
Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting the noradrenergic-metabolic axis: A new strategy for sugar-induced depression subtypes
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
bpspubs.onlinelibrary.wiley.com
December 22, 2025 at 9:52 AM
Targeting the noradrenergic-metabolic axis: A new strategy for sugar-induced depression subtypes
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N- DMT in Rats
doi.org/10.1523/jneu...
doi.org/10.1523/jneu...
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats
N , N -dimethyltryptamine (DMT) is a serotonergic psychedelic that is being investigated clinically for the treatment of psychiatric disorders. Although the neurophysiological effects of DMT in humans...
doi.org
December 22, 2025 at 9:47 AM
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N- DMT in Rats
doi.org/10.1523/jneu...
doi.org/10.1523/jneu...
The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
doi.org/10.1038/s413...
doi.org/10.1038/s413...
The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice - Molecular Psychiatry
Molecular Psychiatry - The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
doi.org
December 22, 2025 at 9:46 AM
The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
doi.org/10.1038/s413...
doi.org/10.1038/s413...
Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera) - Nature Communications
Here, authors investigate how gut microbiota contribute to defensive behaviours in honeybees, finding evidence that gut-associated bacteria affect aversive learning and memory of sting extension refle...
www.nature.com
December 19, 2025 at 9:31 AM
Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication - Nature Communications
Early postnatal interneuron-oligodendroglia communication may shape neuronal networks underlying cognition. Here, the authors show that disrupting this signaling in mice impairs interneuron myelinatio...
www.nature.com
December 19, 2025 at 9:28 AM
Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How does DMT (N,N-dimethyltryptamine) from ayahuasca help extinguish aversive memories? In this infographic, we summarize the main findings of our new research article: www.sciencedirect.com/science/arti...
December 18, 2025 at 10:28 AM
How does DMT (N,N-dimethyltryptamine) from ayahuasca help extinguish aversive memories? In this infographic, we summarize the main findings of our new research article: www.sciencedirect.com/science/arti...
🆕Lab study shows that ayahuasca enhances fear extinction, including under stress-induced deficits, and reduces fear generalization; cortical BDNF-TrkB receptor signaling contributes to these effects @isabel-werle.bsky.social @ecnp.eu
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 18, 2025 at 9:19 AM
🆕Lab study shows that ayahuasca enhances fear extinction, including under stress-induced deficits, and reduces fear generalization; cortical BDNF-TrkB receptor signaling contributes to these effects @isabel-werle.bsky.social @ecnp.eu
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Threat acquisition and extinction differences between patients with panic disorder or specific phobia and non-clinical controls: A systematic review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Threat acquisition and extinction differences between patients with panic disorder or specific phobia and non-clinical controls: A systematic review
The study of threat conditioning and extinction processes in anxiety disorders (AD) may further our understanding of the genesis, maintenance, and tre…
www.sciencedirect.com
December 17, 2025 at 8:59 AM
Threat acquisition and extinction differences between patients with panic disorder or specific phobia and non-clinical controls: A systematic review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Breaking boundaries: Dopamine’s role in prediction error, salient novelty, and memory reconsolidation
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Breaking boundaries: Dopamine’s role in prediction error, salient novelty, and memory reconsolidation
For memories to remain relevant and adaptive over the lifespan, modifications under specific conditions are required. Memory reconsolidation theory su…
www.sciencedirect.com
December 17, 2025 at 8:58 AM
Breaking boundaries: Dopamine’s role in prediction error, salient novelty, and memory reconsolidation
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Psychedelic Experiences Elicited by Serotonergic Psychedelics; Molecular Mechanisms and Functional Connectivity Changes in /the Brain
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Psychedelic Experiences Elicited by Serotonergic Psychedelics; Molecular Mechanisms and Functional Connectivity Changes in /the Brain.
Classical psychedelics, like lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), and psilocybin, can alter perception, emotion, and cognit…
www.sciencedirect.com
December 16, 2025 at 4:43 PM
Psychedelic Experiences Elicited by Serotonergic Psychedelics; Molecular Mechanisms and Functional Connectivity Changes in /the Brain
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Differential effects of chronic restraint stress on two active avoidance tasks in rats
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Differential effects of chronic restraint stress on two active avoidance tasks in rats
Although avoidance can serve an adaptive function in daily life, excessive or persistent avoidance can form a debilitating symptom of anxiety-related …
www.sciencedirect.com
December 16, 2025 at 9:36 AM
Differential effects of chronic restraint stress on two active avoidance tasks in rats
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Associative memory neurons are recruited in PFC-centered circuits to encode schizophrenia-like behavior by dopaminergic receptor-II
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Associative memory neurons are recruited in PFC-centered circuits to encode schizophrenia-like behavior by dopaminergic receptor-II - Molecular Psychiatry
Molecular Psychiatry - Associative memory neurons are recruited in PFC-centered circuits to encode schizophrenia-like behavior by dopaminergic receptor-II
www.nature.com
December 16, 2025 at 9:34 AM
Associative memory neurons are recruited in PFC-centered circuits to encode schizophrenia-like behavior by dopaminergic receptor-II
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Amygdala reactivity to threat, negative facial perception, and risk of future psychiatric hospitalizations
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Amygdala reactivity to threat, negative facial perception, and risk of future psychiatric hospitalizations: a longitudinal study in major depressive and bipolar disorders - Neuropsychopharmacology
Neuropsychopharmacology - Amygdala reactivity to threat, negative facial perception, and risk of future psychiatric hospitalizations: a longitudinal study in major depressive and bipolar disorders
www.nature.com
December 16, 2025 at 9:26 AM
Amygdala reactivity to threat, negative facial perception, and risk of future psychiatric hospitalizations
www.nature.com/articles/s41...
www.nature.com/articles/s41...
When the science alone is not enough: embracing our responsibility as science communicators
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
December 16, 2025 at 9:24 AM
When the science alone is not enough: embracing our responsibility as science communicators
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How nature nurtures: prenatal exposure to green space buffers the effects of maternal stress on neonatal BDNF methylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How nature nurtures: prenatal exposure to green space buffers the effects of maternal stress on neonatal BDNF methylation - Molecular Psychiatry
Molecular Psychiatry - How nature nurtures: prenatal exposure to green space buffers the effects of maternal stress on neonatal BDNF methylation
www.nature.com
December 15, 2025 at 10:29 AM
How nature nurtures: prenatal exposure to green space buffers the effects of maternal stress on neonatal BDNF methylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons - Nature Communications
Synaptic vesicle fusion is essential for neuronal communication, yet its nanoscale sequence has not been directly confirmed. Here, the authors use timed in situ cryo-electron tomography to visualize t...
www.nature.com
December 15, 2025 at 10:27 AM
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour - Nature Communications
Molecular drivers of sex-specific brain plasticity are unknown. Here, authors show estrogen-driven Egr1 controls chromatin accessibility sex-dependently, driving gene expression, structural plasticity...
www.nature.com
December 15, 2025 at 10:26 AM
Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics - Nature Communications
Tong and colleagues reveal a cross-species conserved mechanism where locus coeruleus-norepinephrine mediated arousal fluctuations drive an inverted U-shaped pattern of global functional connectivity, ...
www.nature.com
December 15, 2025 at 10:25 AM
Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Resilience or vulnerability? thalamic subdivision connectivity in trauma-exposed individuals: a 7 t resting-state fMRI study
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
December 15, 2025 at 10:24 AM
Resilience or vulnerability? thalamic subdivision connectivity in trauma-exposed individuals: a 7 t resting-state fMRI study
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Antidepressant-like effects of extinction learning as an animal model of behavioral therapy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Antidepressant-like effects of extinction learning as an animal model of behavioral therapy - Molecular Psychiatry
Molecular Psychiatry - Antidepressant-like effects of extinction learning as an animal model of behavioral therapy
www.nature.com
December 13, 2025 at 9:57 PM
Antidepressant-like effects of extinction learning as an animal model of behavioral therapy
www.nature.com/articles/s41...
www.nature.com/articles/s41...