Mark Goldberg 🧠
@markgoldbergmd.bsky.social
Professor of Neurology, UT Health San Antonio. Vascular neurology | Neuroscience | Research: stroke recovery, AI, long covid | Cat family | He, him
Finally found something Copilot can do:
January 23, 2026 at 10:04 PM
Finally found something Copilot can do:
Reposted by Mark Goldberg 🧠
Yesterday an interview was posted with Mike Lauer about the state of science.
I strongly disagree with it.
I will write more later. But for now: I agree w/ Lauer’s central points about budgets and paperwork and institutional incentives. But he seems to not realize the political minefield he is in.
I strongly disagree with it.
I will write more later. But for now: I agree w/ Lauer’s central points about budgets and paperwork and institutional incentives. But he seems to not realize the political minefield he is in.
January 10, 2026 at 6:34 PM
Yesterday an interview was posted with Mike Lauer about the state of science.
I strongly disagree with it.
I will write more later. But for now: I agree w/ Lauer’s central points about budgets and paperwork and institutional incentives. But he seems to not realize the political minefield he is in.
I strongly disagree with it.
I will write more later. But for now: I agree w/ Lauer’s central points about budgets and paperwork and institutional incentives. But he seems to not realize the political minefield he is in.
Reposted by Mark Goldberg 🧠
“The system of funding science is fundamentally broken. In some respects, it’s been an unmitigated disaster. It was a house of cards, and it’s not surprising that it’s now falling apart.”
-Mike Lauer, former director of extramural research 🧪
www.statecraft.pub/p/whats-wron...
-Mike Lauer, former director of extramural research 🧪
www.statecraft.pub/p/whats-wron...
What’s Wrong with NIH Grants?
“Science is fundamentally different than remodeling a kitchen”
www.statecraft.pub
January 10, 2026 at 1:44 AM
“The system of funding science is fundamentally broken. In some respects, it’s been an unmitigated disaster. It was a house of cards, and it’s not surprising that it’s now falling apart.”
-Mike Lauer, former director of extramural research 🧪
www.statecraft.pub/p/whats-wron...
-Mike Lauer, former director of extramural research 🧪
www.statecraft.pub/p/whats-wron...
Don’t miss the 2025 Stroke Review from bluesky’s vascular neurologist, Dr. Dymm, @befast.bsky.social!
2025 was a landmark year for stroke neurology.
From the MeVO trials to news of AI-driven systems of care and Factor XIa inhibitors on the horizon, the landscape of vascular neurology has shifted.
Here's a month-by-month recap of the year! 🧵
From the MeVO trials to news of AI-driven systems of care and Factor XIa inhibitors on the horizon, the landscape of vascular neurology has shifted.
Here's a month-by-month recap of the year! 🧵
December 18, 2025 at 7:59 AM
Don’t miss the 2025 Stroke Review from bluesky’s vascular neurologist, Dr. Dymm, @befast.bsky.social!
Movie you’ve watched more than six times in a gif. Hard mode: no Star Wars, Marvel.
December 9, 2025 at 6:27 AM
Movie you’ve watched more than six times in a gif. Hard mode: no Star Wars, Marvel.
Important change: no pre-approval required for NIH proposals > $500K.
Updates to the submission process for LOIs and grants requesting more than $500K in any budget periods. grants.nih.gov/grants/guide...
NOT-OD-26-019: Updated Application Policies: NIH Administrative Burden Reduction Effort Removal of Requirements for Letters of Intent and Unsolicited Applications Requesting $500,000 or More in Dire...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Application Policies: NIH Administrative Burden Reduction Effort Removal of Requirements for Letters of Inten...
grants.nih.gov
December 4, 2025 at 3:06 PM
Important change: no pre-approval required for NIH proposals > $500K.
Reposted by Mark Goldberg 🧠
Ancillary studies are open. We’re working hard to get these samples into your hands.
Please apply.
recovercovid.org/ancillary
Please apply.
recovercovid.org/ancillary
December 3, 2025 at 3:47 PM
Ancillary studies are open. We’re working hard to get these samples into your hands.
Please apply.
recovercovid.org/ancillary
Please apply.
recovercovid.org/ancillary
Did Apple Watch VO₂ max suddenly get way more flattering?
Maybe something in the iOS 26 update? No explanation from Apple — but I’m not complaining.
Maybe something in the iOS 26 update? No explanation from Apple — but I’m not complaining.
November 30, 2025 at 12:56 AM
Did Apple Watch VO₂ max suddenly get way more flattering?
Maybe something in the iOS 26 update? No explanation from Apple — but I’m not complaining.
Maybe something in the iOS 26 update? No explanation from Apple — but I’m not complaining.
Fellow scientists, enjoy this low-calorie treat from Nature Scientific Reports, topped with the very best #AI. Thanks @erikangner.com for brightening my holiday.
"Runctitiononal features"? "Medical fymblal"? "1 Tol Line storee"? This gets worse the longer you look at it. But it's got to be good, because it was published in Nature Scientific Reports last week: www.nature.com/articles/s41... h/t @asa.tsbalans.se
November 27, 2025 at 8:08 PM
Fellow scientists, enjoy this low-calorie treat from Nature Scientific Reports, topped with the very best #AI. Thanks @erikangner.com for brightening my holiday.
Thrilled to be at #sfn25 with some of the best #NeurorepairLab science ever!
First up: a method to trace sparsely labeled, long distance neuronal projections across entire mouse spinal cords and brains.
Sunday afternoon (today, board NN12).
Cajal would be proud!
eppro02.ativ.me/appinfo.php?...
First up: a method to trace sparsely labeled, long distance neuronal projections across entire mouse spinal cords and brains.
Sunday afternoon (today, board NN12).
Cajal would be proud!
eppro02.ativ.me/appinfo.php?...
EventPilot
eppro02.ativ.me
November 16, 2025 at 7:09 PM
Thrilled to be at #sfn25 with some of the best #NeurorepairLab science ever!
First up: a method to trace sparsely labeled, long distance neuronal projections across entire mouse spinal cords and brains.
Sunday afternoon (today, board NN12).
Cajal would be proud!
eppro02.ativ.me/appinfo.php?...
First up: a method to trace sparsely labeled, long distance neuronal projections across entire mouse spinal cords and brains.
Sunday afternoon (today, board NN12).
Cajal would be proud!
eppro02.ativ.me/appinfo.php?...
#NIH proposals due soon? Have you seen this? All upcoming deadlines will be extended. (Mine was … tomorrow.)
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
November 15, 2025 at 9:13 PM
#NIH proposals due soon? Have you seen this? All upcoming deadlines will be extended. (Mine was … tomorrow.)
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Am I the only one who sees a field of myelinated axons?
Day 5 of #inktober - the prompt is deer
#inksketch #sketch #sketchbook #deer #inktober2025 #inktober2025deer
#drawdaily #drawchallenge
#inksketch #sketch #sketchbook #deer #inktober2025 #inktober2025deer
#drawdaily #drawchallenge
October 6, 2025 at 7:21 AM
Am I the only one who sees a field of myelinated axons?
Incredible story of genius, art, and neuroscience.
September 9, 2025 at 6:42 AM
Incredible story of genius, art, and neuroscience.
Reposted by Mark Goldberg 🧠
New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com!
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
September 8, 2025 at 8:58 PM
New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com!
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??
jamanetwork.com/journals/jam...
Reposted by Mark Goldberg 🧠
Dallas and New Hampshire researchers tested 128 long COVID patients with suspected dysautonomia.
Despite heavy symptoms, most showed normal results.
Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon.
www.sciencedirect.com/science/arti...
Despite heavy symptoms, most showed normal results.
Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon.
www.sciencedirect.com/science/arti...
Minimal Objective Autonomic Dysfunction in Long COVID
www.sciencedirect.com
September 4, 2025 at 2:23 PM
Dallas and New Hampshire researchers tested 128 long COVID patients with suspected dysautonomia.
Despite heavy symptoms, most showed normal results.
Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon.
www.sciencedirect.com/science/arti...
Despite heavy symptoms, most showed normal results.
Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon.
www.sciencedirect.com/science/arti...
US stroke neurologist here. Who can explain the new AI tool that tripled good outcomes and reduced treatment times by one hour, according to this article?
From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?
From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?
Stroke centres in England given AI tool that will help 50% of patients recover
Stroke centres in England given AI tool that will help 50% of patients recover
NHS equips all centres with life-saving software that will increase number of patients avoiding serious disability
Half of all people who experience a stroke in England will now recover thanks to a revolutionary AI scanning system that increases the number of patients avoiding serious disability.
The NHS has equipped every stroke centre in England with life-saving software that quickly tells doctors if they need to perform emergency surgery and can triple the rate of recovery. Continue reading...
www.theguardian.com
September 3, 2025 at 8:16 AM
US stroke neurologist here. Who can explain the new AI tool that tripled good outcomes and reduced treatment times by one hour, according to this article?
From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?
From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?
That’s what happened to Google search? Proof that one person really can change the world!
I can hear Ed Zitron chanting the name of Prabhakar Raghavan over and over again
www.wheresyoured.at/the-men-who-...
www.wheresyoured.at/the-men-who-...
The Man Who Killed Google Search
Wanna listen to this story instead? Check out this week's Better Offline podcast, "The Man That Destroyed Google Search," available on Apple Podcasts, Spotify, and anywhere else you get your podcasts....
www.wheresyoured.at
August 23, 2025 at 10:56 PM
That’s what happened to Google search? Proof that one person really can change the world!
Greatly appreciate this review of epigenetic mechanisms underlying regeneration competency only in young animals. Especially timely perspective for those of us puzzling over CNS repair.
Excited to share our recent viewpoint with @storerlab.bsky.social led by Kirsten Sadler, on epigenetic mechanisms of regenerative resilience.
Ageing versus developmental silencing: Answers from the epigenome - Sadler - The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/...
Ageing versus developmental silencing: Answers from the epigenome - Sadler - The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
It is easier for young animals to regenerate damaged or missing tissues. In this Viewpoint, we propose that this is, in part, attributed to epigenetic changes, with chromatin becoming more closed and....
febs.onlinelibrary.wiley.com
August 22, 2025 at 10:52 PM
Greatly appreciate this review of epigenetic mechanisms underlying regeneration competency only in young animals. Especially timely perspective for those of us puzzling over CNS repair.
Happy Birthday, new Parkland Hospital!
Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*!
While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care.
www.parklandhealth.org/news-and-upd...
Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*!
While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care.
www.parklandhealth.org/news-and-upd...
News & Updates | Parkland Health
www.parklandhealth.org
August 20, 2025 at 9:22 PM
Happy Birthday, new Parkland Hospital!
Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*!
While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care.
www.parklandhealth.org/news-and-upd...
Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*!
While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care.
www.parklandhealth.org/news-and-upd...
As owner of the stroke service “black cloud” it’s good to see the ED is well prepared for our kind of day.
August 10, 2025 at 5:14 PM
As owner of the stroke service “black cloud” it’s good to see the ED is well prepared for our kind of day.
Reposted by Mark Goldberg 🧠
Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary
Spatial transcriptomics reveals human cortical layer and area specification - Nature
Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially res...
www.nature.com
August 8, 2025 at 8:13 AM
Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary
Reposted by Mark Goldberg 🧠
Multi-omic underpinnings of Alzheimer's disease promote inflammation (particularly via T cells)whereas those for stroke relate to vascular integrity @cp-neuron.bsky.social
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Human brain vascular multi-omics elucidates disease-risk associations
Reid et al. develop MultiVINE-seq to map thousands of non-coding disease variants
to genes in human brain vascular cells. Cerebrovascular disease variants compromise
vessel integrity, whereas Alzheime...
www.cell.com
July 28, 2025 at 3:04 PM
Multi-omic underpinnings of Alzheimer's disease promote inflammation (particularly via T cells)whereas those for stroke relate to vascular integrity @cp-neuron.bsky.social
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Reposted by Mark Goldberg 🧠
Post-stroke fatigue can be long-lasting and disabling in patients recovering from a #stroke. New research identified a machine learning-based model that effectively predicted early post-stroke fatigue. Knowing who is at greatest risk can inform treatment. 🧪 🧠🔄 🧠📈
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...
July 28, 2025 at 4:09 PM
Post-stroke fatigue can be long-lasting and disabling in patients recovering from a #stroke. New research identified a machine learning-based model that effectively predicted early post-stroke fatigue. Knowing who is at greatest risk can inform treatment. 🧪 🧠🔄 🧠📈
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...
Spectacular view from the 2025 Gordon Research Conference on CNS Injury & Repair near Barga, Italy. Terrific science happening here.
Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.
Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.
July 10, 2025 at 4:07 PM
Spectacular view from the 2025 Gordon Research Conference on CNS Injury & Repair near Barga, Italy. Terrific science happening here.
Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.
Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.
Reposted by Mark Goldberg 🧠
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution - Nature
A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promise...
www.nature.com
July 2, 2025 at 4:27 PM
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
www.nature.com/articles/s41...
www.nature.com/articles/s41...