Martí-Mateos et al. show that red blood cells explain improved glucose tolerance at high altitude. By manipulating red blood cell number, they determine that these cells are necessary and sufficient f...

Post-COVID-19 Syndrome (PCS) frequently presents with persistent fatigue, cognitive impairment, and emotional symptoms. Although structural brain chan…

Post-acute sequelae of SARS-CoV-2 infection (PASC) can affect multiple organ systems, but the role of preinfectional body mass index (BMI) in these ou…

The novel coronavirus (SARS-CoV-2) is a highly infectious respiratory virus with significant pathogenicity. Although its impact has lessened in many countries, its ongoing mutations and sporadic outbr...

SARS-CoV-2, the causative agent of COVID-19, remains a global concern due to gaps in understanding its pathogenesis. Peptidyl-arginine deiminases (PADs) are emerging as key regulators of viral replica...

Viruses and their hosts have been co-evolving in a continual arms race for fitness and survival, respectively (1). In humans, the innate and adaptive arms of immunity intimately interact to control infection. Antibodies (Abs), secreted by certain activated B cells, are an essential portion of the adaptive immune response and are a major pillar in the viral clearance of both enveloped viruses as well as some non-enveloped viruses (1–5). Certain antibodies are developed with the ability, through their fragment antigen-binding region, to bind to viral epitopes and, through a variety of methods (e.g., steric obstruction or changing conformation), result in the neutralization of the target antigen (4).

Myalgic encephalomyelitis (ME), commonly known as chronic fatigue syndrome (CFS), is a long-lasting neurological disease. The cause of ME remains unce…

Background Carditis (myocarditis, pericarditis, and endocarditis) is a rare but serious complication of SARS-CoV-2 infection. While COVID-19 has been associated with heightened long-term cardiovascula...

Background Many adults with Long COVID experience adverse mental health outcomes, but the long-term persistence of these associations remains unclear. We examined the prospective associations of Long ...

The emergence of resistance to SARS-CoV-2 main protease (Mpro) inhibitors such as nirmatrelvir poses a significant threat to the long-term effectiveness of COVID-19 antivirals. Ibuzatrelvir (PF-078178...

Nature - Host control of persistent Epstein–Barr virus infection

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

npj Biosensing - Plasmon-enhanced bioassay for amplification-free detection and quantification of SARS-CoV-2 RNA

Scientific Reports - Altered NGF and GDNF levels reveal neuroimmune dysregulation in COVID-19 patients

COVID-19 has been shown to cause a range of harmful long-term effects on nearly every organ system [1-3]. These findings are based on retrospective studies comparing COVID-19 patients to patients with...

Microscopic imaging and biochemical studies show that sinuses in mouse and human form a highly dynamic surface that regulates fluid movement and immune cell surveillance via RAMP1-dependent regul...

Veins in the skull can rearrange their borders to accommodate patrolling immune cells, a strange behaviour called ruffling.

The Ca2+ channel Orai1 in microglia links systemic inflammation to depressive-like behaviors in mice.

The Australian framework for early-stage trials has been around for 30 years and shows speed and safety do not have to come at each other's expense

Neuroimmune interactions shape neurodegenerative disease progression. This Review examines how microglia integrate signals from central and peripheral immune cells, outlines emerging therapeutic targe...

With more than 200 possible symptoms, long Covid isn’t easy to treat and diagnose. Rolled-back federal funding has led longhaulers to ask: is this all in my head?

Scientific Reports - Harmonization of IgG antibody values against the SARS-CoV-2 Spike protein