thetranscendedman
@atranscendedman.bsky.social
Transparent to the transcendent.
Wrote a book on Long Covid. - https://jondouglas.dev/longhaul/
Extraordinary claims require extraordinary evidence. - Sagan
Wrote a book on Long Covid. - https://jondouglas.dev/longhaul/
Extraordinary claims require extraordinary evidence. - Sagan
Johns Hopkins researchers studied over 2,600 people and found that those with long COVID who were boosted before infection reported significantly less mental fatigue than unvaccinated peers.
No effect was seen in those who never had long COVID.
www.medrxiv.org/content/10.1...
No effect was seen in those who never had long COVID.
www.medrxiv.org/content/10.1...
Pre-infection COVID-19 vaccination and long-COVID mental fatigue severity: Findings from the Johns Hopkins COVID Long Study
Background Long-COVID is a post-acute sequela of SARS-CoV-2 infection characterized by persistent, multi-system symptoms. Neurologic symptoms, such as mental fatigue, are often reported. While vaccina...
www.medrxiv.org
November 11, 2025 at 9:07 PM
Johns Hopkins researchers studied over 2,600 people and found that those with long COVID who were boosted before infection reported significantly less mental fatigue than unvaccinated peers.
No effect was seen in those who never had long COVID.
www.medrxiv.org/content/10.1...
No effect was seen in those who never had long COVID.
www.medrxiv.org/content/10.1...
In Rio de Janeiro, researchers studied 60 people and found that postural balance in those with long COVID was linked to depression symptoms.
Emotional health may play a key role in physical stability after infection.
www.sciencedirect.com/science/arti...
Emotional health may play a key role in physical stability after infection.
www.sciencedirect.com/science/arti...
DEPRESSION IS ASSOCIATED WITH POSTURAL BALANCE IN INDIVIDUALS WITH LONG COVID: A CROSS-SECTIONAL STUDY
COVID-19 is a multisystemic condition that can cause persistent symptoms, including emotional alterations such as anxiety, depression, and stress. The…
www.sciencedirect.com
November 11, 2025 at 9:05 PM
In Rio de Janeiro, researchers studied 60 people and found that postural balance in those with long COVID was linked to depression symptoms.
Emotional health may play a key role in physical stability after infection.
www.sciencedirect.com/science/arti...
Emotional health may play a key role in physical stability after infection.
www.sciencedirect.com/science/arti...
In a trial across hospitals in Scotland, 233 adults recovering from COVID-19 saw better walking ability, mental health, and grip strength after 3 months of personalized resistance exercise compared to usual care.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Resistance Exercise Therapy After COVID-19 Infection
This randomized clinical trial assesses the effects of a personalized resistance exercise intervention on exercise capacity, health status, and psychological function among adults after COVID-19 infec...
jamanetwork.com
November 11, 2025 at 8:59 PM
In a trial across hospitals in Scotland, 233 adults recovering from COVID-19 saw better walking ability, mental health, and grip strength after 3 months of personalized resistance exercise compared to usual care.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
In Brazil 105 Alzheimer patients were tracked for 5 years.
Those who survived COVID had nearly 5 times the risk of rapid disease progression and were more likely to die compared to those who never got infected.
journals.lww.com/alzheimerjou...
Those who survived COVID had nearly 5 times the risk of rapid disease progression and were more likely to die compared to those who never got infected.
journals.lww.com/alzheimerjou...
journals.lww.com
November 11, 2025 at 8:58 PM
In Brazil 105 Alzheimer patients were tracked for 5 years.
Those who survived COVID had nearly 5 times the risk of rapid disease progression and were more likely to die compared to those who never got infected.
journals.lww.com/alzheimerjou...
Those who survived COVID had nearly 5 times the risk of rapid disease progression and were more likely to die compared to those who never got infected.
journals.lww.com/alzheimerjou...
Twelve years of love. Always by my side. I’ll miss you, Andie. Forever my best girl.
November 11, 2025 at 11:58 AM
Twelve years of love. Always by my side. I’ll miss you, Andie. Forever my best girl.
At 22 US sites, a trial with 328 adults tested 3 remote therapies for cognitive long COVID.
None outperformed computer games on self-reported cognition.
All groups improved slightly over time, suggesting a placebo or natural recovery effect.
jamanetwork.com/journals/jam...
None outperformed computer games on self-reported cognition.
All groups improved slightly over time, suggesting a placebo or natural recovery effect.
jamanetwork.com/journals/jam...
Interventions for Cognitive Symptoms in Long COVID
This randomized clinical trial investigates if evidence-based rehabilitation strategies improve cognitive symptoms in persons with long COVID.
jamanetwork.com
November 10, 2025 at 4:57 PM
At 22 US sites, a trial with 328 adults tested 3 remote therapies for cognitive long COVID.
None outperformed computer games on self-reported cognition.
All groups improved slightly over time, suggesting a placebo or natural recovery effect.
jamanetwork.com/journals/jam...
None outperformed computer games on self-reported cognition.
All groups improved slightly over time, suggesting a placebo or natural recovery effect.
jamanetwork.com/journals/jam...
In a Texas-based study of 11,516 children with atopic dermatitis, COVID-19 vaccination was linked to lower rates of asthma, skin infections, and multiple respiratory illnesses, suggesting broader immune protection in this group.
www.annallergy.org/article/S108...
www.annallergy.org/article/S108...
COVID-19 VACCINATION IS ASSOCIATED WITH REDUCED COMPLICATIONS IN PEDIATRIC PATIENTS WITH ATOPIC DERMATITIS
Atopic dermatitis (AD) involves immune dysregulation and increases the risk of allergic
and infectious conditions, often preceding asthma and allergic rhinitis in the atopic
triad. This study evaluate...
www.annallergy.org
November 10, 2025 at 2:29 PM
In a Texas-based study of 11,516 children with atopic dermatitis, COVID-19 vaccination was linked to lower rates of asthma, skin infections, and multiple respiratory illnesses, suggesting broader immune protection in this group.
www.annallergy.org/article/S108...
www.annallergy.org/article/S108...
In England, researchers studied 13.9 million children and found that COVID-19 infection raised the risk of rare heart and blood conditions for at least 12 months, while vaccination raised a smaller short-term risk of heart inflammation.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Vascular and inflammatory diseases after COVID-19 infection and vaccination in children and young people in England: a retrospective, population-based cohort study using linked electronic health recor...
Children and young people have higher risks of rare vascular and inflammatory diseases
up to 12 months after a first COVID-19 diagnosis and higher risk of rare myocarditis
or pericarditis up to 4 week...
www.thelancet.com
November 10, 2025 at 1:09 PM
In England, researchers studied 13.9 million children and found that COVID-19 infection raised the risk of rare heart and blood conditions for at least 12 months, while vaccination raised a smaller short-term risk of heart inflammation.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
South Africa’s University of Cape Town studied 333 children and found that severe COVID-19 in kids shows unique immune suppression patterns in blood genes, distinct from RSV or TB.
Over 5000 genes differed, hinting at new diagnostic and drug targets.
www.biorxiv.org/content/10.1...
Over 5000 genes differed, hinting at new diagnostic and drug targets.
www.biorxiv.org/content/10.1...
Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections
The clinical severity of SARS-CoV-2 infection in children varies, with asymptomatic or mild illness predominating and a minority developing severe disease. Understanding the immunological responses th...
www.biorxiv.org
November 10, 2025 at 1:07 PM
South Africa’s University of Cape Town studied 333 children and found that severe COVID-19 in kids shows unique immune suppression patterns in blood genes, distinct from RSV or TB.
Over 5000 genes differed, hinting at new diagnostic and drug targets.
www.biorxiv.org/content/10.1...
Over 5000 genes differed, hinting at new diagnostic and drug targets.
www.biorxiv.org/content/10.1...
Researchers studied 187 people in Western India and found that fatigue, cough and anxiety persisted in long COVID patients even 3 to 4 years after infection.
Mechanical ventilation and Remdesivir were linked to higher long COVID risk.
www.sciencedirect.com/science/arti...
Mechanical ventilation and Remdesivir were linked to higher long COVID risk.
www.sciencedirect.com/science/arti...
Persistence of post-acute COVID-19 sequelae up to four years in patients with long COVID from Western India: A cross-sectional descriptive study
Post-Acute Sequelae of COVID-19 or Long COVID (LC) affects millions globally, with persistent immune, neurological, and cardiovascular symptoms posing…
www.sciencedirect.com
November 10, 2025 at 1:04 PM
Researchers studied 187 people in Western India and found that fatigue, cough and anxiety persisted in long COVID patients even 3 to 4 years after infection.
Mechanical ventilation and Remdesivir were linked to higher long COVID risk.
www.sciencedirect.com/science/arti...
Mechanical ventilation and Remdesivir were linked to higher long COVID risk.
www.sciencedirect.com/science/arti...
Mass General researchers studied 300 lymphoma patients and found that 12 months of atorvastatin cut the odds of aortic stiffening from 50% to 5% during anthracycline chemotherapy.
Vascular function was preserved even in younger adults.
jamanetwork.com/journals/jam...
Vascular function was preserved even in younger adults.
jamanetwork.com/journals/jam...
Atorvastatin and Aortic Stiffness During Anthracycline-Based Chemotherapy
This secondary analysis of a randomized clinical trial examines whether atorvastatin pretreatment is associated with attenuation of anthracycline-induced increased aortic stiffness among patients with...
jamanetwork.com
November 10, 2025 at 1:03 PM
Mass General researchers studied 300 lymphoma patients and found that 12 months of atorvastatin cut the odds of aortic stiffening from 50% to 5% during anthracycline chemotherapy.
Vascular function was preserved even in younger adults.
jamanetwork.com/journals/jam...
Vascular function was preserved even in younger adults.
jamanetwork.com/journals/jam...
University of Alberta researchers studied 78 long COVID patients with ME/CFS and found women showed stronger immune activation, more inflammation, and disrupted hormone levels.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
Shahbaz et al. find that female long COVID patients with ME/CFS exhibit heightened
inflammation, altered hematopoiesis, disrupted hormone levels, and neuroinflammatory
gene signatures. In parallel, ou...
www.cell.com
November 10, 2025 at 1:01 PM
University of Alberta researchers studied 78 long COVID patients with ME/CFS and found women showed stronger immune activation, more inflammation, and disrupted hormone levels.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Karolinska Institutet tracked over 292,000 Swedish retail and wholesale workers and found only 2.7% had long sickness absence due to COVID-19.
Respiratory disease, diabetes, hypertension, and immunodeficiency raised that risk even after past sick leave.
academic.oup.com/eurpub/advan...
Respiratory disease, diabetes, hypertension, and immunodeficiency raised that risk even after past sick leave.
academic.oup.com/eurpub/advan...
Associations between diagnoses linked with adverse COVID-19-related outcomes and sickness absence due to COVID-19 or COVID-19 like diagnoses: a prospective Swedish cohort study of 292 274 blue-collar ...
Abstract. Several diagnoses have been associated with increased risk for adverse health outcomes following COVID-19 infection. Whether these diagnoses also
academic.oup.com
November 10, 2025 at 1:00 PM
Karolinska Institutet tracked over 292,000 Swedish retail and wholesale workers and found only 2.7% had long sickness absence due to COVID-19.
Respiratory disease, diabetes, hypertension, and immunodeficiency raised that risk even after past sick leave.
academic.oup.com/eurpub/advan...
Respiratory disease, diabetes, hypertension, and immunodeficiency raised that risk even after past sick leave.
academic.oup.com/eurpub/advan...
Researchers from Tokyo, Los Alamos, and Washington University reviewed five years of SARS-CoV-2 evolution and found that repeated variant shifts like Delta and Omicron were driven by mutations that helped the virus escape immunity and spread faster.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SARS-CoV-2 variants: biology, pathogenicity, immunity and control - Nature Reviews Microbiology
This Review explores the evolution of SARS-CoV-2 since its emergence in late 2019 and discusses how the changes in the various variants and subvariants have affected the viral life cycle and ongoing t...
www.nature.com
November 10, 2025 at 12:55 PM
Researchers from Tokyo, Los Alamos, and Washington University reviewed five years of SARS-CoV-2 evolution and found that repeated variant shifts like Delta and Omicron were driven by mutations that helped the virus escape immunity and spread faster.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hong Kong researchers studied over 38,000 hospitalized COVID-19 patients and found those who started nirmatrelvir-ritonavir the same day as diagnosis had a 49% lower risk of death and 27% lower risk of hospitalization than untreated patients.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Greater benefits of immediate nirmatrelvir-ritonavir initiation for post-COVID outcomes: a population-based retrospective cohort study - Nature Communications
Antiviral treatment with nirmatrelvir-ritonavir has been associated with improved post-COVID outcomes. Here, the authors perform a retrospective cohort study using electronic health record data from H...
www.nature.com
November 10, 2025 at 12:55 PM
Hong Kong researchers studied over 38,000 hospitalized COVID-19 patients and found those who started nirmatrelvir-ritonavir the same day as diagnosis had a 49% lower risk of death and 27% lower risk of hospitalization than untreated patients.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Researchers from Zhejiang University and UC Davis studied how metformin works differently from other biguanides.
Using cryo-EM, they found metformin enters complex I only when it is open and blocks CoQ10 in the closed state, revealing why it’s safer and effective.
www.nature.com/articles/s41...
Using cryo-EM, they found metformin enters complex I only when it is open and blocks CoQ10 in the closed state, revealing why it’s safer and effective.
www.nature.com/articles/s41...
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms - Nature Structural & Molecular Biology
He, Teng and Yang et al. report how metformin, the widely used antidiabetic drug, inhibit its target, the respiratory complex I, through a distinct state-dependent, inhibitor trapping mechanism, thus ...
www.nature.com
November 10, 2025 at 12:53 PM
Researchers from Zhejiang University and UC Davis studied how metformin works differently from other biguanides.
Using cryo-EM, they found metformin enters complex I only when it is open and blocks CoQ10 in the closed state, revealing why it’s safer and effective.
www.nature.com/articles/s41...
Using cryo-EM, they found metformin enters complex I only when it is open and blocks CoQ10 in the closed state, revealing why it’s safer and effective.
www.nature.com/articles/s41...
Korea National Institute of Health researchers gave SARS-CoV-2 spike protein to rats and found it entered the brain, disrupted synapses, triggered Alzheimer’s and Parkinson’s-related protein buildup, and impaired memory
Metformin prevented these effects
journals.plos.org/plosone/arti...
Metformin prevented these effects
journals.plos.org/plosone/arti...
SARS-CoV-2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin
Patients recovering from post-coronavirus disease 2019 (COVID-19) often experience cognitive dysfunction, including difficulties with focusing, conversation, or memory issues, which can persist for we...
journals.plos.org
November 9, 2025 at 1:57 PM
Korea National Institute of Health researchers gave SARS-CoV-2 spike protein to rats and found it entered the brain, disrupted synapses, triggered Alzheimer’s and Parkinson’s-related protein buildup, and impaired memory
Metformin prevented these effects
journals.plos.org/plosone/arti...
Metformin prevented these effects
journals.plos.org/plosone/arti...
University of Copenhagen researchers show that gut barrier breakdown allows bacterial products to leak into the bloodstream, fueling low-grade inflammation linked to obesity, type 2 diabetes, and fatty liver disease.
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
From Gut to Blood: Barrier Dysfunction as a Driver of Systemic Low-grade Inflammation in Cardiometabolic Disease | American Journal of Physiology-Cell Physiology | American Physiological Society
Chronic, low-grade inflammation is increasingly recognized as a fundamental driver of non-communicable diseases – including obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), a...
journals.physiology.org
November 9, 2025 at 1:55 PM
University of Copenhagen researchers show that gut barrier breakdown allows bacterial products to leak into the bloodstream, fueling low-grade inflammation linked to obesity, type 2 diabetes, and fatty liver disease.
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
RMIT University gave male rats an ACE2 inhibitor during childhood and found they showed lasting anxiety-like behavior as adults, linked to disrupted brain circuits in the amygdala and hippocampus.
Female rats were unaffected.
www.sciencedirect.com/science/arti...
Female rats were unaffected.
www.sciencedirect.com/science/arti...
Early life ACE2 inhibition leads to long term anxiety-like behaviour in rats by disrupting the amygdala
Angiotensin-converting enzyme 2 (ACE2) is important for cardiac and renal development as well as appropriate perinatal growth. In addition, ACE2 has r…
www.sciencedirect.com
November 6, 2025 at 7:03 PM
RMIT University gave male rats an ACE2 inhibitor during childhood and found they showed lasting anxiety-like behavior as adults, linked to disrupted brain circuits in the amygdala and hippocampus.
Female rats were unaffected.
www.sciencedirect.com/science/arti...
Female rats were unaffected.
www.sciencedirect.com/science/arti...
UNC researchers found that Omicron BA.5 infection in mice can lead to long-term lung fibrosis, even after the virus is cleared.
This model could help study chronic COVID symptoms and test new treatments.
journals.asm.org/doi/10.1128/...
This model could help study chronic COVID symptoms and test new treatments.
journals.asm.org/doi/10.1128/...
Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice | Journal of Virology
To best combat the evolving landscape of SARS-CoV-2 variants of interest and variants
of concern, the development of effective small animal models is of critical importance.
Herein, we describe the de...
journals.asm.org
November 6, 2025 at 6:35 PM
UNC researchers found that Omicron BA.5 infection in mice can lead to long-term lung fibrosis, even after the virus is cleared.
This model could help study chronic COVID symptoms and test new treatments.
journals.asm.org/doi/10.1128/...
This model could help study chronic COVID symptoms and test new treatments.
journals.asm.org/doi/10.1128/...
Researchers at Vel Tech Institute trained deep learning models on cough sounds to detect COVID-19.
Their ResNet-18 model achieved 98.5% accuracy and only 1% false positives, showing strong potential for rapid, low-cost screening.
www.nature.com/articles/s41...
Their ResNet-18 model achieved 98.5% accuracy and only 1% false positives, showing strong potential for rapid, low-cost screening.
www.nature.com/articles/s41...
ResNet-EfficientNet powered framework for high-precision cough-based classification of infectious diseases - Scientific Reports
Scientific Reports - ResNet-EfficientNet powered framework for high-precision cough-based classification of infectious diseases
www.nature.com
November 6, 2025 at 6:32 PM
Researchers at Vel Tech Institute trained deep learning models on cough sounds to detect COVID-19.
Their ResNet-18 model achieved 98.5% accuracy and only 1% false positives, showing strong potential for rapid, low-cost screening.
www.nature.com/articles/s41...
Their ResNet-18 model achieved 98.5% accuracy and only 1% false positives, showing strong potential for rapid, low-cost screening.
www.nature.com/articles/s41...
Call me crazy, but pouring millions into deep dives on a few Long COVID patients and testing promising treatments like it’s House MD actually feels… sensible.
At least while the trials catch up.
At least while the trials catch up.
November 6, 2025 at 1:54 PM
Call me crazy, but pouring millions into deep dives on a few Long COVID patients and testing promising treatments like it’s House MD actually feels… sensible.
At least while the trials catch up.
At least while the trials catch up.
In a study across five Italian hospitals with 282 patients, researchers found that hypertensive individuals who had COVID-19 showed increased arterial stiffness, higher systolic blood pressure, and needed more medications to stay controlled.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
COVID-19 induces greater difficulty in blood pressure control due to increased arterial stiffness - Internal and Emergency Medicine
COVID-19 infection induces widespread endotheliitis, with long-term effects on the vascular system and arterial hypertension that are still under investigation. This study verified the possible correl...
link.springer.com
November 5, 2025 at 7:44 PM
In a study across five Italian hospitals with 282 patients, researchers found that hypertensive individuals who had COVID-19 showed increased arterial stiffness, higher systolic blood pressure, and needed more medications to stay controlled.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
UCSF researchers studied 26 people and found that those with Long COVID had higher heart rates and more symptoms during tilt table testing, but most did not meet criteria for POTS or orthostatic hypotension, suggesting subtler autonomic issues.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Case-control study of autonomic symptoms in the setting of Long COVID with tilt table testing
Background Autonomic symptoms and orthostatic syndromes have been reported in Long COVID, but few studies have characterized findings using head up tilt table testing. Objective To characterize auto...
journals.plos.org
November 5, 2025 at 7:35 PM
UCSF researchers studied 26 people and found that those with Long COVID had higher heart rates and more symptoms during tilt table testing, but most did not meet criteria for POTS or orthostatic hypotension, suggesting subtler autonomic issues.
journals.plos.org/plosone/arti...
journals.plos.org/plosone/arti...
Researchers at Sungkyunkwan University reviewed how chronic stress drives disease by altering the body’s stress response.
Using allostasis and new tools like iPSC models and multi-omics, they aim to better detect and treat complex diseases.
www.nature.com/articles/s42...
Using allostasis and new tools like iPSC models and multi-omics, they aim to better detect and treat complex diseases.
www.nature.com/articles/s42...
Integrating allostasis and emerging technologies to study complex diseases - Communications Biology
This review applies the allostasis framework to complex diseases, linking chronic stress and allostatic load to drug addiction, immune diseases, and cancer, and highlights multi-omics, iPSC, and organ...
www.nature.com
November 5, 2025 at 5:41 PM
Researchers at Sungkyunkwan University reviewed how chronic stress drives disease by altering the body’s stress response.
Using allostasis and new tools like iPSC models and multi-omics, they aim to better detect and treat complex diseases.
www.nature.com/articles/s42...
Using allostasis and new tools like iPSC models and multi-omics, they aim to better detect and treat complex diseases.
www.nature.com/articles/s42...