People with certain forms of the MC4R gene have lower cholesterol levels than do other individuals with a high body-mass index.

The scientist and conservationist made waves with her observations and advocacy

Applications for 2026 entry will open on Tuesday 7 October 2025 at midday (BST) and close at 23:59 (GMT), Tuesday 18 November 2025.

Nature Reviews Bioengineering, Published online: 22 August 2025; doi:10.1038/s44222-025-00346-xHigh-throughput sequencing and artificial intelligence-driven structural biology have vastly expanded our understanding of the human metagenome, yet microbial functions remain largely elusive. In this Review, metagenomics analysis is explored across taxonomic, genetic, structural and spatial–temporal dimensions, highlighting emerging tools and opportunities to decode microbial roles in health and disease.

Nature Reviews Gastroenterology & Hepatology, Published online: 31 July 2025; doi:10.1038/s41575-025-01100-9Artificial intelligence (AI) is a powerful tool that could be applied to microbiome research. This Perspective discusses best practices and current limitations with the application of AI in microbiome data research, giving insights into future use and practical advice and recommendations on its use.

In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthsp...

Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library containing hundreds of N-acyl lipids, including conjugates with short-chain fatty acids. This resource enabled the...

A dataset of 2,997 metagenomes from 913 genetically diverse mice provides insights into microbiome interactions with ageing, dietary restriction, host genetics and longevity.

In this Perspective, Deiner, Gibbons and colleagues describe the current strengths and limitations of microbial community-scale metabolic models in microbiome research.

This Review critically examines the evidence base in precision nutrition research, discusses the challenges in translating short-term studies into long-term clinical effectiveness and highlights the m...

Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis. Understanding th…

Abstract. Weberviruses are bacteriophages (phages) that can infect and lyse clinically relevant, multidrug-resistant (MDR) strains of Klebsiella. They are

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...