@lenzlab.bsky.social
Reposted
Hey @nature.com What's up with your share buttons? Can we please also get 🦋 and 🦣 options to not exclusively promote the network of the guy who has done more than most to harm US science?
July 16, 2025 at 5:46 PM
Hey @nature.com What's up with your share buttons? Can we please also get 🦋 and 🦣 options to not exclusively promote the network of the guy who has done more than most to harm US science?
Reposted
Always good to remember.
July 15, 2025 at 8:36 PM
Always good to remember.
Reposted
Best image of the day:
June 15, 2025 at 2:30 AM
Best image of the day:
Reposted
![[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreid7lnvd7afmasx3nxi6anxmyhbatpaw54za3kiw3eaoclrf722faq@jpeg)
Reposted
Discover HistoGPT! Trained on 15,129 slides, it transforms gigapixel histology images into instant pathology reports, revolutionizing diagnostics. PMID:40419470, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-60014-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Generating dermatopathology reports from gigapixel whole slide images with HistoGPT | Nature Communications
Histopathology is the reference standard for diagnosing the presence and nature of many diseases, including cancer. However, analyzing tissue samples under a microscope and summarizing the findings in a comprehensive pathology report is time-consuming, labor-intensive, and non-standardized. To address this problem, we present HistoGPT, a vision language model that generates pathology reports from a patient’s multiple full-resolution histology images. It is trained on 15,129 whole slide images from 6705 dermatology patients with corresponding pathology reports. The generated reports match the quality of human-written reports for common and homogeneous malignancies, as confirmed by natural language processing metrics and domain expert analysis. We evaluate HistoGPT in an international, multi-center clinical study and show that it can accurately predict tumor subtypes, tumor thickness, and tumor margins in a zero-shot fashion. Our model demonstrates the potential of artificial intelligenc
doi.org
May 28, 2025 at 12:10 PM
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If a foreign adversary snuck into our Federal budget and cut science research and education the way we’re cutting it ourselves — strategically undermining America’s long-term health, wealth, and security — we would likely consider it an act of war.
May 19, 2025 at 7:36 PM
If a foreign adversary snuck into our Federal budget and cut science research and education the way we’re cutting it ourselves — strategically undermining America’s long-term health, wealth, and security — we would likely consider it an act of war.
Reposted
I would wager that most university systems generate money far in excess of what they receive from federal funding and tuition.
They are massive economic engines for local and national economies, employ collectively hundreds of thousands of people across the country, and generate new economies.
They are massive economic engines for local and national economies, employ collectively hundreds of thousands of people across the country, and generate new economies.
According to a 2021 report, the University of California system:
• generated $82B in economic activity in California
• supported 529K jobs in the state
• generated $21 in economic output for every $1 received
Public divestment from higher ed makes no sense, even in the narrowest economic terms.
• generated $82B in economic activity in California
• supported 529K jobs in the state
• generated $21 in economic output for every $1 received
Public divestment from higher ed makes no sense, even in the narrowest economic terms.
There is a false dichotomy drawn between "the ivory tower" and "the real world," and I'm here to report that in a post-industrial society, your real-world economy absolutely hinges on the university.
University towns are factory towns. Universities drive economic activity, not the other way around.
University towns are factory towns. Universities drive economic activity, not the other way around.
May 19, 2025 at 3:51 AM
I would wager that most university systems generate money far in excess of what they receive from federal funding and tuition.
They are massive economic engines for local and national economies, employ collectively hundreds of thousands of people across the country, and generate new economies.
They are massive economic engines for local and national economies, employ collectively hundreds of thousands of people across the country, and generate new economies.
Reposted
Does it matter if the pilot has never landed an aircraft before?
May 18, 2025 at 7:36 PM
Does it matter if the pilot has never landed an aircraft before?
Reposted
Happy 99th birthday to the man who gave voice to the wild. 🎉
Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.
You've inspired generations to fall in love with nature.
Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.
You've inspired generations to fall in love with nature.
May 8, 2025 at 7:09 AM
Happy 99th birthday to the man who gave voice to the wild. 🎉
Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.
You've inspired generations to fall in love with nature.
Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.
You've inspired generations to fall in love with nature.
Many additions to the bonfire since it was published, but this is a thoughtful essay to share with friends and family. Perhaps it will help them understand why the current efforts to break and burn the science infrastructure will be so damaging and hard to undo.
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
We are witnessing the destruction of science in America | Paul Darren Bieniasz
If we stay on this administration’s course, future life-saving medicines may never be invented
www.theguardian.com
May 7, 2025 at 7:35 PM
Many additions to the bonfire since it was published, but this is a thoughtful essay to share with friends and family. Perhaps it will help them understand why the current efforts to break and burn the science infrastructure will be so damaging and hard to undo.
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
Reposted
New NYT story on the letters from Acting US Attorney to Editors of science journals.
www.nytimes.com/2025/04/25/h...
www.nytimes.com/2025/04/25/h...
‘Vaguely Threatening’: Federal Prosecutor Queries Leading Medical Journal (Gift Article)
The New England Journal of Medicine received a letter suggesting that it was biased and compromised by external pressure. Other journals have also received the letter.
www.nytimes.com
April 25, 2025 at 9:36 PM
New NYT story on the letters from Acting US Attorney to Editors of science journals.
www.nytimes.com/2025/04/25/h...
www.nytimes.com/2025/04/25/h...
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UNLEASH THE LAWSUITS
April 21, 2025 at 6:51 PM
UNLEASH THE LAWSUITS
Reposted
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
www.wsj.com
April 21, 2025 at 6:21 PM
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
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Not to state the obvious, but none of them were sent to a terrorist prison in El Salvador. They all had lawyers, indictment by grand jury, a trial or a guilty plea where a judge ensured it was knowing & voluntary & access to an appeals process. In other words, all the hallmarks of due process.
April 21, 2025 at 8:53 PM
Not to state the obvious, but none of them were sent to a terrorist prison in El Salvador. They all had lawyers, indictment by grand jury, a trial or a guilty plea where a judge ensured it was knowing & voluntary & access to an appeals process. In other words, all the hallmarks of due process.
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🧪Holy shit. The Covid.gov website directs to the WH website claiming that covid came from a lab leak. And they are blaming Anthony Fauci. And calling the NIH a failure. I am utterly speechless. Anti-science propaganda running its wheels in real time.
Lab Leak: The True Origins of Covid-19
THE ORIGIN “The Proximal Origin of SARS-CoV-2” publication — which was used repeatedly by public health officials and the media to discredit the lab leak
Covid.gov
April 19, 2025 at 12:19 AM
🧪Holy shit. The Covid.gov website directs to the WH website claiming that covid came from a lab leak. And they are blaming Anthony Fauci. And calling the NIH a failure. I am utterly speechless. Anti-science propaganda running its wheels in real time.
I read this editorial in Science magazine today. It is focused on science in Latin America and how political decisions have scuttled progress. It struck me as being eerily similar to what is currently happening at the NIH in the U.S.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
When state support for science fails
The establishment and growth of scientific communities require long-term planning, political backing, and social and economic support. In many Latin American countries, these entities have been repeat...
www.science.org
April 18, 2025 at 6:09 PM
I read this editorial in Science magazine today. It is focused on science in Latin America and how political decisions have scuttled progress. It struck me as being eerily similar to what is currently happening at the NIH in the U.S.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
🧪
Do folks have a favorite tutorial for modeling potential fusion protein constructs using Alphafold or similar in silico tools? I want to see how a fluorescent protein affects the accessibility of an adjacent domain.
April 18, 2025 at 12:14 AM
🧪
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Sen. Booker’s speech was a substantive and moral account of this moment. He did not read the phone book. He did not babble.
For 24 hours @booker.senate.gov laid out a detailed, damning, and critical narrative of truth, history, politics, morality, humanity.
What will you do?
For 24 hours @booker.senate.gov laid out a detailed, damning, and critical narrative of truth, history, politics, morality, humanity.
What will you do?
April 1, 2025 at 11:46 PM
Sen. Booker’s speech was a substantive and moral account of this moment. He did not read the phone book. He did not babble.
For 24 hours @booker.senate.gov laid out a detailed, damning, and critical narrative of truth, history, politics, morality, humanity.
What will you do?
For 24 hours @booker.senate.gov laid out a detailed, damning, and critical narrative of truth, history, politics, morality, humanity.
What will you do?
Reposted
Records are meant to be broken. Congrats @booker.senate.gov for stepping up and standing up for the American people.
Blazing your own path for the W
👏👏👏👏👏
Blazing your own path for the W
👏👏👏👏👏
April 1, 2025 at 11:15 PM
Records are meant to be broken. Congrats @booker.senate.gov for stepping up and standing up for the American people.
Blazing your own path for the W
👏👏👏👏👏
Blazing your own path for the W
👏👏👏👏👏
Reposted
Happy to share DEBIAS-M, our new method for domain adaptation and bias correction in #microbiome data.🧬🖥️
Microbiome data is very variable, with substantial study- and batch-effects. DEBIAS-M corrects these, enabling robust and generalizable analyses.
A quick thread:
www.nature.com/articles/s41...
Microbiome data is very variable, with substantial study- and batch-effects. DEBIAS-M corrects these, enabling robust and generalizable analyses.
A quick thread:
www.nature.com/articles/s41...
Processing-bias correction with DEBIAS-M improves cross-study generalization of microbiome-based prediction models - Nature Microbiology
DEBIAS-M corrects technical variability in microbiome data in a manner both interpretable and suitable for machine learning. In extensive benchmarks, DEBIAS-M facilitates robust analyses that generali...
www.nature.com
March 27, 2025 at 4:01 PM
Happy to share DEBIAS-M, our new method for domain adaptation and bias correction in #microbiome data.🧬🖥️
Microbiome data is very variable, with substantial study- and batch-effects. DEBIAS-M corrects these, enabling robust and generalizable analyses.
A quick thread:
www.nature.com/articles/s41...
Microbiome data is very variable, with substantial study- and batch-effects. DEBIAS-M corrects these, enabling robust and generalizable analyses.
A quick thread:
www.nature.com/articles/s41...
Reposted
“There is terrifically interesting stuff hiding in plain sight”
New antibiotic that kills drug-resistant bacteria discovered in technician’s garden
🧪
@nature.com
www.nature.com/articles/d41...
New antibiotic that kills drug-resistant bacteria discovered in technician’s garden
🧪
@nature.com
www.nature.com/articles/d41...
New antibiotic that kills drug-resistant bacteria discovered in technician’s garden
The molecule targets bacteria in a way that other drugs don’t.
www.nature.com
March 27, 2025 at 6:41 AM
“There is terrifically interesting stuff hiding in plain sight”
New antibiotic that kills drug-resistant bacteria discovered in technician’s garden
🧪
@nature.com
www.nature.com/articles/d41...
New antibiotic that kills drug-resistant bacteria discovered in technician’s garden
🧪
@nature.com
www.nature.com/articles/d41...