Lara Labarta-Bajo, PhD
@larallbb.bsky.social
NeuroImmunology & Aging enthusiast | Postdoc Allen Lab @SalkInstitute.bsky.social | Alumni in the Zuniga Lab at UC San Diego
Pinned
authors.elsevier.com
Astrocytes shape neuronal circuits, but their role in aging remains unclear. How do they change with age? What promotes aging in astrocytes, and how do they affect brain health 🧠✨? Thanks to @cp-neuron.bsky.social , my fabulous mentor Nicola J Allen & reviewers authors.elsevier.com/c/1kPEa3BtfH...
Why does the cerebellum age earlier than other brain regions? Why are cerebellar astrocytes so profoundly altered in advanced age? How do these changes affect motor coordination? Check out my postdoc work here: www.biorxiv.org/content/10.1...
The antiviral Interferon pathway drives astrocyte aging and motor decline
Aging encompasses low-level inflammation and motor decline. Astrocytes are neuroregulatory glial cells that change in aging, particularly in the cerebellum, which is essential for movement coordinatio...
www.biorxiv.org
November 21, 2025 at 5:51 AM
Why does the cerebellum age earlier than other brain regions? Why are cerebellar astrocytes so profoundly altered in advanced age? How do these changes affect motor coordination? Check out my postdoc work here: www.biorxiv.org/content/10.1...
Reposted by Lara Labarta-Bajo, PhD
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
www.sciencedirect.com
October 10, 2025 at 11:13 PM
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Lara Labarta-Bajo, PhD
M.I.T. Rejects a White House Offer for Special Funding Treatment
www.nytimes.com
October 10, 2025 at 5:19 PM
Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems www.nytimes.com/2025/10/06/h...
Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems
www.nytimes.com
October 6, 2025 at 2:49 PM
Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems www.nytimes.com/2025/10/06/h...
Reposted by Lara Labarta-Bajo, PhD
The courts aren’t falling for Trump’s chaos
They’ve blocked him 200+ times, including when trying to deploy the Nat’l Guard to Portland w/ no emergency on the ground
At @democracydefendersfund.org we’ve led 150+ legal actions to stop this lawless power grab
I explain on @velshimsnbc.bsky.social👇
They’ve blocked him 200+ times, including when trying to deploy the Nat’l Guard to Portland w/ no emergency on the ground
At @democracydefendersfund.org we’ve led 150+ legal actions to stop this lawless power grab
I explain on @velshimsnbc.bsky.social👇
October 5, 2025 at 6:08 PM
The courts aren’t falling for Trump’s chaos
They’ve blocked him 200+ times, including when trying to deploy the Nat’l Guard to Portland w/ no emergency on the ground
At @democracydefendersfund.org we’ve led 150+ legal actions to stop this lawless power grab
I explain on @velshimsnbc.bsky.social👇
They’ve blocked him 200+ times, including when trying to deploy the Nat’l Guard to Portland w/ no emergency on the ground
At @democracydefendersfund.org we’ve led 150+ legal actions to stop this lawless power grab
I explain on @velshimsnbc.bsky.social👇
Reposted by Lara Labarta-Bajo, PhD
🔬 New preprint out!
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Just a moment...
Verifying you are human. This may take a few seconds.
https://biorxiv.org/content/10.110…
July 29, 2025 at 7:05 AM
🔬 New preprint out!
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
I am thrilled to be attending Cytokines2025. See you in beautiful Seattle @cytokinesociety.bsky.social signals.cytokinesociety.org/2025/06/30/n...
New Member Lara Labarta Bajo, PhD, The Salk Institute for Biological Studies, La Jolla, CA, USA - Biweekly newsletter of the International Cytokine & Interferon Society
Lara Labarta Bajo, PhD, is a postdoc in Nicola Allen's lab at the Salk Institute, studying the crosstalk between astrocytes and the immune system and its implications for synapses during healthy aging.
signals.cytokinesociety.org
July 25, 2025 at 4:09 PM
I am thrilled to be attending Cytokines2025. See you in beautiful Seattle @cytokinesociety.bsky.social signals.cytokinesociety.org/2025/06/30/n...
Reposted by Lara Labarta-Bajo, PhD
Repost if you're planning to go.
Cytokines 2025: Call for abstracts for oral or poster presentations. Topics include adaptive immunity, cytokine signaling, clinical applications, interferon stimulated genes, structure- function of cytokines, and more.
seattle.cytokinesociety.org/call-for-abs...
The deadline is May 18, 2025.
seattle.cytokinesociety.org/call-for-abs...
The deadline is May 18, 2025.
March 26, 2025 at 6:40 PM
Repost if you're planning to go.
Reposted by Lara Labarta-Bajo, PhD
Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com
gleichmanlab.com
The Gleichman lab
gleichmanlab.com
May 1, 2025 at 8:24 PM
Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com
gleichmanlab.com
Reposted by Lara Labarta-Bajo, PhD
Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice www.nature.com/articles/s41...
Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice - Nature Communications
Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve mitochondria...
www.nature.com
March 23, 2025 at 3:29 PM
Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice www.nature.com/articles/s41...
Reposted by Lara Labarta-Bajo, PhD
I'll be talking about some of this at the rally at UCSD tomorrow, thanks for having me!
March 6, 2025 at 8:48 PM
I'll be talking about some of this at the rally at UCSD tomorrow, thanks for having me!
Very interesting review by @neuronoeker.bsky.social et al aging-longevity.org.ua/journal-desc...
View of Astrocyte-neuron signaling in aging
aging-longevity.org.ua
March 5, 2025 at 4:20 PM
Very interesting review by @neuronoeker.bsky.social et al aging-longevity.org.ua/journal-desc...
Reposted by Lara Labarta-Bajo, PhD
Important reference for anyone planning to Stand Up for Science this week.
Apropos of nothing, now is a good time to brush up on your rights as a protester or protest organizer. You are largely protected under the first amendment, thiugh there are limitations. www.aclu.org/know-your-ri...
Know Your Rights | Protesters’ Rights | ACLU
The First Amendment protects your right to assemble and express your views through protest. However, police and other government officials are allowed to place certain narrow restrictions on the exerc...
www.aclu.org
March 4, 2025 at 8:43 PM
Important reference for anyone planning to Stand Up for Science this week.
Reposted by Lara Labarta-Bajo, PhD
Looks like tomorrow will bring votes on a Republican plan to fund tax cuts for the rich by slashing Medicaid.
So this is a great time to contact your Member of Congress.
So this is a great time to contact your Member of Congress.
February 25, 2025 at 12:54 AM
Looks like tomorrow will bring votes on a Republican plan to fund tax cuts for the rich by slashing Medicaid.
So this is a great time to contact your Member of Congress.
So this is a great time to contact your Member of Congress.
Reposted by Lara Labarta-Bajo, PhD
Reposted by Lara Labarta-Bajo, PhD
Thank you @thetransmitter.bsky.social for bringing attention to this.
Read @minicontreras.bsky.social's full interview: www.thetransmitter.org/funding/a-gu...
#neuroskyence
#neuroskyence
February 14, 2025 at 9:01 PM
Thank you @thetransmitter.bsky.social for bringing attention to this.
Reposted by Lara Labarta-Bajo, PhD
Reposted by Lara Labarta-Bajo, PhD
JUST IN: A federal judge in Massachusetts has blocked the Trump administration's rate change to NIH grants.
storage.courtlistener.com/recap/gov.us...
storage.courtlistener.com/recap/gov.us...
February 10, 2025 at 10:25 PM
JUST IN: A federal judge in Massachusetts has blocked the Trump administration's rate change to NIH grants.
storage.courtlistener.com/recap/gov.us...
storage.courtlistener.com/recap/gov.us...
Reposted by Lara Labarta-Bajo, PhD
Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/
Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed
Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%
datawrapper.dwcdn.net
February 9, 2025 at 4:24 PM
Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/
Reposted by Lara Labarta-Bajo, PhD
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH
grants.nih.gov
February 8, 2025 at 12:56 AM
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
Reposted by Lara Labarta-Bajo, PhD
🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313
Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…
sciencedirect.com
February 4, 2025 at 8:50 PM
🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
Reposted by Lara Labarta-Bajo, PhD
New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe
#MucosalImmunology #TumorImmunology
#MucosalImmunology #TumorImmunology
January 22, 2025 at 5:14 PM
New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe
#MucosalImmunology #TumorImmunology
#MucosalImmunology #TumorImmunology