Sirio Dupont
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labdupont.bsky.social
Sirio Dupont
@labdupont.bsky.social
1.1K followers 230 following 8 posts
We study #mechanobiology focusing on mechanotransduction, mitochondria, metabolism, and transcription factors @University of Padua.
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Reposted by Sirio Dupont
robertarkowitz.bsky.social
Forcing Golgi -
www.biorxiv.org/content/10.1...
Mechanical forces stimulate Golgi export
Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...
www.biorxiv.org
September 3, 2025 at 5:24 AM
Reposted by Sirio Dupont
lammerdinglab.bsky.social
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
July 16, 2025 at 6:35 PM
Reposted by Sirio Dupont
felixmendu.bsky.social
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio

meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
July 4, 2025 at 3:50 PM
Reposted by Sirio Dupont
biologists.bsky.social
The Company of Biologists Workshop - Mechanometabolism Unleashed: The Interface of Cell Mechanics and Metabolism

Thank you to Workshop organisers Marco Foiani, Ana-Maria Lennon-Duménil, Victoria Sanz-Moreno and Giorgio Scita.

#Workshop #Biology #CellBiology #Community #Collaboration #Research
Group photo from the Mechanometabolism Unleashed: The Interface of Cell Mechanics and Metabolism Workshop Held at Buxted Park, East Sussex, UK 22-25 June 2025
June 26, 2025 at 8:57 AM
Reposted by Sirio Dupont
metastasisresearch.bsky.social
Register for our next ECLC webinar by Marco Montagner, PhD on Understanding the determinants of the invisible phase of metastasis - June 26th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - tinyurl.com/ujer8yw8
June 23, 2025 at 8:25 PM
Reposted by Sirio Dupont
ahcells.bsky.social
There’s tons out there on fibroblast #mechanobiology in disease. In our new review in @aip-publishing.bsky.social, Yeji @cyj8.bsky.social gives the who/what/where/when/how/why of mechanosensitive fibroblast activation, from CAFs to FAFs and nearly everything in between!
pubs.aip.org/aip/apb/arti...
The mechanobiology of fibroblast activation in disease
Fibroblasts play crucial roles in wound healing, cancer, and fibrosis. Many aspects of these roles are driven by the process known as fibroblast activation. The
pubs.aip.org
June 23, 2025 at 1:38 PM
Reposted by Sirio Dupont
ardemp.bskyverified.social
Check out this remarkable debut paper from @jie-xu.bsky.social, a very creative lab alumnus. Very proud!

www.nature.com/articles/s41...
June 9, 2025 at 3:30 PM
Reposted by Sirio Dupont
carstenschulte4.bsky.social
#Science Bluesky, do your thing:
We're organising the International Symposium on Mechanobiology (ISMB) 2026 in #Glasgow & we're looking for research groups in Latin America & Africa who are doing great work in #Mechanobiology or adjacent areas.
Can you indicate some names to me?
May 30, 2025 at 8:24 PM
Reposted by Sirio Dupont
jdhl18.bsky.social
Shaping epithelial tissues by stem cell mechanics in development and cancer
www.nature.com/articles/s41...
Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology
Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...
www.nature.com
May 28, 2025 at 7:05 AM
Reposted by Sirio Dupont
sgabriele.bsky.social
My lab is co-organizing the CellMech2025 conference @cellmech2025.bsky.social. I’m excited to announce that the scientific program is now online!
👉🏼 cellmech2025.org/programme/

There’s still time to submit your abstract for the Scientific Art Contest and compete for prizes !
May 14, 2025 at 8:39 PM
Reposted by Sirio Dupont
natalieadye.bsky.social
Join us in Singapore in September for the "Mechanobiology in Time and Space" meeting hosted by the Mechanobiology Institute at NUS @mbisg.bsky.social and Max Planck Society @maxplanck.de. Abstracts due soon! www.mbi.nus.edu.sg/events/mbico...
May 13, 2025 at 3:25 AM
Reposted by Sirio Dupont
rodrigofg.bsky.social
Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!
Program and application instructions for the 2025 Mechanobiology of tissue morphogenesis and disease workshop in Baeza, Spain, October 21-23. Apply at https://www.unia.es/estudios-y-acceso/oferta-academica/formacion-continua/workshop-mechanobiology-of-tissue-morphogenesis-and-disease
April 25, 2025 at 2:08 PM
Reposted by Sirio Dupont
mpi-scienceoflight.bsky.social
Exploring the Frontiers of #Mechanobiology

Mechanobiology Conference III, organized by Prof. @bladoux.bsky.social ( #MPZPM), takes place July 6–12, 2025 in Vietnam. Topics include cell signaling, biomaterials & more.

📅 Deadlines: Abstracts – Apr 30 | Reg – Jun 6

👉 icisequynhon.com/conferences/...
The picture shows the official flyer with more information about the conference, for example the scientific organizing committee and the invited speakers.
April 16, 2025 at 7:28 AM
Reposted by Sirio Dupont
tanentzapflab.bsky.social
A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...
2025 Fibronectin, Integrins and Related Molecules Conference GRC
The 2025 Gordon Research Conference on Fibronectin, Integrins and Related Molecules will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 22, 2025 at 4:54 AM
labdupont.bsky.social
🚨 Last minute call we have an open call for post-docs expiring soon dm me if you’re interested! Several projects on the table around mitochondrial mechanotransduction and its functional roles in vivo!!
December 20, 2024 at 1:15 PM
labdupont.bsky.social
Culturing epithelial basal cells on a stiff ECM reactivates embryonic-like multipotency via integrin-AP1(YAP?) signaling from @cedric-blanpain.bsky.social www.nature.com/articles/s41...
Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice - Nature Communications
The mechanisms regulating multipotency in glandular epithelia remain unclear. Here, the authors identify the key role of collagen signaling and ECM stiffness in regulating stem cell multipotency in gl...
www.nature.com
December 18, 2024 at 9:56 PM
Reposted by Sirio Dupont
ardemp.bskyverified.social
TMC1/2 activation by mechanical forces in cell lines is compelling! The hearing field has struggled with membrane expression of these proteins, but a CRISPR screen offers a clever workaround. Excited to see if another lab can replicate these findings.
www.cell.com/neuron/fullt...
Human TMC1 and TMC2 are mechanically gated ion channels
Fu et al. showed that point mutations in MmTMC1/2 are localized in plasma membrane, and knockdown of UROD, RGP1, or ARL1 promotes plasma membrane localization of HsTMC1/2 in heterologous cells. HsTMC1/2 are activated by mechanical stimuli and function as pore-forming ion channels, supporting their roles as mechanotransduction channels in hair cells.
www.cell.com
December 13, 2024 at 7:17 PM
Reposted by Sirio Dupont
cellmech2025.bsky.social
👋Hello #mechanobiology community in 🦋!

This is the official account of the 10th Edition of the Cell Mech conference!

🔧We will soon announce the invited speaker list! Visit our website, subscribe to the mailing list, and follow us!:
cellmech2025.org

😍Join us in Leuven 2025!
The organizing committee, Sylvain Gabriele, Marine Luciano, Jorge Barrasa Fano, Yohalie Kalukula, Bart Smeets, Apeksha Shapeti, Hans Van Oosterwyck
cellmech2025.org
December 10, 2024 at 10:02 AM
labdupont.bsky.social
Looks like SREBP, triglycerides and cholesterol synthesis is a general #mitochondrial #mechanotransduction response to both ECM elasticity (Romani+Bertolio 2019, Romani 2024) and shear stress
www.nature.com/articles/s41...
Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression - Scientific Reports
Scientific Reports - Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression
www.nature.com
December 10, 2024 at 8:25 AM
Reposted by Sirio Dupont
niethammerlab.bsky.social
New preprint from the lab! www.researchsquare.com/article/rs-5...
Buffering of nuclear membrane tension and mechanotransduction by the endoplasmic reticulum revealed by quantitative ALPIN imaging
Nuclear deformation by osmotic shock or necrosis activates the cytosolic phospholipase A2 (cPla2) nuclear shape sensing pathway, a key regulator of tissue inflammation and repair. Ca²⁺ and inner nucle...
www.researchsquare.com
December 9, 2024 at 5:35 PM
Reposted by Sirio Dupont
xaviertrepat.bsky.social
Next week in London: Mechanobiology Shaping Life.
The deadline for registration is tomorrow, 26/11.
iop.eventsair.com/msl2025/
November 25, 2024 at 5:25 PM
labdupont.bsky.social
New links between forces, AMPK, and metabolism in endothelia by Kris DeMali's group on JCS @biologists.bsky.social doi.org/10.1242/jcs....
Shear stress-stimulated AMPK couples endothelial cell mechanics, metabolism, and vasodilation
Endothelial cells respond to mechanical force by stimulating cellular signaling, but how these pathways are linked to elevations in cell metabolism and whether metabolism supports the mechanical respo...
doi.org
November 20, 2024 at 2:49 PM
Reposted by Sirio Dupont
delphe.bsky.social
Hi #cancer, #ECMatrix, #biomaterials and #mechanobiology folks:
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:

www.nature.com/articles/s41...
Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option - Nature Cell Biology
Uroz et al. report that the distinct mechanical properties of brain vasculature versus parenchyma drive cancer cell migration through a talin-dependent mechanism, enabling vessel co-option and metasta...
www.nature.com
November 18, 2024 at 10:14 AM
labdupont.bsky.social
See you at the Workshop on 'Mechanometabolism Unleashed: The Interface of Cell Mechanics and Metabolism', organized by M.Foiani A.Lennon @vickysanzmoreno.bsky.social and
@lab-scita.bsky.social
Apply by 13 Dec biologists.com/workshops/ju...
#BiologistsWorkshops
November 18, 2024 at 8:46 AM