Kilchert lab
@kilchertlab.bsky.social
We are an RNA biology lab @JLU Giessen interested in RNA quality control, RNP remodelling and post-transcriptional gene regulation - branching into chromatin
Reposted by Kilchert lab
📣 Our lab is looking for a PhD student to join us in exploring RNA biology! Details in the announcement. Feel free to reach out with any questions—and please RT!
March 25, 2025 at 8:00 PM
📣 Our lab is looking for a PhD student to join us in exploring RNA biology! Details in the announcement. Feel free to reach out with any questions—and please RT!
Reposted by Kilchert lab
Postdoc positions in structural biology of RNA processing complexes.
An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.
Details: tinyurl.com/postdoc-RNA-...
An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.
Details: tinyurl.com/postdoc-RNA-...
Postdoc in Structural Biology of RNA processing complexes
Postdoctoral positions in structural biology of macromolecular complexes are available in the laboratory of Dr. Eva Kowalinski at the EMBL Grenoble, France. We are looking for highly motivated and amb...
tinyurl.com
July 17, 2025 at 9:50 AM
Postdoc positions in structural biology of RNA processing complexes.
An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.
Details: tinyurl.com/postdoc-RNA-...
An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.
Details: tinyurl.com/postdoc-RNA-...
Reposted by Kilchert lab
#Postdoc position - at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"
Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages)
Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...
Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages)
Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...
April 2, 2025 at 3:39 PM
#Postdoc position - at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"
Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages)
Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...
Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages)
Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...
Reposted by Kilchert lab
Congratulations to Anne Spang @spanglab.bsky.social for being elected as a new #AAASFellow by @aaas.org ! The world’s largest scientific society recognizes her outstanding contributions to the field of cell #biology and #biochemistry. @unibas.ch
www.biozentrum.unibas.ch/news/detail/...
www.biozentrum.unibas.ch/news/detail/...
Anne Spang awarded distinction of AAAS Fellow
The AAAS has elected Prof. Anne Spang at the Biozentrum, University of Basel, as a Fellow. With this honor, the world’s largest scientific society recognizes her outstanding contributions to the field...
www.biozentrum.unibas.ch
March 28, 2025 at 8:17 AM
Congratulations to Anne Spang @spanglab.bsky.social for being elected as a new #AAASFellow by @aaas.org ! The world’s largest scientific society recognizes her outstanding contributions to the field of cell #biology and #biochemistry. @unibas.ch
www.biozentrum.unibas.ch/news/detail/...
www.biozentrum.unibas.ch/news/detail/...
Reposted by Kilchert lab
I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
authors.elsevier.com
March 26, 2025 at 12:12 PM
I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
Reposted by Kilchert lab
A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
March 26, 2025 at 5:40 PM
A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Enables ‘watching’ of RNP assemblies inside living cells
Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...
Reposted by Kilchert lab
RNA Salon in mRNA Translation
We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft)
Please RT
@goetheuni.bsky.social @cpi-exstra.bsky.social
We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft)
Please RT
@goetheuni.bsky.social @cpi-exstra.bsky.social
March 24, 2025 at 6:57 AM
RNA Salon in mRNA Translation
We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft)
Please RT
@goetheuni.bsky.social @cpi-exstra.bsky.social
We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft)
Please RT
@goetheuni.bsky.social @cpi-exstra.bsky.social
Reposted by Kilchert lab
📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
Postdoctoral Researcher
Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...
elxw.fa.em3.oraclecloud.com
March 20, 2025 at 9:22 AM
📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
Reposted by Kilchert lab
Cool! #MTR4 #RNADecay #RNA #RNAExosome
The #nuclear #exosome co-factor #MTR4 shapes the #transcriptome for #meiotic initiation
Li Zhang, Jianshu Wang, Zhidong Tang, Zhen Lin, Ruibao Su, Naijing Hu, Yao Tang, Gaoxiang Ge, Jing Fan, Ming-Han Tong, Yuanchao Xue, Yu Zhou & Hong Cheng
rdcu.be/ed5WM
The #nuclear #exosome co-factor #MTR4 shapes the #transcriptome for #meiotic initiation
Li Zhang, Jianshu Wang, Zhidong Tang, Zhen Lin, Ruibao Su, Naijing Hu, Yao Tang, Gaoxiang Ge, Jing Fan, Ming-Han Tong, Yuanchao Xue, Yu Zhou & Hong Cheng
rdcu.be/ed5WM
The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation
Nature Communications - Nuclear RNA decay regulates gene expression in cultured cells, but its role in animals is largely unclear. Here, authors found that the nuclear exosome co-factor MTR4...
rdcu.be
March 18, 2025 at 9:08 PM
Cool! #MTR4 #RNADecay #RNA #RNAExosome
The #nuclear #exosome co-factor #MTR4 shapes the #transcriptome for #meiotic initiation
Li Zhang, Jianshu Wang, Zhidong Tang, Zhen Lin, Ruibao Su, Naijing Hu, Yao Tang, Gaoxiang Ge, Jing Fan, Ming-Han Tong, Yuanchao Xue, Yu Zhou & Hong Cheng
rdcu.be/ed5WM
The #nuclear #exosome co-factor #MTR4 shapes the #transcriptome for #meiotic initiation
Li Zhang, Jianshu Wang, Zhidong Tang, Zhen Lin, Ruibao Su, Naijing Hu, Yao Tang, Gaoxiang Ge, Jing Fan, Ming-Han Tong, Yuanchao Xue, Yu Zhou & Hong Cheng
rdcu.be/ed5WM
Reposted by Kilchert lab
✨New online!✨
@altmeyerlab.bsky.social, @karimmekhail.bsky.social et al. discuss how DNA double-strand break repair is modulated by nucleus and genome reshaping through chromatin state, condensates of repair proteins, and cytoskeleton reorganization.
🔗 go.nature.com/3DBSVCP
@altmeyerlab.bsky.social, @karimmekhail.bsky.social et al. discuss how DNA double-strand break repair is modulated by nucleus and genome reshaping through chromatin state, condensates of repair proteins, and cytoskeleton reorganization.
🔗 go.nature.com/3DBSVCP
Nuclear and genome dynamics underlying DNA double-strand break repair - Nature Reviews Molecular Cell Biology
Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the modulation of chromatin state, condensates of re...
go.nature.com
March 18, 2025 at 8:35 AM
✨New online!✨
@altmeyerlab.bsky.social, @karimmekhail.bsky.social et al. discuss how DNA double-strand break repair is modulated by nucleus and genome reshaping through chromatin state, condensates of repair proteins, and cytoskeleton reorganization.
🔗 go.nature.com/3DBSVCP
@altmeyerlab.bsky.social, @karimmekhail.bsky.social et al. discuss how DNA double-strand break repair is modulated by nucleus and genome reshaping through chromatin state, condensates of repair proteins, and cytoskeleton reorganization.
🔗 go.nature.com/3DBSVCP
Super proud! Congrats and well done!
Another Dr. from our RTG - Ebru Aydin from @kilchertlab.bsky.social successfully defended her thesis yesterday. Congratulations, Ebru! 🎓And a great party, too 🥳🍾🥂
March 7, 2025 at 9:16 AM
Super proud! Congrats and well done!
Reposted by Kilchert lab
Congratulations to RTG2355-member Jennifer Kothe from Elena Evguenieva-Hackenberg's lab for successfully defending her dissertation - well done, Jenni! 🎓🥳
(And please note the DNA, RNAP, RNA and ribosome on the cake!)
(And please note the DNA, RNAP, RNA and ribosome on the cake!)
February 28, 2025 at 10:17 AM
Congratulations to RTG2355-member Jennifer Kothe from Elena Evguenieva-Hackenberg's lab for successfully defending her dissertation - well done, Jenni! 🎓🥳
(And please note the DNA, RNAP, RNA and ribosome on the cake!)
(And please note the DNA, RNAP, RNA and ribosome on the cake!)
Reposted by Kilchert lab
Excited to share the work of Jennifer Kothe et al suggesting a mechanism to be used by bacteria for fine-tuning gene expression according to ribosome availability and translation efficiency: www.biorxiv.org/content/10.1...
Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene
The Gram-negative, soil-dwelling plant symbiont Sinorhizobium meliloti shares its free-living habitat with antibiotic producers. To learn about early steps of its adaptation to antibiotics, we analyze...
www.biorxiv.org
February 28, 2025 at 11:56 AM
Excited to share the work of Jennifer Kothe et al suggesting a mechanism to be used by bacteria for fine-tuning gene expression according to ribosome availability and translation efficiency: www.biorxiv.org/content/10.1...
Reposted by Kilchert lab
Open PhD position in our RTG2355 - great diversity in topics, invited speakers, retreats and symposia, workshops, soft skill courses - and very nice people!
Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 🧪🧫🔬
More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...
More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...
Doctoral student (m/f/d) in the field of RNA Biology
www.uni-giessen.de
February 28, 2025 at 1:00 PM
Open PhD position in our RTG2355 - great diversity in topics, invited speakers, retreats and symposia, workshops, soft skill courses - and very nice people!
Reposted by Kilchert lab
We have a 4 year PhD position available to study the impact of the RNA exosome on ribosome specialisation! Get in touch if you are interested or just apply. March 31st deadline.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
The impact of the RNA exosome on ribosome specialisation in different cell types at Newcastle University on FindAPhD.com
PhD Project - The impact of the RNA exosome on ribosome specialisation in different cell types at Newcastle University, listed on FindAPhD.com
www.findaphd.com
March 4, 2025 at 7:16 PM
We have a 4 year PhD position available to study the impact of the RNA exosome on ribosome specialisation! Get in touch if you are interested or just apply. March 31st deadline.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Kilchert lab
Second call for a postdoc position in my lab. Please read more and apply here: mbg.au.dk/aktuelt/ledi...
Postdoc positions in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet
Ledig stilling ved Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet
mbg.au.dk
March 4, 2025 at 3:23 PM
Second call for a postdoc position in my lab. Please read more and apply here: mbg.au.dk/aktuelt/ledi...
Reposted by Kilchert lab
We are excited to share the work of Nataliia Stefanyshena who showed that maintenance of an optimal Mex67 level in nuclear mRNPs is required for efficient mRNA export: www.biorxiv.org/content/10.1...
An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA export
In eukaryotes, a crucial step in gene expression is the export of the mRNA out of nucleus. The conserved mRNA exporter Mex67-Mtr2 (NXF1-NXT1 in human) is a key factor in this process. In S. cerevisiae...
www.biorxiv.org
February 28, 2025 at 11:25 AM
We are excited to share the work of Nataliia Stefanyshena who showed that maintenance of an optimal Mex67 level in nuclear mRNPs is required for efficient mRNA export: www.biorxiv.org/content/10.1...
Reposted by Kilchert lab
Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 🧪🧫🔬
More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...
More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...
Doctoral student (m/f/d) in the field of RNA Biology
www.uni-giessen.de
February 28, 2025 at 12:36 PM
Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 🧪🧫🔬
More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...
More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...
Reposted by Kilchert lab
Wolfgang! @wkhuber.bsky.social Read my slow analysis manifesto and join the slow analysis movement. Let's make data analysis healthy again!
February 27, 2025 at 8:27 PM
Wolfgang! @wkhuber.bsky.social Read my slow analysis manifesto and join the slow analysis movement. Let's make data analysis healthy again!
Reposted by Kilchert lab
The rise and shine of yeast optogenetics
Full text: onlinelibrary.wiley.com/doi/10.1002/...
#yeast #saccharomyces #microbiology
Full text: onlinelibrary.wiley.com/doi/10.1002/...
#yeast #saccharomyces #microbiology
February 27, 2025 at 9:39 PM
The rise and shine of yeast optogenetics
Full text: onlinelibrary.wiley.com/doi/10.1002/...
#yeast #saccharomyces #microbiology
Full text: onlinelibrary.wiley.com/doi/10.1002/...
#yeast #saccharomyces #microbiology
Reposted by Kilchert lab
This work is not only an amazing resource for the community, it is also a total masterclass in code reusability, data FAIRness and reproducibility. Hopefully, this is the future!
www.sciencedirect.com/science/arti...
I am very excited to share our latest work on the protein and chromatin interactomes of transcription factors! 🧬
Huge thanks to everyone who contributed, especially @csoneson.bsky.social and @mbstadler.bsky.social for driving this story with me! 🙌
I am very excited to share our latest work on the protein and chromatin interactomes of transcription factors! 🧬
Huge thanks to everyone who contributed, especially @csoneson.bsky.social and @mbstadler.bsky.social for driving this story with me! 🙌
A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin
Transcription factors (TFs) are key regulators of gene expression, yet many of their targets and modes of action remain unknown. In Schizosaccharomyce…
www.sciencedirect.com
February 26, 2025 at 4:58 PM
This work is not only an amazing resource for the community, it is also a total masterclass in code reusability, data FAIRness and reproducibility. Hopefully, this is the future!
Reposted by Kilchert lab
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 19, 2025 at 7:35 PM
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Reposted by Kilchert lab
PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk
February 20, 2025 at 9:53 AM
PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk
Reposted by Kilchert lab
A proteome-wide yeast degron collection for the dynamic study of protein function
Full text: rupress.org/jcb/article-...
#yeast #saccharomyces #microbiology
Full text: rupress.org/jcb/article-...
#yeast #saccharomyces #microbiology
February 18, 2025 at 3:27 PM
A proteome-wide yeast degron collection for the dynamic study of protein function
Full text: rupress.org/jcb/article-...
#yeast #saccharomyces #microbiology
Full text: rupress.org/jcb/article-...
#yeast #saccharomyces #microbiology
Reposted by Kilchert lab
FYI: New online! Cytoplasmic mRNA decay and quality control machineries in eukaryotes
Cytoplasmic mRNA decay and quality control machineries in eukaryotes
Nature Reviews Genetics, Published online: 27 January 2025; doi:10.1038/s41576-024-00810-1In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and…
www.nature.com
February 17, 2025 at 2:27 PM
FYI: New online! Cytoplasmic mRNA decay and quality control machineries in eukaryotes