Karla Feijs-Žaja
@kfeijszaja.bsky.social
First gen scientist studying protein & RNA ADP-ribosylation as part of a husband-and-wife team!
Current location: Aachen
Past: Zagreb, Oxford, Amsterdam, Maastricht
Mum of 🧒👧
Current location: Aachen
Past: Zagreb, Oxford, Amsterdam, Maastricht
Mum of 🧒👧
Reposted by Karla Feijs-Žaja
A general rather than site- & function-specific role for protein modification by ADP-ribosylation?
@kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress
www.embopress.org/doi/full/10....
@kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress
www.embopress.org/doi/full/10....
August 29, 2025 at 9:49 AM
A general rather than site- & function-specific role for protein modification by ADP-ribosylation?
@kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress
www.embopress.org/doi/full/10....
@kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress
www.embopress.org/doi/full/10....
Job alert! We are recruiting a postdoc to study a novel RNA modification: ADP-ribose.
🔬Do you have experience working with RNA? Are you eager to explore new frontiers in RNA biology? Join our team and help uncover the secrets of RNA ADP-ribosylation: adpribosylationlab.wordpress.com/2025/10/28/p...
🔬Do you have experience working with RNA? Are you eager to explore new frontiers in RNA biology? Join our team and help uncover the secrets of RNA ADP-ribosylation: adpribosylationlab.wordpress.com/2025/10/28/p...
October 28, 2025 at 8:14 PM
Job alert! We are recruiting a postdoc to study a novel RNA modification: ADP-ribose.
🔬Do you have experience working with RNA? Are you eager to explore new frontiers in RNA biology? Join our team and help uncover the secrets of RNA ADP-ribosylation: adpribosylationlab.wordpress.com/2025/10/28/p...
🔬Do you have experience working with RNA? Are you eager to explore new frontiers in RNA biology? Join our team and help uncover the secrets of RNA ADP-ribosylation: adpribosylationlab.wordpress.com/2025/10/28/p...
Reposted by Karla Feijs-Žaja
🎯 𝐒𝐭𝐫𝐚𝐭𝐞𝐠𝐢𝐜 𝐏𝐥𝐚𝐧𝐧𝐢𝐧𝐠 𝐟𝐨𝐫 𝐘𝐨𝐮𝐫 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐂𝐚𝐫𝐞𝐞𝐫 – 𝐉𝐨𝐢𝐧 𝐔𝐬!
📅 Workshop Details (Limited to 8 participants)
𝐃𝐚𝐭𝐞: January 20, 2026 (online)
𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐃𝐞𝐚𝐝𝐥𝐢𝐧𝐞: November 1, 2025
Led by: Dr. Beate Scholz (Scholz CTC GmbH)
Not a member of the GBM-YI? You can register here: gbm-online.de/de/young-inv...
📅 Workshop Details (Limited to 8 participants)
𝐃𝐚𝐭𝐞: January 20, 2026 (online)
𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐃𝐞𝐚𝐝𝐥𝐢𝐧𝐞: November 1, 2025
Led by: Dr. Beate Scholz (Scholz CTC GmbH)
Not a member of the GBM-YI? You can register here: gbm-online.de/de/young-inv...
October 22, 2025 at 8:30 AM
🎯 𝐒𝐭𝐫𝐚𝐭𝐞𝐠𝐢𝐜 𝐏𝐥𝐚𝐧𝐧𝐢𝐧𝐠 𝐟𝐨𝐫 𝐘𝐨𝐮𝐫 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐂𝐚𝐫𝐞𝐞𝐫 – 𝐉𝐨𝐢𝐧 𝐔𝐬!
📅 Workshop Details (Limited to 8 participants)
𝐃𝐚𝐭𝐞: January 20, 2026 (online)
𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐃𝐞𝐚𝐝𝐥𝐢𝐧𝐞: November 1, 2025
Led by: Dr. Beate Scholz (Scholz CTC GmbH)
Not a member of the GBM-YI? You can register here: gbm-online.de/de/young-inv...
📅 Workshop Details (Limited to 8 participants)
𝐃𝐚𝐭𝐞: January 20, 2026 (online)
𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐃𝐞𝐚𝐝𝐥𝐢𝐧𝐞: November 1, 2025
Led by: Dr. Beate Scholz (Scholz CTC GmbH)
Not a member of the GBM-YI? You can register here: gbm-online.de/de/young-inv...
Seeing how I always comment on train connections when traveling in Germany... My train is on time 🎉 Which means I'll be arriving an hour and a half early 😅 See you later at the @gbmev.bsky.social GBM Compact Meeting in Frankfurt!
September 18, 2025 at 8:12 AM
Seeing how I always comment on train connections when traveling in Germany... My train is on time 🎉 Which means I'll be arriving an hour and a half early 😅 See you later at the @gbmev.bsky.social GBM Compact Meeting in Frankfurt!
I'm very excited to be able to share the latest work from our group with you:
doi.org/10.1038/s443...
We find that PARP7 is stabilised following proteotoxic stress and ADP-ribosylates proteins to enable their degradation. This occurs in a ubiquitin-dependent manner.
doi.org/10.1038/s443...
We find that PARP7 is stabilised following proteotoxic stress and ADP-ribosylates proteins to enable their degradation. This occurs in a ubiquitin-dependent manner.
PARP7 is a proteotoxic stress sensor that labels proteins for degradation | The EMBO Journal
imageimageADP-ribosylation is thought to occur on specific sites to affect specific characteristics of target proteins. Here, it is found to play a more promiscuous role, with PARP7 labelling proteins for efficient degradation during proteotoxic ...
doi.org
August 22, 2025 at 8:09 AM
I'm very excited to be able to share the latest work from our group with you:
doi.org/10.1038/s443...
We find that PARP7 is stabilised following proteotoxic stress and ADP-ribosylates proteins to enable their degradation. This occurs in a ubiquitin-dependent manner.
doi.org/10.1038/s443...
We find that PARP7 is stabilised following proteotoxic stress and ADP-ribosylates proteins to enable their degradation. This occurs in a ubiquitin-dependent manner.
The advantage of having a Croatian husband, is that you can find beautiful spots to spend some time away from everything 😏
August 17, 2025 at 7:14 AM
The advantage of having a Croatian husband, is that you can find beautiful spots to spend some time away from everything 😏
Reposted by Karla Feijs-Žaja
Upcoming Event: "From Academia to Industry – Working at Novo Nordisk A/S"
📅 Date: August 21, 2025
🕟 Time: 4:30 p.m.
🎤 Speaker: Dr. Martin Peter
🔗 Register here: gbm-online.de/de/nachwuchs...
Zoom link will be sent to registered participants.
Please share with your postdoc colleagues!
📅 Date: August 21, 2025
🕟 Time: 4:30 p.m.
🎤 Speaker: Dr. Martin Peter
🔗 Register here: gbm-online.de/de/nachwuchs...
Zoom link will be sent to registered participants.
Please share with your postdoc colleagues!
August 4, 2025 at 8:32 AM
Upcoming Event: "From Academia to Industry – Working at Novo Nordisk A/S"
📅 Date: August 21, 2025
🕟 Time: 4:30 p.m.
🎤 Speaker: Dr. Martin Peter
🔗 Register here: gbm-online.de/de/nachwuchs...
Zoom link will be sent to registered participants.
Please share with your postdoc colleagues!
📅 Date: August 21, 2025
🕟 Time: 4:30 p.m.
🎤 Speaker: Dr. Martin Peter
🔗 Register here: gbm-online.de/de/nachwuchs...
Zoom link will be sent to registered participants.
Please share with your postdoc colleagues!
Reposted by Karla Feijs-Žaja
Nominations are now open for the 2027 Awards! With 12 categories spanning all career stages, there's never been a better time to recognise the outstanding work of your colleagues. Visit our website to find out how to nominate #BiochemAwards buff.ly/FHTSGz8
August 4, 2025 at 2:08 PM
Nominations are now open for the 2027 Awards! With 12 categories spanning all career stages, there's never been a better time to recognise the outstanding work of your colleagues. Visit our website to find out how to nominate #BiochemAwards buff.ly/FHTSGz8
Reposted by Karla Feijs-Žaja
An incomparable legend.
July 22, 2025 at 7:17 PM
An incomparable legend.
Reposted by Karla Feijs-Žaja
"m6A in the coding sequence: linking deposition, translation and decay"
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues
"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."
Read it here:
authors.elsevier.com/sd/article/S...
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues
"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."
Read it here:
authors.elsevier.com/sd/article/S...
July 8, 2025 at 12:07 PM
"m6A in the coding sequence: linking deposition, translation and decay"
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues
"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."
Read it here:
authors.elsevier.com/sd/article/S...
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues
"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."
Read it here:
authors.elsevier.com/sd/article/S...
Almost 80 but what an energy - Neil Young! I am so grateful to have seen him play with the Chrome Hearts yesterday 🤩 Rock 'n' roll will never die...
July 5, 2025 at 6:25 PM
Almost 80 but what an energy - Neil Young! I am so grateful to have seen him play with the Chrome Hearts yesterday 🤩 Rock 'n' roll will never die...
Reposted by Karla Feijs-Žaja
Enter our essay competition and win £250. Share with us your ideas on how to innovate event organisation to have a lower environmental impact.
Entry deadline: Friday 20 June
Enter now: www.biologists.com/stories/essa...
#Innovation #Sustainability #Environment
Entry deadline: Friday 20 June
Enter now: www.biologists.com/stories/essa...
#Innovation #Sustainability #Environment
June 19, 2025 at 12:11 PM
Enter our essay competition and win £250. Share with us your ideas on how to innovate event organisation to have a lower environmental impact.
Entry deadline: Friday 20 June
Enter now: www.biologists.com/stories/essa...
#Innovation #Sustainability #Environment
Entry deadline: Friday 20 June
Enter now: www.biologists.com/stories/essa...
#Innovation #Sustainability #Environment
Reposted by Karla Feijs-Žaja
Q for the hive-mind 🧠: What transfection reagents do people like for big constructs these days? (I am thinking #HSV encoding BACs, ~170 kb). We've recently had poor performance with Trans-IT LT1 and Lipofectamine 2000, our two go-tos. Target cells are U2OS. Suggestions or RTs greatly appreciated 🙏
June 19, 2025 at 11:09 AM
Q for the hive-mind 🧠: What transfection reagents do people like for big constructs these days? (I am thinking #HSV encoding BACs, ~170 kb). We've recently had poor performance with Trans-IT LT1 and Lipofectamine 2000, our two go-tos. Target cells are U2OS. Suggestions or RTs greatly appreciated 🙏
Reposted by Karla Feijs-Žaja
Autophagy-lysosome pathways are known targets of intracellular bacteria – Ivan Đikić @idikic.bsky.social et al find Legionella uses phosphoribosyl-ubiquitination via SidE to alter autophagic SNAREs & create a bacteria-containing vacuole unable to fuse with lysosomes
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
June 12, 2025 at 11:17 AM
Autophagy-lysosome pathways are known targets of intracellular bacteria – Ivan Đikić @idikic.bsky.social et al find Legionella uses phosphoribosyl-ubiquitination via SidE to alter autophagic SNAREs & create a bacteria-containing vacuole unable to fuse with lysosomes
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Karla Feijs-Žaja
Registration is OPEN for the 28th Signal Transduction Society Meeting—first-ever #CellCommSummit!
🗓️ November 3–5, 2025, Leonardo Hotel, Weimar
Join us for talks, poster sessions, and networking. Travel grants for young researchers available.
🔗 www.sigtrans.de
#SignalTransduction #CellCommSummit
🗓️ November 3–5, 2025, Leonardo Hotel, Weimar
Join us for talks, poster sessions, and networking. Travel grants for young researchers available.
🔗 www.sigtrans.de
#SignalTransduction #CellCommSummit
May 26, 2025 at 7:44 AM
Registration is OPEN for the 28th Signal Transduction Society Meeting—first-ever #CellCommSummit!
🗓️ November 3–5, 2025, Leonardo Hotel, Weimar
Join us for talks, poster sessions, and networking. Travel grants for young researchers available.
🔗 www.sigtrans.de
#SignalTransduction #CellCommSummit
🗓️ November 3–5, 2025, Leonardo Hotel, Weimar
Join us for talks, poster sessions, and networking. Travel grants for young researchers available.
🔗 www.sigtrans.de
#SignalTransduction #CellCommSummit
Reposted by Karla Feijs-Žaja
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
www.richmondscientific.com
June 8, 2025 at 9:09 PM
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
Reposted by Karla Feijs-Žaja
We're hiring! The Journal of Cell Biology (JCB) seeks Scientific Editor or Senior Scientific Editor, dependent on experience. Join our team in New York City! Apply here 👉 careers.rockefeller.edu/jobs?keyword...
#STEMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs
#STEMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs
June 5, 2025 at 8:16 PM
We're hiring! The Journal of Cell Biology (JCB) seeks Scientific Editor or Senior Scientific Editor, dependent on experience. Join our team in New York City! Apply here 👉 careers.rockefeller.edu/jobs?keyword...
#STEMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs
#STEMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs
The newest addition to my board game collection just arrived 🤩 Need a game night soon then 😁 #publishorperish
June 5, 2025 at 5:56 PM
The newest addition to my board game collection just arrived 🤩 Need a game night soon then 😁 #publishorperish
Reposted by Karla Feijs-Žaja
🏆 𝐑𝐨𝐥𝐚𝐧𝐝 𝐒𝐜𝐡𝐚𝐮𝐞𝐫 𝐍𝐚𝐜𝐡𝐰𝐮𝐜𝐡𝐬𝐩𝐫𝐞𝐢𝐬: Deadline bis 30.06.2025 verlängert! 2.000 € für exzellente Forschung in #Glykobiologie. Bewerben können sich junge Wissenschaftler:innen. Infos & Bewerbung: awards@gbm-online.de und gbm-online.de/en/news-even... #Nachwuchsförderung #GBM
June 4, 2025 at 9:29 AM
🏆 𝐑𝐨𝐥𝐚𝐧𝐝 𝐒𝐜𝐡𝐚𝐮𝐞𝐫 𝐍𝐚𝐜𝐡𝐰𝐮𝐜𝐡𝐬𝐩𝐫𝐞𝐢𝐬: Deadline bis 30.06.2025 verlängert! 2.000 € für exzellente Forschung in #Glykobiologie. Bewerben können sich junge Wissenschaftler:innen. Infos & Bewerbung: awards@gbm-online.de und gbm-online.de/en/news-even... #Nachwuchsförderung #GBM
Interested in doing a postdoc in Germany, on a topic involving ADP-ribosylation of proteins or RNA? Or even the novel dual modification with ubiquitin attached to proteins via ADP-ribose?? If yes ➡️ do get in touch 😊
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
May 28, 2025 at 12:15 PM
Interested in doing a postdoc in Germany, on a topic involving ADP-ribosylation of proteins or RNA? Or even the novel dual modification with ubiquitin attached to proteins via ADP-ribose?? If yes ➡️ do get in touch 😊
Reposted by Karla Feijs-Žaja
Calling all last-minute legends!
The formal deadline to apply for the GMI GLs call is tomorrow—so there’s still time to make it look like you planned this all along 😉
The formal deadline to apply for the GMI GLs call is tomorrow—so there’s still time to make it look like you planned this all along 😉
If you’re a scientist who values strong institutional support, join us! The GMI is currently hiring new Group Leader positions, including a Junior Group Leader to lead an independent research group addressing fundamental questions in molecular plant biology. Links below.
May 19, 2025 at 6:17 PM
Calling all last-minute legends!
The formal deadline to apply for the GMI GLs call is tomorrow—so there’s still time to make it look like you planned this all along 😉
The formal deadline to apply for the GMI GLs call is tomorrow—so there’s still time to make it look like you planned this all along 😉
Reposted by Karla Feijs-Žaja
Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!
Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation
Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...
www.biorxiv.org
May 17, 2025 at 4:29 PM
Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!
I recently rediscovered Terry Pratchett. The little nuggets of wisdom sprinkled throughout his works are amazing. I do appreciate them much more these days then when first reading Pratchett 20 years ago...
May 17, 2025 at 7:21 PM
I recently rediscovered Terry Pratchett. The little nuggets of wisdom sprinkled throughout his works are amazing. I do appreciate them much more these days then when first reading Pratchett 20 years ago...
Reposted by Karla Feijs-Žaja
I'd like to share this short piece on a topic I hope you will find useful. It is the result of a personl journey and many discussions with friends and peers. Let me know your thoughts.
network.febs.org/posts/the-pr...
network.febs.org/posts/the-pr...
The Professional Self: The Enemy Inside
network.febs.org
May 9, 2025 at 6:05 PM
I'd like to share this short piece on a topic I hope you will find useful. It is the result of a personl journey and many discussions with friends and peers. Let me know your thoughts.
network.febs.org/posts/the-pr...
network.febs.org/posts/the-pr...
Only one week to go to the PARP meeting in Strasbourg! It's the first meeting that both me and my husband will attend! Usually one of us is stuck at home with the kids... And even better - we're both planning to show some new stuff 🤩
May 6, 2025 at 12:22 PM
Only one week to go to the PARP meeting in Strasbourg! It's the first meeting that both me and my husband will attend! Usually one of us is stuck at home with the kids... And even better - we're both planning to show some new stuff 🤩