Kathrin Leppek
@katleppek.bsky.social
Prof TT Uni Bonn & University Hospital Bonn | RNA & ribosome & biochemistry & innate immunology | Postdoc Barna Lab Stanford | PhD Stoecklin Lab DKFZ ZMBH Uni Heidelberg | triplet | https://www.leppeklab.org
It was a double ribosome talk day for us in Bonn with talks today by Ranen Aviner from @czbiohub.bsky.social and Simon @bekkerjensenlab.bsky.social from BRIC Copenhagen. Simon is visiting for the @rhinelandrna.bsky.social tomorrow and Ranen is a visiting scientist in my and Ina‘s lab. #RNAsky
November 13, 2025 at 4:44 PM
It was a double ribosome talk day for us in Bonn with talks today by Ranen Aviner from @czbiohub.bsky.social and Simon @bekkerjensenlab.bsky.social from BRIC Copenhagen. Simon is visiting for the @rhinelandrna.bsky.social tomorrow and Ranen is a visiting scientist in my and Ina‘s lab. #RNAsky
Lab pumpkins 🎃 2025. Vivian, Ranen, Martin and Lisa were missed (2 people not from our team).
November 1, 2025 at 8:37 AM
Lab pumpkins 🎃 2025. Vivian, Ranen, Martin and Lisa were missed (2 people not from our team).
Reposted by Kathrin Leppek
We would like to invite all Rhineland RNA enthusiasts to attend our next series of in-person talks, featuring local and invited speakers. Highlights include the external talks by Didier Stainier, Simon Bekker-Jensen and Ranen Aviner. Please, register: tinyurl.com/RhinelandRNA
October 21, 2025 at 10:15 AM
We would like to invite all Rhineland RNA enthusiasts to attend our next series of in-person talks, featuring local and invited speakers. Highlights include the external talks by Didier Stainier, Simon Bekker-Jensen and Ranen Aviner. Please, register: tinyurl.com/RhinelandRNA
Reposted by Kathrin Leppek
🎓RNAmed met at LMU on May 19 for a Topic Day on the immune recognition of RNA. Special thanks to Prof. Veit Hornung, Prof. Kathrin Leppek, and Prof. Min Ae Lee-Krisch for sharing their insights & joining the panel discussion. 📅On May 20, PhD students shared their methods in our first Methods Seminar
July 18, 2025 at 7:52 AM
🎓RNAmed met at LMU on May 19 for a Topic Day on the immune recognition of RNA. Special thanks to Prof. Veit Hornung, Prof. Kathrin Leppek, and Prof. Min Ae Lee-Krisch for sharing their insights & joining the panel discussion. 📅On May 20, PhD students shared their methods in our first Methods Seminar
Reposted by Kathrin Leppek
I often think it would be great to have chloroplasts, do photosynthesis, and live off the sun.
September 25, 2025 at 8:59 PM
I often think it would be great to have chloroplasts, do photosynthesis, and live off the sun.
Reposted by Kathrin Leppek
Kathrin is definitely larger than life! Best recruit ever!!
This massive poster of the ad campaign for the new recruits at the @unibonn.bsky.social is the nerdiest version and the closest I’ll ever get to a superhero movie poster. #Bauzaun
September 25, 2025 at 2:42 AM
Kathrin is definitely larger than life! Best recruit ever!!
This massive poster of the ad campaign for the new recruits at the @unibonn.bsky.social is the nerdiest version and the closest I’ll ever get to a superhero movie poster. #Bauzaun
September 24, 2025 at 8:34 PM
This massive poster of the ad campaign for the new recruits at the @unibonn.bsky.social is the nerdiest version and the closest I’ll ever get to a superhero movie poster. #Bauzaun
Reposted by Kathrin Leppek
“Government plays an incredibly important role in supporting innovative work and discovery research,” Nobel laureate Jennifer Doudna tells Jeffrey Goldberg at #TAF25. This is work that “just doesn’t get done in companies.”
Watch here: bit.ly/46a5DUE
Watch here: bit.ly/46a5DUE
September 18, 2025 at 5:35 PM
“Government plays an incredibly important role in supporting innovative work and discovery research,” Nobel laureate Jennifer Doudna tells Jeffrey Goldberg at #TAF25. This is work that “just doesn’t get done in companies.”
Watch here: bit.ly/46a5DUE
Watch here: bit.ly/46a5DUE
Reposted by Kathrin Leppek
Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features.
In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome
In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome
September 1, 2025 at 3:37 PM
Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features.
In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome
In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome
We are happy to finally present our brand new lab website of the Leppek Lab! About time after 3.5 years of the lab. Perfectly in time for the #EMBLProtein meeting in Heidelberg where our 4 PhDs have posters and I have a talk! We would be happy about any feedback! 🎉 leppeklab.org
September 5, 2025 at 1:49 PM
We are happy to finally present our brand new lab website of the Leppek Lab! About time after 3.5 years of the lab. Perfectly in time for the #EMBLProtein meeting in Heidelberg where our 4 PhDs have posters and I have a talk! We would be happy about any feedback! 🎉 leppeklab.org
Reposted by Kathrin Leppek
Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!
August 25, 2025 at 8:03 PM
Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!
Reposted by Kathrin Leppek
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...
doi.org
August 24, 2025 at 11:29 AM
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Reposted by Kathrin Leppek
We’re #hiring! 2 #post-doc positions for an interdisciplinary project funded by the @hfspo.bsky.social in #axolotl and #Drosophila #wound healing at @sickkidsto.bsky.social #Canada and @umontpellier.bsky.social #France @laghalab.bsky.social. Share and apply here: www.nature.com/naturecareer...
Interdisciplinary Post-doctoral fellowships (2 positions) in wound healing - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 1284...
Two Postdoc positions to identify & visualize translation dynamics & function of proteins that drive epithelial cell migration during wound healing.
www.nature.com
August 9, 2025 at 2:27 PM
We’re #hiring! 2 #post-doc positions for an interdisciplinary project funded by the @hfspo.bsky.social in #axolotl and #Drosophila #wound healing at @sickkidsto.bsky.social #Canada and @umontpellier.bsky.social #France @laghalab.bsky.social. Share and apply here: www.nature.com/naturecareer...
Reposted by Kathrin Leppek
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 3:36 PM
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Happy 1000th citation anniversary, dear review ;)
August 6, 2025 at 2:45 PM
Happy 1000th citation anniversary, dear review ;)
Reposted by Kathrin Leppek
The 9th Rhineland RNA Club on 1AUG #RNADay with great local speakers and @lenasteckelberg.bsky.social as invited speaker from Columbia was a super fun and well attended event with lots of #RNA discussions and networking. Organized and hosted by @katleppek.bsky.social at @dzne.science. #RNAsky
August 3, 2025 at 5:15 PM
The 9th Rhineland RNA Club on 1AUG #RNADay with great local speakers and @lenasteckelberg.bsky.social as invited speaker from Columbia was a super fun and well attended event with lots of #RNA discussions and networking. Organized and hosted by @katleppek.bsky.social at @dzne.science. #RNAsky
Reminder for the Rhineland RNA Club this Friday (1st AUG)
We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky
July 28, 2025 at 12:51 PM
Reminder for the Rhineland RNA Club this Friday (1st AUG)
The 70s in RNA were quite a time.
July 24, 2025 at 10:41 AM
The 70s in RNA were quite a time.
Reposted by Kathrin Leppek
Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization
Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...
www.science.org
July 10, 2025 at 9:26 PM
Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
This week, we welcome Lana Ho (right), PhD student from @mengmengfu.bsky.social's lab at @ucberkeleyofficial.bsky.social, to our lab to teach us some cool smFISH (in a heatwave) as part of a lab exchange in the @hfspo.bsky.social Early Career Award.
July 1, 2025 at 7:14 PM
This week, we welcome Lana Ho (right), PhD student from @mengmengfu.bsky.social's lab at @ucberkeleyofficial.bsky.social, to our lab to teach us some cool smFISH (in a heatwave) as part of a lab exchange in the @hfspo.bsky.social Early Career Award.
Back to the roots. Literally. It's been a while since my days of working on plant riboswitches with Breaker people. I kind of missed the combination of a dirty bench and RNA work. This time, we want their ribosomes for a crazy idea. #RNA
July 1, 2025 at 7:06 PM
Back to the roots. Literally. It's been a while since my days of working on plant riboswitches with Breaker people. I kind of missed the combination of a dirty bench and RNA work. This time, we want their ribosomes for a crazy idea. #RNA
After recent visits to the Munich RNAmed Day and Tampere(FIN) RNA Club, I was happy to return to Heidelberg for their #RNA Translation Club Retreat. Fun fact: For me, first time all my 3 TAC members (Georg Stoecklin, Bernd Bukau, Matthias Hentze) were in one room since my PhD defense. Fun times! ;)
July 1, 2025 at 6:53 PM
After recent visits to the Munich RNAmed Day and Tampere(FIN) RNA Club, I was happy to return to Heidelberg for their #RNA Translation Club Retreat. Fun fact: For me, first time all my 3 TAC members (Georg Stoecklin, Bernd Bukau, Matthias Hentze) were in one room since my PhD defense. Fun times! ;)
Reposted by Kathrin Leppek
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
June 30, 2025 at 9:15 PM
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
Reposted by Kathrin Leppek
We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky
June 24, 2025 at 4:56 PM
We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky
Reposted by Kathrin Leppek
The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3
May 22, 2025 at 6:10 PM
The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3