Ina Huppertz
@inahuppertz.bsky.social
Research group leader at the Max Planck Institute for Biology of Ageing in Cologne, Germany.
Excited by RNA-binding proteins, metabolism, stem cells and ageing research
Excited by RNA-binding proteins, metabolism, stem cells and ageing research
Last Friday, we had an inspiring 10th Rhineland RNA Club meeting with top class speakers. It's great to see how the community is growing and the range of topics we're covering. Special thanks to Didier Stainier @stainierlab.bsky.social Simon Bekker-Jensen @bekkerjensenlab.bsky.social, Ranen Aviner!
November 19, 2025 at 10:17 AM
Last Friday, we had an inspiring 10th Rhineland RNA Club meeting with top class speakers. It's great to see how the community is growing and the range of topics we're covering. Special thanks to Didier Stainier @stainierlab.bsky.social Simon Bekker-Jensen @bekkerjensenlab.bsky.social, Ranen Aviner!
Reposted by Ina Huppertz
It was a double ribosome talk day for us in Bonn with talks today by Ranen Aviner from @czbiohub.bsky.social and Simon @bekkerjensenlab.bsky.social from BRIC Copenhagen. Simon is visiting for the @rhinelandrna.bsky.social tomorrow and Ranen is a visiting scientist in my and Ina‘s lab. #RNAsky
November 13, 2025 at 4:44 PM
It was a double ribosome talk day for us in Bonn with talks today by Ranen Aviner from @czbiohub.bsky.social and Simon @bekkerjensenlab.bsky.social from BRIC Copenhagen. Simon is visiting for the @rhinelandrna.bsky.social tomorrow and Ranen is a visiting scientist in my and Ina‘s lab. #RNAsky
Reposted by Ina Huppertz
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
November 1, 2025 at 5:56 AM
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Reposted by Ina Huppertz
🚨 Lecture 🚨
Our #CRC1678 / MPI-Age guest Dr. Ranen Aviner will give a lecture on "Decoding Translation Dynamics with Riboseq"
📅 November 12, 2025
🕐 1:00–3:00 PM
📍 Seminar Room 2+3, MPI for Biology of Ageing, Joseph-Stelzmann-Str. 9b, Cologne
Hosted by @inahuppertz.bsky.social
Don’t miss out!
Our #CRC1678 / MPI-Age guest Dr. Ranen Aviner will give a lecture on "Decoding Translation Dynamics with Riboseq"
📅 November 12, 2025
🕐 1:00–3:00 PM
📍 Seminar Room 2+3, MPI for Biology of Ageing, Joseph-Stelzmann-Str. 9b, Cologne
Hosted by @inahuppertz.bsky.social
Don’t miss out!
October 29, 2025 at 3:11 PM
🚨 Lecture 🚨
Our #CRC1678 / MPI-Age guest Dr. Ranen Aviner will give a lecture on "Decoding Translation Dynamics with Riboseq"
📅 November 12, 2025
🕐 1:00–3:00 PM
📍 Seminar Room 2+3, MPI for Biology of Ageing, Joseph-Stelzmann-Str. 9b, Cologne
Hosted by @inahuppertz.bsky.social
Don’t miss out!
Our #CRC1678 / MPI-Age guest Dr. Ranen Aviner will give a lecture on "Decoding Translation Dynamics with Riboseq"
📅 November 12, 2025
🕐 1:00–3:00 PM
📍 Seminar Room 2+3, MPI for Biology of Ageing, Joseph-Stelzmann-Str. 9b, Cologne
Hosted by @inahuppertz.bsky.social
Don’t miss out!
Don't miss our cool event in Cologne @mpiage.bsky.social on 14 November!
We would like to invite all Rhineland RNA enthusiasts to attend our next series of in-person talks, featuring local and invited speakers. Highlights include the external talks by Didier Stainier, Simon Bekker-Jensen and Ranen Aviner. Please, register: tinyurl.com/RhinelandRNA
October 21, 2025 at 10:17 AM
Don't miss our cool event in Cologne @mpiage.bsky.social on 14 November!
Reposted by Ina Huppertz
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 6:12 AM
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ina Huppertz
Excited to share my PhD research, now on bioRxiv! We report a proteo-transcriptomic reprogramming and resource reallocation in the aging brain.
Co–first author with Verena Kluever. Grateful to @forna.bsky.social for mentorship, and to @tatjanat.bsky.social, Carlos López Otín & all collaborators🧠
Co–first author with Verena Kluever. Grateful to @forna.bsky.social for mentorship, and to @tatjanat.bsky.social, Carlos López Otín & all collaborators🧠
August 20, 2025 at 8:45 AM
Excited to share my PhD research, now on bioRxiv! We report a proteo-transcriptomic reprogramming and resource reallocation in the aging brain.
Co–first author with Verena Kluever. Grateful to @forna.bsky.social for mentorship, and to @tatjanat.bsky.social, Carlos López Otín & all collaborators🧠
Co–first author with Verena Kluever. Grateful to @forna.bsky.social for mentorship, and to @tatjanat.bsky.social, Carlos López Otín & all collaborators🧠
Reposted by Ina Huppertz
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...
febs.onlinelibrary.wiley.com
September 2, 2025 at 7:11 AM
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Ina Huppertz
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2025.08.20.671247v1
August 24, 2025 at 5:17 AM
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2025.08.20.671247v1
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...
doi.org
August 24, 2025 at 11:29 AM
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Reposted by Ina Huppertz
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 3:36 PM
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Reposted by Ina Huppertz
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions
rdcu.be/ezlhg
rdcu.be/ezlhg
A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies
Nature Communications - Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a...
rdcu.be
August 5, 2025 at 1:19 PM
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions
rdcu.be/ezlhg
rdcu.be/ezlhg
Reposted by Ina Huppertz
Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.
A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology
Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...
www.nature.com
August 4, 2025 at 4:33 PM
Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.
Reposted by Ina Huppertz
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Principles of ribosome-associated protein quality control during the synthesis of CFTR
Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...
www.biorxiv.org
August 1, 2025 at 10:36 AM
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Reposted by Ina Huppertz
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Ina Huppertz
I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Fatty Acid Synthase binds endogenous dsRNAs and dampens the innate immune response to exogenous dsRNAs by limiting their accumulation.
In mammalian cells, the presence of double-stranded RNA (dsRNA) in the cytoplasm is a danger signal indicative of viral infection. Cells establish and maintain an antiviral state via the production of...
www.biorxiv.org
July 18, 2025 at 8:37 PM
I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Ina Huppertz
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
July 23, 2025 at 2:28 PM
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Reposted by Ina Huppertz
Postdoc positions in structural biology of RNA processing complexes.
An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.
Details: tinyurl.com/postdoc-RNA-...
An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.
Details: tinyurl.com/postdoc-RNA-...
Postdoc in Structural Biology of RNA processing complexes
Postdoctoral positions in structural biology of macromolecular complexes are available in the laboratory of Dr. Eva Kowalinski at the EMBL Grenoble, France. We are looking for highly motivated and amb...
tinyurl.com
July 17, 2025 at 9:50 AM
Postdoc positions in structural biology of RNA processing complexes.
An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.
Details: tinyurl.com/postdoc-RNA-...
An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.
Details: tinyurl.com/postdoc-RNA-...
So shiny ✨I am so happy to be part of this amazing initiative!
Freshly launched! 🚀 Check out the new CRC 1678 website 🌐
👉 crc1678.uni-koeln.de
👉 crc1678.uni-koeln.de
About CRC 1678 - CRC1678 - Collaborative Research Center
CRC 1678 investigates how age and stress-driven declines in the accuracy of mRNA and protein production affect cellular and organismal health. By taking an
crc1678.uni-koeln.de
July 11, 2025 at 6:12 PM
So shiny ✨I am so happy to be part of this amazing initiative!
Reposted by Ina Huppertz
Freshly launched! 🚀 Check out the new CRC 1678 website 🌐
👉 crc1678.uni-koeln.de
👉 crc1678.uni-koeln.de
About CRC 1678 - CRC1678 - Collaborative Research Center
CRC 1678 investigates how age and stress-driven declines in the accuracy of mRNA and protein production affect cellular and organismal health. By taking an
crc1678.uni-koeln.de
July 11, 2025 at 3:48 PM
Freshly launched! 🚀 Check out the new CRC 1678 website 🌐
👉 crc1678.uni-koeln.de
👉 crc1678.uni-koeln.de
Reposted by Ina Huppertz
Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization
Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...
www.science.org
July 10, 2025 at 9:26 PM
Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ina Huppertz
Currently our Mercator Fellow Alice E. Lee from Harvard Medical School is visiting us. We very much welcome Alice in Cologne and we are looking forward to many stimulating discussions with her! 👉 labs.childrenshospital.org/lee-lab
July 9, 2025 at 11:50 AM
Currently our Mercator Fellow Alice E. Lee from Harvard Medical School is visiting us. We very much welcome Alice in Cologne and we are looking forward to many stimulating discussions with her! 👉 labs.childrenshospital.org/lee-lab
Reposted by Ina Huppertz
We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky
June 24, 2025 at 4:56 PM
We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky
Reposted by Ina Huppertz
🚀 Big news for kidney research! CRC/TRR 422 ‘PodoSigN’ has been funded to explore podocyte signaling networks. Proud to see two of our CRC 1678 Group Leaders @muellerrom.bsky.social and @inahuppertz.bsky.social involved in this groundbreaking work! #KidneyResearch #PodoSigN #DFGFunding
Great News!! Looking forward to working on RNA-binding metabolic enzymes in podocyte health with @inahuppertz.bsky.social
@cecad.bsky.social @mpiage.bsky.social
@cecad.bsky.social @mpiage.bsky.social
🎉 New Collaborative Research Center at the University of Cologne!🎉
In collaboration with researchers from the Universities of Hamburg and Münster, the control processes at the kidney filter will be investigated.🫘🧬
Read more▶️ uni.koeln/LTLCM
#uniköln #unicologne @cecad.bsky.social #research #kidney
In collaboration with researchers from the Universities of Hamburg and Münster, the control processes at the kidney filter will be investigated.🫘🧬
Read more▶️ uni.koeln/LTLCM
#uniköln #unicologne @cecad.bsky.social #research #kidney
June 10, 2025 at 2:45 PM
🚀 Big news for kidney research! CRC/TRR 422 ‘PodoSigN’ has been funded to explore podocyte signaling networks. Proud to see two of our CRC 1678 Group Leaders @muellerrom.bsky.social and @inahuppertz.bsky.social involved in this groundbreaking work! #KidneyResearch #PodoSigN #DFGFunding
Reposted by Ina Huppertz
Join the Hallegger Lab in Oxford! A post-doc position available to develop neuronal cell models to characterise how TDP-43 aggregation leads to its dysfunction in MND.
Highly collaborative project funded by My Name'5 Doddie Foundation
@MNDoddie5
Please repost and share widely!
Highly collaborative project funded by My Name'5 Doddie Foundation
@MNDoddie5
Please repost and share widely!
June 3, 2025 at 7:31 PM
Join the Hallegger Lab in Oxford! A post-doc position available to develop neuronal cell models to characterise how TDP-43 aggregation leads to its dysfunction in MND.
Highly collaborative project funded by My Name'5 Doddie Foundation
@MNDoddie5
Please repost and share widely!
Highly collaborative project funded by My Name'5 Doddie Foundation
@MNDoddie5
Please repost and share widely!