Two Postdoc positions to identify & visualize translation dynamics & function of proteins that drive epithelial cell migration during wound healing.

Two Postdoc positions to identify & visualize translation dynamics & function of proteins that drive epithelial cell migration during wound healing.

Its architect's daughter has cystic fibrosis—and benefits from a "miracle drug" backed by an agency he's attacking.

The Developmental, Stem Cell & Cancer Biology program has led significant discoveries in developmental genetics, genomics, stem cell and cancer biology.

Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

About 10.3 million would lose Medicaid or the Children’s Health Insurance Program, with 7.6 million becoming uninsured, the CBO said.

SynbioBeta 2025: a failure of a synthetic biology conference

In the same way that the mRNA-binding specificities of transfer RNAs define the genetic code, the DNA-binding specificities of transcription factors (TFs) form the molecular basis of the gene regulatory code1,2. The human gene regulatory code is much more complex than the genetic code, in particular because there are more than 1,600 TFs that commonly interact with each other. TF–TF interactions are required for specifying cell fate and executing cell-type-specific transcriptional programs. Despite this, the landscape of interactions between DNA-bound TFs is poorly defined. Here we map the biochemical interactions between DNA-bound TFs using CAP-SELEX, a method that can simultaneously identify individual TF binding preferences, TF–TF interactions and the DNA sequences that are bound by the interacting complexes. A screen of more than 58,000 TF–TF pairs identified 2,198 interacting TF pairs, 1,329 of which preferentially bound to their motifs arranged in a distinct spacing and/or orienta