Julie Zhou
@juliezhou.bsky.social
NRSA-funded postdoc in the Stappenbeck Lab at Cleveland Clinic studying how epithelial interactions can shape immunity. Views my own.
Reposted by Julie Zhou
Chris Hunter @kingofpathogens.bsky.social and colleagues review parasite and host immune factors that impact the development of a mucosal vaccine for #Cryptosporidium : www.mucosalimmunology.org/article/S193...
May 28, 2025 at 2:53 PM
Chris Hunter @kingofpathogens.bsky.social and colleagues review parasite and host immune factors that impact the development of a mucosal vaccine for #Cryptosporidium : www.mucosalimmunology.org/article/S193...
Reposted by Julie Zhou
Quote
Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world. Science is the highest personification of the nation because that nation will remain the first which carries the furthest the works of thought and intelligence.
Louis Pasteur
Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world. Science is the highest personification of the nation because that nation will remain the first which carries the furthest the works of thought and intelligence.
Louis Pasteur
May 28, 2025 at 1:22 PM
Quote
Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world. Science is the highest personification of the nation because that nation will remain the first which carries the furthest the works of thought and intelligence.
Louis Pasteur
Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world. Science is the highest personification of the nation because that nation will remain the first which carries the furthest the works of thought and intelligence.
Louis Pasteur
Reposted by Julie Zhou
This is incredibly sad...I strongly believe that pivoting to different fields is a cornerstone of creativity and originality www.nature.com/articles/s41...
The pivot penalty in research - Nature
An analysis of millions of scientific papers and patents reveals a ‘pivot penalty’ when researchers shift direction, with the impact of studies decreasing rapidly the further they move from their prev...
www.nature.com
May 28, 2025 at 4:08 PM
This is incredibly sad...I strongly believe that pivoting to different fields is a cornerstone of creativity and originality www.nature.com/articles/s41...
Reposted by Julie Zhou
Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1
May 27, 2025 at 6:50 PM
Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1
Reposted by Julie Zhou
#WeekendRead #NoTimeToDie! Matt, Better &co show @ Science Immunology that efferocytosis of apoptotic neutrophils (not epithelial cells) by alveolar macrophages reprograms their metabolism, boosting glutaminolysis & decreasing ROS, thus favoring repair but facilitating secondary bacterial infections
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages
MPO activates an immunometabolic rheostat to restrict the functional plasticity of macrophages in favor of proresolving properties.
www.science.org
May 3, 2025 at 2:49 PM
#WeekendRead #NoTimeToDie! Matt, Better &co show @ Science Immunology that efferocytosis of apoptotic neutrophils (not epithelial cells) by alveolar macrophages reprograms their metabolism, boosting glutaminolysis & decreasing ROS, thus favoring repair but facilitating secondary bacterial infections
Reposted by Julie Zhou
Bluetorial: Pathways to Independence: The K99-R00 award program
NIH’s response to a 2005 National Academy report led to a new program based on its initial goal of reducing the age of investigators achieving research independence
NIH’s response to a 2005 National Academy report led to a new program based on its initial goal of reducing the age of investigators achieving research independence
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
April 16, 2025 at 5:07 PM
Bluetorial: Pathways to Independence: The K99-R00 award program
NIH’s response to a 2005 National Academy report led to a new program based on its initial goal of reducing the age of investigators achieving research independence
NIH’s response to a 2005 National Academy report led to a new program based on its initial goal of reducing the age of investigators achieving research independence
Reposted by Julie Zhou
#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n
two men are riding a bicycle with a basket on it .
ALT: two men are riding a bicycle with a basket on it .
media.tenor.com
March 22, 2025 at 8:05 PM
#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n
Reposted by Julie Zhou
So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...
GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus
During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.
www.science.org
March 21, 2025 at 7:57 PM
So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...
Reposted by Julie Zhou
Bluetorial: Women, courage, and leadership
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
March 9, 2025 at 4:33 AM
Bluetorial: Women, courage, and leadership
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
Reposted by Julie Zhou
What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?
March 8, 2025 at 2:39 PM
What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?
Reposted by Julie Zhou
Thrilled for Johan Garaude’s @inserm.fr new work in Nature! I’m proud to see this Blander lab alumnus shine. His group shows bacterial cAMP accumulation signals death, fueling macrophage recycling—a fresh live-vs-dead immune twist. Stellar work with huge impact! www.nature.com/articles/s41...
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
March 7, 2025 at 10:34 PM
Thrilled for Johan Garaude’s @inserm.fr new work in Nature! I’m proud to see this Blander lab alumnus shine. His group shows bacterial cAMP accumulation signals death, fueling macrophage recycling—a fresh live-vs-dead immune twist. Stellar work with huge impact! www.nature.com/articles/s41...
Reposted by Julie Zhou
NIH funding is frozen. @annikabarber.bsky.social is keeping score: 50%+ of study sections planned for this year (77/148) have been cancelled.
I talked to Dr. Barber about why these delays are disastrous, and why scientists should be pooling info and speaking up: www.chronicle.com/article/nih-...
I talked to Dr. Barber about why these delays are disastrous, and why scientists should be pooling info and speaking up: www.chronicle.com/article/nih-...
NIH Funding Is at a Standstill. This Professor Is Tracking the Delays.
More than half of the NIH grant-review meetings that were supposed to take place this year have been cancelled, she says. “Without these meetings happening, nothing can get funded.”
www.chronicle.com
February 26, 2025 at 10:17 PM
NIH funding is frozen. @annikabarber.bsky.social is keeping score: 50%+ of study sections planned for this year (77/148) have been cancelled.
I talked to Dr. Barber about why these delays are disastrous, and why scientists should be pooling info and speaking up: www.chronicle.com/article/nih-...
I talked to Dr. Barber about why these delays are disastrous, and why scientists should be pooling info and speaking up: www.chronicle.com/article/nih-...
Reposted by Julie Zhou
Dear TCR researchers of #immunosky, you may be interested to know that our tool Stitchr - for the automated production of full-length T cell receptor sequences - has just had a nice little update:
jamieheather.github.io/stitchr/
jamieheather.github.io/stitchr/
stitchr — stitchr documentation
jamieheather.github.io
February 25, 2025 at 4:24 AM
Dear TCR researchers of #immunosky, you may be interested to know that our tool Stitchr - for the automated production of full-length T cell receptor sequences - has just had a nice little update:
jamieheather.github.io/stitchr/
jamieheather.github.io/stitchr/
Reposted by Julie Zhou
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
2025 Study section tracking
docs.google.com
February 24, 2025 at 4:17 PM
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
Reposted by Julie Zhou
Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...
February 23, 2025 at 4:30 PM
Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...
Reposted by Julie Zhou
Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs…
“I think they're being short-sighted, because fear does that to you.”
“I think they're being short-sighted, because fear does that to you.”
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Silence gives consent. And no one should consent to this.
Stand Up And Be Counted
www.science.org
February 12, 2025 at 7:41 PM
Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs…
“I think they're being short-sighted, because fear does that to you.”
“I think they're being short-sighted, because fear does that to you.”
Reposted by Julie Zhou
To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.
The Senate HELP Committee has jurisdiction over NIH.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
February 8, 2025 at 3:27 AM
To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.
Reposted by Julie Zhou
"... I ended up being reluctant to work with undergraduate researchers at all—until a new student helped me realize what is required to mentor undergraduates, and the rewards it can bring." #NationalMentoringMonth https://scim.ag/3E1bAYj
January 26, 2025 at 3:07 PM
"... I ended up being reluctant to work with undergraduate researchers at all—until a new student helped me realize what is required to mentor undergraduates, and the rewards it can bring." #NationalMentoringMonth https://scim.ag/3E1bAYj
Reposted by Julie Zhou
The NIH diversity supplement pages have all been pulled down. What is a diversity supplement and why should the public care? A diversity supplement is funding to help diversify the research workforce. You may be wondering, “so what?”. Let me explain. www.nigms.nih.gov/Pages/PageNo...
National Institute of General Medical Sciences
NIGMS supports basic research to understand biological processes and lay the foundation for advances in disease diagnosis, treatment, and prevention.
www.nigms.nih.gov
January 25, 2025 at 3:59 PM
The NIH diversity supplement pages have all been pulled down. What is a diversity supplement and why should the public care? A diversity supplement is funding to help diversify the research workforce. You may be wondering, “so what?”. Let me explain. www.nigms.nih.gov/Pages/PageNo...
Reposted by Julie Zhou
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 8:46 PM
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
Reposted by Julie Zhou
In toxic cultures, people get promoted for results even if they destroy relationships. Abuse is a price to pay for high performance.
In healthy cultures, no level of individual excellence justifies undermining people. You’re not a high performer if you don't elevate others.
In healthy cultures, no level of individual excellence justifies undermining people. You’re not a high performer if you don't elevate others.
January 22, 2025 at 10:20 PM
In toxic cultures, people get promoted for results even if they destroy relationships. Abuse is a price to pay for high performance.
In healthy cultures, no level of individual excellence justifies undermining people. You’re not a high performer if you don't elevate others.
In healthy cultures, no level of individual excellence justifies undermining people. You’re not a high performer if you don't elevate others.
Reposted by Julie Zhou
Looks like I’ll need to update my lymph node lectures. Very nice explanation for why there is preferential leukocyte recruitment to inflamed nodes. #immunosky
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes
Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.
www.cell.com
January 5, 2025 at 9:21 PM
Looks like I’ll need to update my lymph node lectures. Very nice explanation for why there is preferential leukocyte recruitment to inflamed nodes. #immunosky
Reposted by Julie Zhou
Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.
Happy to share here: www.nature.com/articles/s41...
Happy to share here: www.nature.com/articles/s41...
A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology
Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.
www.nature.com
January 6, 2025 at 12:29 AM
Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.
Happy to share here: www.nature.com/articles/s41...
Happy to share here: www.nature.com/articles/s41...
Reposted by Julie Zhou
One main pain point: interdisciplinary work is often judged by the highest standards in *both* disciplines. This creates an almost impossible burden, effectively extinguishing creative work. Sure, some standards are there for a reason, but more often than not, they are just stock critiques.
💯. Most aspects of the system subtly (or not-so-subtly) push you back in your lane, making interdisciplinary work very hard.
Expert's Dilemma: the more specialized you become, the less open you are to creative solutions from other fields. But the more you explore other fields, the more you risk losing credibility in your home field.
Interdisciplinary work is still not really embraced by academia.
Interdisciplinary work is still not really embraced by academia.
January 5, 2025 at 5:00 PM
One main pain point: interdisciplinary work is often judged by the highest standards in *both* disciplines. This creates an almost impossible burden, effectively extinguishing creative work. Sure, some standards are there for a reason, but more often than not, they are just stock critiques.