Ranit Kedmi
@kedmiranit.bsky.social
#newPI at @WeizmannScience | study immunity through the lens of antigen presentation | Dan Littman alum
https://www.kedmilabweizmann.com
https://www.kedmilabweizmann.com
Pinned
Ranit Kedmi
@kedmiranit.bsky.social
· May 27
Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1
Reposted by Ranit Kedmi
Another excellent #Viewpoint! Thank you to our contributors @priyadevarajan.bsky.social, @rzappasodi.bsky.social, Novalia Pishesha, Jui-Hsia Weng, Kate Alexander, Yadira Soto-Feliciano, and @kedmiranit.bsky.social ✨
Latest in our #WomenInSTEM series from researchers discussing their science and the process of setting up a lab as an independent researcher, as well as the unique challenges they face as women scientists in their respective scientific environments: rupress.org/jem/article/...
October 21, 2025 at 1:27 PM
Another excellent #Viewpoint! Thank you to our contributors @priyadevarajan.bsky.social, @rzappasodi.bsky.social, Novalia Pishesha, Jui-Hsia Weng, Kate Alexander, Yadira Soto-Feliciano, and @kedmiranit.bsky.social ✨
Reposted by Ranit Kedmi
Latest in our #WomenInSTEM series from researchers discussing their science and the process of setting up a lab as an independent researcher, as well as the unique challenges they face as women scientists in their respective scientific environments: rupress.org/jem/article/...
October 17, 2025 at 4:02 PM
Latest in our #WomenInSTEM series from researchers discussing their science and the process of setting up a lab as an independent researcher, as well as the unique challenges they face as women scientists in their respective scientific environments: rupress.org/jem/article/...
👇🏻👇🏻
Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal immunity and tolerance @natimmunol.nature.com rdcu.be/eLtB1
Antigen-presenting cells as arbiters of mucosal tolerance and immunity
Nature Immunology - Brown and colleagues review the heterogeneity of mucosal antigen-presenting cells that orchestrate T cell immunity to intestinal antigens.
urldefense.com
October 17, 2025 at 2:15 PM
👇🏻👇🏻
Reposted by Ranit Kedmi
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells
Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...
www.biorxiv.org
October 10, 2025 at 7:22 PM
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Nice!
To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025!
bit.ly/SciImm_free
bit.ly/SciImm_free
October 9, 2025 at 8:41 PM
Nice!
Simply wonderful!
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
October 6, 2025 at 1:00 PM
Simply wonderful!
Reposted by Ranit Kedmi
“If you look back at the data, 250 years ago, 40% of kids never made it to adulthood. Today, it’s 4%. The majority of that decrease is due to vaccines. Vaccines have saved more lives than any other type of medical intervention, including antibiotics... -Dr. Drew Weissman, Nobel Laureate.
September 22, 2025 at 7:04 AM
“If you look back at the data, 250 years ago, 40% of kids never made it to adulthood. Today, it’s 4%. The majority of that decrease is due to vaccines. Vaccines have saved more lives than any other type of medical intervention, including antibiotics... -Dr. Drew Weissman, Nobel Laureate.
Simply wonderful!
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
September 20, 2025 at 9:16 AM
Simply wonderful!
Reposted by Ranit Kedmi
Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology
Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...
www.nature.com
September 12, 2025 at 2:20 AM
Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
I wish I could be there!
Our amazing @annarudnitsky.bsky.social will give a talk on Friday — don’t miss it!
www.nature.com/articles/s41...
Our amazing @annarudnitsky.bsky.social will give a talk on Friday — don’t miss it!
www.nature.com/articles/s41...
August 27, 2025 at 5:46 PM
I wish I could be there!
Our amazing @annarudnitsky.bsky.social will give a talk on Friday — don’t miss it!
www.nature.com/articles/s41...
Our amazing @annarudnitsky.bsky.social will give a talk on Friday — don’t miss it!
www.nature.com/articles/s41...
The #IUIS2025 was way above my expectations! It was so great to meet old and new friends and to share our work. @iuis-online.bsky.social
August 23, 2025 at 1:33 PM
The #IUIS2025 was way above my expectations! It was so great to meet old and new friends and to share our work. @iuis-online.bsky.social
It was mind blowing
Great keynote lecture by Ruslan Medzhitov on how the “educated” immune system of pet shop mice allows them to resist experimental allergic sensitisation. Thought provoking, as usual. #IUIS2025.
August 20, 2025 at 10:27 PM
It was mind blowing
Reposted by Ranit Kedmi
Great keynote lecture by Ruslan Medzhitov on how the “educated” immune system of pet shop mice allows them to resist experimental allergic sensitisation. Thought provoking, as usual. #IUIS2025.
August 20, 2025 at 5:27 PM
Great keynote lecture by Ruslan Medzhitov on how the “educated” immune system of pet shop mice allows them to resist experimental allergic sensitisation. Thought provoking, as usual. #IUIS2025.
Reposted by Ranit Kedmi
Some pics from the #RisingStars Day 2!
Don't forget to share — which sessions have you liked the most so far?
#ImmunologyWithoutBorders
Don't forget to share — which sessions have you liked the most so far?
#ImmunologyWithoutBorders
August 20, 2025 at 7:30 AM
Some pics from the #RisingStars Day 2!
Don't forget to share — which sessions have you liked the most so far?
#ImmunologyWithoutBorders
Don't forget to share — which sessions have you liked the most so far?
#ImmunologyWithoutBorders
Reposted by Ranit Kedmi
Meet Dr @KedmiRanit, PI at Weizmann Institute. Her research reveals how immune cells coordinate to shape T cell responses. At #IUIS2025, she’ll present “A coordinated cellular network regulates intestinal tolerance.” 🔬🌍 https://loom.ly/CwagY2g #RisingStars2025 #RoadtoVienna
July 28, 2025 at 12:03 PM
Meet Dr @KedmiRanit, PI at Weizmann Institute. Her research reveals how immune cells coordinate to shape T cell responses. At #IUIS2025, she’ll present “A coordinated cellular network regulates intestinal tolerance.” 🔬🌍 https://loom.ly/CwagY2g #RisingStars2025 #RoadtoVienna
Reposted by Ranit Kedmi
Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity, says Alon Chen
https://go.nature.com/40wXMx6
https://go.nature.com/40wXMx6
How we’re rebuilding the Weizmann Institute — and our hopes for a better future
Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.
go.nature.com
July 3, 2025 at 1:30 PM
Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity, says Alon Chen
https://go.nature.com/40wXMx6
https://go.nature.com/40wXMx6
Thanks for choosing me!
See you there 🌟
See you there 🌟
IUIS and its Early Career Committee are thrilled to announce the IUIS #RisingStars2025 Cohort! 🌟
https://loom.ly/f5Gq1f8
Fifteen exceptional early-career scientists from across the globe to join our #RisingStars Program
Don’t miss your chance to meet them https://loom.ly/CwagY2g
https://loom.ly/f5Gq1f8
Fifteen exceptional early-career scientists from across the globe to join our #RisingStars Program
Don’t miss your chance to meet them https://loom.ly/CwagY2g
June 28, 2025 at 12:25 PM
Thanks for choosing me!
See you there 🌟
See you there 🌟
Reposted by Ranit Kedmi
'However, we now report that food-specific pTreg cells are exclusively induced by the recently identified RORγt APCs4–8 and not by cDCs. Instead, our data suggest that pTreg–cDC1 interactions in steady-state limit the expansion of food-specific CD8αβ T cells.'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A coordinated cellular network regulates tolerance to food - Nature
Nature - A coordinated cellular network regulates tolerance to food
www.nature.com
May 28, 2025 at 12:41 PM
'However, we now report that food-specific pTreg cells are exclusively induced by the recently identified RORγt APCs4–8 and not by cDCs. Instead, our data suggest that pTreg–cDC1 interactions in steady-state limit the expansion of food-specific CD8αβ T cells.'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1
May 27, 2025 at 6:50 PM
Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1
Reposted by Ranit Kedmi
Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere.
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
Beyond the lab: trust, storytelling and the fight for America’s attention - Nature Reviews Immunology
Shruti Naik, an immunologist and a strong advocate for diversity in science, has joined forces with Aaron Mertz, who leads programmes that help to explain, connect and maximize the benefits of science...
www.nature.com
May 8, 2025 at 4:36 PM
Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere.
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
Loved the episode! @itaiyanai.bsky.social In one of my many chats with ChatGPT, I asked about a protein—got: “Don’t you have something better to do in the holiday?”
Rather than keeping our techniques private, how can we as a scientific community promote more transparency and open sharing for the kind of prompts that make AI good for creativity and ideation?@emollick.bsky.social on the Night Science Podcast.
nightscience.buzzsprout.com/1744020/epis...
nightscience.buzzsprout.com/1744020/epis...
April 12, 2025 at 11:36 AM
Loved the episode! @itaiyanai.bsky.social In one of my many chats with ChatGPT, I asked about a protein—got: “Don’t you have something better to do in the holiday?”
A must read
"We propose that the initial T cell priming phase functions like an education phase...of a broad T cell repertoire. The second priming phase serves to promote the proliferation and differentiation of high-affinity CD8 T cell clones by coordinating paracrine signals" #Immunology
A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their diff...
www.science.org
April 11, 2025 at 6:59 PM
A must read
Reposted by Ranit Kedmi
#FirstLove #DendriticCellPower! Fernandes Rodrigues, Wu, Colonna &co show @CellCellPress that Rorgt DCs, not ILC3s, are fundamental to maintain gut Tregs, preventing Th2 cell expansion & #food #allergy! www.cell.com/cell/fulltex...
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens
Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from
the intestine in mice, leading to a reduction of regulatory T cells and impaired oral
tolerance to antigens. This wo...
www.cell.com
April 4, 2025 at 10:54 AM
#FirstLove #DendriticCellPower! Fernandes Rodrigues, Wu, Colonna &co show @CellCellPress that Rorgt DCs, not ILC3s, are fundamental to maintain gut Tregs, preventing Th2 cell expansion & #food #allergy! www.cell.com/cell/fulltex...