John Humphreys
@johnpharmd.bsky.social
Python, data, therapeutics and culture. US Army veteran in PNW.
Reposts recognize great single-post content but do not imply agreement with any individual poster’s politics.
Reposts recognize great single-post content but do not imply agreement with any individual poster’s politics.
We don’t talk about it often, but there’s an interesting epiphenomenon that occurs in social media.
It’s almost like a handshake with Adam Smith’s “invisible hand”—the result of a society of individuals pursuing their respective interests.
It’s almost like a handshake with Adam Smith’s “invisible hand”—the result of a society of individuals pursuing their respective interests.
January 6, 2026 at 10:03 PM
We don’t talk about it often, but there’s an interesting epiphenomenon that occurs in social media.
It’s almost like a handshake with Adam Smith’s “invisible hand”—the result of a society of individuals pursuing their respective interests.
It’s almost like a handshake with Adam Smith’s “invisible hand”—the result of a society of individuals pursuing their respective interests.
Reposted by John Humphreys
tap tap tap
"vaccines are good, nazis are bad" are not takes that I thought would be controversial
January 6, 2026 at 3:44 PM
tap tap tap
Reposted by John Humphreys
Yes, you can be anti-Maduro AND critical of what Trump’s done—especially since he’s now leaving that regime in place without Maduro. And Trump’s threatening to take his vanity bully project to other countries. This will not end well. It’s not even going well now.
www.thebulwark.com/p/bill-krist...
www.thebulwark.com/p/bill-krist...
Bill Kristol: A Stupid and Insane Foreign Intervention
Toppling the leader of Venezuela looks to be about greed and Trump's vanity.
www.thebulwark.com
January 6, 2026 at 1:51 AM
Yes, you can be anti-Maduro AND critical of what Trump’s done—especially since he’s now leaving that regime in place without Maduro. And Trump’s threatening to take his vanity bully project to other countries. This will not end well. It’s not even going well now.
www.thebulwark.com/p/bill-krist...
www.thebulwark.com/p/bill-krist...
Reposted by John Humphreys
Here's my latest contribution to the @nytimes "Lost Science" series. Brenna Henn's sweeping study of African genetics has been frozen. Gift link: nyti.ms/3Ypmm1A
January 5, 2026 at 5:32 PM
Here's my latest contribution to the @nytimes "Lost Science" series. Brenna Henn's sweeping study of African genetics has been frozen. Gift link: nyti.ms/3Ypmm1A
I’m old enough that I remember that my parents’ generation watched comedians roast each other on US television. For some reason, I recall Don Rickles being hilarious at it.
January 5, 2026 at 6:02 PM
I’m old enough that I remember that my parents’ generation watched comedians roast each other on US television. For some reason, I recall Don Rickles being hilarious at it.
Reposted by John Humphreys
Hoping the pivotal finding of increased inflammation with #LongCovid will be responsive to tirzepatide (Zepbound) in our ongoing 1,000+ participant randomized, placebo-controlled trial (full enrollment completed in <1 month!)
www.nature.com/articles/s41... @natimmunol.nature.com
www.nature.com/articles/s41... @natimmunol.nature.com
Long COVID involves activation of proinflammatory and immune exhaustion pathways - Nature Immunology
Long COVID (LC) involves a spectrum of chronic symptoms after resolution of acute severe acute respiratory syndrome coronavirus 2 infection. Barouch and colleagues show that LC is characterized by per...
www.nature.com
January 4, 2026 at 5:16 PM
Hoping the pivotal finding of increased inflammation with #LongCovid will be responsive to tirzepatide (Zepbound) in our ongoing 1,000+ participant randomized, placebo-controlled trial (full enrollment completed in <1 month!)
www.nature.com/articles/s41... @natimmunol.nature.com
www.nature.com/articles/s41... @natimmunol.nature.com
Reposted by John Humphreys
Full performance here:
Edvard Grieg, Piano Concerto in A minor, Op. 16
Jan Lisiecki, piano
Frankfurt Radio Symphony
Alain Altinoglu, conductor
hr-Sinfonieorchester©️
🙏🏼🎼🕊️
youtu.be/pZtKXXrm-Xs?...
Edvard Grieg, Piano Concerto in A minor, Op. 16
Jan Lisiecki, piano
Frankfurt Radio Symphony
Alain Altinoglu, conductor
hr-Sinfonieorchester©️
🙏🏼🎼🕊️
youtu.be/pZtKXXrm-Xs?...
Grieg: Klavierkonzert ∙ hr-Sinfonieorchester ∙ Jan Lisiecki ∙ Alain Altinoglu
YouTube video by hr-Sinfonieorchester – Frankfurt Radio Symphony
youtu.be
December 31, 2025 at 12:57 AM
Full performance here:
Edvard Grieg, Piano Concerto in A minor, Op. 16
Jan Lisiecki, piano
Frankfurt Radio Symphony
Alain Altinoglu, conductor
hr-Sinfonieorchester©️
🙏🏼🎼🕊️
youtu.be/pZtKXXrm-Xs?...
Edvard Grieg, Piano Concerto in A minor, Op. 16
Jan Lisiecki, piano
Frankfurt Radio Symphony
Alain Altinoglu, conductor
hr-Sinfonieorchester©️
🙏🏼🎼🕊️
youtu.be/pZtKXXrm-Xs?...
Reposted by John Humphreys
From Donald Trump’s continued assault on the press to the open war for Warner Bros. Discovery—and A.I.’s disruption of everything—these are the big questions hanging over media in 2026.
More in @status.news: www.status.news/p/26-questio...
More in @status.news: www.status.news/p/26-questio...
26 Questions for 2026
From Donald Trump’s continued assault on the press to the open war for Warner Bros. Discovery—and A.I.’s disruption of everything—these are the big questions hanging over media in 2026.
www.status.news
January 1, 2026 at 11:29 PM
From Donald Trump’s continued assault on the press to the open war for Warner Bros. Discovery—and A.I.’s disruption of everything—these are the big questions hanging over media in 2026.
More in @status.news: www.status.news/p/26-questio...
More in @status.news: www.status.news/p/26-questio...
Reposted by John Humphreys
Am expecting 2026 to be a big year for @costplusdrugs.com (added insurance products?), @natolambert.sky.social (breakthrough paper?) and others (;-).
Timeline greetings—all the best this year!
Timeline greetings—all the best this year!
January 1, 2026 at 5:31 PM
Am expecting 2026 to be a big year for @costplusdrugs.com (added insurance products?), @natolambert.sky.social (breakthrough paper?) and others (;-).
Timeline greetings—all the best this year!
Timeline greetings—all the best this year!
Sama be like (but my USD is on Google)
December 31, 2025 at 12:40 AM
Sama be like (but my USD is on Google)
Reposted by John Humphreys
Merry Christmas 🎄🧪! Here's a video I made of the predicted structure for the protein MERRYCHRISTMAS. I used AlphaFold to predict the structure and then colored the backbone (green), amino acids by index (rainbow), and noncovalent interactions (dotted lines). #sciart #science #MolBio
December 25, 2025 at 5:59 PM
Reposted by John Humphreys
From @danielrigden.bsky.social & @xosegb.bsky.social in an #Editorial in @narjournal.bsky.social #NARDatabaseIssue | The 2026 Nucleic Acids Research database issue and the online molecular biology database collection | #Bioinformatics #Database #OpenScience 🧬🖥️🧪🔓
⬇️
academic.oup.com/nar/advance-...
⬇️
academic.oup.com/nar/advance-...
The 2026 Nucleic Acids Research database issue and the online molecular biology database collection
Abstract. The 2026 Nucleic Acids Research database issue has 182 papers from across biology and neighbouring fields. Eighty-four of these papers describe n
academic.oup.com
December 24, 2025 at 12:36 PM
From @danielrigden.bsky.social & @xosegb.bsky.social in an #Editorial in @narjournal.bsky.social #NARDatabaseIssue | The 2026 Nucleic Acids Research database issue and the online molecular biology database collection | #Bioinformatics #Database #OpenScience 🧬🖥️🧪🔓
⬇️
academic.oup.com/nar/advance-...
⬇️
academic.oup.com/nar/advance-...
Reposted by John Humphreys
One day something will happen — a wedding, a graduation, a job promotion, Jake Paul getting knocked out, Andrew Tate getting knocked out the next day — and you’ll want the right outfit to celebrate. Buy that special outfit now, so you’re ready when that next unexpected moment arrives.
December 21, 2025 at 7:19 AM
One day something will happen — a wedding, a graduation, a job promotion, Jake Paul getting knocked out, Andrew Tate getting knocked out the next day — and you’ll want the right outfit to celebrate. Buy that special outfit now, so you’re ready when that next unexpected moment arrives.
Dreaming about February, but planning for May.
December 22, 2025 at 2:25 AM
Dreaming about February, but planning for May.
It’s almost like we need a yearly end-of-year “will __ happen next year” y/n poll on:
-level 4 automobile autonomy
-AGI
-level 4 automobile autonomy
-AGI
in AI speak this is what we call an out of distribution event
Waymo has halted service in San Francisco after numerous videos & images showed its autonomous cars snarling traffic during the blackout.
With traffic lights down, Waymos across the city stopped dead in their tracks at intersections.
missionlocal.org/2025/12/sf-w...
With traffic lights down, Waymos across the city stopped dead in their tracks at intersections.
missionlocal.org/2025/12/sf-w...
December 21, 2025 at 12:43 PM
It’s almost like we need a yearly end-of-year “will __ happen next year” y/n poll on:
-level 4 automobile autonomy
-AGI
-level 4 automobile autonomy
-AGI
Reposted by John Humphreys
Natural daylight and improved glucose control in Type 2 diabetes
cell.com/cell-metabol...
cell.com/cell-metabol...
Natural daylight during office hours improves glucose control and whole-body substrate metabolism
Harmsen et al. compared the metabolic impact of natural daylight vs. artificial office
lighting in individuals with type 2 diabetes over 5 days. Daylight improved glucose
homeostasis, whole-body fat u...
cell.com
December 18, 2025 at 6:00 PM
Natural daylight and improved glucose control in Type 2 diabetes
cell.com/cell-metabol...
cell.com/cell-metabol...
Reposted by John Humphreys
The information processing by individual cells is remarkable and fascinating, especially by combining different time scales.
Even simple calcium <-> protein binding dynamics can perform powerful calculations beyond common hardware logic.
2/2
pubs.acs.org/doi/abs/10.1...
Even simple calcium <-> protein binding dynamics can perform powerful calculations beyond common hardware logic.
2/2
pubs.acs.org/doi/abs/10.1...
Calmodulin Transduces Ca2+ Oscillations into Differential Regulation of Its Target Proteins
Diverse physiological processes are regulated differentially by Ca2+ oscillations through the common regulatory hub calmodulin. The capacity of calmodulin to combine specificity with promiscuity remai...
pubs.acs.org
December 14, 2025 at 4:22 PM
The information processing by individual cells is remarkable and fascinating, especially by combining different time scales.
Even simple calcium <-> protein binding dynamics can perform powerful calculations beyond common hardware logic.
2/2
pubs.acs.org/doi/abs/10.1...
Even simple calcium <-> protein binding dynamics can perform powerful calculations beyond common hardware logic.
2/2
pubs.acs.org/doi/abs/10.1...
Reposted by John Humphreys
We won’t understand brains by wiring diagrams alone.
Single neurons are not transistors: they’re powerful information processing units with rich logic and capabilities.
Mapping topology is just step one. We also need the computational physics of each neuron.
1/2
Single neurons are not transistors: they’re powerful information processing units with rich logic and capabilities.
Mapping topology is just step one. We also need the computational physics of each neuron.
1/2
December 14, 2025 at 4:18 PM
We won’t understand brains by wiring diagrams alone.
Single neurons are not transistors: they’re powerful information processing units with rich logic and capabilities.
Mapping topology is just step one. We also need the computational physics of each neuron.
1/2
Single neurons are not transistors: they’re powerful information processing units with rich logic and capabilities.
Mapping topology is just step one. We also need the computational physics of each neuron.
1/2
Reposted by John Humphreys
Cinema will find a way. 💕
December 6, 2025 at 3:42 PM
Cinema will find a way. 💕
Reposted by John Humphreys
Together, JAX and NYSCF combine strengths in genetics, stem cells and data science to accelerate discovery and deliver solutions that will make a lasting difference for patients around the world. 🧬 🐁 🔬
Stronger together: Fueling the future of medicine
Our organizations are joining forces to tackle some of the world’s greatest health challenges.
www.jax.org
December 5, 2025 at 9:13 PM
Together, JAX and NYSCF combine strengths in genetics, stem cells and data science to accelerate discovery and deliver solutions that will make a lasting difference for patients around the world. 🧬 🐁 🔬
December 5, 2025 at 10:20 AM
Reposted by John Humphreys
1. Channing and Kirsten are right, and 2. ROOFMAN is great, and I wish more people had seen it in theaters.
I recently got to spend five minutes talking with Channing Tatum and Kirsten Dunst about the movie ROOFMAN, and I wrote up those five minutes as a print piece because I really needed everyone to know what movie Mr. Tatum was recommending to people in 2022. consequence.net/2025/12/chan...
Channing Tatum: Theaters Show Lots of Great Movies, “You’re Just Not Going to See Them”
Tatum and Roofman co-star Kirsten Dunst explain why smaller movies deserve our attention theatrically.
consequence.net
December 3, 2025 at 9:30 PM
1. Channing and Kirsten are right, and 2. ROOFMAN is great, and I wish more people had seen it in theaters.