Jorge García
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jgarcia-cal.bsky.social
Jorge García
@jgarcia-cal.bsky.social
150 followers 260 following 20 posts
PhD candidate at the Institute of Evolutionary Biology (IBE, UPF-CSIC), Barcelona.
Bioinformatician inferring local adaptation and introgression in Humans 🧬
Fan of coalescence theory.
Posts Replies Media Videos
Reposted by Jorge García
genetics-gsa.bsky.social
Latest in #GENETICS: @petrelharp.bsky.social and the team show how non-coalescing haplotypes can be inserted into ancestral recombination graphs (ARGs), resulting in ARGs that are smaller, faster to compute with, and have additional ancestral information. buff.ly/X801LTO
November 21, 2025 at 7:02 PM
Reposted by Jorge García
kuhlwilm.bsky.social
And another paper from the admixlab: SAI - statistics for adaptive introgression!
doi.org/10.1093/molb...
SAI: A Python Package for Statistics for Adaptive Introgression
Abstract. Adaptive introgression is an important evolutionary process, which can be identified with widely used summary statistics, such as the number of u
doi.org
November 20, 2025 at 12:51 PM
Reposted by Jorge García
kuhlwilm.bsky.social
Paper out now: A curated dataset of the great ape genome diversity!
rdcu.be/eQLCi
A curated dataset of great ape genome diversity
Scientific Data - A curated dataset of great ape genome diversity
rdcu.be
November 19, 2025 at 2:27 PM
Reposted by Jorge García
jbenning.bsky.social
We detail how multiple modes of confounding are incompletely understood and underappreciated in many contemporary papers. We illustrate these issues through reanalysis of data from case studies and discussion of the literature. We focus on…
November 7, 2025 at 7:06 PM
Reposted by Jorge García
samuelmoore.org
Newly released Stockholm Declaration recommends the following reforms to publishing:

1. Academia resumes control of publishing

2. Incentive systems to merit quality, not quantity

3. Independent fraud detection and prevention

4. Legislation and policies to protect science quality and integrity
Reformation of science publishing: the Stockholm Declaration | Royal Society Open Science
Science relies on integrity and trustworthiness. But scientists under career pressure are lured to purchase fake publications from ‘paper mills’ that use AI-generated data, text and image fabrication....
royalsocietypublishing.org
November 5, 2025 at 7:07 PM
Reposted by Jorge García
elife.bsky.social
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.
October 28, 2025 at 9:03 PM
Reposted by Jorge García
johriparul.bsky.social
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
October 28, 2025 at 9:31 PM
Reposted by Jorge García
kuhlwilm.bsky.social
New paper on a late Neanderthal, with contribution from the lab:
dx.doi.org/10.1073/pnas...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
dx.doi.org
October 27, 2025 at 7:29 PM
Reposted by Jorge García
pleunipennings.bsky.social
I started a new job in Montpellier, France!
Happy about new opportunities, sad about the state of things in the US.

abetterscientist.wordpress.com/2025/10/26/w...
We left the US and moved to France
Hello readers, I got big updates! Some of you already know this, but it’s getting more real and more official every month: my family and I have left the US and moved to France! A few months ago I q…
abetterscientist.wordpress.com
October 27, 2025 at 7:19 PM
Reposted by Jorge García
fridowelker.bsky.social
I'm hiring!⭐ As part of the DFF Sapere Aude-funded project MiddleEarth, I am looking for 1 postdoctoral researcher and 1 research assistant.
October 27, 2025 at 9:54 AM
Reposted by Jorge García
ybrandvain.bsky.social
Proud of the latest edition of my free intro biostats book.

gitrepo: github.com/ybrandvain/b...
book: ybrandvain.github.io/biostats/

Not complete but at a good point to take a break, and I think its quite usable

dm me with comments , ideas etc
Applied Biostatistics
ybrandvain.github.io
October 24, 2025 at 2:33 PM
Reposted by Jorge García
janetk.bsky.social
In a new paper led by Jiaqi Yang we trace the distribution of Denisovan introgressed DNA in ancient modern human genomes over time.

www.cell.com/current-biol...
An early East Asian lineage with unexpectedly low Denisovan ancestry
Yang et al. study Denisovan ancestry in ancient and present-day humans. In contrast to other East Asians, genomic comparisons suggest that the Jomon derived most of their ancestry from a deep lineage ...
www.cell.com
October 20, 2025 at 7:39 PM
Reposted by Jorge García
boothicus.bsky.social
A hearty Denisovan stew ripe with stories of mixing and more mixing, even with a third more ‘archaic’ hominid.

www.biorxiv.org/content/10.1...
A high-coverage genome from a 200,000-year-old Denisovan
Denisovans, an extinct sister group of Neandertals who lived in Eastern Eurasia during the Middle and Late Pleistocene, are known only from a handful of skeletal remains and limited genetic data, incl...
www.biorxiv.org
October 20, 2025 at 7:07 PM
Reposted by Jorge García
lperezsorribes.bsky.social
🐈🧬I recently presented the preliminary results of my first PhD chapter at Biología Investiga 2025, the scientific #outreach days organized by the @unisevilla.bsky.social

A great space for scientific exchange within the Faculty of Biology.

#PhDlife #WomenInSTEM #Genomics @ebdonana.bsky.social
October 17, 2025 at 8:51 AM
Reposted by Jorge García
gcbias.bsky.social
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
October 15, 2025 at 3:53 PM
Reposted by Jorge García
roshnipatel.bsky.social
I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!
roshnipatel.bsky.social Roshni Patel @roshnipatel.bsky.social · Aug 6
We'll primarily work at the intersection of statistical and population genetics, and we also have active projects related to the ethical and social implications of human genetics (ELSI). Please get in touch if that's a combination that sounds interesting to you!
October 15, 2025 at 12:52 PM
Reposted by Jorge García
biorxiv-evobio.bsky.social
The persistence and loss of hard selective sweeps amid ancient human admixture https://www.biorxiv.org/content/10.1101/2025.10.14.682443v1
October 15, 2025 at 7:32 AM
Reposted by Jorge García
seananderson.bsky.social
Now available in Systematic Biology, a new paper (and R package) in which we outline an approach to account for non-independence in comparative analyses of lineage-pair traits academic.oup.com/sysbio/advan...
The Comparative Analysis of Lineage-Pair Traits
Abstract. For many questions in ecology and evolution, the most relevant data to consider are attributes of lineage pairs. Comparative tests for causal rel
academic.oup.com
October 13, 2025 at 6:46 PM
Reposted by Jorge García
mexpositoalonso.bsky.social
We are searching for a technician in Next Generation Sequencing!

Come to our lab University of California, Berkeley Howard Hughes Medical Institute (HHMI)

See ad:

careerspub.universityofcalifornia.edu/psp/ucb/EMPL...
An error has occurred.
careerspub.universityofcalifornia.edu
October 13, 2025 at 7:27 PM
Reposted by Jorge García
albanietoh.bsky.social
Take a look at my first preprint as a first author!
We analyse the effect of population structure in SMC methods and find two systematic biases that have indeed extra information about the population! We model the nature of these biases and find a link with the isolation of the population and Fst.
biorxiv-evobio.bsky.social bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · Oct 11
Performance of Sequential Markovian Coalescence Methods when Populations are Structured https://www.biorxiv.org/content/10.1101/2025.10.09.681379v1
October 11, 2025 at 4:22 PM
Reposted by Jorge García
epigenci.bsky.social
academic.oup.com/genetics/adv...

I recently realized that I have overlooked mutational models. Especially, how it related to our ability to observe them.
Mutation-selection-drift balance models of complex diseases
Abstract. Genetic variation that influences complex disease susceptibility is introduced into the population by mutation and removed by natural selection a
academic.oup.com
October 11, 2025 at 4:50 PM
Reposted by Jorge García
castellanoed.bsky.social
Working link: academic.oup.com/mbe/advance-...
Interpreting supervised machine learning inferences in population genomics using haplotype matrix permutations
Abstract. Supervised machine learning methods, such as convolutional neural networks (CNNs), that use haplotype matrices as input data have become powerful
academic.oup.com
October 7, 2025 at 8:36 AM
Reposted by Jorge García
anaignatieva.bsky.social
Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE academic.oup.com/mbe/article/... (1/n)
The Length of Haplotype Blocks and Signals of Structural Variation in Reconstructed Genealogies
Abstract. Recent breakthroughs have enabled the accurate inference of large-scale genealogies. Through modelling the impact of recombination on the correla
academic.oup.com
October 3, 2025 at 9:54 AM
Reposted by Jorge García
biorxiv-evobio.bsky.social
A maternal-fetal PIEZO1 incompatibility as a barrier to Neanderthal-modern human admixture https://www.biorxiv.org/content/10.1101/2025.09.29.679417v1
October 1, 2025 at 8:32 AM
Reposted by Jorge García
biorxiv-evobio.bsky.social
Bridging forward-in-time and coalescent simulations using pyslim https://www.biorxiv.org/content/10.1101/2025.09.30.679676v1
October 1, 2025 at 10:33 AM