Hanbin Lee
@epigenci.bsky.social
PhD Student at UMich Statistics.
The account mostly trashes about urban planning and infrastructure.
Probability, Statistics, and Evolutionary Biology.
https://hanbin973.github.io
The account mostly trashes about urban planning and infrastructure.
Probability, Statistics, and Evolutionary Biology.
https://hanbin973.github.io
Pinned
Hanbin Lee
@epigenci.bsky.social
· Nov 30
Genetic prediction with ARG-powered linear algebra
Ancestral recombination graphs (ARGs) are an attractive means for quantitative genetic analysis of complex traits because they encode the realized genetic relatedness between a sample of individuals i...
www.biorxiv.org
www.biorxiv.org/content/10.1...
We finally submitted the earlier preprint to a journal after massive restructuring.
We've expanded the REML section for those interested in the method. We clarify that ARG-LMM estimates mutational variance and not additive variance.
We finally submitted the earlier preprint to a journal after massive restructuring.
We've expanded the REML section for those interested in the method. We clarify that ARG-LMM estimates mutational variance and not additive variance.
Reposted by Hanbin Lee
Fast, accurate construction of multiple sequence alignments from protein language embeddings www.biorxiv.org/content/10.6... 🧬🖥️🧪 github.com/Singh-Lab/AR...
January 4, 2026 at 5:00 PM
Fast, accurate construction of multiple sequence alignments from protein language embeddings www.biorxiv.org/content/10.6... 🧬🖥️🧪 github.com/Singh-Lab/AR...
Reposted by Hanbin Lee
One thing I wrote about here is how technology has made buses *way* more convenient while techno-futurists were obsessed with flying taxis and self-driving cars.
January 2, 2026 at 2:17 PM
One thing I wrote about here is how technology has made buses *way* more convenient while techno-futurists were obsessed with flying taxis and self-driving cars.
The car hostile env. around major cities in this area is sooooo lovely.
January 2, 2026 at 3:13 PM
The car hostile env. around major cities in this area is sooooo lovely.
Reposted by Hanbin Lee
I'm John Fallon, a labor economist on the job market. My JMP uncovers something wild: when chiropractors got licensed in the early 1900s, medical boards responded by making it HARDER to become a doctor.
Why would competition lead to stricter regulations?
🧵
john-fallon-econ.com
(1/9)
Why would competition lead to stricter regulations?
🧵
john-fallon-econ.com
(1/9)
November 24, 2025 at 8:37 PM
I'm John Fallon, a labor economist on the job market. My JMP uncovers something wild: when chiropractors got licensed in the early 1900s, medical boards responded by making it HARDER to become a doctor.
Why would competition lead to stricter regulations?
🧵
john-fallon-econ.com
(1/9)
Why would competition lead to stricter regulations?
🧵
john-fallon-econ.com
(1/9)
www.biorxiv.org/content/10.6...
Another formal causal treatment in gene mapping. It looks like an extension of an earlier work in a thesis (unpublished in a journal) from the same lab.
dataspace.princeton.edu/handle/88435...
Another formal causal treatment in gene mapping. It looks like an extension of an earlier work in a thesis (unpublished in a journal) from the same lab.
dataspace.princeton.edu/handle/88435...
www.biorxiv.org
December 31, 2025 at 9:34 AM
www.biorxiv.org/content/10.6...
Another formal causal treatment in gene mapping. It looks like an extension of an earlier work in a thesis (unpublished in a journal) from the same lab.
dataspace.princeton.edu/handle/88435...
Another formal causal treatment in gene mapping. It looks like an extension of an earlier work in a thesis (unpublished in a journal) from the same lab.
dataspace.princeton.edu/handle/88435...
Reposted by Hanbin Lee
She managed to turn the meme tourism into an extremely lucrative enterprise and donated the profits to the city and to the church, an absolute legend
December 30, 2025 at 5:55 PM
She managed to turn the meme tourism into an extremely lucrative enterprise and donated the profits to the city and to the church, an absolute legend
Southern France is basically California without zoning lol (of course with better food)
December 30, 2025 at 5:34 PM
Southern France is basically California without zoning lol (of course with better food)
This is also largely my prejudice but physics, especially optics and solid physics, is most relevant to whatever applications thereof compared to any branch of math 😂
December 28, 2025 at 7:02 AM
This is also largely my prejudice but physics, especially optics and solid physics, is most relevant to whatever applications thereof compared to any branch of math 😂
Reposted by Hanbin Lee
another robot highlight for 2025: man wearing humanoid mocap suit kicks himself in the balls
December 27, 2025 at 5:27 PM
another robot highlight for 2025: man wearing humanoid mocap suit kicks himself in the balls
Anyone with a TA experience should not make claims about grades really
December 25, 2025 at 4:09 PM
Anyone with a TA experience should not make claims about grades really
The very basic requirement of a legitimate city is a train connection from the airport to the city center.
December 25, 2025 at 10:26 AM
The very basic requirement of a legitimate city is a train connection from the airport to the city center.
Reposted by Hanbin Lee
Balanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1
December 25, 2025 at 12:31 AM
Balanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1
good to be in a car free city on Christmas. fuck cars.
December 25, 2025 at 6:55 AM
good to be in a car free city on Christmas. fuck cars.
This reminds me of the secret texts on ML conference papers.
So apparently there are many Epstein files on the DOJ website where you can highlight the redacted text, copy it, and paste it onto another document to read the redactions
December 23, 2025 at 1:36 AM
This reminds me of the secret texts on ML conference papers.
Reposted by Hanbin Lee
Now accepted in Genetics!
academic.oup.com/genetics/adv...
We ask why and when rescaling of forward simulations in population genetics is not accurate. There are some interesting results for people performing simulations with selection.
academic.oup.com/genetics/adv...
We ask why and when rescaling of forward simulations in population genetics is not accurate. There are some interesting results for people performing simulations with selection.
Effects of rescaling forward-in-time population genetic simulations
Abstract. Forward-in-time population genetic simulations enable modelling of a wide array of complex evolutionary scenarios. Simulating small genomic regio
academic.oup.com
December 22, 2025 at 3:25 PM
Now accepted in Genetics!
academic.oup.com/genetics/adv...
We ask why and when rescaling of forward simulations in population genetics is not accurate. There are some interesting results for people performing simulations with selection.
academic.oup.com/genetics/adv...
We ask why and when rescaling of forward simulations in population genetics is not accurate. There are some interesting results for people performing simulations with selection.
Reposted by Hanbin Lee
Somehow makes me think of this: youtu.be/RJXiep-yGBw?...
Hamlet "to be or not to be"
YouTube video by Sergio Cano Molina
youtu.be
December 18, 2025 at 8:50 PM
Somehow makes me think of this: youtu.be/RJXiep-yGBw?...
Reposted by Hanbin Lee
Starting to think about agentic systems at scale which means learning about mean field games. Finding this survey really helpful!
arxiv.org/abs/2205.12944
arxiv.org/abs/2205.12944
Learning in Mean Field Games: A Survey
Non-cooperative and cooperative games with a very large number of players have many applications but remain generally intractable when the number of players increases. Introduced by Lasry and Lions, a...
arxiv.org
December 22, 2025 at 4:49 PM
Starting to think about agentic systems at scale which means learning about mean field games. Finding this survey really helpful!
arxiv.org/abs/2205.12944
arxiv.org/abs/2205.12944
Wonder if suburbs are more impacted by new data centers than urban areas.
December 22, 2025 at 3:01 PM
Wonder if suburbs are more impacted by new data centers than urban areas.
Reposted by Hanbin Lee
No contest. Just read the first two sentences of the abstract. www.nature.com/articles/s41...
All right it’s time for the annual “please tell us about one (or a few if you are ambitious) paper from 2025 that really impressed you and why we should all read it“! Go! If you tell us how it changed your view of the world and what makes it so powerful and consequential It would be excellent.
December 21, 2025 at 8:31 PM
No contest. Just read the first two sentences of the abstract. www.nature.com/articles/s41...
Im pretty sure that someone must have done this maybe like 5 years ago at least as sort of a rediscovery of an older paper.
I think any optimization on a quotient manifold can be relaxed to an unconstrained problem in Rn as long as the first function factors through the quotient map.
Anyone?
I think any optimization on a quotient manifold can be relaxed to an unconstrained problem in Rn as long as the first function factors through the quotient map.
Anyone?
December 21, 2025 at 11:32 PM
Im pretty sure that someone must have done this maybe like 5 years ago at least as sort of a rediscovery of an older paper.
I think any optimization on a quotient manifold can be relaxed to an unconstrained problem in Rn as long as the first function factors through the quotient map.
Anyone?
I think any optimization on a quotient manifold can be relaxed to an unconstrained problem in Rn as long as the first function factors through the quotient map.
Anyone?
Reposted by Hanbin Lee
Blows my mind it hasn't even been a full year of congestion pricing in NYC yet. Years of cranks whining about it and then you just DO IT and everything is instantly better and everyone gets used to it and moves on. We should do good things more often!
PS - T-minus 12 days to Streets Mayor Mamdani!
PS - T-minus 12 days to Streets Mayor Mamdani!
I refuse to shut up about this: NYC started charging $9 to bring a car into our most transit-rich zone, the haters & trolls predicted doom, but traffic evaporated instantly and here’s Times Square tonite (even after the holiday tourists have left). For a better future, build transit & price driving!
December 20, 2025 at 4:10 PM
Blows my mind it hasn't even been a full year of congestion pricing in NYC yet. Years of cranks whining about it and then you just DO IT and everything is instantly better and everyone gets used to it and moves on. We should do good things more often!
PS - T-minus 12 days to Streets Mayor Mamdani!
PS - T-minus 12 days to Streets Mayor Mamdani!
damn I still dont get why the same text reads differently everytime
December 18, 2025 at 8:48 PM
damn I still dont get why the same text reads differently everytime
I used to know optimal transport as a purely statistics stuff and just learned today that Cedric Villani made a significant contribution to it. I enjoyed a lot his popular book.
December 18, 2025 at 7:37 PM
I used to know optimal transport as a purely statistics stuff and just learned today that Cedric Villani made a significant contribution to it. I enjoyed a lot his popular book.
Perhaps too early to call but conference driven research seems to work?
December 17, 2025 at 6:27 PM
Perhaps too early to call but conference driven research seems to work?
One of the things I like but I can't (or perhaps only rarely do) after catching a reflux is to inhale of whole cup of cold coffee.
December 17, 2025 at 3:35 PM
One of the things I like but I can't (or perhaps only rarely do) after catching a reflux is to inhale of whole cup of cold coffee.