Hanbin Lee
@epigenci.bsky.social
PhD Student at UMich Statistics.
The account mostly trashes about urban planning and infrastructure.
Probability, Statistics, and Evolutionary Biology.
https://hanbin973.github.io
The account mostly trashes about urban planning and infrastructure.
Probability, Statistics, and Evolutionary Biology.
https://hanbin973.github.io
Pinned
Hanbin Lee
@epigenci.bsky.social
· Nov 30
Genetic prediction with ARG-powered linear algebra
Ancestral recombination graphs (ARGs) are an attractive means for quantitative genetic analysis of complex traits because they encode the realized genetic relatedness between a sample of individuals i...
www.biorxiv.org
www.biorxiv.org/content/10.1...
We finally submitted the earlier preprint to a journal after massive restructuring.
We've expanded the REML section for those interested in the method. We clarify that ARG-LMM estimates mutational variance and not additive variance.
We finally submitted the earlier preprint to a journal after massive restructuring.
We've expanded the REML section for those interested in the method. We clarify that ARG-LMM estimates mutational variance and not additive variance.
It took so long to realize that differentiating an exponential map has the same algebraic form as (f(g(x)) ' = f'(g(x)) g'(x):
f is exp_p, ' is dexp_p, f'(g(x)) is (dexp_p)_{c(p)}, and g'(x) is c'(p).
f is exp_p, ' is dexp_p, f'(g(x)) is (dexp_p)_{c(p)}, and g'(x) is c'(p).
January 26, 2026 at 4:13 PM
It took so long to realize that differentiating an exponential map has the same algebraic form as (f(g(x)) ' = f'(g(x)) g'(x):
f is exp_p, ' is dexp_p, f'(g(x)) is (dexp_p)_{c(p)}, and g'(x) is c'(p).
f is exp_p, ' is dexp_p, f'(g(x)) is (dexp_p)_{c(p)}, and g'(x) is c'(p).
It took so long to understand that the exponential map is a means to map a linear perturbation in vector onto the full space...
January 26, 2026 at 1:20 AM
It took so long to understand that the exponential map is a means to map a linear perturbation in vector onto the full space...
Reposted by Hanbin Lee
Hot take: it's 2026 we don't need to be manually doing citations or asking llms to do them overleaf should just autogenerate the citations from dois
January 24, 2026 at 1:51 AM
Hot take: it's 2026 we don't need to be manually doing citations or asking llms to do them overleaf should just autogenerate the citations from dois
So-called centrists are just trolls just like the atheists who were popular some time ago.
January 24, 2026 at 5:35 PM
So-called centrists are just trolls just like the atheists who were popular some time ago.
Reposted by Hanbin Lee
Scientific racism is bad-faith, dishonest bullshit, but "it's not real science" only holds true for overly simplistic and (with apologies) kind of naive views of what science has been and is.
January 24, 2026 at 4:16 PM
Scientific racism is bad-faith, dishonest bullshit, but "it's not real science" only holds true for overly simplistic and (with apologies) kind of naive views of what science has been and is.
Reposted by Hanbin Lee
Appears this is also true for fascism.
January 24, 2026 at 3:56 PM
Appears this is also true for fascism.
My biggest problem now is that it's still hard to think naturally with v \mapsto (f \mapsto d/dt f(p+vt) \vert_{t=0}).
January 24, 2026 at 2:43 PM
My biggest problem now is that it's still hard to think naturally with v \mapsto (f \mapsto d/dt f(p+vt) \vert_{t=0}).
Reposted by Hanbin Lee
미국에서 이상한 일이 일어났을 때는 인종차별을 찍으면 대충 맞습니다.
January 24, 2026 at 5:39 AM
미국에서 이상한 일이 일어났을 때는 인종차별을 찍으면 대충 맞습니다.
Reposted by Hanbin Lee
Is this too spicy for BlueSky
January 24, 2026 at 1:43 PM
Is this too spicy for BlueSky
Like ppl think it's the system that matters but it turns out that politics is what ultimately protects that system or the other way around.
January 23, 2026 at 5:43 PM
Like ppl think it's the system that matters but it turns out that politics is what ultimately protects that system or the other way around.
I'm tired of this linear algebra gymnastics and want to take some time looking at variational inference on graphs but the weather is too cold.
January 23, 2026 at 4:38 PM
I'm tired of this linear algebra gymnastics and want to take some time looking at variational inference on graphs but the weather is too cold.
www.biorxiv.org
January 23, 2026 at 10:28 AM
Reposted by Hanbin Lee
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
Common variation in meiosis genes shapes human recombination and aneuploidy - Nature
Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...
www.nature.com
January 21, 2026 at 9:14 PM
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
How is the new SMTPB journal different from TPB?
January 22, 2026 at 2:10 AM
How is the new SMTPB journal different from TPB?
Reposted by Hanbin Lee
Integrating Structural Variants into Sequence-Based GWAS Using a Pangenome and Imputation Framework in French Dairy Cattle https://www.biorxiv.org/content/10.64898/2026.01.18.700144v1
January 22, 2026 at 1:32 AM
Integrating Structural Variants into Sequence-Based GWAS Using a Pangenome and Imputation Framework in French Dairy Cattle https://www.biorxiv.org/content/10.64898/2026.01.18.700144v1
lol a paper got accepted immediately w/o major revision
January 21, 2026 at 9:29 PM
lol a paper got accepted immediately w/o major revision
Reposted by Hanbin Lee
Full-body scans are not foolproof open.substack.com/pub/garyschw... @garyschw.bsky.social
"...look for more emphasis on evidence (eg, data on false positives, false negatives, etc) - than emphasis on the gee-whiz factor"
Reality: "MRI is not generally recommended for patients without symptoms."
"...look for more emphasis on evidence (eg, data on false positives, false negatives, etc) - than emphasis on the gee-whiz factor"
Reality: "MRI is not generally recommended for patients without symptoms."
Full-body scans are not foolproof
Man gets clean bill of health on $2,500 scan, then a paralyzing stroke
open.substack.com
January 21, 2026 at 3:46 PM
Full-body scans are not foolproof open.substack.com/pub/garyschw... @garyschw.bsky.social
"...look for more emphasis on evidence (eg, data on false positives, false negatives, etc) - than emphasis on the gee-whiz factor"
Reality: "MRI is not generally recommended for patients without symptoms."
"...look for more emphasis on evidence (eg, data on false positives, false negatives, etc) - than emphasis on the gee-whiz factor"
Reality: "MRI is not generally recommended for patients without symptoms."
To an ordinary person, math books have too many gaps but LLMs these days are very helpful in filling in these gaps.
January 20, 2026 at 11:35 PM
To an ordinary person, math books have too many gaps but LLMs these days are very helpful in filling in these gaps.
Reposted by Hanbin Lee
weird a story about how our building and zoning codes prevent perimeter blocks - and i'm not even mentioned
www.vox.com/future-perfe...
www.vox.com/future-perfe...
Can America build beautiful places again?
Ugliness has more to do with the housing crisis than you think.
www.vox.com
January 20, 2026 at 4:05 PM
weird a story about how our building and zoning codes prevent perimeter blocks - and i'm not even mentioned
www.vox.com/future-perfe...
www.vox.com/future-perfe...
Reposted by Hanbin Lee
Important perspective from Greenland.
January 20, 2026 at 1:31 PM
Important perspective from Greenland.
Washtenaw ave. is a main transit corridor but the surroining area is mostly just single family homes except downtown and a short segment near WCC.
January 20, 2026 at 2:05 PM
Washtenaw ave. is a main transit corridor but the surroining area is mostly just single family homes except downtown and a short segment near WCC.
Journal sites should really kick "decision in progress" status bar out of business.
January 19, 2026 at 4:18 PM
Journal sites should really kick "decision in progress" status bar out of business.
I believe that car (차) and gun (총) having the same consonant in Korean is not a coincidence.
January 19, 2026 at 12:30 AM
I believe that car (차) and gun (총) having the same consonant in Korean is not a coincidence.