James
@jameshow12.bsky.social
Psychology undergraduate at the University of Liverpool. Student Member of the British Psychological association. I will be posting my articles for Scientia News here.
Pinned
James
@jameshow12.bsky.social
· Nov 27
A primer on the Mutualism theory of general intelligence | Scientia News
www.scientianews.org
Very proud to announce my first article for Scientia News in which I evaluate the evidence for the Mutualism model of general intelligence.
www.scientianews.org/articles/a-p...
www.scientianews.org/articles/a-p...
Reposted by James
Looks like a nice resource:
* Array genetic data for 80,638 Japanese children
* 1,163 child health and developmental traits (e.g. food allergy, anthropometric, developmental)
* Parental environmental exposures
www.medrxiv.org/content/10.1...
* Array genetic data for 80,638 Japanese children
* 1,163 child health and developmental traits (e.g. food allergy, anthropometric, developmental)
* Parental environmental exposures
www.medrxiv.org/content/10.1...
March 10, 2025 at 10:18 AM
Looks like a nice resource:
* Array genetic data for 80,638 Japanese children
* 1,163 child health and developmental traits (e.g. food allergy, anthropometric, developmental)
* Parental environmental exposures
www.medrxiv.org/content/10.1...
* Array genetic data for 80,638 Japanese children
* 1,163 child health and developmental traits (e.g. food allergy, anthropometric, developmental)
* Parental environmental exposures
www.medrxiv.org/content/10.1...
If you missed the last ten years of behaviour genetics you can pretty much catch up on everything by reading all his blogposts.
I wrote about how population stratification in genetic analyses led to a decade of false findings and almost certainly continues to bias emerging results. But we are starting to have statistical tools to sniff it out. A 🧵:
How population stratification led to a decade of sensationally false genetic findings
Stratification makes environments look like genes
open.substack.com
March 29, 2025 at 7:41 PM
If you missed the last ten years of behaviour genetics you can pretty much catch up on everything by reading all his blogposts.
Reposted by James
Diagnostic categories in mental health do not distinguish people or brains "Our results did not support the validity of existing diagnostic labels of ASD, ADHD, and OCD as distinct entities with respect to phenotype and cortical morphology." www.nature.com/articles/s41...
Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach - Translational Psychiatry
Translational Psychiatry - Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach
www.nature.com
December 10, 2024 at 1:02 PM
Diagnostic categories in mental health do not distinguish people or brains "Our results did not support the validity of existing diagnostic labels of ASD, ADHD, and OCD as distinct entities with respect to phenotype and cortical morphology." www.nature.com/articles/s41...
Are there any good blogposts or commentaries on the 2025 depression gwas?
February 1, 2025 at 1:20 PM
Are there any good blogposts or commentaries on the 2025 depression gwas?
Reposted by James
Thoughtful piece by Greg Gibson pushing strongly back on the "Heritable polygenic editing" article
genomestake.substack.com/p/genome-edi...
genomestake.substack.com/p/genome-edi...
Genome Editing and Eugenics
The one hundred and third Take:
genomestake.substack.com
January 16, 2025 at 10:49 PM
Thoughtful piece by Greg Gibson pushing strongly back on the "Heritable polygenic editing" article
genomestake.substack.com/p/genome-edi...
genomestake.substack.com/p/genome-edi...
Reposted by James
RIP, David Lynch. Truly one of the great weirdoes in film and television history.
January 16, 2025 at 6:19 PM
RIP, David Lynch. Truly one of the great weirdoes in film and television history.
Reposted by James
A Green New Deal makes sense if you’re in a recession, but a full employment economy needs a different approach to energy and prosperity.
www.slowboring.com/p/after-the-...
www.slowboring.com/p/after-the-...
After the Green New Deal
We need a clean energy strategy for a full employment economy
www.slowboring.com
January 16, 2025 at 11:53 AM
A Green New Deal makes sense if you’re in a recession, but a full employment economy needs a different approach to energy and prosperity.
www.slowboring.com/p/after-the-...
www.slowboring.com/p/after-the-...
Reposted by James
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
www.cell.com/cell/fulltex...
A thread 🧵:
January 14, 2025 at 5:31 PM
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
www.cell.com/cell/fulltex...
A thread 🧵:
Reposted by James
The Dimensional Turn in Psychopathology: Q&A with Robert F. Krueger
“Everything we try as a field ends up illustrating how murky and complex the origins of psychopathology tend to be.”
www.psychiatrymargins.com/p/the-dimens...
“Everything we try as a field ends up illustrating how murky and complex the origins of psychopathology tend to be.”
www.psychiatrymargins.com/p/the-dimens...
The Dimensional Turn in Psychopathology: Q&A with Robert Krueger
Distinguished McKnight University Professor at the University of Minnesota
www.psychiatrymargins.com
January 11, 2025 at 2:18 PM
The Dimensional Turn in Psychopathology: Q&A with Robert F. Krueger
“Everything we try as a field ends up illustrating how murky and complex the origins of psychopathology tend to be.”
www.psychiatrymargins.com/p/the-dimens...
“Everything we try as a field ends up illustrating how murky and complex the origins of psychopathology tend to be.”
www.psychiatrymargins.com/p/the-dimens...
Reposted by James
Who likes categories anyway?
I wonder what this means for the concept of "areas"...
#neuroscience
www.thetransmitter.org/neural-codin...
I wonder what this means for the concept of "areas"...
#neuroscience
www.thetransmitter.org/neural-codin...
Most neurons in mouse cortex defy functional categories
The majority of cells in the cerebral cortex are unspecialized, according to an unpublished analysis—and scientists need to take care in naming neurons, the researchers warn.
www.thetransmitter.org
January 11, 2025 at 2:20 PM
Who likes categories anyway?
I wonder what this means for the concept of "areas"...
#neuroscience
www.thetransmitter.org/neural-codin...
I wonder what this means for the concept of "areas"...
#neuroscience
www.thetransmitter.org/neural-codin...
Reposted by James
Very glad to be invited at this Conference!
Royal Society of Medicine,6-7 March
"After Kraepelin: Ambitions, Images, Practices and the History of Psychiatry 1926-2026"
I'll discuss the role of social values and collective emotions in the making of Asperger diagnosis
www.rsm.ac.uk/events/psych...
Royal Society of Medicine,6-7 March
"After Kraepelin: Ambitions, Images, Practices and the History of Psychiatry 1926-2026"
I'll discuss the role of social values and collective emotions in the making of Asperger diagnosis
www.rsm.ac.uk/events/psych...
After Kraepelin: Ambitions, images, Practices and the History of Psychiatry 1926-2026
This two-day event will review the ambitions, images and practices of psychiatry, as they have evolved during the period under review and seek pointers for continuity and transformation in the future.
www.rsm.ac.uk
January 6, 2025 at 9:56 AM
Very glad to be invited at this Conference!
Royal Society of Medicine,6-7 March
"After Kraepelin: Ambitions, Images, Practices and the History of Psychiatry 1926-2026"
I'll discuss the role of social values and collective emotions in the making of Asperger diagnosis
www.rsm.ac.uk/events/psych...
Royal Society of Medicine,6-7 March
"After Kraepelin: Ambitions, Images, Practices and the History of Psychiatry 1926-2026"
I'll discuss the role of social values and collective emotions in the making of Asperger diagnosis
www.rsm.ac.uk/events/psych...
Reposted by James
I tried this BTW but while I approached both men and women, and both groups considered it, the men took me up on the offer, or volunteered (which is great!!). I decided I am not going forward if I can’t keep balance… ( pls volunteer!). This chat with eiko last yr is what I have in mind, sorta…
is this an accidental Podcast? Eiko Fried & Michel Nivard discuss a new GWAS of depression preprint
YouTube video by Michel's Science Speedrun
youtu.be
January 2, 2025 at 1:38 PM
I tried this BTW but while I approached both men and women, and both groups considered it, the men took me up on the offer, or volunteered (which is great!!). I decided I am not going forward if I can’t keep balance… ( pls volunteer!). This chat with eiko last yr is what I have in mind, sorta…
Reposted by James
Good resource. A well-written op-ed can sometimes end up as impactful as a full paper...
Where can you pitch your global health blog or op-ed?
See this crowdsourced list!
communities.springernature.com/posts/where-...
See this crowdsourced list!
communities.springernature.com/posts/where-...
Where Can I Publish My Global Health Blog Post or Op-Ed?
This is a crowd-sourced list of blogs and media platforms that publish opinion pieces and commentaries
communities.springernature.com
January 2, 2025 at 12:18 PM
Good resource. A well-written op-ed can sometimes end up as impactful as a full paper...
Reposted by James
Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research - Molecular Psychiatry
Molecular Psychiatry - Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
www.nature.com
December 27, 2024 at 4:28 PM
Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...
Reposted by James
Now published (Neuroscience & Biobehavioral Reviews):
"Relational neuroscience: Insights from hyperscanning research"
We introduce #RelationalNeuroscience as a framework for research on inter-brain dynamics.
We state that #hyperscanning is the prime methodology informing Relational Neuroscience.
"Relational neuroscience: Insights from hyperscanning research"
We introduce #RelationalNeuroscience as a framework for research on inter-brain dynamics.
We state that #hyperscanning is the prime methodology informing Relational Neuroscience.
Relational neuroscience: Insights from hyperscanning research
Humans are highly social, typically without this ability requiring noticeable efforts. Yet, such social fluency poses challenges both for the human br…
www.sciencedirect.com
December 27, 2024 at 10:36 AM
Now published (Neuroscience & Biobehavioral Reviews):
"Relational neuroscience: Insights from hyperscanning research"
We introduce #RelationalNeuroscience as a framework for research on inter-brain dynamics.
We state that #hyperscanning is the prime methodology informing Relational Neuroscience.
"Relational neuroscience: Insights from hyperscanning research"
We introduce #RelationalNeuroscience as a framework for research on inter-brain dynamics.
We state that #hyperscanning is the prime methodology informing Relational Neuroscience.
Reposted by James
I wrote about how polygenic heritable conditions present in families and the liability threshold model. This has some counterintuitive implications for considering the risk of a condition in offspring as well as the impact of multi-generational selection. A 🧵:
What happens to heritable conditions across generations?
some counterintuitive properties of the polygenic liability threshold model
open.substack.com
December 26, 2024 at 6:44 PM
I wrote about how polygenic heritable conditions present in families and the liability threshold model. This has some counterintuitive implications for considering the risk of a condition in offspring as well as the impact of multi-generational selection. A 🧵:
Trout-in-the-milk level of uncertainty
December 26, 2024 at 11:57 AM
Trout-in-the-milk level of uncertainty
Reposted by James
You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Genomic network analysis characterizes genetic architecture and identifies trait-specific biology
Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...
www.medrxiv.org
December 6, 2024 at 3:56 PM
You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by James
www.biorxiv.org/content/10.1...
Smart study to test whether lower prediction accuracy in non-Europeans is due to between-population differences in population structure, genetic nurture, or assortative mating.
Smart study to test whether lower prediction accuracy in non-Europeans is due to between-population differences in population structure, genetic nurture, or assortative mating.
Within-Family GWAS does not Ameliorate the Decline in Prediction Accuracy across Populations
As polygenic prediction extends beyond the research domain to involve clinical applications, the urgency of solving the "portability problem" becomes amplified -- that is, the fact that polygenic indi...
www.biorxiv.org
December 15, 2024 at 7:18 AM
www.biorxiv.org/content/10.1...
Smart study to test whether lower prediction accuracy in non-Europeans is due to between-population differences in population structure, genetic nurture, or assortative mating.
Smart study to test whether lower prediction accuracy in non-Europeans is due to between-population differences in population structure, genetic nurture, or assortative mating.
Reposted by James
Reposted by James
I am proud to share our latest paper📜 “The multi-scale complexity of human genetic variation beyond continental groups”, just pre-printed on @biorxivpreprint.bsky.social !
Link Here ➡️ www.biorxiv.org/content/10.1...
Link Here ➡️ www.biorxiv.org/content/10.1...
The multi-scale complexity of human genetic variation beyond continental groups
Traditional clustering and visualization approaches in human genetics often operate under frameworks that assume inherent, discrete groupings1,2. These methods can inadvertently simplify multifaceted ...
www.biorxiv.org
December 18, 2024 at 4:18 AM
I am proud to share our latest paper📜 “The multi-scale complexity of human genetic variation beyond continental groups”, just pre-printed on @biorxivpreprint.bsky.social !
Link Here ➡️ www.biorxiv.org/content/10.1...
Link Here ➡️ www.biorxiv.org/content/10.1...
Reposted by James
Racism-based potentially traumatic experiences (rPTEs) can be seen as a form of moral injury, reflecting the deep psychological distress tied to violations of core moral values. This perspective highlights their link to PTSD, emphasizing the profound impact of systemic injustice on mental health.
Is racism like other trauma exposures? Examining the unique mental health effects of racial/ethnic discrimination on posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and generali...
Galán, C. A., et al. (2024). The American journal of orthopsychiatry, 10.1037/ort0000807. Advance online publication. https://doi.org/10.103...
www.ethicalpsychology.com
December 20, 2024 at 10:53 AM
Racism-based potentially traumatic experiences (rPTEs) can be seen as a form of moral injury, reflecting the deep psychological distress tied to violations of core moral values. This perspective highlights their link to PTSD, emphasizing the profound impact of systemic injustice on mental health.
Reposted by James
Time spent on social media among the least influential factors in adolescent mental health: preliminary results from a panel network analysis. www.nature.com/articles/s44...
Time spent on social media among the least influential factors in adolescent mental health: preliminary results from a panel network analysis - Nature Mental Health
Panayiotou et al. performed a panel network analysis to investigate the relationship between time spent on social media and mental health in a large cohort of UK adolescents.
www.nature.com
December 20, 2024 at 11:03 AM
Time spent on social media among the least influential factors in adolescent mental health: preliminary results from a panel network analysis. www.nature.com/articles/s44...
Reposted by James
Out now in Nature from @behrenstimb.bsky.social and crew:
www.nature.com/articles/s41...
Understanding this kind of schematic pattern learning and transfer will be key, IMO, to moving towards models of what we might call "higher-order cognition" or "reasoning".
🧠📈 🧪
www.nature.com/articles/s41...
Understanding this kind of schematic pattern learning and transfer will be key, IMO, to moving towards models of what we might call "higher-order cognition" or "reasoning".
🧠📈 🧪
A cellular basis for mapping behavioural structure - Nature
Mice generalize complex task structures by using neurons in the medial frontal cortex that encode progress to task goals and embed behavioural sequences.
www.nature.com
December 19, 2024 at 3:07 PM
Out now in Nature from @behrenstimb.bsky.social and crew:
www.nature.com/articles/s41...
Understanding this kind of schematic pattern learning and transfer will be key, IMO, to moving towards models of what we might call "higher-order cognition" or "reasoning".
🧠📈 🧪
www.nature.com/articles/s41...
Understanding this kind of schematic pattern learning and transfer will be key, IMO, to moving towards models of what we might call "higher-order cognition" or "reasoning".
🧠📈 🧪