Na Cai
@caina89.bsky.social
Assistant Prof at D-BSSE, ETH Zurich, studying genetics of psychiatric disorders
www.nacailab.com
www.nacailab.com
Reposted by Na Cai
The PGC Suicide Working Group will provide a symposium at #WCPG2025 🇲🇽 covering our latest multi-ancestry GWAS and CNV meta-analyses, sex-specific meta-analyses, and GxEHR analyses. 🥳
@lcstoshio.bsky.social @andreyshabalin.bsky.social @sarahcolbert.bsky.social @caina89.bsky.social
@lcstoshio.bsky.social @andreyshabalin.bsky.social @sarahcolbert.bsky.social @caina89.bsky.social
October 19, 2025 at 6:18 PM
The PGC Suicide Working Group will provide a symposium at #WCPG2025 🇲🇽 covering our latest multi-ancestry GWAS and CNV meta-analyses, sex-specific meta-analyses, and GxEHR analyses. 🥳
@lcstoshio.bsky.social @andreyshabalin.bsky.social @sarahcolbert.bsky.social @caina89.bsky.social
@lcstoshio.bsky.social @andreyshabalin.bsky.social @sarahcolbert.bsky.social @caina89.bsky.social
Reposted by Na Cai
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
September 22, 2025 at 5:29 AM
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
Reposted by Na Cai
🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵
Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
September 3, 2025 at 8:39 AM
🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵
Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
Reposted by Na Cai
The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052
Postdoctoral Scholar – Genomics, Aging, Somatic Mutation, Structural Variation, Evolution , Cancer – Integrative Biology
University of California, Berkeley is hiring. Apply now!
aprecruit.berkeley.edu
August 13, 2025 at 4:22 AM
The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052
Reposted by Na Cai
The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs:
probgen2026.github.io
Please help spread the news.
probgen2026.github.io
Please help spread the news.
Home - ProbGen 2026
Your Site Description
probgen2026.github.io
June 6, 2025 at 5:52 PM
The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs:
probgen2026.github.io
Please help spread the news.
probgen2026.github.io
Please help spread the news.
Reposted by Na Cai
‘Genetic Risk Effects on Psychiatric Disorders Act in Sets’, the title of our new preprint on
@medrxivpreprint.bsky.social! This huge collaborative effort advances our understanding of psychiatric genetic architecture and emphasizes the importance of looking beyond additive effects. 🧵1/n; 🧪👩🏽🔬🧬
@medrxivpreprint.bsky.social! This huge collaborative effort advances our understanding of psychiatric genetic architecture and emphasizes the importance of looking beyond additive effects. 🧵1/n; 🧪👩🏽🔬🧬
July 24, 2025 at 8:16 AM
‘Genetic Risk Effects on Psychiatric Disorders Act in Sets’, the title of our new preprint on
@medrxivpreprint.bsky.social! This huge collaborative effort advances our understanding of psychiatric genetic architecture and emphasizes the importance of looking beyond additive effects. 🧵1/n; 🧪👩🏽🔬🧬
@medrxivpreprint.bsky.social! This huge collaborative effort advances our understanding of psychiatric genetic architecture and emphasizes the importance of looking beyond additive effects. 🧵1/n; 🧪👩🏽🔬🧬
Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects on psychiatric disorders act in sets”, a great effort led my PhD student @jolienrietkerk.bsky.social, and performed together with collaborators Andy Dahl, Jonathan Flint, Andrew Schork etc. Thread 1/n
July 24, 2025 at 5:24 AM
Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects on psychiatric disorders act in sets”, a great effort led my PhD student @jolienrietkerk.bsky.social, and performed together with collaborators Andy Dahl, Jonathan Flint, Andrew Schork etc. Thread 1/n
Reposted by Na Cai
Today, our two new faculty members held their inaugural lectures @ethzurich.bsky.social. Basile Wicky | Biomedical Design Lab, presented on designing proteins that interface with life; Michael Moor @michaelmoor.bsky.social | Medical AI Lab, spoke about AI in medicine. Recordings > u.ethz.ch/hQdQl
March 10, 2025 at 7:15 PM
Today, our two new faculty members held their inaugural lectures @ethzurich.bsky.social. Basile Wicky | Biomedical Design Lab, presented on designing proteins that interface with life; Michael Moor @michaelmoor.bsky.social | Medical AI Lab, spoke about AI in medicine. Recordings > u.ethz.ch/hQdQl
I just had the most wonderful time at the Quantgen GRC in Italy with these lovely and brilliant people :) hope to see everyone again in Ventura for the next Quantgen GRC in 2 years time, and sooner on other occasions!
February 21, 2025 at 10:26 AM
I just had the most wonderful time at the Quantgen GRC in Italy with these lovely and brilliant people :) hope to see everyone again in Ventura for the next Quantgen GRC in 2 years time, and sooner on other occasions!
New year new start! My group has moved to the Dept of Biosystems Science and Engineering in ETH Zurich - very excited to work with new colleagues here! We’re also hiring soon, if interested in a PhD/postdoc in quantitative genetics and genomics, esp with focus in psych disorders, pls get in touch!
February 5, 2025 at 7:56 AM
New year new start! My group has moved to the Dept of Biosystems Science and Engineering in ETH Zurich - very excited to work with new colleagues here! We’re also hiring soon, if interested in a PhD/postdoc in quantitative genetics and genomics, esp with focus in psych disorders, pls get in touch!
Reposted by Na Cai
How population stratification makes environments look like genes. A short 🧵:
January 20, 2025 at 7:09 PM
How population stratification makes environments look like genes. A short 🧵:
Reposted by Na Cai
Unsure how recent changes in U.S. policy regarding the NIH will impact the psychiatric genetics world? You're not alone. Join ISPG for a Member’s Meetup for community discussion and support:
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
January 24, 2025 at 5:55 PM
Unsure how recent changes in U.S. policy regarding the NIH will impact the psychiatric genetics world? You're not alone. Join ISPG for a Member’s Meetup for community discussion and support:
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
📢 Quantgen friends:
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
2025 Quantitative Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 20, 2025 at 3:35 PM
📢 Quantgen friends:
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
🚨 RECOMB-Genetics Deadline 🚨
The RECOMB-Genetics 2025 workshop is in Seoul 🌏 on April 25, 2025, just before the main RECOMB conference (April 26–29).
📅 Submission deadline: Feb 14, 2025 (AoE)
👉recomb.org/recomb2025/rec…
Submit your work and join us for this exciting event!
The RECOMB-Genetics 2025 workshop is in Seoul 🌏 on April 25, 2025, just before the main RECOMB conference (April 26–29).
📅 Submission deadline: Feb 14, 2025 (AoE)
👉recomb.org/recomb2025/rec…
Submit your work and join us for this exciting event!
January 14, 2025 at 12:15 PM
🚨 RECOMB-Genetics Deadline 🚨
The RECOMB-Genetics 2025 workshop is in Seoul 🌏 on April 25, 2025, just before the main RECOMB conference (April 26–29).
📅 Submission deadline: Feb 14, 2025 (AoE)
👉recomb.org/recomb2025/rec…
Submit your work and join us for this exciting event!
The RECOMB-Genetics 2025 workshop is in Seoul 🌏 on April 25, 2025, just before the main RECOMB conference (April 26–29).
📅 Submission deadline: Feb 14, 2025 (AoE)
👉recomb.org/recomb2025/rec…
Submit your work and join us for this exciting event!
Reposted by Na Cai
I wrote about the ongoing debates over genomic data sharing and the use of such data for "abhorrent science", including some perspective papers that came out last month. A few key points: 🧵
On abhorrent science and the weaponization of genomic data
How to balance open data sharing and public responsibility
open.substack.com
January 12, 2025 at 7:11 PM
I wrote about the ongoing debates over genomic data sharing and the use of such data for "abhorrent science", including some perspective papers that came out last month. A few key points: 🧵
Quantgen GRC (16-21 Feb 2025) in Lucca, Italy: we are still accepting applications and poster abstracts!
Deadline: 19 Jan 2025
Apply now - we have a great selection of invited speakers and the posters abstracts are amazing. It’s going to be a blast 💥
www.grc.org/quantitative...
Deadline: 19 Jan 2025
Apply now - we have a great selection of invited speakers and the posters abstracts are amazing. It’s going to be a blast 💥
www.grc.org/quantitative...
2025 Quantitative Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 9, 2025 at 3:43 PM
Quantgen GRC (16-21 Feb 2025) in Lucca, Italy: we are still accepting applications and poster abstracts!
Deadline: 19 Jan 2025
Apply now - we have a great selection of invited speakers and the posters abstracts are amazing. It’s going to be a blast 💥
www.grc.org/quantitative...
Deadline: 19 Jan 2025
Apply now - we have a great selection of invited speakers and the posters abstracts are amazing. It’s going to be a blast 💥
www.grc.org/quantitative...
Reposted by Na Cai
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
doi.org
January 3, 2025 at 7:18 PM
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Na Cai
December 31, 2024 at 11:55 AM
Reposted by Na Cai
Great to see this out. From @caina89.bsky.social and @pgcgenetics.bsky.social Cross-disorder group
rdcu.be/d4ZF0
rdcu.be/d4ZF0
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
Molecular Psychiatry - Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
rdcu.be
December 27, 2024 at 3:42 PM
Great to see this out. From @caina89.bsky.social and @pgcgenetics.bsky.social Cross-disorder group
rdcu.be/d4ZF0
rdcu.be/d4ZF0
Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research - Molecular Psychiatry
Molecular Psychiatry - Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
www.nature.com
December 27, 2024 at 4:28 PM
Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...
Very happy to share *two* new projects from my group now on @biorxivpreprint.bsky.social on mtDNA variation effects on tissue-specific gene expression conducted using RNAseq data in 49 tissues in the GTEx project! 🧵
1/n
1/n
December 19, 2024 at 9:11 AM
Very happy to share *two* new projects from my group now on @biorxivpreprint.bsky.social on mtDNA variation effects on tissue-specific gene expression conducted using RNAseq data in 49 tissues in the GTEx project! 🧵
1/n
1/n
Reposted by Na Cai
After 4 fantastic years of research, together with @caina89.bsky.social & Matthias Heinig, I’m thrilled to share the first tissue specific map of apparent mtDNA heteroplasmy in humans and their relationships with donor age and mtDNA gene expr across 49 tissues!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 18, 2024 at 10:35 AM
After 4 fantastic years of research, together with @caina89.bsky.social & Matthias Heinig, I’m thrilled to share the first tissue specific map of apparent mtDNA heteroplasmy in humans and their relationships with donor age and mtDNA gene expr across 49 tissues!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
My first PhD student Lianyun Huang has now successfully defended her PhD and is now Dr Huang! 🎉🎉🎉 Thank you for 4 years of hard work, it’s an honor to be part of your academic journey!
December 12, 2024 at 4:13 PM
My first PhD student Lianyun Huang has now successfully defended her PhD and is now Dr Huang! 🎉🎉🎉 Thank you for 4 years of hard work, it’s an honor to be part of your academic journey!
Quantgen GRC (16-21 Feb 2025) updates: we are now 75% subscribed!
Deadline: 19 Jan 2025
BUT: We will pick talks from submitted abstracts 16 Dec and aim to send decisions before Xmas. So submit your abstracts now (even if not perfect - editable after submission)!
www.grc.org/quantitative...
Deadline: 19 Jan 2025
BUT: We will pick talks from submitted abstracts 16 Dec and aim to send decisions before Xmas. So submit your abstracts now (even if not perfect - editable after submission)!
www.grc.org/quantitative...
2025 Quantitative Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
December 5, 2024 at 9:47 AM
Quantgen GRC (16-21 Feb 2025) updates: we are now 75% subscribed!
Deadline: 19 Jan 2025
BUT: We will pick talks from submitted abstracts 16 Dec and aim to send decisions before Xmas. So submit your abstracts now (even if not perfect - editable after submission)!
www.grc.org/quantitative...
Deadline: 19 Jan 2025
BUT: We will pick talks from submitted abstracts 16 Dec and aim to send decisions before Xmas. So submit your abstracts now (even if not perfect - editable after submission)!
www.grc.org/quantitative...
New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...
Characterizing the genetic architecture of drug response using gene-context interaction methods
Sadowski et al. propose a framework to study the genetics of response to commonly prescribed drugs in large biobanks. They quantify the heritability of response to statins, metformin, warfarin, and methotrexate, and identify associated genes. Their analysis also shows the importance of accounting for drug use in genetic risk prediction.
www.cell.com
December 4, 2024 at 8:46 PM
New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...