Simone Immler
@immler.bsky.social
Professor of Genetics & Reproduction, University of East Anglia
Founder and Scientific Director, Virilitas Labs
Founder and Scientific Director, Virilitas Labs
Reposted by Simone Immler
🧬 Our latest paper out in Scientific Reports!
We explored how Gum Arabic (a dietary fibre) affects the microbiota–gut–brain axis and whole-organism fitness in zebrafish.
🔗 www.nature.com/articles/s41...
@immler.bsky.social @biouea.bsky.social
What we found ⬇️
We explored how Gum Arabic (a dietary fibre) affects the microbiota–gut–brain axis and whole-organism fitness in zebrafish.
🔗 www.nature.com/articles/s41...
@immler.bsky.social @biouea.bsky.social
What we found ⬇️
Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish - Scientific Reports
Scientific Reports - Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish
www.nature.com
October 2, 2025 at 11:08 AM
🧬 Our latest paper out in Scientific Reports!
We explored how Gum Arabic (a dietary fibre) affects the microbiota–gut–brain axis and whole-organism fitness in zebrafish.
🔗 www.nature.com/articles/s41...
@immler.bsky.social @biouea.bsky.social
What we found ⬇️
We explored how Gum Arabic (a dietary fibre) affects the microbiota–gut–brain axis and whole-organism fitness in zebrafish.
🔗 www.nature.com/articles/s41...
@immler.bsky.social @biouea.bsky.social
What we found ⬇️
This is a simple parsimonious model to explain the evolution of lifespan extension by dietary restriction and other forms of stress that suppress fertility.
Happy to be part of this exciting study!
Happy to be part of this exciting study!
Why does eating less extend lifespan? 🧬
Mutation accumulation underpins evolution of lifespan extension by dietary restriction
We often think about saving energy or recycling waste - but we show how evolution acting on mutation load can generate longer life on low food 🧵
🔗 tinyurl.com/jn5ryhxv
Mutation accumulation underpins evolution of lifespan extension by dietary restriction
We often think about saving energy or recycling waste - but we show how evolution acting on mutation load can generate longer life on low food 🧵
🔗 tinyurl.com/jn5ryhxv
June 26, 2025 at 4:25 PM
This is a simple parsimonious model to explain the evolution of lifespan extension by dietary restriction and other forms of stress that suppress fertility.
Happy to be part of this exciting study!
Happy to be part of this exciting study!
Reposted by Simone Immler
Reposted by Simone Immler
1/7: Proud to present our next study on aging microbiome - a massive experimental effort led by the Rosenstiel and Sommer labs and contributions by @sci-witch.bsky.social. @uni-kiel.de @crc1182.bsky.social microbiomejournal.biomedcentral.com/articles/10....
Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice - Microbiome
Background Alterations in the composition and function of the intestinal microbiota have been observed in organismal aging across a broad spectrum of animal phyla. Recent findings, which have been der...
microbiomejournal.biomedcentral.com
April 4, 2025 at 7:40 AM
1/7: Proud to present our next study on aging microbiome - a massive experimental effort led by the Rosenstiel and Sommer labs and contributions by @sci-witch.bsky.social. @uni-kiel.de @crc1182.bsky.social microbiomejournal.biomedcentral.com/articles/10....
Reposted by Simone Immler
🔬 My latest work w/ @immler.bsky.social et al: Env. stress alters sperm sRNAs, linking gene expr. + transposons in #zebrafish offspring. @heredityjournal.bsky.social
🧬 Social stress shapes RNA/TE activity across generations
#Sperm #miRNA #piRNA #Transposons #TEsky @biouea.bsky.social
rdcu.be/eeAwB
🧬 Social stress shapes RNA/TE activity across generations
#Sperm #miRNA #piRNA #Transposons #TEsky @biouea.bsky.social
rdcu.be/eeAwB
Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring
Heredity - Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring
rdcu.be
March 22, 2025 at 2:16 PM
🔬 My latest work w/ @immler.bsky.social et al: Env. stress alters sperm sRNAs, linking gene expr. + transposons in #zebrafish offspring. @heredityjournal.bsky.social
🧬 Social stress shapes RNA/TE activity across generations
#Sperm #miRNA #piRNA #Transposons #TEsky @biouea.bsky.social
rdcu.be/eeAwB
🧬 Social stress shapes RNA/TE activity across generations
#Sperm #miRNA #piRNA #Transposons #TEsky @biouea.bsky.social
rdcu.be/eeAwB
Reposted by Simone Immler
A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.
go.nature.com
March 1, 2025 at 2:34 AM
A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪
Happy International Women in Science day! I owe a lot to all of you that I met along the way, as my supervisors, mentors, friends, colleagues, PhD students, postdocs, research assistants, daughters, mothers and… and.. and…
February 11, 2025 at 9:10 PM
Happy International Women in Science day! I owe a lot to all of you that I met along the way, as my supervisors, mentors, friends, colleagues, PhD students, postdocs, research assistants, daughters, mothers and… and.. and…
Reposted by Simone Immler
Celebrate 'International Day of Women and Girls in Science Day' by strengthening your timeline with these outstanding Scientists! *Now in two volumes below* 🧪
#WomenInScience (Volume 1): go.bsky.app/4BegEjv
#WomenInScience (Volume 2): go.bsky.app/VoebYrt
#WomenInScience (Volume 1): go.bsky.app/4BegEjv
#WomenInScience (Volume 2): go.bsky.app/VoebYrt
February 11, 2025 at 3:58 PM
Celebrate 'International Day of Women and Girls in Science Day' by strengthening your timeline with these outstanding Scientists! *Now in two volumes below* 🧪
#WomenInScience (Volume 1): go.bsky.app/4BegEjv
#WomenInScience (Volume 2): go.bsky.app/VoebYrt
#WomenInScience (Volume 1): go.bsky.app/4BegEjv
#WomenInScience (Volume 2): go.bsky.app/VoebYrt
Reposted by Simone Immler
🚀 Join us to learn about genome assembly, and annotation, exploring cutting-edge sequencing tech like Illumina @pacbio.bsky.social , @nanoporetech.com 🧬🔬 Don't miss out—join us: www.physalia-courses.org/courses-work...
#Genomics #Bioinformatics #GenomeAssembly
#Genomics #Bioinformatics #GenomeAssembly
February 11, 2025 at 1:45 PM
🚀 Join us to learn about genome assembly, and annotation, exploring cutting-edge sequencing tech like Illumina @pacbio.bsky.social , @nanoporetech.com 🧬🔬 Don't miss out—join us: www.physalia-courses.org/courses-work...
#Genomics #Bioinformatics #GenomeAssembly
#Genomics #Bioinformatics #GenomeAssembly
Reposted by Simone Immler
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
February 7, 2025 at 2:57 PM
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
Reposted by Simone Immler
New model of premature #aging in #zebrafish 👏
"Loss of wrn leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration."
Go Fish! 🐟
www.pnas.org/doi/10.1073/...
"Loss of wrn leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration."
Go Fish! 🐟
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
February 3, 2025 at 12:40 PM
New model of premature #aging in #zebrafish 👏
"Loss of wrn leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration."
Go Fish! 🐟
www.pnas.org/doi/10.1073/...
"Loss of wrn leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration."
Go Fish! 🐟
www.pnas.org/doi/10.1073/...
Reposted by Simone Immler
Join our online course on Genome-Wide Prediction of Complex Traits with @oscargenomics.bsky.social & Evangelina (March 24-28).
You will learn the essential steps to implement genome-wide prediction analyses in animals, plants and humans
Limited spots! 👉 www.physalia-courses.org/courses-work...
You will learn the essential steps to implement genome-wide prediction analyses in animals, plants and humans
Limited spots! 👉 www.physalia-courses.org/courses-work...
GENOME-WIDE PREDICTION OF COMPLEX TRAITS
Dates 24-28 March 2025 To foster international participation, this course will be held online
www.physalia-courses.org
February 4, 2025 at 7:11 AM
Join our online course on Genome-Wide Prediction of Complex Traits with @oscargenomics.bsky.social & Evangelina (March 24-28).
You will learn the essential steps to implement genome-wide prediction analyses in animals, plants and humans
Limited spots! 👉 www.physalia-courses.org/courses-work...
You will learn the essential steps to implement genome-wide prediction analyses in animals, plants and humans
Limited spots! 👉 www.physalia-courses.org/courses-work...
Reposted by Simone Immler
Hand-drawn images of larval and juvenile zebrafish. Credit to @stednitz.bsky.social. #ZebrafishZunday 🧪
February 2, 2025 at 12:26 PM
Hand-drawn images of larval and juvenile zebrafish. Credit to @stednitz.bsky.social. #ZebrafishZunday 🧪
Reposted by Simone Immler
Try our new in silico PCR (sPCR) tool sharkmer- github.com/caseywdunn/s.... You give it primers and fastq reads, it gives you sequences that would be amplified by PCR. Works in minutes on a laptop for high copy regions like rRNA, great for species id etc. Feedback welcome. #bioinformatics #ngs
GitHub - caseywdunn/sharkmer
Contribute to caseywdunn/sharkmer development by creating an account on GitHub.
github.com
January 29, 2025 at 7:49 PM
Try our new in silico PCR (sPCR) tool sharkmer- github.com/caseywdunn/s.... You give it primers and fastq reads, it gives you sequences that would be amplified by PCR. Works in minutes on a laptop for high copy regions like rRNA, great for species id etc. Feedback welcome. #bioinformatics #ngs
Reposted by Simone Immler
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea!
And enjoy the fish 🐟 eating the Pi(e) 🥧
And enjoy the fish 🐟 eating the Pi(e) 🥧
🚨Our new paper @immler.bsky.social @biouea.bsky.social 🚨
FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements
Read now in Mobile DNA >> rdcu.be/d7Jub
✅ Covers many species (more to come)
✅ GUI based software
#TESky #zebrafish #transposons
@zebrafishrock.bsky.social
FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements
Read now in Mobile DNA >> rdcu.be/d7Jub
✅ Covers many species (more to come)
✅ GUI based software
#TESky #zebrafish #transposons
@zebrafishrock.bsky.social
January 28, 2025 at 10:15 AM
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea!
And enjoy the fish 🐟 eating the Pi(e) 🥧
And enjoy the fish 🐟 eating the Pi(e) 🥧
Reposted by Simone Immler
FishPi software is freely available here: github.com/alicegodden/...
January 28, 2025 at 9:22 AM
FishPi software is freely available here: github.com/alicegodden/...
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea!
And enjoy the fish 🐟 eating the Pi(e) 🥧
And enjoy the fish 🐟 eating the Pi(e) 🥧
🚨Our new paper @immler.bsky.social @biouea.bsky.social 🚨
FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements
Read now in Mobile DNA >> rdcu.be/d7Jub
✅ Covers many species (more to come)
✅ GUI based software
#TESky #zebrafish #transposons
@zebrafishrock.bsky.social
FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements
Read now in Mobile DNA >> rdcu.be/d7Jub
✅ Covers many species (more to come)
✅ GUI based software
#TESky #zebrafish #transposons
@zebrafishrock.bsky.social
January 28, 2025 at 10:15 AM
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea!
And enjoy the fish 🐟 eating the Pi(e) 🥧
And enjoy the fish 🐟 eating the Pi(e) 🥧
Reposted by Simone Immler
Reposted by Simone Immler
The maintenance of genetic polymorphism underlying sexually antagonistic traits
doi.org/10.1093/evle...
Now in @evolletters.bsky.social by Ewan Flintham et al.
doi.org/10.1093/evle...
Now in @evolletters.bsky.social by Ewan Flintham et al.
The maintenance of genetic polymorphism underlying sexually antagonistic traits
Abstract. Selection often favors different trait values in males and females, leading to genetic conflicts between the sexes when traits have a shared gene
doi.org
January 23, 2025 at 4:02 PM
The maintenance of genetic polymorphism underlying sexually antagonistic traits
doi.org/10.1093/evle...
Now in @evolletters.bsky.social by Ewan Flintham et al.
doi.org/10.1093/evle...
Now in @evolletters.bsky.social by Ewan Flintham et al.
Reposted by Simone Immler
Reversing Type 2 diabetes
A randomized trial of an SGLT-2 drug and moderate caloric restriction (vs placebo drug) led to remission in 44% vs 28% in the control group
A randomized trial of an SGLT-2 drug and moderate caloric restriction (vs placebo drug) led to remission in 44% vs 28% in the control group
January 22, 2025 at 11:35 PM
Reversing Type 2 diabetes
A randomized trial of an SGLT-2 drug and moderate caloric restriction (vs placebo drug) led to remission in 44% vs 28% in the control group
A randomized trial of an SGLT-2 drug and moderate caloric restriction (vs placebo drug) led to remission in 44% vs 28% in the control group
Reposted by Simone Immler
Tour de force! @metorrespadilla.bsky.social & team develop Smart-seq+5′ to map TSS in single embryos with unprecedented res revealing plethora of TE-driven transcripts in 5 mammal species. Some surprisingly old & conserved. Treasure trove of new biology for yrs to come!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development
Mapping transcription start sites across five mammalian species before, during, and
after embryonic genome activation unveils widespread transposable element-driven transcription
and co-option of evol...
www.cell.com
January 20, 2025 at 7:41 PM
Tour de force! @metorrespadilla.bsky.social & team develop Smart-seq+5′ to map TSS in single embryos with unprecedented res revealing plethora of TE-driven transcripts in 5 mammal species. Some surprisingly old & conserved. Treasure trove of new biology for yrs to come!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
I still enjoy looking at zebrafish embryos even after many years. New lab members and students seeing them for the first time never fail to express their amazement
Developing #zebrafish embryos about 18 hours post fertilization. Can you see the tail or eye?
January 18, 2025 at 2:04 PM
I still enjoy looking at zebrafish embryos even after many years. New lab members and students seeing them for the first time never fail to express their amazement
Reposted by Simone Immler
A great end to 2024:
The Zebrafish Sperm Proteome
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
We described >5400 sperm proteins!
Spearheaded by PhD student Jayme Cohen in collaboration with many people at
@uniofeastanglia.bsky.social
@johninnescentre.bsky.social
The Zebrafish Sperm Proteome
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
We described >5400 sperm proteins!
Spearheaded by PhD student Jayme Cohen in collaboration with many people at
@uniofeastanglia.bsky.social
@johninnescentre.bsky.social
The Zebrafish Sperm Proteome
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...
analyticalsciencejournals.onlinelibrary.wiley.com
January 8, 2025 at 9:57 AM
A great end to 2024:
The Zebrafish Sperm Proteome
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
We described >5400 sperm proteins!
Spearheaded by PhD student Jayme Cohen in collaboration with many people at
@uniofeastanglia.bsky.social
@johninnescentre.bsky.social
The Zebrafish Sperm Proteome
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
We described >5400 sperm proteins!
Spearheaded by PhD student Jayme Cohen in collaboration with many people at
@uniofeastanglia.bsky.social
@johninnescentre.bsky.social
A great end to 2024:
The Zebrafish Sperm Proteome
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
We described >5400 sperm proteins!
Spearheaded by PhD student Jayme Cohen in collaboration with many people at
@uniofeastanglia.bsky.social
@johninnescentre.bsky.social
The Zebrafish Sperm Proteome
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
We described >5400 sperm proteins!
Spearheaded by PhD student Jayme Cohen in collaboration with many people at
@uniofeastanglia.bsky.social
@johninnescentre.bsky.social
The Zebrafish Sperm Proteome
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...
analyticalsciencejournals.onlinelibrary.wiley.com
January 8, 2025 at 9:57 AM
A great end to 2024:
The Zebrafish Sperm Proteome
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
We described >5400 sperm proteins!
Spearheaded by PhD student Jayme Cohen in collaboration with many people at
@uniofeastanglia.bsky.social
@johninnescentre.bsky.social
The Zebrafish Sperm Proteome
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
We described >5400 sperm proteins!
Spearheaded by PhD student Jayme Cohen in collaboration with many people at
@uniofeastanglia.bsky.social
@johninnescentre.bsky.social
Reposted by Simone Immler
🚨New paper from @immler.bsky.social lab
Led by Jayme Cohen doi.org/10.1002/pmic...
On the #Zebrafish #sperm proteome out now! 🐠
Led by Jayme Cohen doi.org/10.1002/pmic...
On the #Zebrafish #sperm proteome out now! 🐠
The Zebrafish Sperm Proteome
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...
doi.org
December 31, 2024 at 5:51 PM
🚨New paper from @immler.bsky.social lab
Led by Jayme Cohen doi.org/10.1002/pmic...
On the #Zebrafish #sperm proteome out now! 🐠
Led by Jayme Cohen doi.org/10.1002/pmic...
On the #Zebrafish #sperm proteome out now! 🐠