Gui Villagomez
@guiviol.bsky.social
Craniofacial Development & Tissue Regeneration 🇲🇽
Reposted by Gui Villagomez
Our most recent study shows that stem cells in Schmidtea mediterranea do not rely on physical contacts or fixed structures to maintain their identity and regenerative potential.
@stowersinstitute.bsky.social @cp-cellreports.bsky.social @vilcekfoundation.bsky.social
www.cell.com/cell-reports...
@stowersinstitute.bsky.social @cp-cellreports.bsky.social @vilcekfoundation.bsky.social
www.cell.com/cell-reports...
October 19, 2025 at 7:56 PM
Our most recent study shows that stem cells in Schmidtea mediterranea do not rely on physical contacts or fixed structures to maintain their identity and regenerative potential.
@stowersinstitute.bsky.social @cp-cellreports.bsky.social @vilcekfoundation.bsky.social
www.cell.com/cell-reports...
@stowersinstitute.bsky.social @cp-cellreports.bsky.social @vilcekfoundation.bsky.social
www.cell.com/cell-reports...
Reposted by Gui Villagomez
What is RNA velocity in situ? ChatGPT kept getting it wrong...
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
RNA velocity in situ infers gene expression dynamics using spatial transcriptomics data
YouTube video by Prof. Jean Fan
youtu.be
October 13, 2025 at 7:09 PM
What is RNA velocity in situ? ChatGPT kept getting it wrong...
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
Reposted by Gui Villagomez
It's mushroom season in the Northern Hemisphere 🍄
Here's a look at the chemistry of arguably the most iconic mushroom, fly agaric, and what makes them so brightly coloured and hallucinogenic: www.compoundchem.com/2024/11/11/f...
#ChemSky 🧪
Here's a look at the chemistry of arguably the most iconic mushroom, fly agaric, and what makes them so brightly coloured and hallucinogenic: www.compoundchem.com/2024/11/11/f...
#ChemSky 🧪
October 13, 2025 at 7:34 PM
It's mushroom season in the Northern Hemisphere 🍄
Here's a look at the chemistry of arguably the most iconic mushroom, fly agaric, and what makes them so brightly coloured and hallucinogenic: www.compoundchem.com/2024/11/11/f...
#ChemSky 🧪
Here's a look at the chemistry of arguably the most iconic mushroom, fly agaric, and what makes them so brightly coloured and hallucinogenic: www.compoundchem.com/2024/11/11/f...
#ChemSky 🧪
Reposted by Gui Villagomez
scRetinaDB: A Comprehensive Database of Single-Cell and Spatial Omics from Cross-Species Retinas https://www.biorxiv.org/content/10.1101/2025.10.11.681556v1
October 14, 2025 at 2:48 AM
scRetinaDB: A Comprehensive Database of Single-Cell and Spatial Omics from Cross-Species Retinas https://www.biorxiv.org/content/10.1101/2025.10.11.681556v1
Reposted by Gui Villagomez
🔔SAVE THE DATE!🔔
Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.
More info➡️ bit.ly/474De1E
Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.
More info➡️ bit.ly/474De1E
3rd Stem Cell - Niche Interactions in the Gastrointestinal Tract Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
bit.ly
October 13, 2025 at 2:37 PM
🔔SAVE THE DATE!🔔
Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.
More info➡️ bit.ly/474De1E
Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.
More info➡️ bit.ly/474De1E
Reposted by Gui Villagomez
A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 Oct. Not only did he make a discovery that laid the foundations for stem cell research, he also created one of the best environments for research at the Wellcome/CRUK Gurdon Institute wellcome.org/news/sir-joh...
Sir John Gurdon, 1933-2025 | Wellcome
A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 October. He made a discovery that opened up the field of cloning research, and created one of the best environments for res...
wellcome.org
October 9, 2025 at 1:39 PM
A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 Oct. Not only did he make a discovery that laid the foundations for stem cell research, he also created one of the best environments for research at the Wellcome/CRUK Gurdon Institute wellcome.org/news/sir-joh...
Reposted by Gui Villagomez
There are a few people that are inspirations to almost all scientists that I know, and Jane Goodall was one of them. RIP. 😢
Jane Goodall, the celebrated primatologist and conservationist, has died
Jane Goodall, the conservationist renowned for her groundbreaking chimpanzee field research and globe-spanning environmental advocacy, has died. She was 91.
apnews.com
October 1, 2025 at 8:53 PM
There are a few people that are inspirations to almost all scientists that I know, and Jane Goodall was one of them. RIP. 😢
Reposted by Gui Villagomez
🚨 The International Developmental Mechanics Zoom Seminar Series is back on Sept 25!
🎤 We have an exciting line-up of speakers this fall. See the image below for details
🌐 Website: sites.google.com/view/devmech...
📝 Interested in presenting? Sign up here: tinyurl.com/2munv5bv
🎤 We have an exciting line-up of speakers this fall. See the image below for details
🌐 Website: sites.google.com/view/devmech...
📝 Interested in presenting? Sign up here: tinyurl.com/2munv5bv
September 16, 2025 at 6:08 PM
🚨 The International Developmental Mechanics Zoom Seminar Series is back on Sept 25!
🎤 We have an exciting line-up of speakers this fall. See the image below for details
🌐 Website: sites.google.com/view/devmech...
📝 Interested in presenting? Sign up here: tinyurl.com/2munv5bv
🎤 We have an exciting line-up of speakers this fall. See the image below for details
🌐 Website: sites.google.com/view/devmech...
📝 Interested in presenting? Sign up here: tinyurl.com/2munv5bv
Reposted by Gui Villagomez
Schwann cells in peripheral nerves help bone healing by transforming into MSCs, which aid bone growth and blood vessel repair. This process is driven by Shh signaling. This discovery could enhance bone regeneration in aging or disease.👍
#bone
@brjournal.bsky.social
www.nature.com/articles/s41...
#bone
@brjournal.bsky.social
www.nature.com/articles/s41...
September 12, 2025 at 6:31 AM
Schwann cells in peripheral nerves help bone healing by transforming into MSCs, which aid bone growth and blood vessel repair. This process is driven by Shh signaling. This discovery could enhance bone regeneration in aging or disease.👍
#bone
@brjournal.bsky.social
www.nature.com/articles/s41...
#bone
@brjournal.bsky.social
www.nature.com/articles/s41...
Reposted by Gui Villagomez
Arne C. Lekven, Sarah Empie, and Richard Saoud review the history of Wnt1, its gene structure and regulation, expression, loss-of-function consequences, and connection to human disease. Read “One Wnt to lead them all: a Wnt1 primer” to learn more: doi.org/10.1016/j.di...
September 8, 2025 at 9:05 PM
Arne C. Lekven, Sarah Empie, and Richard Saoud review the history of Wnt1, its gene structure and regulation, expression, loss-of-function consequences, and connection to human disease. Read “One Wnt to lead them all: a Wnt1 primer” to learn more: doi.org/10.1016/j.di...
Reposted by Gui Villagomez
Hao's Preprint Reading List Sep 4, 2025
BCAA metabolism, Pulmonary hypertension, Hepatopathy
Fibroblast-myonuclei crosstalk in muscle-tendon unit
GLI3 Neural crest
Morpho-mechanics of developing outflow tract
Time-series Multi-organ transcriptomics Hypertension
docs.google.com/document/d/e...
BCAA metabolism, Pulmonary hypertension, Hepatopathy
Fibroblast-myonuclei crosstalk in muscle-tendon unit
GLI3 Neural crest
Morpho-mechanics of developing outflow tract
Time-series Multi-organ transcriptomics Hypertension
docs.google.com/document/d/e...
September 4, 2025 at 7:16 PM
Hao's Preprint Reading List Sep 4, 2025
BCAA metabolism, Pulmonary hypertension, Hepatopathy
Fibroblast-myonuclei crosstalk in muscle-tendon unit
GLI3 Neural crest
Morpho-mechanics of developing outflow tract
Time-series Multi-organ transcriptomics Hypertension
docs.google.com/document/d/e...
BCAA metabolism, Pulmonary hypertension, Hepatopathy
Fibroblast-myonuclei crosstalk in muscle-tendon unit
GLI3 Neural crest
Morpho-mechanics of developing outflow tract
Time-series Multi-organ transcriptomics Hypertension
docs.google.com/document/d/e...
Reposted by Gui Villagomez
#DBfeature
Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development
by Maria Bergamasco, Jacqueline Ogier, Alexandra Garnham, Lachlan Whitehead, Kelly Rogers, Gordon Smyth, Rachel Burt, Anne Voss, Tim Thomas
tiom33.short.gy/DB520,141-154
Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development
by Maria Bergamasco, Jacqueline Ogier, Alexandra Garnham, Lachlan Whitehead, Kelly Rogers, Gordon Smyth, Rachel Burt, Anne Voss, Tim Thomas
tiom33.short.gy/DB520,141-154
September 2, 2025 at 11:24 AM
#DBfeature
Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development
by Maria Bergamasco, Jacqueline Ogier, Alexandra Garnham, Lachlan Whitehead, Kelly Rogers, Gordon Smyth, Rachel Burt, Anne Voss, Tim Thomas
tiom33.short.gy/DB520,141-154
Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development
by Maria Bergamasco, Jacqueline Ogier, Alexandra Garnham, Lachlan Whitehead, Kelly Rogers, Gordon Smyth, Rachel Burt, Anne Voss, Tim Thomas
tiom33.short.gy/DB520,141-154
Reposted by Gui Villagomez
Possible causes of your problems. It’s a diagram that (sadly) still seems relevant in 2025, so reposting a year and a bit on.
August 25, 2025 at 5:18 PM
Possible causes of your problems. It’s a diagram that (sadly) still seems relevant in 2025, so reposting a year and a bit on.
Reposted by Gui Villagomez
How can we improve the #training of future #biology researchers? This Community Page presents a competency-based framework to use to align curriculum and trainee outcomes with educational objectives in the life sciences. 🧪 #academicsky
plos.io/3HIpuB1
plos.io/3HIpuB1
Flexible competency framework: A tool for optimizing life science training
Life sciences research requires high standards of rigor and professionalism, which need to be woven into the training future scientists. This Community Page presents a competency-based framework to us...
plos.io
August 28, 2025 at 4:26 PM
How can we improve the #training of future #biology researchers? This Community Page presents a competency-based framework to use to align curriculum and trainee outcomes with educational objectives in the life sciences. 🧪 #academicsky
plos.io/3HIpuB1
plos.io/3HIpuB1
Reposted by Gui Villagomez
Time flies, so if you're an early-career researcher that is eligible to apply for one of our junior faculty grants, start thinking about your application now because the next deadline is 28 November
@biologists.bsky.social
www.biologists.com/grants/kicks...
www.biologists.com/grants/ecr-v...
@biologists.bsky.social
www.biologists.com/grants/kicks...
www.biologists.com/grants/ecr-v...
August 28, 2025 at 5:07 PM
Time flies, so if you're an early-career researcher that is eligible to apply for one of our junior faculty grants, start thinking about your application now because the next deadline is 28 November
@biologists.bsky.social
www.biologists.com/grants/kicks...
www.biologists.com/grants/ecr-v...
@biologists.bsky.social
www.biologists.com/grants/kicks...
www.biologists.com/grants/ecr-v...
Reposted by Gui Villagomez
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
August 28, 2025 at 3:15 PM
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
Reposted by Gui Villagomez
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
August 28, 2025 at 12:48 PM
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
Reposted by Gui Villagomez
Beautiful work!! 🎉
Finally out on @devbiol.bsky.social: we find that Epop mutant mice have near-perfect Polycomb phenotype (orderly posterior shift of vertebral identity🩻) linked to accelerated HOX clock⏰.
Bonus: Epop has maternal effect!
Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social
Bonus: Epop has maternal effect!
Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social
The PRC2-associated factor EPOP is required for Hox gene regulation during axial development in mice
The Polycomb repressive complex 2 (PRC2) is an essential modulator of gene repression. We previously reported that, in mouse embryonic stem cells, PRC…
www.sciencedirect.com
August 27, 2025 at 10:45 PM
Beautiful work!! 🎉
Reposted by Gui Villagomez
Bluesky for Science
Starter packs for genomics, bioinformatics, #Rstats, Nextflow. Moderation lists. Feeds. Let's rebuild the old scitwitter community and keep this place nice
blog.stephenturner.us/p/bluesky-fo... 🧬🖥️🧪
Starter packs for genomics, bioinformatics, #Rstats, Nextflow. Moderation lists. Feeds. Let's rebuild the old scitwitter community and keep this place nice
blog.stephenturner.us/p/bluesky-fo... 🧬🖥️🧪
Bluesky for Science
Bluesky starter packs for genomics, bioinformatics, R, and Nextflow
blog.stephenturner.us
November 16, 2024 at 10:25 AM
Bluesky for Science
Starter packs for genomics, bioinformatics, #Rstats, Nextflow. Moderation lists. Feeds. Let's rebuild the old scitwitter community and keep this place nice
blog.stephenturner.us/p/bluesky-fo... 🧬🖥️🧪
Starter packs for genomics, bioinformatics, #Rstats, Nextflow. Moderation lists. Feeds. Let's rebuild the old scitwitter community and keep this place nice
blog.stephenturner.us/p/bluesky-fo... 🧬🖥️🧪
Reposted by Gui Villagomez
New online! Imaging-based multimodal profiling of single cells with STAMP
Imaging-based multimodal profiling of single cells with STAMP
Nature Reviews Genetics, Published online: 21 August 2025; doi:10.1038/s41576-025-00891-6In this Tools of the Trade article, Kellie Wise and Anna Pascual-Reguant introduce STAMP (single-cell transcriptomics analysis and multimodal profiling), which harnesses imaging to measure RNA and/or protein expression in fixed cells or nuclei.
www.nature.com
August 21, 2025 at 11:29 AM
New online! Imaging-based multimodal profiling of single cells with STAMP
Reposted by Gui Villagomez
#DBfeature 🐣
Stage‑matched scRNA‑seq uncovers a “trailblazer” gene network shared between mouse and chick, driving neural crest migration into craniofacial arches.
by J.A. Morrison et al.
www.sciencedirect.com/science/arti...
#EvoDevo #ComparativeGenomics #SingleCell
Stage‑matched scRNA‑seq uncovers a “trailblazer” gene network shared between mouse and chick, driving neural crest migration into craniofacial arches.
by J.A. Morrison et al.
www.sciencedirect.com/science/arti...
#EvoDevo #ComparativeGenomics #SingleCell
August 18, 2025 at 6:22 PM
#DBfeature 🐣
Stage‑matched scRNA‑seq uncovers a “trailblazer” gene network shared between mouse and chick, driving neural crest migration into craniofacial arches.
by J.A. Morrison et al.
www.sciencedirect.com/science/arti...
#EvoDevo #ComparativeGenomics #SingleCell
Stage‑matched scRNA‑seq uncovers a “trailblazer” gene network shared between mouse and chick, driving neural crest migration into craniofacial arches.
by J.A. Morrison et al.
www.sciencedirect.com/science/arti...
#EvoDevo #ComparativeGenomics #SingleCell
Reposted by Gui Villagomez
Podcast recommendation: The Lab Detective
Tells the story of a miscarriage of justice & @crick.ac.uk's @carovinuesa.bsky.social role in righting it
Compelling human interest story with major implications for how courts deal with scientific evidence
shows.acast.com/the-tortoise...
Tells the story of a miscarriage of justice & @crick.ac.uk's @carovinuesa.bsky.social role in righting it
Compelling human interest story with major implications for how courts deal with scientific evidence
shows.acast.com/the-tortoise...
The Lab Detective | The Slow Newscast
shows.acast.com
August 18, 2025 at 7:57 AM
Podcast recommendation: The Lab Detective
Tells the story of a miscarriage of justice & @crick.ac.uk's @carovinuesa.bsky.social role in righting it
Compelling human interest story with major implications for how courts deal with scientific evidence
shows.acast.com/the-tortoise...
Tells the story of a miscarriage of justice & @crick.ac.uk's @carovinuesa.bsky.social role in righting it
Compelling human interest story with major implications for how courts deal with scientific evidence
shows.acast.com/the-tortoise...
Reposted by Gui Villagomez
Please consider supporting our students! The only Latin American team 🇲🇽 in BIOMOD, an international #science competition. They worked on an innovative treatment for colon cancer using nanotechnology & DNA origami 🧬🔬
Learn more!
youtu.be/GV0cnb3biJQ?...
Donate:
crowdfunding.tec.mx/s/detallepro...
Learn more!
youtu.be/GV0cnb3biJQ?...
Donate:
crowdfunding.tec.mx/s/detallepro...
Biotecnología sin Fronteras: Nanotecnología Mexicana
YouTube video by Biomod
youtu.be
August 19, 2025 at 5:35 AM
Please consider supporting our students! The only Latin American team 🇲🇽 in BIOMOD, an international #science competition. They worked on an innovative treatment for colon cancer using nanotechnology & DNA origami 🧬🔬
Learn more!
youtu.be/GV0cnb3biJQ?...
Donate:
crowdfunding.tec.mx/s/detallepro...
Learn more!
youtu.be/GV0cnb3biJQ?...
Donate:
crowdfunding.tec.mx/s/detallepro...
Reposted by Gui Villagomez
Super interesting review on astrocyte development by @m-r-williamson.bsky.social and colleagues ! #astrocytes #glia #review
Development and diversity of astrocytes
Summary: This Development at a Glance article provides an overview of astrocyte ontogeny and morphogenesis, highlighting mechanisms that regulate the development of astrocytes, the most abundant glial...
doi.org
July 20, 2025 at 5:56 PM
Super interesting review on astrocyte development by @m-r-williamson.bsky.social and colleagues ! #astrocytes #glia #review
Reposted by Gui Villagomez
Please check it out! In this paper with lead author- Tess Leathers- we visualized the expression of enzymes that regulate the COX-mediated inflammation pathway during embryonic development. We are continuing to study this pathway to discover its early roles in brain and neural crest development!
#DBfeature #Avian
Spatiotemporal characterization of cyclooxygenase pathway enzymes during vertebrate embryonic development
by Tess Leathers, Raneesh Ramarapu, Crystal Rogers @rogerslabucd.bsky.social
www.sciencedirect.com/science/arti...
Spatiotemporal characterization of cyclooxygenase pathway enzymes during vertebrate embryonic development
by Tess Leathers, Raneesh Ramarapu, Crystal Rogers @rogerslabucd.bsky.social
www.sciencedirect.com/science/arti...
June 30, 2025 at 6:18 PM
Please check it out! In this paper with lead author- Tess Leathers- we visualized the expression of enzymes that regulate the COX-mediated inflammation pathway during embryonic development. We are continuing to study this pathway to discover its early roles in brain and neural crest development!