@ophirklein.bsky.social
CNPY4 joins the growing list of lipid-binding regulators keeping cellular membranes balanced — exciting times for membrane & lipid biology!
#lipidbiology #cellbiology #biorxiv #sphingolipids
#lipidbiology #cellbiology #biorxiv #sphingolipids
October 18, 2025 at 6:10 PM
CNPY4 joins the growing list of lipid-binding regulators keeping cellular membranes balanced — exciting times for membrane & lipid biology!
#lipidbiology #cellbiology #biorxiv #sphingolipids
#lipidbiology #cellbiology #biorxiv #sphingolipids
Why it matters 🧠
🧩 Reveals a new lipid-binding regulator in cells
⚙️ Links SAPLIP family proteins to membrane lipid regulation
🧪 Opens questions: how is CNPY4 controlled? disease relevance?
🧩 Reveals a new lipid-binding regulator in cells
⚙️ Links SAPLIP family proteins to membrane lipid regulation
🧪 Opens questions: how is CNPY4 controlled? disease relevance?
October 18, 2025 at 6:10 PM
Why it matters 🧠
🧩 Reveals a new lipid-binding regulator in cells
⚙️ Links SAPLIP family proteins to membrane lipid regulation
🧪 Opens questions: how is CNPY4 controlled? disease relevance?
🧩 Reveals a new lipid-binding regulator in cells
⚙️ Links SAPLIP family proteins to membrane lipid regulation
🧪 Opens questions: how is CNPY4 controlled? disease relevance?
Our work uncovers a new molecular player: CNPY4.
CNPY4, a saposin-like protein, directly binds sphingolipids
Loss or perturbation of CNPY4 disrupts lipid distribution + abundance → reshaping membrane architecture & possibly signaling pathways. This is a new layer of control in lipid homeostasis.
CNPY4, a saposin-like protein, directly binds sphingolipids
Loss or perturbation of CNPY4 disrupts lipid distribution + abundance → reshaping membrane architecture & possibly signaling pathways. This is a new layer of control in lipid homeostasis.
October 18, 2025 at 6:10 PM
Our work uncovers a new molecular player: CNPY4.
CNPY4, a saposin-like protein, directly binds sphingolipids
Loss or perturbation of CNPY4 disrupts lipid distribution + abundance → reshaping membrane architecture & possibly signaling pathways. This is a new layer of control in lipid homeostasis.
CNPY4, a saposin-like protein, directly binds sphingolipids
Loss or perturbation of CNPY4 disrupts lipid distribution + abundance → reshaping membrane architecture & possibly signaling pathways. This is a new layer of control in lipid homeostasis.
Happy to share our new preprint in collaboration with Natalia Jura's lab! 🧬
CNPY4 is a lipid-binding regulator of sphingolipid homeostasis
👉 biorxiv.org/content/10.1101/2025.10.13.682155v1
Sphingolipids shape membranes & signaling — but how their balance is maintained is still unclear.
CNPY4 is a lipid-binding regulator of sphingolipid homeostasis
👉 biorxiv.org/content/10.1101/2025.10.13.682155v1
Sphingolipids shape membranes & signaling — but how their balance is maintained is still unclear.
CNPY4 is a Lipid-Binding Regulator of Sphingolipid Homeostasis
Sphingolipids function both as signaling molecules and as organizers of cell membranes, and their dysregulation has been linked to cancer, metabolic disorders, and neurodegeneration. A central node in...
biorxiv.org
October 18, 2025 at 6:10 PM
Happy to share our new preprint in collaboration with Natalia Jura's lab! 🧬
CNPY4 is a lipid-binding regulator of sphingolipid homeostasis
👉 biorxiv.org/content/10.1101/2025.10.13.682155v1
Sphingolipids shape membranes & signaling — but how their balance is maintained is still unclear.
CNPY4 is a lipid-binding regulator of sphingolipid homeostasis
👉 biorxiv.org/content/10.1101/2025.10.13.682155v1
Sphingolipids shape membranes & signaling — but how their balance is maintained is still unclear.
🔔SAVE THE DATE!🔔
Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.
More info➡️ bit.ly/474De1E
Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.
More info➡️ bit.ly/474De1E
3rd Stem Cell - Niche Interactions in the Gastrointestinal Tract Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
bit.ly
October 13, 2025 at 2:37 PM
🔔SAVE THE DATE!🔔
Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.
More info➡️ bit.ly/474De1E
Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed.
More info➡️ bit.ly/474De1E
Reposted
YOUR PHONE EXISTS because the government invested in "useless" basic research decades ago!
It's the same with medical research - today's basic science leads to tomorrow's life-saving treatments.
Visit FundResearch.org to tell Congress to keep funding research
#SaveOurCures #PhoneForGood #FundNIH
It's the same with medical research - today's basic science leads to tomorrow's life-saving treatments.
Visit FundResearch.org to tell Congress to keep funding research
#SaveOurCures #PhoneForGood #FundNIH
September 25, 2025 at 6:49 PM
YOUR PHONE EXISTS because the government invested in "useless" basic research decades ago!
It's the same with medical research - today's basic science leads to tomorrow's life-saving treatments.
Visit FundResearch.org to tell Congress to keep funding research
#SaveOurCures #PhoneForGood #FundNIH
It's the same with medical research - today's basic science leads to tomorrow's life-saving treatments.
Visit FundResearch.org to tell Congress to keep funding research
#SaveOurCures #PhoneForGood #FundNIH
Reposted
🎉 INTRODUCING #SaveOurCures🎉
Federal biomedical research represents less than 1% of the federal budget but delivers life-saving treatments for millions of American families.
93% of cancer treatments started with American government-funded research.
🧵:
1/8
Federal biomedical research represents less than 1% of the federal budget but delivers life-saving treatments for millions of American families.
93% of cancer treatments started with American government-funded research.
🧵:
1/8
August 28, 2025 at 10:56 AM
🎉 INTRODUCING #SaveOurCures🎉
Federal biomedical research represents less than 1% of the federal budget but delivers life-saving treatments for millions of American families.
93% of cancer treatments started with American government-funded research.
🧵:
1/8
Federal biomedical research represents less than 1% of the federal budget but delivers life-saving treatments for millions of American families.
93% of cancer treatments started with American government-funded research.
🧵:
1/8
Trump Is Shutting Down the War On Cancer www.nytimes.com/2025/09/14/m...
Trump Is Shutting Down the War On Cancer
www.nytimes.com
September 15, 2025 at 11:43 AM
Trump Is Shutting Down the War On Cancer www.nytimes.com/2025/09/14/m...
We're very excited to launch a search for a founding director of our new reproductive sciences program at Cedars-Sinai! careers.cshs.org/job/los-ange...
Director, Reproductive Sciences Program at CEDARS-SINAI
Learn more about applying for Director, Reproductive Sciences Program at CEDARS-SINAI
careers.cshs.org
August 31, 2025 at 4:50 PM
We're very excited to launch a search for a founding director of our new reproductive sciences program at Cedars-Sinai! careers.cshs.org/job/los-ange...
Reposted
🎖️Congratulations to Carole Ober, PhD, winner of the ASHG 2025 Mentorship Award! Learn more about the award and Dr. Ober's work: https://www.ashg.org/membership/awards/2025-awardees/ #ASHG #HumanGenetic
August 28, 2025 at 6:45 PM
🎖️Congratulations to Carole Ober, PhD, winner of the ASHG 2025 Mentorship Award! Learn more about the award and Dr. Ober's work: https://www.ashg.org/membership/awards/2025-awardees/ #ASHG #HumanGenetic
Reposted
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 22, 2025 at 9:04 PM
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
UCLA professor Bill Lowry: My current basic-research grant from the National Institutes of Health, which is a continuation of the work that led to this discovery on alopecia, was suspended last week. I don’t know what interesting discoveries won’t be made the longer this thing stays suspended. 🧪
The Great Unbalding Draws Nearer
Decades of science have not found a way to regrow lost hair. Until, maybe, now.
nymag.com
August 12, 2025 at 3:44 PM
UCLA professor Bill Lowry: My current basic-research grant from the National Institutes of Health, which is a continuation of the work that led to this discovery on alopecia, was suspended last week. I don’t know what interesting discoveries won’t be made the longer this thing stays suspended. 🧪
The findings, if confirmed in humans, could one day lead to treatments that enable rapid, scarless recovery from skin wounds on other parts of the body."
www.cedars-sinai.org/newsroom/pre...
www.cedars-sinai.org/newsroom/pre...
Preclinical Study Unlocks a Mystery of Rapid Mouth Healing
Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University ...
www.cedars-sinai.org
July 4, 2025 at 7:27 AM
The findings, if confirmed in humans, could one day lead to treatments that enable rapid, scarless recovery from skin wounds on other parts of the body."
www.cedars-sinai.org/newsroom/pre...
www.cedars-sinai.org/newsroom/pre...
"Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A new study has discovered one secret of this disappearing act.
Preclinical Study Unlocks a Mystery of Rapid Mouth Healing
Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University ...
www.cedars-sinai.org
July 4, 2025 at 7:27 AM
"Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A new study has discovered one secret of this disappearing act.
Excited to share our new paper by Jessi Cook in collaboration with Michelle Griffin from Mike Longaker's group at Stanford.
www.science.org/stoken/autho...
As nicely described by our communications team:
www.science.org/stoken/autho...
As nicely described by our communications team:
Growth arrest specific–6 and angiotoxin receptor–like signaling drive oral regenerative wound repair
Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa.
urldefense.com
July 4, 2025 at 7:27 AM
Excited to share our new paper by Jessi Cook in collaboration with Michelle Griffin from Mike Longaker's group at Stanford.
www.science.org/stoken/autho...
As nicely described by our communications team:
www.science.org/stoken/autho...
As nicely described by our communications team:
Join us in Crete in the fall to discuss stem cells! The early bird deadline has been extended to July 15th. This date will be the final deadline for abstracts being considered for short talk selection. www.aegeanconferences.org/src/App/spea...
Looking forward to seeing you there!
Looking forward to seeing you there!
Aegean Conferences
https://www.aegeanconferences.org/src/App/speakers/189”
July 4, 2025 at 6:06 AM
Join us in Crete in the fall to discuss stem cells! The early bird deadline has been extended to July 15th. This date will be the final deadline for abstracts being considered for short talk selection. www.aegeanconferences.org/src/App/spea...
Looking forward to seeing you there!
Looking forward to seeing you there!
Reposted
Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa
www.science.org/doi/10.1126/...
@ophirklein.bsky.social
www.science.org/doi/10.1126/...
@ophirklein.bsky.social
July 2, 2025 at 8:49 PM
Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa
www.science.org/doi/10.1126/...
@ophirklein.bsky.social
www.science.org/doi/10.1126/...
@ophirklein.bsky.social
Here Is All the Science at Risk in Trump’s Clash With Harvard www.nytimes.com/interactive/...
Here Is All the Science at Risk in Trump’s Clash With Harvard
More than 900 research grants worth $2.6 billion are in jeopardy. So is the 80-year-old model of American science.
www.nytimes.com
June 23, 2025 at 8:55 AM
Here Is All the Science at Risk in Trump’s Clash With Harvard www.nytimes.com/interactive/...
Help Save the NIH www.congressweb.com/UCSF/9?frame...
Help Save the NIH
As the second largest recipient of NIH funding in the nation, UCSF depends on NIH funding to support our researchers in advancing health worldwide.
Unfortunately, the White House's budget request pr...
www.congressweb.com
June 18, 2025 at 8:19 PM
Help Save the NIH www.congressweb.com/UCSF/9?frame...
Reposted
Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.
“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming
www.nytimes.com
June 3, 2025 at 10:58 AM
Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.
“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
Sorry to read this and glad you are on the mend!
June 3, 2025 at 11:23 PM
Sorry to read this and glad you are on the mend!
