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brjournal.bsky.social
Bone Research_Editorial Office
@brjournal.bsky.social
24 followers 60 following 41 posts
Bone Research is an open access, fully peer-reviewed journal publishing the foremost progress and novel understanding of all aspects of bone science.
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brjournal.bsky.social
Investigating circadian rhythm regulation, a study finds Gala-SR, a small-molecule compound, effectively restores rhythm disorders and mitigates inflammation in periodontitis, offering potential for treating inflammatory diseases.👍
#bone
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www.nature.com/articles/s41...
November 21, 2025 at 7:55 AM
brjournal.bsky.social
Exploring the links between ossification of the posterior longitudinal ligament and endocrine-metabolic dysregulation, a review highlights potential factors and pathways, crucial for advancing early intervention and therapeutic strategies.😀
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www.nature.com/articles/s41...
November 19, 2025 at 6:34 AM
brjournal.bsky.social
Discogenic lower back pain is a distinct pathological entity linked to intervertebral disc degeneration. Recent review synthesizes current knowledge on its pathophysiology, risk factors, and diagnostic challenges, highlighting the need for targeted treatments.👇
#bone
www.nature.com/articles/s41...
November 14, 2025 at 2:38 AM
brjournal.bsky.social
Traumatic heterotopic ossification (HO) is an abnormal bone formation after injury. A study explores how necroptotic macrophages and p21-activated kinase 4 (Pak4) influence this process, revealing potential therapeutic targets.👍
#bone #Pak4
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November 11, 2025 at 5:46 AM
brjournal.bsky.social
Osteoarthritis (OA), a common joint disorder, is a significant global healthcare challenge. This review explores how advanced materials and AI enhance OA diagnosis and treatment, offering insights for next-generation smart materials with improved performance.😀
#joint
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November 7, 2025 at 5:20 AM
brjournal.bsky.social
cPLA2, a key inflammation mediator, drives cartilage degeneration in osteoarthritis (OA) and intervertebral disc degeneration (IVDD). Inhibiting it reduces inflammation and preserves cartilage, offering hope for new therapies.👇
#osteoarthritis
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www.nature.com/articles/s41...
November 7, 2025 at 5:16 AM
brjournal.bsky.social
A new review explores how aging affects osteoarthritis, identifying immune imbalance, cell aging, and stem cell exhaustion as key factors, guiding future treatments.👇
#osteoarthritis #cell #bone #aging
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www.nature.com/articles/s41...
October 31, 2025 at 2:36 AM
brjournal.bsky.social
Using bone injury strategies, a recent study explores diabetic patients' foot wound healing, revealing osteokines' role in accelerating repair and offering new treatment insights.😀
#bone #diabetic #osteokines
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www.nature.com/articles/s41...
October 30, 2025 at 8:02 AM
brjournal.bsky.social
Dendritic cells play a key role in bone repair and regeneration. New research explores their impact on bone health and potential for innovative treatments in osteoimmunology！😀
#osteoimmunology #bone
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www.nature.com/articles/s41...
October 24, 2025 at 3:40 AM
brjournal.bsky.social
Piezo1, a key protein in bone health, boosts fracture healing by enhancing mitochondrial energy production. A new study shows it works through a pathway involving β-catenin and Lars2, offering new ways to treat fractures！👇
#Piezo1 #bone #Lars2
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October 22, 2025 at 6:00 AM
brjournal.bsky.social
According to a new study, basic fibroblast growth factor (FGF2), a key protein, regulates rRNA expression in stem cells via chromatin architecture, impacting cell fate and proliferation. These insights could enhance regenerative medicine and tissue engineering!👍
#bone
www.nature.com/articles/s41...
October 17, 2025 at 1:50 AM
brjournal.bsky.social
Sarcopenia, or muscle loss in the elderly, is linked to falls, fractures, and other issues. This review explores its connection to musculoskeletal disorders and potential treatments, helping develop targeted interventions！👍
#sarcopenia #bone
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www.nature.com/articles/s41...
October 13, 2025 at 9:12 AM
brjournal.bsky.social
Featured in Bone Research's [Top 5 Articles in the first half of 2025]😀：Bone formation and blood vessel growth are closely linked. This review explores how cells talk to each other to coordinate these processes, offering insights for bone healing and treatment！👇
www.nature.com/articles/s41...
September 26, 2025 at 2:24 AM
brjournal.bsky.social
Featured in Bone Research's [Top 5 Articles in the first half of 2025]👏：PINK1 is a protein vital for cellular health. In this research, boosting PINK1 protected joints by clearing bad mitochondria, shielding them from osteoarthritis. New hope for healthier cartilage!🥳
www.nature.com/articles/s41...
September 24, 2025 at 2:17 AM
brjournal.bsky.social
Featured in Bone Research's [Top 5 Articles in the first half of 2025]👏：Circadian rhythm genes like Bmal1 play key roles in bone and cartilage health. This review explores how Bmal1 regulates these tissues, offering insights for treating related diseases.😀
#bone #Bmal1
www.nature.com/articles/s41...
September 19, 2025 at 9:43 AM
brjournal.bsky.social
Featured in Bone Research's [Top 5 Articles in the first half of 2025] 🥳DDR2, a collagen receptor, helps bones heal better and stops abnormal bone growth, making it a promising target for improving bone health and treating related conditions.👏
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www.nature.com/articles/s41...
September 18, 2025 at 9:41 AM
brjournal.bsky.social
Highlight from BoneResearch! Don’t miss【Top 5 articles in the first half of 2025】Macrophages play a key role in intervertebral disc degeneration. This review provides insights into their regulatory mechanisms and potential therapeutic strategies
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www.nature.com/articles/s41...
September 17, 2025 at 7:54 AM
brjournal.bsky.social
Schwann cells in peripheral nerves help bone healing by transforming into MSCs, which aid bone growth and blood vessel repair. This process is driven by Shh signaling. This discovery could enhance bone regeneration in aging or disease.👍
#bone
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www.nature.com/articles/s41...
September 12, 2025 at 6:31 AM
brjournal.bsky.social
Mitochondrial dysfunction in cartilage cells drives osteoarthritis progression（OA）, but new therapies offer hope. Researchers are exploring targeted treatments to improve mitochondrial health and reduce symptoms.👇
#cartilage #mitochondrial #bone
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www.nature.com/articles/s41...
September 10, 2025 at 8:09 AM
brjournal.bsky.social
Check out our video!👍The impact of mitochondrial dysfunction on osteoarthritis cartilage: current insights and emerging mitochondria-targeted therapies
#mitochondrial #osteoarthritis #bone
@brjournal.bsky.social
www.nature.com/articles/s41...
September 8, 2025 at 6:45 AM
brjournal.bsky.social
This review examines the unfolded protein response (UPR) in cancer-associated bone disease, highlighting its mechanisms and potential as a target for innovative treatments, offering new directions for research.👇
#protein #cancer #bone
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www.nature.com/articles/s41...
September 5, 2025 at 9:14 AM
brjournal.bsky.social
Osteoporosis significantly raises the risk of rotator cuff tears, with genetic links identified. Managing osteoporosis is key to prevention.👇
#bone #osteoporosis
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www.nature.com/articles/s41...
September 3, 2025 at 7:04 AM
brjournal.bsky.social
Cover image showing pseudo-colored trabeculae of the Sost -/- proximal tibiae, highlighting how bone thickness varies, measured by µCT. This cover image was contributed by @Scott Roberts, the Royal Veterinary College, London, UK.
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www.nature.com/articles/s41...
August 29, 2025 at 7:04 AM
brjournal.bsky.social
According to new research, the G3BP1 protein helps cancer cells evade chemotherapy. Targeting this protein could enhance treatment efficacy！👇
#G3BP1 #cancer #bone
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www.nature.com/articles/s41...
August 29, 2025 at 5:48 AM
brjournal.bsky.social
New research shows LRP1, a key protein, is crucial for bone formation. Its deficiency can lead to severe skeletal defects. This study provides insights into bone development and related diseases.😀
#bone #skeletal
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www.nature.com/articles/s41...
August 27, 2025 at 6:14 AM