Gabriel McKinsey
@gabrielmckinsey.bsky.social
Neuroimmunologist and developmental biologist at the University of California San Francisco Department of Pediatrics.
Google scholar: https://scholar.google.com/citations?user=ZaUcPIkAAAAJ&hl=en
Google scholar: https://scholar.google.com/citations?user=ZaUcPIkAAAAJ&hl=en
Pinned
Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity
Nature Communications - Microglial states are dynamically regulated during development and disease. Here, the authors show that these changes are mediated by cell autonomous TGF-β signaling in...
rdcu.be
1) Heya! For anyone interested in microglia and neuroimmunology, please feel free to check out my recent publication: rdcu.be/eeEbB. In this study, we explored the cell-cell signaling that regulates microglial specification and homeostasis in the developing brain! (1/21)
Reposted by Gabriel McKinsey
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
November 18, 2025 at 11:22 AM
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Reposted by Gabriel McKinsey
From a reddit post discussing ICE moving into Charlotte
November 16, 2025 at 2:57 PM
From a reddit post discussing ICE moving into Charlotte
Reposted by Gabriel McKinsey
The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum.
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
Sosa Lab - Postdoctoral Researchers
We are seeking postdocs to start in 2026!
www.sosaneurolab.com
November 7, 2025 at 10:53 PM
The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum.
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
Reposted by Gabriel McKinsey
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
November 5, 2025 at 6:53 PM
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
Reposted by Gabriel McKinsey
With the RSF takeover of El Fasher, there has been another round horrific, genocidal violence in Darfur.
2.5 years in, this conflict remains the world's worst humanitarian disaster. If you would like to help, Sudanese organizer Sarah Elhassan has curated a list of organizations linktr.ee/bsonblast
2.5 years in, this conflict remains the world's worst humanitarian disaster. If you would like to help, Sudanese organizer Sarah Elhassan has curated a list of organizations linktr.ee/bsonblast
@bsonblast | Linktree
Linktree. Make your link do more.
linktr.ee
November 2, 2025 at 7:58 PM
With the RSF takeover of El Fasher, there has been another round horrific, genocidal violence in Darfur.
2.5 years in, this conflict remains the world's worst humanitarian disaster. If you would like to help, Sudanese organizer Sarah Elhassan has curated a list of organizations linktr.ee/bsonblast
2.5 years in, this conflict remains the world's worst humanitarian disaster. If you would like to help, Sudanese organizer Sarah Elhassan has curated a list of organizations linktr.ee/bsonblast
Reposted by Gabriel McKinsey
Pennsylvania has an important Supreme Court race coming up on Tuesday, November 4. If you live in the Keystone State, or know someone who does, vote YES to retain three justices who will protect your fundamental rights and freedoms.
October 29, 2025 at 8:38 PM
Pennsylvania has an important Supreme Court race coming up on Tuesday, November 4. If you live in the Keystone State, or know someone who does, vote YES to retain three justices who will protect your fundamental rights and freedoms.
Reposted by Gabriel McKinsey
Sometimes I feel like I’m losing my mind listening to the news because how does “he sought her gynecological records” not move people? Why is Cuomo even considered an option? This is all so absurd.
October 24, 2025 at 1:51 AM
Sometimes I feel like I’m losing my mind listening to the news because how does “he sought her gynecological records” not move people? Why is Cuomo even considered an option? This is all so absurd.
Reposted by Gabriel McKinsey
October 23, 2025 at 2:25 AM
Reposted by Gabriel McKinsey
California, this November 4th, the whole country is counting on you.
Prop 50 puts our elections back on a level playing field, preserves independent redistricting over the long term, and lets the people decide.
So return your ballot today. Vote yes on 50.
Prop 50 puts our elections back on a level playing field, preserves independent redistricting over the long term, and lets the people decide.
So return your ballot today. Vote yes on 50.
October 14, 2025 at 5:04 PM
California, this November 4th, the whole country is counting on you.
Prop 50 puts our elections back on a level playing field, preserves independent redistricting over the long term, and lets the people decide.
So return your ballot today. Vote yes on 50.
Prop 50 puts our elections back on a level playing field, preserves independent redistricting over the long term, and lets the people decide.
So return your ballot today. Vote yes on 50.
Reposted by Gabriel McKinsey
Decades of research have found that acetaminophen is safe for children when administered as recommended. Misleading claims link the medicine to autism. These false claims send a dangerous message to parents and does a disservice to autistic individuals. www.aap.org/en/news-room...
September 23, 2025 at 9:25 PM
Decades of research have found that acetaminophen is safe for children when administered as recommended. Misleading claims link the medicine to autism. These false claims send a dangerous message to parents and does a disservice to autistic individuals. www.aap.org/en/news-room...
Reposted by Gabriel McKinsey
Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.
September 20, 2025 at 4:09 AM
Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.
Reposted by Gabriel McKinsey
If you live in:
California
New Jersey
New York
Pennsylvania
Virginia
The deadline to register to vote in the November elections is coming up. Check your registration now: IWillVote.com.
California
New Jersey
New York
Pennsylvania
Virginia
The deadline to register to vote in the November elections is coming up. Check your registration now: IWillVote.com.
September 16, 2025 at 2:28 PM
If you live in:
California
New Jersey
New York
Pennsylvania
Virginia
The deadline to register to vote in the November elections is coming up. Check your registration now: IWillVote.com.
California
New Jersey
New York
Pennsylvania
Virginia
The deadline to register to vote in the November elections is coming up. Check your registration now: IWillVote.com.
Reposted by Gabriel McKinsey
“What shocked me, when I was kidnapped [by US immigration], was just how reminiscent that was to cases I witnessed in Syria. You would have plainclothed officers without any warrant come and take you just because of your political speech.”
@oliverlaughland.bsky.social interviews Mahmoud Khalil
@oliverlaughland.bsky.social interviews Mahmoud Khalil
Mahmoud Khalil on exile, liberation and Ice detention: ‘It was a clear act of cruelty’
His grandparents survived the Nakba and he fled Assad’s Syria. Khalil is no stranger to political persecution, but not even Trump’s crackdown can silence him
www.theguardian.com
September 8, 2025 at 1:44 PM
“What shocked me, when I was kidnapped [by US immigration], was just how reminiscent that was to cases I witnessed in Syria. You would have plainclothed officers without any warrant come and take you just because of your political speech.”
@oliverlaughland.bsky.social interviews Mahmoud Khalil
@oliverlaughland.bsky.social interviews Mahmoud Khalil
Reposted by Gabriel McKinsey
1/ Thrilled to share that my PhD thesis work is now out in its final form @nature.com! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @arimolofskylab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamic fibroblast–immune interactions shape recovery after brain injury - Nature
Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local im...
www.nature.com
September 3, 2025 at 4:43 PM
1/ Thrilled to share that my PhD thesis work is now out in its final form @nature.com! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @arimolofskylab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gabriel McKinsey
We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
www.nature.com
August 21, 2025 at 12:16 PM
We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gabriel McKinsey
PA-ADOPT is pleased to announce it's 16th free and open eTextbook: "Developmental Biology Laboratory: Experiments in Classical and Experimental Embryology" by Judith A. Cebra-Thomas, Assoc. Prof. of Biology @millersvilleuni.bsky.social and Matthew E. Smith, Graduate Student @udelaware.bsky.social
August 12, 2025 at 6:04 PM
PA-ADOPT is pleased to announce it's 16th free and open eTextbook: "Developmental Biology Laboratory: Experiments in Classical and Experimental Embryology" by Judith A. Cebra-Thomas, Assoc. Prof. of Biology @millersvilleuni.bsky.social and Matthew E. Smith, Graduate Student @udelaware.bsky.social
Reposted by Gabriel McKinsey
As stressful as it is to run a laboratory in the US right now, my thoughts are often with the NIH staff living in the awful chaos trying to preserve the whole enterprise. I’m grateful for every moment they choose not to give up. These people are the only thing keeping it from entirely collapsing.
July 31, 2025 at 12:15 AM
As stressful as it is to run a laboratory in the US right now, my thoughts are often with the NIH staff living in the awful chaos trying to preserve the whole enterprise. I’m grateful for every moment they choose not to give up. These people are the only thing keeping it from entirely collapsing.
Reposted by Gabriel McKinsey
When you strip away humanity
July 26, 2025 at 11:31 AM
When you strip away humanity
Reposted by Gabriel McKinsey
This is getting lots of good traction, so if you are a student looking for a PHD STUDENT POSITION in biology, I would love to add you! Be sure to add your research interests in your bio and/or a pinned post so PIs can find you.
Are you a PI in a biology field looking for students to join your lab as a PhD student? I made a Starter Pack to help PIs and potential PhD students connect! If you would like to be added to this pack, please let me know! go.bsky.app/EFj87fi
July 17, 2025 at 2:50 PM
This is getting lots of good traction, so if you are a student looking for a PHD STUDENT POSITION in biology, I would love to add you! Be sure to add your research interests in your bio and/or a pinned post so PIs can find you.
Reposted by Gabriel McKinsey
The Ku Klux Klan Acts (passed in 1870 & 1871 to protect 14th amend rights) were a response to masked violent men who terrorized Black communities, violating their civil rights.The deployment of violent masked ICE ofcrs are tapping into this unique form of terror.
open.substack.com/pub/sherrily...
open.substack.com/pub/sherrily...
Masked Terror
At this point, we have all seen the videos.
open.substack.com
July 10, 2025 at 2:42 PM
The Ku Klux Klan Acts (passed in 1870 & 1871 to protect 14th amend rights) were a response to masked violent men who terrorized Black communities, violating their civil rights.The deployment of violent masked ICE ofcrs are tapping into this unique form of terror.
open.substack.com/pub/sherrily...
open.substack.com/pub/sherrily...
Reposted by Gabriel McKinsey
Every American should read this ACLU lawsuit about what is happening in Los Angeles and California. It is the stuff of dystopian nightmares. This is not immigration enforcement. It is positively stuffed with videos and articles documenting racial profiling on a scale unseen since Jim Crow.
July 9, 2025 at 8:21 PM
Every American should read this ACLU lawsuit about what is happening in Los Angeles and California. It is the stuff of dystopian nightmares. This is not immigration enforcement. It is positively stuffed with videos and articles documenting racial profiling on a scale unseen since Jim Crow.
Reposted by Gabriel McKinsey
New paper:
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.
www.biorxiv.org/content/10.1...
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.
www.biorxiv.org/content/10.1...
mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity
More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding. ### Competing Interest Statement The authors have declared no competing interest. Pershing Square Foundation, https://ror.org/04tce9s05 G. Harold & Leila Y. Mathers Foundation National Institutes of Health, DP1GM123454, R35GM144046 Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748
www.biorxiv.org
July 7, 2025 at 2:28 PM
New paper:
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.
www.biorxiv.org/content/10.1...
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.
www.biorxiv.org/content/10.1...
Reposted by Gabriel McKinsey
“Northwestern reassigned her grant funding, closed her lab and FORCIBLY ADMITTED HER TO THE UNIVERSITY’s PSYCHOATRIC HOSPITAL”
Never ever ever forget how racist the China initiative was, how it was pushed by both parties, and how it ruined the careers and terrorized the lives of many scientists.
Never ever ever forget how racist the China initiative was, how it was pushed by both parties, and how it ruined the careers and terrorized the lives of many scientists.
"Andrea Chu, the Midwest organizing director for Asian American Advancing Justice Chicago, said that Wu’s death shows the “devastating” impact of the China Initiative."
www.chicagotribune.com/2025/07/04/n...
www.chicagotribune.com/2025/07/04/n...
Northwestern sued over suicide of professor targeted in China investigation
The estate of Northwestern University Professor Jane Wu, who died by suicide last year after being investigated in a controversial federal probe, is suing the school for allegedly discriminating ag…
www.chicagotribune.com
July 6, 2025 at 1:55 AM
“Northwestern reassigned her grant funding, closed her lab and FORCIBLY ADMITTED HER TO THE UNIVERSITY’s PSYCHOATRIC HOSPITAL”
Never ever ever forget how racist the China initiative was, how it was pushed by both parties, and how it ruined the careers and terrorized the lives of many scientists.
Never ever ever forget how racist the China initiative was, how it was pushed by both parties, and how it ruined the careers and terrorized the lives of many scientists.