@furkanoflaz.bsky.social
Postdoc @Stanford. Interested in mitochondrial biology
Pinned
I’m happy to share that my latest PhD work is published in
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....
Reposted
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
Tong Wang and coworkers
www.embopress.org/doi/full/10....
Tong Wang and coworkers
www.embopress.org/doi/full/10....
November 5, 2025 at 6:45 AM
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
Tong Wang and coworkers
www.embopress.org/doi/full/10....
Tong Wang and coworkers
www.embopress.org/doi/full/10....
Reposted
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells
Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ....
onlinelibrary.wiley.com
October 25, 2025 at 8:56 AM
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
Reposted
Sensing within: Mitochondrial inside-out signal transduction http://dlvr.it/TNkqLD
October 17, 2025 at 4:30 PM
Sensing within: Mitochondrial inside-out signal transduction http://dlvr.it/TNkqLD
Reposted
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
October 9, 2025 at 1:08 PM
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
Reposted
Our new review is out! Likely once an independent organism, mitochondria have retained a striking degree of autonomy. We discuss their capacity to sense within—a process we refer to as mitochondrial inside-out signaling. Written by talented @furkanoflaz.bsky.social @signscaztl.bsky.social
Review @cp-cellchembiol.bsky.social @xinnanwanglab.bsky.social @stanforduniversity.bsky.social
Sensing within: Mitochondrial inside-out signal transduction
www.cell.com/cell-chemica...
Sensing within: Mitochondrial inside-out signal transduction
www.cell.com/cell-chemica...
September 25, 2025 at 3:29 PM
Our new review is out! Likely once an independent organism, mitochondria have retained a striking degree of autonomy. We discuss their capacity to sense within—a process we refer to as mitochondrial inside-out signaling. Written by talented @furkanoflaz.bsky.social @signscaztl.bsky.social
Reposted
We have updated our preprint "A green lifetime biosensor for calcium that remains bright over its full dynamic range" with some new data - including this photo showing the difference in color for the Turquoise and Green lifetime probe. www.biorxiv.org/content/10.1...
September 11, 2025 at 1:53 PM
We have updated our preprint "A green lifetime biosensor for calcium that remains bright over its full dynamic range" with some new data - including this photo showing the difference in color for the Turquoise and Green lifetime probe. www.biorxiv.org/content/10.1...
Reposted
Announcing our new PA biosensor, PILS-Nir1 – seen here in HeLa cells during PLC activation #lipidtime #phospholipids
Read the OA paper in JCB
Read the OA paper in JCB
September 10, 2025 at 7:56 PM
Announcing our new PA biosensor, PILS-Nir1 – seen here in HeLa cells during PLC activation #lipidtime #phospholipids
Read the OA paper in JCB
Read the OA paper in JCB
Reposted
Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. show that the #mitophagy receptors BNIP3 and NIX are required for tight attachment & expansion of the isolation membrane along the mitochondrial surface rupress.org/jcb/article/...
#Autophagy #Mitochondria
#Autophagy #Mitochondria
May 13, 2025 at 5:46 PM
Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. show that the #mitophagy receptors BNIP3 and NIX are required for tight attachment & expansion of the isolation membrane along the mitochondrial surface rupress.org/jcb/article/...
#Autophagy #Mitochondria
#Autophagy #Mitochondria
I’m happy to share that my latest PhD work is published in
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....
May 12, 2025 at 8:14 AM
I’m happy to share that my latest PhD work is published in
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....
Reposted
A brain-reading implant that translates neural signals into audible speech has allowed a woman with paralysis to hear what she intends to say nearly instantly
https://go.nature.com/3QStZtI
https://go.nature.com/3QStZtI
Brain implant translates thoughts to speech in an instant
Improvements to brain–computer interfaces are bringing the technology closer to natural conversation speed.
go.nature.com
March 31, 2025 at 3:31 PM
A brain-reading implant that translates neural signals into audible speech has allowed a woman with paralysis to hear what she intends to say nearly instantly
https://go.nature.com/3QStZtI
https://go.nature.com/3QStZtI
Reposted
NitrOFF: An engineered fluorescent biosensor to illuminate nitrate transport in living cells by Sheel Dodani and team: www.biorxiv.org/content/10.1...
March 24, 2025 at 12:34 PM
NitrOFF: An engineered fluorescent biosensor to illuminate nitrate transport in living cells by Sheel Dodani and team: www.biorxiv.org/content/10.1...
Reposted
In-cell architecture of the mitochondrial respiratory chain | Science www.science.org/doi/10.1126/...
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
www.science.org
March 21, 2025 at 9:33 AM
In-cell architecture of the mitochondrial respiratory chain | Science www.science.org/doi/10.1126/...
Reposted
Check out our new fluorescent probe for imaging f-actin dynamics: 𝗦𝗶𝗥-𝗫𝗔𝗰𝘁𝗶𝗻: 𝗔 𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁 𝗽𝗿𝗼𝗯𝗲 𝗳𝗼𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗮𝗰𝘁𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗹𝗶𝘃𝗲 𝗰𝗲𝗹𝗹𝘀 www.biorxiv.org/content/10.1...
Thank you @veselin-nasufovic.bsky.social
Thank you @veselin-nasufovic.bsky.social
SiR-XActin: A fluorescent probe for imaging actin dynamics in live cells
Imaging actin-dependent processes in live cells is important for understanding numerous biological processes. However, currently used natural-product based fluorescent probes for actin filaments affec...
www.biorxiv.org
February 7, 2025 at 7:42 PM
Check out our new fluorescent probe for imaging f-actin dynamics: 𝗦𝗶𝗥-𝗫𝗔𝗰𝘁𝗶𝗻: 𝗔 𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁 𝗽𝗿𝗼𝗯𝗲 𝗳𝗼𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗮𝗰𝘁𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗹𝗶𝘃𝗲 𝗰𝗲𝗹𝗹𝘀 www.biorxiv.org/content/10.1...
Thank you @veselin-nasufovic.bsky.social
Thank you @veselin-nasufovic.bsky.social
Reposted
Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
Synaptic basis of feature selectivity in hippocampal neurons - Nature
A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.
www.nature.com
December 18, 2024 at 10:00 PM
Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
Reposted
Beautiful paper on mitochondrial DNA (mtDNA) stress sensing, from our postdoc Alva Sainz @signscaztl.bsky.social of her Ph.D work in the Shadel lab!
New: Sainz, Shadel et al. @salkinstitute.bsky.social investigate mitochondrial respiration-independent signaling induced by acute mtDNA depletion and uncover a role for FAM43A in a CHK2-dependent mitochondrial stress signaling pathway. https://buff.ly/40MBmIW
#mitochondria
#mitochondria
January 28, 2025 at 5:40 PM
Beautiful paper on mitochondrial DNA (mtDNA) stress sensing, from our postdoc Alva Sainz @signscaztl.bsky.social of her Ph.D work in the Shadel lab!