Xinnan Wang Lab
@xinnanwanglab.bsky.social
@Stanford, we study mitochondrial dynamics, transport, behaviors, signal transductions, and contacts in brain cells.
http://xinnanwanglab.stanford.edu
http://xinnanwanglab.stanford.edu
Our new review is out! Likely once an independent organism, mitochondria have retained a striking degree of autonomy. We discuss their capacity to sense within—a process we refer to as mitochondrial inside-out signaling. Written by talented @furkanoflaz.bsky.social @signscaztl.bsky.social
Review @cp-cellchembiol.bsky.social @xinnanwanglab.bsky.social @stanforduniversity.bsky.social
Sensing within: Mitochondrial inside-out signal transduction
www.cell.com/cell-chemica...
Sensing within: Mitochondrial inside-out signal transduction
www.cell.com/cell-chemica...
September 25, 2025 at 3:29 PM
Our new review is out! Likely once an independent organism, mitochondria have retained a striking degree of autonomy. We discuss their capacity to sense within—a process we refer to as mitochondrial inside-out signaling. Written by talented @furkanoflaz.bsky.social @signscaztl.bsky.social
Congratulations Andy on this beautiful study! Thanks for including us!
We have an uncorrected proof published for Bhagaban Mallik's study on Mitochondrial Complex I and how it regulates synapse function. You can find it in @plosbiology.org. I am so proud!
H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social
journals.plos.org/plosbiology/...
H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social
journals.plos.org/plosbiology/...
Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms
How do neurons adapt to mitochondrial dysfunction in different tissues? This study shows that Mitochondrial Complex I depletion triggers ROS-driven compensatory signaling in motor neurons that preserv...
journals.plos.org
September 22, 2025 at 11:57 PM
Congratulations Andy on this beautiful study! Thanks for including us!
Happy to see our previous studies showing Miro1 resistance to mitochondrial depolarization in PD and the efficacy of Miro1-binding compounds are fully validated in independent cohorts by Julia Fitzgerald's group: doi: 10.1038/s41531-025-01115-8
September 16, 2025 at 10:37 AM
Happy to see our previous studies showing Miro1 resistance to mitochondrial depolarization in PD and the efficacy of Miro1-binding compounds are fully validated in independent cohorts by Julia Fitzgerald's group: doi: 10.1038/s41531-025-01115-8
We had so much fun presenting 5 posters at Stanford Bio-X Symposium!
August 29, 2025 at 5:35 PM
We had so much fun presenting 5 posters at Stanford Bio-X Symposium!
Reposted by Xinnan Wang Lab
Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress www.science.org/doi/10.1126/...
Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress
Drugs targeting mitochondrial removal show unexpected mechanisms with implications for Parkinson’s therapeutics.
www.science.org
August 28, 2025 at 2:51 PM
Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress www.science.org/doi/10.1126/...
Mitochondrial pearling and zipping 🤔! So cool! Inspiring talk from @sulianamanley.bsky.social
August 23, 2025 at 12:04 AM
Mitochondrial pearling and zipping 🤔! So cool! Inspiring talk from @sulianamanley.bsky.social
Reposted by Xinnan Wang Lab
Delighted to share our latest work looking at the role of the RNA-binding proteins Clu1 (yeast)/Clu (flies) in regulating the translation of #mitochondria proteins. Really interesting regulator of mito biology.
Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...
Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...
Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions
Author summary Mitochondria are essential cellular organelles that perform many important roles in regulating metabolism. They are dynamic in form, function and composition which is crucial to maintai...
dx.plos.org
July 16, 2025 at 11:35 AM
Delighted to share our latest work looking at the role of the RNA-binding proteins Clu1 (yeast)/Clu (flies) in regulating the translation of #mitochondria proteins. Really interesting regulator of mito biology.
Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...
Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...
Reposted by Xinnan Wang Lab
Please share! We are accepting applications for the Biology Preview Program, which aims to make the PhD application process accessible and work with students to strenghten applications. Participants will receive a fee waiver, work 1:1 w/ a mentor, and meet w/faculty. Link: forms.gle/1xBShmvot5Vr...
2025 Stanford Biology Preview Program Application
The Stanford Biology Preview Program (BPP) aims to support scholars through the PhD application process. The Stanford BPP offers virtual workshops to provide insight into the Stanford Biology PhD Prog...
forms.gle
June 16, 2025 at 6:44 PM
Please share! We are accepting applications for the Biology Preview Program, which aims to make the PhD application process accessible and work with students to strenghten applications. Participants will receive a fee waiver, work 1:1 w/ a mentor, and meet w/faculty. Link: forms.gle/1xBShmvot5Vr...
Reposted by Xinnan Wang Lab
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications
Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...
www.nature.com
June 1, 2025 at 1:16 AM
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...
Reposted by Xinnan Wang Lab
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma
Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.
www.science.org
May 31, 2025 at 6:24 AM
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Reposted by Xinnan Wang Lab
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Silencing mitochondrial gene expression in living cells
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...
scim.ag
May 23, 2025 at 7:23 PM
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Congratulations Furkan!
I’m happy to share that my latest PhD work is published in
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....
May 12, 2025 at 7:25 PM
Congratulations Furkan!
Reposted by Xinnan Wang Lab
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
April 21, 2025 at 7:21 PM
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution | Science Advances www.science.org/doi/10.1126/...
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution
ARMC1 partitions between distinct outer mitochondrial membrane complexes and the cytosol to control mitochondrial distribution.
www.science.org
April 10, 2025 at 3:10 PM
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution | Science Advances www.science.org/doi/10.1126/...
Reposted by Xinnan Wang Lab
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
www.nature.com
April 9, 2025 at 4:30 PM
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Xinnan Wang Lab
Reposted by Xinnan Wang Lab
Thrilled to announce that the registration for the EMBO workshop „Mitochondria in the Nervous System“ is now open.
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...
Mitochondria in the Nervous System
The brain is a high energy-demanding tissue with an heterogenous cellular composition. Most of the energy consumed is used for maintenance of neuronal synaptic transmission, and neurons almost exclus…
meetings.embo.org
April 4, 2025 at 1:44 PM
Thrilled to announce that the registration for the EMBO workshop „Mitochondria in the Nervous System“ is now open.
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...
Beautiful paper on mitochondrial DNA (mtDNA) stress sensing, from our postdoc Alva Sainz @signscaztl.bsky.social of her Ph.D work in the Shadel lab!
New: Sainz, Shadel et al. @salkinstitute.bsky.social investigate mitochondrial respiration-independent signaling induced by acute mtDNA depletion and uncover a role for FAM43A in a CHK2-dependent mitochondrial stress signaling pathway. https://buff.ly/40MBmIW
#mitochondria
#mitochondria
January 28, 2025 at 5:40 PM
Beautiful paper on mitochondrial DNA (mtDNA) stress sensing, from our postdoc Alva Sainz @signscaztl.bsky.social of her Ph.D work in the Shadel lab!
November 30, 2024 at 3:21 AM
We had a nice lab visit from Gordon Freedman, the mastermind of MitoWorld - seems a great initiative: mitoworld.org
November 22, 2024 at 1:40 AM
We had a nice lab visit from Gordon Freedman, the mastermind of MitoWorld - seems a great initiative: mitoworld.org
Hi everyone, really enjoy the fresh air here and meeting new people! Thanks to @colemanlab.bsky.social for the nudge! We study everything related to mitochondria. Hope to form more connections and conversations! Some blue sky pics from a fantastic nature conference on mito and immunity in September.
November 20, 2024 at 2:01 AM
Hi everyone, really enjoy the fresh air here and meeting new people! Thanks to @colemanlab.bsky.social for the nudge! We study everything related to mitochondria. Hope to form more connections and conversations! Some blue sky pics from a fantastic nature conference on mito and immunity in September.
Reposted by Xinnan Wang Lab
Welcome to @xinnanwanglab.bsky.social - a star of mitochondrial dynamics in neurons!😀
November 10, 2024 at 11:13 PM
Welcome to @xinnanwanglab.bsky.social - a star of mitochondrial dynamics in neurons!😀