Eleanna
@eleannak.bsky.social
Assistant professor, Rutgers university
Pinned
Eleanna
@eleannak.bsky.social
· May 5
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease
Eubanks et al. found that gene expression networks that are specific for brain regions
that develop high degrees of alpha-synuclein pathology carry an increased frequency
of rare risk variants in pati...
www.cell.com
Our lab's first paper has been published! www.cell.com/cell-reports...
www.cell.com/cell/fulltex...
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Grammars inferred using NARDINI+ (GIN) is a resource that uncovers molecular grammars
of intrinsically disordered regions (IDRs) across the human proteome, revealing how
distinct grammars underlie pro...
www.cell.com
November 13, 2025 at 1:38 AM
www.cell.com/cell/fulltex...
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Reposted by Eleanna
Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available
go.nature.com/479Sni6
go.nature.com/479Sni6
Is academic research becoming too competitive? Nature examines the data
Applications for European research grants increased in 2025. Scientists say they’re feeling the competition.
go.nature.com
October 17, 2025 at 10:12 AM
Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available
go.nature.com/479Sni6
go.nature.com/479Sni6
Reposted by Eleanna
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 1:26 PM
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Pleased to present the unboxing of our lab’s labubus! The green macaron named Lewy (after Lewy bodies) has officially decided to join our lab for its PhD thesis and is already learning how to write Python code 🔬 www.instagram.com/share/BAGYdC...
September 15, 2025 at 11:50 PM
Pleased to present the unboxing of our lab’s labubus! The green macaron named Lewy (after Lewy bodies) has officially decided to join our lab for its PhD thesis and is already learning how to write Python code 🔬 www.instagram.com/share/BAGYdC...
We celebrated the lab’s second anniversary! Proud of our accomplishments so far, including our paper in Cell Reports, several student awards, invited talks and good scores on NIH grants 🥳 Exciting new research is in progress and we will be ready to share it soon 🔬
September 8, 2025 at 7:43 PM
We celebrated the lab’s second anniversary! Proud of our accomplishments so far, including our paper in Cell Reports, several student awards, invited talks and good scores on NIH grants 🥳 Exciting new research is in progress and we will be ready to share it soon 🔬
Quote of the century from yesterday’s amazing Chan Zuckerberg bio hub Cell Biology at Scale symposium, which is now decorating our lab! 🐈
August 1, 2025 at 3:47 PM
Quote of the century from yesterday’s amazing Chan Zuckerberg bio hub Cell Biology at Scale symposium, which is now decorating our lab! 🐈
Group imaging on our new confocal! 🔬👩🔬🧑🔬
July 6, 2025 at 10:46 PM
Group imaging on our new confocal! 🔬👩🔬🧑🔬
Adding the first drop of oil to my lab’s new in-house confocal 🤩🔬👩🔬
June 27, 2025 at 10:37 PM
Adding the first drop of oil to my lab’s new in-house confocal 🤩🔬👩🔬
Proud that 2 students in the lab recently received 4 fellowships and awards! Michael David Rothstein Endowed Scholarship; AΩA Carolyn L. Kuckein Student Research Fellowship; Cell Biology & Neuroscience undergraduate research excellence award; Henry Rutgers Scholar Award 🥳
June 3, 2025 at 3:51 AM
Proud that 2 students in the lab recently received 4 fellowships and awards! Michael David Rothstein Endowed Scholarship; AΩA Carolyn L. Kuckein Student Research Fellowship; Cell Biology & Neuroscience undergraduate research excellence award; Henry Rutgers Scholar Award 🥳
Reposted by Eleanna
A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F
#ASGCT2025 #MedSky @asgct.bsky.social
#ASGCT2025 #MedSky @asgct.bsky.social
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
Base editors can correct disease-causing genetic variants. After a neonate had received
a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with
an estimated 50% mortality ...
nej.md
May 15, 2025 at 5:06 PM
A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F
#ASGCT2025 #MedSky @asgct.bsky.social
#ASGCT2025 #MedSky @asgct.bsky.social
Our lab's first paper has been published! www.cell.com/cell-reports...
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease
Eubanks et al. found that gene expression networks that are specific for brain regions
that develop high degrees of alpha-synuclein pathology carry an increased frequency
of rare risk variants in pati...
www.cell.com
May 5, 2025 at 1:50 PM
Our lab's first paper has been published! www.cell.com/cell-reports...
Reposted by Eleanna
“We have evidence that this is fluid-driven, swarm-type seismicity that comes in pulses. This is not unheard of in other volcanic regions; however, this time it is evolving on top of active faults that complicate the expression of seismicity.”
🧪⚒️
🧪⚒️
🧪⚒️ Use of machine learning algorithms to reliably detect smaller magnitude earthquakes around Santorini:
- Detected swarm about 5 days earlier;
- Located 10 times more earthquakes, which gives us more insight into what is going on.
- Detected swarm about 5 days earlier;
- Located 10 times more earthquakes, which gives us more insight into what is going on.
Artificial intelligence is proving a game changer in tracking the Santorini earthquake swarm - British Geological Survey
An online tool that shows which roads are most likely to cause river pollution is being expanded to assess pollution from agricultural areas.
www.bgs.ac.uk
February 11, 2025 at 12:55 PM
“We have evidence that this is fluid-driven, swarm-type seismicity that comes in pulses. This is not unheard of in other volcanic regions; however, this time it is evolving on top of active faults that complicate the expression of seismicity.”
🧪⚒️
🧪⚒️
Reposted by Eleanna
Hi Seismo-Bluesky! I decided to test a pipeline with SeisBench, PyOcto, NonLinLoc, and HypoDD on the Santorini sequence. The level of activity (>4,500 events) is truly stunning! There are repeated bursts migrating backwards and forwards, spreading outwards from a narrow, almost linear channel.
February 10, 2025 at 1:23 PM
Hi Seismo-Bluesky! I decided to test a pipeline with SeisBench, PyOcto, NonLinLoc, and HypoDD on the Santorini sequence. The level of activity (>4,500 events) is truly stunning! There are repeated bursts migrating backwards and forwards, spreading outwards from a narrow, almost linear channel.
Reposted by Eleanna
Reposted by Eleanna
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 31, 2025 at 10:28 AM
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Eleanna
Is anyone else starting to think that its all about cillia?
Researchers report PINK1 knock-out mice display cilia defects & reduced GDNF expression akin to LRRK2 mutant mice
A convergent mechanism for #Parkinsons?
www.pnas.org/doi/10.1073/...
Researchers report PINK1 knock-out mice display cilia defects & reduced GDNF expression akin to LRRK2 mutant mice
A convergent mechanism for #Parkinsons?
www.pnas.org/doi/10.1073/...
January 29, 2025 at 7:01 AM
Is anyone else starting to think that its all about cillia?
Researchers report PINK1 knock-out mice display cilia defects & reduced GDNF expression akin to LRRK2 mutant mice
A convergent mechanism for #Parkinsons?
www.pnas.org/doi/10.1073/...
Researchers report PINK1 knock-out mice display cilia defects & reduced GDNF expression akin to LRRK2 mutant mice
A convergent mechanism for #Parkinsons?
www.pnas.org/doi/10.1073/...
Reposted by Eleanna
Ten simple rules for developing good reading habits during graduate school and beyond
journals.plos.org/ploscompbiol...
journals.plos.org/ploscompbiol...
January 26, 2025 at 9:41 AM
Ten simple rules for developing good reading habits during graduate school and beyond
journals.plos.org/ploscompbiol...
journals.plos.org/ploscompbiol...
Reposted by Eleanna
I started working on genetic therapies for Mendelian disease in 2000 - and in the subsequent 25 years have never seen a disease where the molecular aetiology has undergone as giant an "OH WOW" moment as this.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease
Single-cell measurement of the Huntington’s disease-causing CAG repeat reveals that
somatic expansion of this repeat drives pathological changes in neurons, providing
insights into disease progression...
www.cell.com
January 16, 2025 at 10:29 PM
I started working on genetic therapies for Mendelian disease in 2000 - and in the subsequent 25 years have never seen a disease where the molecular aetiology has undergone as giant an "OH WOW" moment as this.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Eleanna
This pretty much settles it: we're entering the era of low-cost, on-demand binders for everything
Excited to see what people build now that "inject a llama with some junk and bleed it a month later" is no longer the cutting-edge tech
www.nature.com/articles/s41...
Excited to see what people build now that "inject a llama with some junk and bleed it a month later" is no longer the cutting-edge tech
www.nature.com/articles/s41...
De novo designed proteins neutralize lethal snake venom toxins - Nature
Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...
www.nature.com
January 15, 2025 at 9:04 PM
This pretty much settles it: we're entering the era of low-cost, on-demand binders for everything
Excited to see what people build now that "inject a llama with some junk and bleed it a month later" is no longer the cutting-edge tech
www.nature.com/articles/s41...
Excited to see what people build now that "inject a llama with some junk and bleed it a month later" is no longer the cutting-edge tech
www.nature.com/articles/s41...
Last western blot of 2024!
December 31, 2024 at 9:52 PM
Last western blot of 2024!