Edu Calpena
@educalpena.bsky.social
Miguel Servet fellow interested in rare genetic + genomic disorders | focused in the genetics of craniosynostosis @IISLaFe @CIBERER. Previously @universityofoxford.bsky.social @Wilkie_Lab
Reposted by Edu Calpena
Camino de Valencia. Mañana participo en una jornada muy chula sobre comunicación y divulgación científica: #CuentaCienciaIISLaFe.
Con gente 🔝:
@conchilillo.bsky.social. Kristin Suleng.
Carlos Romá.
@sergioefe.bsky.social.
@bayesana.bsky.social. @raticosdeciencia.bsky.social.
Qué ganas.
Con gente 🔝:
@conchilillo.bsky.social. Kristin Suleng.
Carlos Romá.
@sergioefe.bsky.social.
@bayesana.bsky.social. @raticosdeciencia.bsky.social.
Qué ganas.
January 15, 2025 at 5:47 PM
Camino de Valencia. Mañana participo en una jornada muy chula sobre comunicación y divulgación científica: #CuentaCienciaIISLaFe.
Con gente 🔝:
@conchilillo.bsky.social. Kristin Suleng.
Carlos Romá.
@sergioefe.bsky.social.
@bayesana.bsky.social. @raticosdeciencia.bsky.social.
Qué ganas.
Con gente 🔝:
@conchilillo.bsky.social. Kristin Suleng.
Carlos Romá.
@sergioefe.bsky.social.
@bayesana.bsky.social. @raticosdeciencia.bsky.social.
Qué ganas.
Reposted by Edu Calpena
The outer ear is a mammalian innovation but where did it come from? In our study in Nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. www.nature.com/articles/s41...
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Repurposing of a gill gene regulatory program for outer ear evolution - Nature
Nature - Repurposing of a gill gene regulatory program for outer ear evolution
www.nature.com
January 9, 2025 at 4:48 PM
The outer ear is a mammalian innovation but where did it come from? In our study in Nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. www.nature.com/articles/s41...
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Reposted by Edu Calpena
Evo-devo aficionados, don't miss this really cool paper by @mathithiru.bsky.social, @crumplab.bsky.social et al.
Development of the mammalian outer ear and fish gills share regulatory programs (with cross-compatible enhancers!), suggesting a common evolutionary origin of these structures.
Development of the mammalian outer ear and fish gills share regulatory programs (with cross-compatible enhancers!), suggesting a common evolutionary origin of these structures.
January 12, 2025 at 3:46 AM
Evo-devo aficionados, don't miss this really cool paper by @mathithiru.bsky.social, @crumplab.bsky.social et al.
Development of the mammalian outer ear and fish gills share regulatory programs (with cross-compatible enhancers!), suggesting a common evolutionary origin of these structures.
Development of the mammalian outer ear and fish gills share regulatory programs (with cross-compatible enhancers!), suggesting a common evolutionary origin of these structures.
Reposted by Edu Calpena
📣 Hiring, please forward widely!!
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Postdoctoral scientist, gene regulatory mechanisms and diabetes | CRG Online Recruitment Portal
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
shorturl.at
December 31, 2024 at 11:20 AM
📣 Hiring, please forward widely!!
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Reposted by Edu Calpena
How to test the functional impact of non-coding variants in vivo? We developed a new method called dual-enSERT, which can quantitatively compare the effects of enhancer variants in live mouse embryos in under two weeks. www.nature.com/articles/s41... 1/n
January 6, 2025 at 2:55 PM
How to test the functional impact of non-coding variants in vivo? We developed a new method called dual-enSERT, which can quantitatively compare the effects of enhancer variants in live mouse embryos in under two weeks. www.nature.com/articles/s41... 1/n
Reposted by Edu Calpena
Con relación a este nuevo proyecto 2025-2028 nuestro laboratorio del CNB del @csic.es busca candidatos/as graduados/as con máster para realizar una tesis doctoral con una contrato de cuatro años. Interesados/as escribidme por email con vuestro CV y expediente académico.
December 26, 2024 at 10:34 AM
Con relación a este nuevo proyecto 2025-2028 nuestro laboratorio del CNB del @csic.es busca candidatos/as graduados/as con máster para realizar una tesis doctoral con una contrato de cuatro años. Interesados/as escribidme por email con vuestro CV y expediente académico.
Reposted by Edu Calpena
How do 250k regulatory sequences coordinate 15k genes in mammalian development?
Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues
New resource with Miao Yu, Ming Hu, Bing Ren, and more.
www.nature.com/articles/s41...
Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues
New resource with Miao Yu, Ming Hu, Bing Ren, and more.
www.nature.com/articles/s41...
December 17, 2024 at 2:36 PM
How do 250k regulatory sequences coordinate 15k genes in mammalian development?
Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues
New resource with Miao Yu, Ming Hu, Bing Ren, and more.
www.nature.com/articles/s41...
Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues
New resource with Miao Yu, Ming Hu, Bing Ren, and more.
www.nature.com/articles/s41...
Reposted by Edu Calpena
How can some vertebrates naturally recover from deafness?
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
December 13, 2024 at 4:58 PM
How can some vertebrates naturally recover from deafness?
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
Reposted by Edu Calpena
Announcing new free ESHG webinar series!
🗓️ Last Wednesday of each month
📅 First episode: Feb 26, 2025 (16:00 CET)
🎤 Speaker: Malte Spielmann
💡 Topic: "The Dark Side of the #Genome: Challenges & Opportunities in the Post-Genomic Era"
🔗 Register now: wma.eventsair.com/eshg-webinar...
🗓️ Last Wednesday of each month
📅 First episode: Feb 26, 2025 (16:00 CET)
🎤 Speaker: Malte Spielmann
💡 Topic: "The Dark Side of the #Genome: Challenges & Opportunities in the Post-Genomic Era"
🔗 Register now: wma.eventsair.com/eshg-webinar...
December 20, 2024 at 8:42 AM
Announcing new free ESHG webinar series!
🗓️ Last Wednesday of each month
📅 First episode: Feb 26, 2025 (16:00 CET)
🎤 Speaker: Malte Spielmann
💡 Topic: "The Dark Side of the #Genome: Challenges & Opportunities in the Post-Genomic Era"
🔗 Register now: wma.eventsair.com/eshg-webinar...
🗓️ Last Wednesday of each month
📅 First episode: Feb 26, 2025 (16:00 CET)
🎤 Speaker: Malte Spielmann
💡 Topic: "The Dark Side of the #Genome: Challenges & Opportunities in the Post-Genomic Era"
🔗 Register now: wma.eventsair.com/eshg-webinar...
Reposted by Edu Calpena
A dozen experts on computational biology to bioengineering to AI have been confirmed for the Eighth Annual Mutational Scanning Symposium, May 21st through 23rd in Barcelona, Spain. Registration opens January 20. Learn more: brotmanbaty.org/news/mss-202...
@varianteffect.bsky.social
@varianteffect.bsky.social
December 17, 2024 at 9:54 PM
A dozen experts on computational biology to bioengineering to AI have been confirmed for the Eighth Annual Mutational Scanning Symposium, May 21st through 23rd in Barcelona, Spain. Registration opens January 20. Learn more: brotmanbaty.org/news/mss-202...
@varianteffect.bsky.social
@varianteffect.bsky.social
Reposted by Edu Calpena
Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce...
And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...
And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...
ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF
ZNF143 has been implicated in gene activation and chromatin looping. Magnitov et al. show that ZNF143 has no general looping factor activity and explain why this function has been misattributed. Instead, ZNF143 regulates transcription of nuclear-encoded mitochondrial genes, ensuring energy homeostasis, proliferation, and differentiation potential of stem cells.
www.cell.com
December 20, 2024 at 4:22 PM
Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce...
And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...
And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...
Reposted by Edu Calpena
We have an opening for a PhD student, for a cryo-EM/biochemistry project at the interface of ubiquitin and DNA repair. Enthousiasm and experience with protein biochemistry and/or structural biology really important. Recruitment will fall under the the NKI PhD program, please see below
📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq
December 16, 2024 at 1:12 PM
We have an opening for a PhD student, for a cryo-EM/biochemistry project at the interface of ubiquitin and DNA repair. Enthousiasm and experience with protein biochemistry and/or structural biology really important. Recruitment will fall under the the NKI PhD program, please see below
Reposted by Edu Calpena
jobs.exeter.ac.uk/hrpr_webrecr...
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!
Powered by MHR
jobs.exeter.ac.uk
December 16, 2024 at 8:44 PM
jobs.exeter.ac.uk/hrpr_webrecr...
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!
Reposted by Edu Calpena
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Evolution and function of chromatin domains across the tree of life - Nature Structural & Molecular Biology
Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...
www.nature.com
November 28, 2024 at 12:48 PM
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Reposted by Edu Calpena
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Redirecting
doi.org
December 2, 2024 at 4:44 PM
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Reposted by Edu Calpena
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role
in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves
this through its TND, which recog...
www.cell.com
November 26, 2024 at 4:18 PM
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
Reposted by Edu Calpena
Honoured to be recognised by @gensocuk.bsky.social and humbled to be named alongside so many incredible geneticists 🤯🧬
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
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But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
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Congratulations to @nickywhiffin.bsky.social on being awarded the Balfour Lecturer! Her innovative contributions on the role of genetic variants in rare diseases are shaping the future of research and discovery. We look forward to her inspiring lecture!
genetics.org.uk/medals-and-p...
genetics.org.uk/medals-and-p...
November 22, 2024 at 11:46 AM
Honoured to be recognised by @gensocuk.bsky.social and humbled to be named alongside so many incredible geneticists 🤯🧬
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
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But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2
Reposted by Edu Calpena
The final countdown 😀
Looking forward to sharing a new publication from the lab tomorrow! Something a bit different from us this time around. Stay tuned….
November 25, 2024 at 8:59 PM
The final countdown 😀
Reposted by Edu Calpena
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues - Nature Biotechnology
Chromatin organization is measured in single cells using droplet microfluidics.
www.nature.com
November 19, 2024 at 1:24 PM
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Edu Calpena
🚀 Ready to immerse yourself in a world-class research environment?
✨Take the first step towards your dream career with the #IRBTarget #PhD program. Your future in science starts here!
Apply now! ➡️bit.ly/4fPW5Rj
@batllelab.bsky.social @milanlab.bsky.social @alejofraticelli.bsky.social
✨Take the first step towards your dream career with the #IRBTarget #PhD program. Your future in science starts here!
Apply now! ➡️bit.ly/4fPW5Rj
@batllelab.bsky.social @milanlab.bsky.social @alejofraticelli.bsky.social
November 20, 2024 at 2:38 PM
🚀 Ready to immerse yourself in a world-class research environment?
✨Take the first step towards your dream career with the #IRBTarget #PhD program. Your future in science starts here!
Apply now! ➡️bit.ly/4fPW5Rj
@batllelab.bsky.social @milanlab.bsky.social @alejofraticelli.bsky.social
✨Take the first step towards your dream career with the #IRBTarget #PhD program. Your future in science starts here!
Apply now! ➡️bit.ly/4fPW5Rj
@batllelab.bsky.social @milanlab.bsky.social @alejofraticelli.bsky.social
Reposted by Edu Calpena
My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.
November 20, 2024 at 4:15 PM
My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.