Mathieu Dedenon
@dedenonmathieu.bsky.social
PostDoc, Kruse lab at UNIGE, working on active living matter and tissue mechanics.
Former PhD at Curie institute on cell & tissue mechanics.
Former PhD at Curie institute on cell & tissue mechanics.
Pinned
Mathieu Dedenon: Three-dimensional formulation of curved nematic shells https://arxiv.org/abs/2510.19412 https://arxiv.org/pdf/2510.19412 https://arxiv.org/html/2510.19412
📢 New preprint !
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Reposted by Mathieu Dedenon
Beussman, K. M., Mollica, M. Y., Leonard, A., Miles, J., Hocter, J., ..., Thomas, W. E., & Sniadecki, N. J. (2023). Black dots: High-yield traction force microscopy reveals structural factors contributing to platelet forces. Acta biomaterialia, 163, 302–311. #EpithelialMechanics
buff.ly/cByoHep
buff.ly/cByoHep
November 7, 2025 at 8:01 AM
Beussman, K. M., Mollica, M. Y., Leonard, A., Miles, J., Hocter, J., ..., Thomas, W. E., & Sniadecki, N. J. (2023). Black dots: High-yield traction force microscopy reveals structural factors contributing to platelet forces. Acta biomaterialia, 163, 302–311. #EpithelialMechanics
buff.ly/cByoHep
buff.ly/cByoHep
Reposted by Mathieu Dedenon
Ever wonder what happens to immune cells when we get a fever? Exicted to share our paper showing that temperature regulates immune cell migration via myosinII! A wonderful collaboration with Ivan, @alempheius.bsky.social, @valeriaventurini.bsky.social & all co-authors!
bit.ly/48XRVGj
bit.ly/48XRVGj
Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses
Effective immune responses rely on the efficient migration of leukocytes. Yet, how temperature regulates migration dynamics at the single-cell level h…
bit.ly
November 4, 2025 at 8:19 PM
Ever wonder what happens to immune cells when we get a fever? Exicted to share our paper showing that temperature regulates immune cell migration via myosinII! A wonderful collaboration with Ivan, @alempheius.bsky.social, @valeriaventurini.bsky.social & all co-authors!
bit.ly/48XRVGj
bit.ly/48XRVGj
Reposted by Mathieu Dedenon
Surface mechanics and compressive stress impact mammalian follicle development
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
Surface mechanics and compressive stress impact mammalian follicle development
Mice were group housed in individually ventilated cages with access to water and food under a 12-h light/12-h dark cycle. Mouse rooms were maintained at 18–25 °C and 30-70% relative humidity. C57BL/6NTac female mice, aged P25 – P28, were euthanized...
www.nature.com
November 2, 2025 at 6:55 AM
Reposted by Mathieu Dedenon
Exciting @centuri-ls.bsky.social internal seminar by @efeilker-phys.bsky.social on energetics and scaling during development 🤩
November 4, 2025 at 8:03 AM
Exciting @centuri-ls.bsky.social internal seminar by @efeilker-phys.bsky.social on energetics and scaling during development 🤩
Reposted by Mathieu Dedenon
Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics?
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
November 2, 2025 at 9:02 AM
Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics?
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
Reposted by Mathieu Dedenon
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
October 31, 2025 at 8:45 AM
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
Reposted by Mathieu Dedenon
Two 2-year postdoc positions in my theory group — for studying the interplay between metabolism and morphogenesis at the edge of the Calanques and the Mediterranean. More information can be found on: euraxess.ec.europa.eu/jobs/381176
#biophysics
#biophysics
Postdoc in Theoretical Biophysics
Two postdoc positions (each for two years, funded by Amidex Foundation) are available in theoretical biophysics within the theory group at DyNaMo (Aix-Marseille University).
euraxess.ec.europa.eu
October 27, 2025 at 4:19 PM
Two 2-year postdoc positions in my theory group — for studying the interplay between metabolism and morphogenesis at the edge of the Calanques and the Mediterranean. More information can be found on: euraxess.ec.europa.eu/jobs/381176
#biophysics
#biophysics
Reposted by Mathieu Dedenon
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
Reposted by Mathieu Dedenon
Too much cell fusion can break your bones, literally!
IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check.
Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments.
📘 @jcb.org shorturl.at/N0Esc
IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check.
Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments.
📘 @jcb.org shorturl.at/N0Esc
Moesin Protein Controls Bone Remodeling by Regulating Osteoclast Fusion and Function - IPBS-Toulouse
Researchers at the Institut de Pharmacologie et Biologie Structurale (IPBS) have uncovered a pivotal role[…]
www.ipbs.fr
October 27, 2025 at 5:17 PM
Too much cell fusion can break your bones, literally!
IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check.
Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments.
📘 @jcb.org shorturl.at/N0Esc
IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check.
Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments.
📘 @jcb.org shorturl.at/N0Esc
Reposted by Mathieu Dedenon
Hot out of press!!!
Studying chloroplast organisation from the perspective of packing problems in confinement.
chloroplasts show multiple configurations for different purposes (optimal light uptake in dim light vs. light avoidance in strong light for photo protection)🌿
www.pnas.org/doi/10.1073/...
Studying chloroplast organisation from the perspective of packing problems in confinement.
chloroplasts show multiple configurations for different purposes (optimal light uptake in dim light vs. light avoidance in strong light for photo protection)🌿
www.pnas.org/doi/10.1073/...
Optimal disk packing of chloroplasts in plant cells | PNAS
Photosynthesis is essential for ecosystem survival, but while plants require light,
excessive exposure can damage cells. Chloroplasts, photosynthet...
www.pnas.org
October 27, 2025 at 8:14 AM
Hot out of press!!!
Studying chloroplast organisation from the perspective of packing problems in confinement.
chloroplasts show multiple configurations for different purposes (optimal light uptake in dim light vs. light avoidance in strong light for photo protection)🌿
www.pnas.org/doi/10.1073/...
Studying chloroplast organisation from the perspective of packing problems in confinement.
chloroplasts show multiple configurations for different purposes (optimal light uptake in dim light vs. light avoidance in strong light for photo protection)🌿
www.pnas.org/doi/10.1073/...
Reposted by Mathieu Dedenon
Join the coolest club on the internet!
#EpithelialMechanics
#EpithelialMechanics
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 3:11 PM
Join the coolest club on the internet!
#EpithelialMechanics
#EpithelialMechanics
Reposted by Mathieu Dedenon
Mechanical forces can affect the way tissue grows. Ideally, we want to characterize them without interfering with the processes we are studying. Is there a way to achieve this?
I am @borgesaugust.bsky.social
Welcome to my stress inference tutorial!
#EpithelialMechanics
I am @borgesaugust.bsky.social
Welcome to my stress inference tutorial!
#EpithelialMechanics
October 25, 2025 at 7:03 AM
Mechanical forces can affect the way tissue grows. Ideally, we want to characterize them without interfering with the processes we are studying. Is there a way to achieve this?
I am @borgesaugust.bsky.social
Welcome to my stress inference tutorial!
#EpithelialMechanics
I am @borgesaugust.bsky.social
Welcome to my stress inference tutorial!
#EpithelialMechanics
Reposted by Mathieu Dedenon
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
October 24, 2025 at 10:57 AM
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
Reposted by Mathieu Dedenon
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 7:00 AM
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Reposted by Mathieu Dedenon
Now out in @biophysj.bsky.social with open access and for the special issue dedicated to Erich Sackmann: our model for mechanochemical signal propagation in cell layers. Led by Dennis Wörthmüller from @institutcurie.bsky.social and implemented with discontinuous Galerkin FEM. doi.org/10.1016/j.bp...
Redirecting
doi.org
October 22, 2025 at 5:59 AM
Now out in @biophysj.bsky.social with open access and for the special issue dedicated to Erich Sackmann: our model for mechanochemical signal propagation in cell layers. Led by Dennis Wörthmüller from @institutcurie.bsky.social and implemented with discontinuous Galerkin FEM. doi.org/10.1016/j.bp...
Reposted by Mathieu Dedenon
Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and @stramerlab.bsky.social discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
August 8, 2025 at 3:06 PM
Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and @stramerlab.bsky.social discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
📢 New preprint !
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Mathieu Dedenon: Three-dimensional formulation of curved nematic shells https://arxiv.org/abs/2510.19412 https://arxiv.org/pdf/2510.19412 https://arxiv.org/html/2510.19412
October 23, 2025 at 10:49 AM
📢 New preprint !
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Reposted by Mathieu Dedenon
Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 7:21 AM
Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
Reposted by Mathieu Dedenon
A useful reminder: A Human on a Bicycle Is among the Most Efficient Forms of Travel in the Animal Kingdom | Scientific American share.google/PItKvNJhK84F...
October 16, 2025 at 5:49 AM
A useful reminder: A Human on a Bicycle Is among the Most Efficient Forms of Travel in the Animal Kingdom | Scientific American share.google/PItKvNJhK84F...
Reposted by Mathieu Dedenon
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Reposted by Mathieu Dedenon
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
October 16, 2025 at 9:55 PM
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
Reposted by Mathieu Dedenon
1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!
October 12, 2025 at 12:51 PM
1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!
Reposted by Mathieu Dedenon
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 12:50 PM
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Reposted by Mathieu Dedenon
How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social
Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc
Tissue folding is a fundamental process occurring in animal organ development. Here, we study the progression of fold shape and the underlying mechanics in the development of the Drosophila wing disc....
doi.org
October 11, 2025 at 3:09 AM
How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social
Reposted by Mathieu Dedenon
Charras, G. and Yap, A. S. (2018). Tensile forces and mechanotransduction at cell–cell junctions. Current Biology, #EpithelialMechanicsReview www.cell.com/current-biol...
October 9, 2025 at 6:40 PM
Charras, G. and Yap, A. S. (2018). Tensile forces and mechanotransduction at cell–cell junctions. Current Biology, #EpithelialMechanicsReview www.cell.com/current-biol...