Mathieu Dedenon
@dedenonmathieu.bsky.social
PostDoc, Kruse lab at UNIGE, working on active living matter and tissue mechanics.
Former PhD at Curie institute on cell & tissue mechanics.
Former PhD at Curie institute on cell & tissue mechanics.
Pinned
Mathieu Dedenon: Three-dimensional formulation of curved nematic shells https://arxiv.org/abs/2510.19412 https://arxiv.org/pdf/2510.19412 https://arxiv.org/html/2510.19412
📢 New preprint !
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Reposted by Mathieu Dedenon
Roffay, C., Molinard, G., ..., & Roux, A. (2021). Passive coupling of membrane tension and cell volume during active response of cells to osmosis. Proceedings of the National Academy of Sciences of the United States of America, 118(47), e2103228118. #EpithelialMechanics
buff.ly/r1Hj7F6
buff.ly/r1Hj7F6
February 3, 2026 at 8:01 AM
Roffay, C., Molinard, G., ..., & Roux, A. (2021). Passive coupling of membrane tension and cell volume during active response of cells to osmosis. Proceedings of the National Academy of Sciences of the United States of America, 118(47), e2103228118. #EpithelialMechanics
buff.ly/r1Hj7F6
buff.ly/r1Hj7F6
Reposted by Mathieu Dedenon
Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS
Intracellular transport of macromolecules is crucial for the proper functioning of
most cellular processes. Although intracellular crowding is know...
www.pnas.org
January 26, 2026 at 9:42 AM
Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Reposted by Mathieu Dedenon
This weekend we projected cells and filaments on the roof of the @museeorsay.bsky.social in Paris, then we contracted it with a pinch of myosin.
And it was fabulous!
Grateful to have been part of this art/science project & thx to @manuelthery.bsky.social @lblanchoin.bsky.social & the CytoMorphoLab
And it was fabulous!
Grateful to have been part of this art/science project & thx to @manuelthery.bsky.social @lblanchoin.bsky.social & the CytoMorphoLab
January 27, 2026 at 4:28 PM
This weekend we projected cells and filaments on the roof of the @museeorsay.bsky.social in Paris, then we contracted it with a pinch of myosin.
And it was fabulous!
Grateful to have been part of this art/science project & thx to @manuelthery.bsky.social @lblanchoin.bsky.social & the CytoMorphoLab
And it was fabulous!
Grateful to have been part of this art/science project & thx to @manuelthery.bsky.social @lblanchoin.bsky.social & the CytoMorphoLab
Reposted by Mathieu Dedenon
Alberto Dinelli, Ludovic Dumoulin, Karsten Kruse: Active topological strings in renewing nematopolar fluids https://arxiv.org/abs/2601.18307 https://arxiv.org/pdf/2601.18307 https://arxiv.org/html/2601.18307
January 27, 2026 at 6:43 AM
Alberto Dinelli, Ludovic Dumoulin, Karsten Kruse: Active topological strings in renewing nematopolar fluids https://arxiv.org/abs/2601.18307 https://arxiv.org/pdf/2601.18307 https://arxiv.org/html/2601.18307
Reposted by Mathieu Dedenon
How do cells orchestrate themselves to achieve a directional movement as a group?
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
January 31, 2026 at 8:55 AM
How do cells orchestrate themselves to achieve a directional movement as a group?
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Reposted by Mathieu Dedenon
New preprint! We show how mesoscopic nonequilibrium fluctuations in active gels emerge from the breaking of detailed balance at the molecular scale. Warning: Long technical paper ahead! Enjoy! @mpipks.bsky.social @ub.edu @ubics.bsky.social @icreacommunity.bsky.social
arxiv.org/abs/2601.20483
arxiv.org/abs/2601.20483
January 30, 2026 at 6:08 PM
New preprint! We show how mesoscopic nonequilibrium fluctuations in active gels emerge from the breaking of detailed balance at the molecular scale. Warning: Long technical paper ahead! Enjoy! @mpipks.bsky.social @ub.edu @ubics.bsky.social @icreacommunity.bsky.social
arxiv.org/abs/2601.20483
arxiv.org/abs/2601.20483
Reposted by Mathieu Dedenon
Reported in #JCellBiol, a method developed in the lab of Associate Professor Danielle Grotjahn (@nanigrotjahn.bsky.social) measures membrane thickness directly inside intact cells and identifies ATP synthase clusters in curved, unusually thick membrane regions.
Scientists measure cellular membrane thickness inside cells for the first time
ow.ly
January 15, 2026 at 7:22 PM
Reported in #JCellBiol, a method developed in the lab of Associate Professor Danielle Grotjahn (@nanigrotjahn.bsky.social) measures membrane thickness directly inside intact cells and identifies ATP synthase clusters in curved, unusually thick membrane regions.
Reposted by Mathieu Dedenon
Guillaume Pernollet shows that epithelial cells adjust their shape to locally flatten, forming scutoids for any geometry, changing our view of cell packing. Thanks to all! @clairedessalles.bsky.social @juanmagararc.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 20, 2026 at 10:51 AM
Guillaume Pernollet shows that epithelial cells adjust their shape to locally flatten, forming scutoids for any geometry, changing our view of cell packing. Thanks to all! @clairedessalles.bsky.social @juanmagararc.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Mathieu Dedenon
How can embryos use pulsatile contraction to shape tissue development during morphogenesis? I'm @weiyiqian.bsky.social and with this thread I want to introduce the roles of pulsatile actomyosin in animal development and the mechanisms that drive actomyosin to pulse
January 10, 2026 at 8:01 PM
How can embryos use pulsatile contraction to shape tissue development during morphogenesis? I'm @weiyiqian.bsky.social and with this thread I want to introduce the roles of pulsatile actomyosin in animal development and the mechanisms that drive actomyosin to pulse
Reposted by Mathieu Dedenon
How can structures at the vertex of 3 cells have effects at the tissue level?
Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...
Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...
January 18, 2026 at 2:08 PM
How can structures at the vertex of 3 cells have effects at the tissue level?
Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...
Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...
Reposted by Mathieu Dedenon
Happy 2026!
May this year be good for your cells,
Discovering all the cool
#EpithelialMechanics as well.
May this year be good for your cells,
Discovering all the cool
#EpithelialMechanics as well.
January 1, 2026 at 8:00 AM
Happy 2026!
May this year be good for your cells,
Discovering all the cool
#EpithelialMechanics as well.
May this year be good for your cells,
Discovering all the cool
#EpithelialMechanics as well.
Reposted by Mathieu Dedenon
Janssen, V., & Huveneers, S. (2024). Cell–cell junctions in focus–imaging junctional architectures and dynamics at high resolution. Journal of Cell Science, #EpithelialMechanicsReview doi.org/10.1242/jcs....
January 2, 2026 at 8:00 AM
Janssen, V., & Huveneers, S. (2024). Cell–cell junctions in focus–imaging junctional architectures and dynamics at high resolution. Journal of Cell Science, #EpithelialMechanicsReview doi.org/10.1242/jcs....
Reposted by Mathieu Dedenon
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
January 2, 2026 at 4:00 PM
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
Reposted by Mathieu Dedenon
Malboubi, M., Esteki, M. H., Vaghela, M. B., Korsak, L. I. T., Petrie, R. J., Moeendarbary, E., & Charras, G. (2025). The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients. Elife. doi.org/10.7554/eLif...
#EpithelialMechanics
#EpithelialMechanics
December 23, 2025 at 8:00 AM
Malboubi, M., Esteki, M. H., Vaghela, M. B., Korsak, L. I. T., Petrie, R. J., Moeendarbary, E., & Charras, G. (2025). The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients. Elife. doi.org/10.7554/eLif...
#EpithelialMechanics
#EpithelialMechanics
Reposted by Mathieu Dedenon
Tristan Guyomar and I wrote a review on physical mechanisms coordinating regeneration - Featured: signalling/mechanical gradients, travelling waves and nematic fields - Dramatis personae: axolotls, hydra, planaria, spiny mice and zebrafish (ofc) with a jellyfish cameo
tinyurl.com/3upzrdbs
tinyurl.com/3upzrdbs
Gradients, waves and nematics: quantitative perspectives on regeneration
Regeneration restores a damaged body part to its original size, shape and structure. Research over the last decades identified signaling pathways, cel…
tinyurl.com
December 16, 2025 at 10:33 AM
Tristan Guyomar and I wrote a review on physical mechanisms coordinating regeneration - Featured: signalling/mechanical gradients, travelling waves and nematic fields - Dramatis personae: axolotls, hydra, planaria, spiny mice and zebrafish (ofc) with a jellyfish cameo
tinyurl.com/3upzrdbs
tinyurl.com/3upzrdbs
Reposted by Mathieu Dedenon
Non-motile microbes are not prisoners of diffusive transport. Just their metabolic activity can be sufficient to stir up the ambient fluid and cause explosive long-range dispersal -- a "metabolic firework".
Our latest work -- arxiv.org/abs/2512.16288
Our latest work -- arxiv.org/abs/2512.16288
December 19, 2025 at 7:04 AM
Non-motile microbes are not prisoners of diffusive transport. Just their metabolic activity can be sufficient to stir up the ambient fluid and cause explosive long-range dispersal -- a "metabolic firework".
Our latest work -- arxiv.org/abs/2512.16288
Our latest work -- arxiv.org/abs/2512.16288
Reposted by Mathieu Dedenon
Leybova, L., Biswas, A., Sharan, R., Trejo, B. M., Kim, K., ..., Phillips, B. K., & Devenport, D. (2024). Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding. Developmental cell, 59(24), 3272–3289.e5. #EpithelialMechanics
buff.ly/z1wX1O6
buff.ly/z1wX1O6
December 19, 2025 at 8:01 AM
Leybova, L., Biswas, A., Sharan, R., Trejo, B. M., Kim, K., ..., Phillips, B. K., & Devenport, D. (2024). Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding. Developmental cell, 59(24), 3272–3289.e5. #EpithelialMechanics
buff.ly/z1wX1O6
buff.ly/z1wX1O6
Reposted by Mathieu Dedenon
Now that you have gathered you raw data from a cell migration assay, how do you analyze that data?
In our review, we describe methods - including AI methods - to track migrating cells and extract as much information as possible.
Read our paper here: www.nature.com/articles/s41...
In our review, we describe methods - including AI methods - to track migrating cells and extract as much information as possible.
Read our paper here: www.nature.com/articles/s41...
December 19, 2025 at 9:02 PM
Now that you have gathered you raw data from a cell migration assay, how do you analyze that data?
In our review, we describe methods - including AI methods - to track migrating cells and extract as much information as possible.
Read our paper here: www.nature.com/articles/s41...
In our review, we describe methods - including AI methods - to track migrating cells and extract as much information as possible.
Read our paper here: www.nature.com/articles/s41...
Reposted by Mathieu Dedenon
Cytoskeleton shapes tissues during development. What signaling drives these changes?
I'm @onenimesa.bsky.social and let's explore FGF signaling's crucial role with examples.
Trust me, you need to know this!
I'm @onenimesa.bsky.social and let's explore FGF signaling's crucial role with examples.
Trust me, you need to know this!
December 6, 2025 at 9:57 AM
Cytoskeleton shapes tissues during development. What signaling drives these changes?
I'm @onenimesa.bsky.social and let's explore FGF signaling's crucial role with examples.
Trust me, you need to know this!
I'm @onenimesa.bsky.social and let's explore FGF signaling's crucial role with examples.
Trust me, you need to know this!
Reposted by Mathieu Dedenon
Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
Epithelial Mechanics Fan Club - FocalPlane
Epithelial Mechanics Fan Club - News
focalplane.biologists.com
December 5, 2025 at 1:35 PM
Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
Reposted by Mathieu Dedenon
New paper alert! We report that #zebrafish endodermal cells use contact inhibition of locomotion as a dispersal and spacing mechanism. It’s a neat example of large-scale patterns emerging from local interactions using a simple set of rules. Summary in the thread below 1/9
doi.org/10.1016/j.is...
doi.org/10.1016/j.is...
December 5, 2025 at 8:08 PM
New paper alert! We report that #zebrafish endodermal cells use contact inhibition of locomotion as a dispersal and spacing mechanism. It’s a neat example of large-scale patterns emerging from local interactions using a simple set of rules. Summary in the thread below 1/9
doi.org/10.1016/j.is...
doi.org/10.1016/j.is...
Reposted by Mathieu Dedenon
Ruppel, A., Wörthmüller, D., Misiak, V., Kelkar, M., Wang, I., Moreau, P., Méry, A., ..., Schwarz, U. S., & Balland, M. (2023). Force propagation between epithelial cells depends on active coupling and mechano-structural polarization. eLife, 12, e83588. #EpithelialMechanics
buff.ly/uPckqNX
buff.ly/uPckqNX
December 9, 2025 at 8:01 AM
Ruppel, A., Wörthmüller, D., Misiak, V., Kelkar, M., Wang, I., Moreau, P., Méry, A., ..., Schwarz, U. S., & Balland, M. (2023). Force propagation between epithelial cells depends on active coupling and mechano-structural polarization. eLife, 12, e83588. #EpithelialMechanics
buff.ly/uPckqNX
buff.ly/uPckqNX
Reposted by Mathieu Dedenon
Hinderling, L., Hadorn, R., Kwasny, M., Frei, J., Grädel, B., Psalmon, S., Blum, Y., ..., Riveline, D., & Pertz, O. (2025). Teach your microscope how to print: low-cost and rapid-iteration microfabrication for biology. Lab on a chip, 25(16), 4091–4105. #EpithelialMechanics
buff.ly/dSMEV1I
buff.ly/dSMEV1I
December 10, 2025 at 11:01 AM
Hinderling, L., Hadorn, R., Kwasny, M., Frei, J., Grädel, B., Psalmon, S., Blum, Y., ..., Riveline, D., & Pertz, O. (2025). Teach your microscope how to print: low-cost and rapid-iteration microfabrication for biology. Lab on a chip, 25(16), 4091–4105. #EpithelialMechanics
buff.ly/dSMEV1I
buff.ly/dSMEV1I
Reposted by Mathieu Dedenon
Hello, here is a review I wrote about how cells sometimes try to synchronise with surrounding cells so that they can do a good job of building tissues during development. It is called "Keeping up with the neighbours"
link.springer.com/article/10.1...
#DevBio 🧪
link.springer.com/article/10.1...
#DevBio 🧪
Keeping up with the neighbours: local synchronisation of cell fate decisions during development - EMBO Reports
Even before the advent of multicellular life, unicellular creatures would communicate with their neighbours to coordinate their behaviours. Multicellular organisms have the particular challenge of orc...
link.springer.com
December 11, 2025 at 3:19 PM
Hello, here is a review I wrote about how cells sometimes try to synchronise with surrounding cells so that they can do a good job of building tissues during development. It is called "Keeping up with the neighbours"
link.springer.com/article/10.1...
#DevBio 🧪
link.springer.com/article/10.1...
#DevBio 🧪
Reposted by Mathieu Dedenon
Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses?
🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!
🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!
December 14, 2025 at 8:08 AM
Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses?
🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!
🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!