Shashi Thutupalli
@stpalli.bsky.social
Scientist, Associate Professor at the Simons Centre for the Study of Living Machines, NCBS Bangalore and ICTS, Bangalore.
Broadly interested in the origins and organisation of living systems.
Bangalore — Toronto — Göttingen — Princeton — Bangalore
Broadly interested in the origins and organisation of living systems.
Bangalore — Toronto — Göttingen — Princeton — Bangalore
Pinned
Shashi Thutupalli
@stpalli.bsky.social
· Jun 29
We're looking for creative engineers/tinkerers/tool builders that want to engage with cutting-edge research questions in our lab at the @ncbsbangalore.bsky.social
Please help me share the word!
Please help me share the word!
We're looking for creative engineers/tinkerers/tool builders that want to engage with cutting-edge research questions in our lab at the @ncbsbangalore.bsky.social
Please help me share the word!
Please help me share the word!
June 29, 2025 at 4:04 PM
We're looking for creative engineers/tinkerers/tool builders that want to engage with cutting-edge research questions in our lab at the @ncbsbangalore.bsky.social
Please help me share the word!
Please help me share the word!
The Skysynth feature of from the Vera Rubin Observatory (@vrubinobs.bsky.social) is absolutely magical. Explore cosmic sounds. To get an idea, turn on your speakers for the movie below -- it's amazing!
rubinobservatory.org/news/rubin-f...
rubinobservatory.org/news/rubin-f...
June 26, 2025 at 5:04 AM
The Skysynth feature of from the Vera Rubin Observatory (@vrubinobs.bsky.social) is absolutely magical. Explore cosmic sounds. To get an idea, turn on your speakers for the movie below -- it's amazing!
rubinobservatory.org/news/rubin-f...
rubinobservatory.org/news/rubin-f...
As always, Will is a master storyteller! Here’s a great thread about our recent paper.
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬
www.science.org/doi/full/10....
www.science.org/doi/full/10....
June 24, 2025 at 5:27 PM
As always, Will is a master storyteller! Here’s a great thread about our recent paper.
We have a new paper out on an issue that has been discussed for more than a century -- how can fundamental biophysical constraints on nutrient transport be overcome to solve one of the most significant challenges associated with the evolution of multicellularity?
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 21, 2025 at 2:25 AM
We have a new paper out on an issue that has been discussed for more than a century -- how can fundamental biophysical constraints on nutrient transport be overcome to solve one of the most significant challenges associated with the evolution of multicellularity?
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
We’re celebrating the newest graduate from my lab — Dr. Charuhansini Tvishamayi!
Those of you in Bangalore, free next Sunday and interested, please come, it will be a pleasure!
Poster courtesy: members of the lab.
Those of you in Bangalore, free next Sunday and interested, please come, it will be a pleasure!
Poster courtesy: members of the lab.
May 30, 2025 at 5:40 PM
We’re celebrating the newest graduate from my lab — Dr. Charuhansini Tvishamayi!
Those of you in Bangalore, free next Sunday and interested, please come, it will be a pleasure!
Poster courtesy: members of the lab.
Those of you in Bangalore, free next Sunday and interested, please come, it will be a pleasure!
Poster courtesy: members of the lab.
Such a cool finding, this! So great to see this since my group and I have discussed for years about how measuring the "energetic content" of cells using so called "bomb calorimetry" can be very misleading -- all gradient information is lost that way and clearly it is significant!
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
May 9, 2025 at 2:50 AM
Such a cool finding, this! So great to see this since my group and I have discussed for years about how measuring the "energetic content" of cells using so called "bomb calorimetry" can be very misleading -- all gradient information is lost that way and clearly it is significant!
We exposed yeast to -196 C freeze-thaw (without cryoprotectants) and interesting things happened -- the survival went up from about 1% to close to 80% in just 25 cycles!
The preprint is out and feedback is highly welcome --
www.biorxiv.org/content/10.1...
The preprint is out and feedback is highly welcome --
www.biorxiv.org/content/10.1...
Convergent cellular adaptation to a quiescence-like state in response to freeze-thaw stress
Rapid freeze-thaw is an extreme mechano-chemical perturbation that results in very low survival of many organisms (as low as a fraction of a percent). Here, using experimental evolution, we show that ...
www.biorxiv.org
December 3, 2024 at 6:24 PM
We exposed yeast to -196 C freeze-thaw (without cryoprotectants) and interesting things happened -- the survival went up from about 1% to close to 80% in just 25 cycles!
The preprint is out and feedback is highly welcome --
www.biorxiv.org/content/10.1...
The preprint is out and feedback is highly welcome --
www.biorxiv.org/content/10.1...
Reposted by Shashi Thutupalli
I first visited KITP-UCSB as a grad student in 2003, and immediately fell in love with it. Here is the story of how my notebook from a 2010 KITP program I co-ran, on evolutionary cell biology, became the source of research questions that keep me busy to this day! www.kitp.ucsb.edu/sites/defaul...
November 24, 2024 at 2:11 AM
I first visited KITP-UCSB as a grad student in 2003, and immediately fell in love with it. Here is the story of how my notebook from a 2010 KITP program I co-ran, on evolutionary cell biology, became the source of research questions that keep me busy to this day! www.kitp.ucsb.edu/sites/defaul...
Before I start posting about newer results on this platform, here is a video from our most recent paper -- www.nature.com/articles/s41...
November 22, 2024 at 4:44 AM
Before I start posting about newer results on this platform, here is a video from our most recent paper -- www.nature.com/articles/s41...