Drug Discovery Unit, University of Dundee
LightNews LightNews
ddu-dundee.bsky.social
Drug Discovery Unit, University of Dundee
@ddu-dundee.bsky.social
340 followers 520 following 39 posts
Posts Replies Media Videos
ddu-dundee.bsky.social
Science is pretty!

Seems like a great time to find out about the incredible impact that #HenriettaLacks had on modern science!
unleash-as.bsky.social UNLEASH @unleash-as.bsky.social · 23d
Happy #Halloween Bluesky!

Hope y'all are having a spellbindingly good time!
Our good friend Nicco is hard at work making witchy potions woooooo......

AKA growing up a biiiiiig batch of #HeLa cells to help study #splicing.

What #spookyscience are you up to today?
October 31, 2025 at 10:16 AM
Reposted by Drug Discovery Unit, University of Dundee
mdr-ddu.bsky.social
Hot off the press: our Target Product Profile to support the development of new medicines to treat #cryptococcal disease:

www.sciencedirect.com/science/arti...

#cryptococcus, #drugdiscovery, #meningitis

@ddu-dundee.bsky.social, @gsk.bsky.social, @dndi.org and many others 🧪
Target product profile and discovery and development path for novel cryptococcal disease treatments
Cryptococcus neoformans and Cryptococcus gattii are World Health Organization critical and medium priority pathogens, respectively. These mainly impac…
www.sciencedirect.com
October 31, 2025 at 8:31 AM
ddu-dundee.bsky.social
Good morning sky-friends! We have exciting news today!
Our head of biology Dr @mdr-ddu.bsky.social has been awarded the WH Pierce Global Impact in Microbiology Prize by @amiposts.bsky.social as part of their International Horizon Awards

drugdiscovery.dundee.ac.uk/news/dr-manu...
Drug Discovery Unit - Dr Manu De Rycker recognised with global honour
Dr Manu De Rycker has been named as the newest winner of the WH Pierce Global Impact in Microbiology Prize.
drugdiscovery.dundee.ac.uk
October 23, 2025 at 7:55 AM
Reposted by Drug Discovery Unit, University of Dundee
mdr-ddu.bsky.social
#Chagas disease remains very neglected, and not only in the US, in spite of an estimated 8 million people being infected with T. cruzi. We, and our collaborators, aim to develop new medicines, but this is becoming increasingly challenging due to lack of funding.

www.theguardian.com/us-news/2025...
‘Kissing bug’ disease should be treated as endemic in US, scientists say
People in at least eight states have been infected with Chagas, new report says, amid low awareness of disease
www.theguardian.com
September 16, 2025 at 11:48 AM
Reposted by Drug Discovery Unit, University of Dundee
unleash-as.bsky.social
Good morning Bluesky!
We have reached the end of our UNLEASH meeting and are all preparing to head home.
We are full of enthusiasm and renewed purpose, and we look forward to keeping you all updated on our work!

Tell us - what do you want to know about us?

#SciComm #RNA #Splicing
September 17, 2025 at 7:02 AM
ddu-dundee.bsky.social
Good morning Sky-Friends!
Our own @biochemtrix.bsky.social (and occasional poster!) is in Germany at the #Unleash consortium meeting. They are joining us here in the sky @unleash-as.bsky.social so follow along to find out about #AlternativeSplicing!
September 16, 2025 at 7:54 AM
Reposted by Drug Discovery Unit, University of Dundee
mdr-ddu.bsky.social
Great opportunity to join our multi-partner collaboration to develop much needed new #antifungal drugs!

#jobs, #drugdiscovery, #Cryptococcus, #Candida

@mrccmm.bsky.social @ddu-dundee.bsky.social @labwyllie.bsky.social @glaxosmithkline.bsky.social
mrccmm.bsky.social The MRC Centre for Medical Mycology @mrccmm.bsky.social · Aug 27
🚨 Join the MRC CMM 🚨

Assay Development Scientist 1:
buff.ly/0RfOxPP

Assay Development Scientist 2:
buff.ly/qEgHd7Z

Postdoc Research Associate Drug Discovery:
buff.ly/8u2TV1S

Technician Assay Development & Drug Discovery:
buff.ly/CITpQ69
August 27, 2025 at 1:03 PM
Reposted by Drug Discovery Unit, University of Dundee
mdr-ddu.bsky.social
Delighted to announce a £17.9 million award from @wellcometrust.bsky.social for the development of new antifungal treatments to a consortium of @ddu-dundee.bsky.social, @labwyllie.bsky.social, @mrccmm.bsky.social and GSK.

#Cryptococcus #Candida #drugdiscovery #antifungal 🧪

tinyurl.com/wywtkpsx
£17.9m research grant to discover new treatments for fungal diseases
A team of leading infectious disease scientists from academia and industry have been awarded £17.9 million to identify new drugs to treat fungal infections
tinyurl.com
July 16, 2025 at 9:22 AM
Reposted by Drug Discovery Unit, University of Dundee
mdr-ddu.bsky.social
Great to have a latest #Chagas disease drug discovery paper published in @rsc.org MedChem: pubs.rsc.org/en/content/a...

This work highlights how we decide to progress or terminate series, and hopefully provides some useful approaches and lessons.

@ddu-dundee.bsky.social 🧪 #NTD #drugdiscovery
Structure–activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi
Chagas disease, caused by infection with the protozoan parasite Trypanosoma cruzi (T. cruzi), is responsible for a large health burden with around 6–8 million people infected globally. The current dru...
pubs.rsc.org
July 9, 2025 at 3:52 PM
Reposted by Drug Discovery Unit, University of Dundee
wisarchive.bsky.social
Nuclear physics pioneer Harriet Brooks was born OTD 149 years ago. The discoverer of Nuclear Recoil, the transmutation of elements through radioactivity, and nuclear series, her productive career was brought short by marriage. Here is her story

tinyurl.com/mvcd3ape

#WomenInSTEM #Physics #HistSci 🧪
Wither: The Many Triumphs and Long Fall of Nuclear Physicist Harriet Brooks.
Reading the life of Harriet Brooks is like watching the gradual, inevitable unfolding of a horror movie. There's that same idyllic, promising beginning that suddenly gives way as the heroine puts her...
tinyurl.com
July 2, 2025 at 2:14 PM
Reposted by Drug Discovery Unit, University of Dundee
pwk2024.bsky.social
Opportunity for computational chemist at Syngenta (Stein Switzerland) #CompChem #cheminformatics #ML #AI #agrochem #ChemJobs #chemsky 🧪
jobs.syngenta.com/job/principa...
Principal Scientist - Computational Chemistry (m/f/d)
jobs.syngenta.com
June 25, 2025 at 7:39 AM
Reposted by Drug Discovery Unit, University of Dundee
dundeecityarchives.bsky.social
Another mystery #WhereisitWednesday picture for you all. Taken probably in the 1920s, this seems to be a road in Broughty Ferry, or possibly towards Monifieth. But aren't sure where it is. Do you have any ideas?
June 25, 2025 at 7:39 AM
Reposted by Drug Discovery Unit, University of Dundee
nature.com
A genetic modification that causes mice to overexpress a particular hormone prevents them from gaining weight and allows them to live longer

https://go.nature.com/4l3rWk2
Hormone helps mice live longer and avoid obesity
Male mice that make high levels of fibroblast growth factor 21 stay lean as they age — a finding that could translate to humans.
go.nature.com
June 25, 2025 at 8:01 AM
Reposted by Drug Discovery Unit, University of Dundee
nature.com
We're gonna need a bigger boat 🦈

https://go.nature.com/463XAch
Happy birthday Jaws! How the movie changed shark science
Half a century after its cinematic release, Jaws is still shaping how we view — and protect — the ocean’s top predators.
go.nature.com
June 20, 2025 at 11:08 AM
Reposted by Drug Discovery Unit, University of Dundee
unisouthampton.bsky.social
50 years on from the release of movie blockbuster Jaws, our shark expert @thesimslab.bsky.social @sotonoceanearth.bsky.social debates the so called 'Jaws effect', charting the fortunes of the 'great white' for @theconversation.com.

Read more 👉 https://tr.ee/5gCSPz
Jaws helped spur a fishing frenzy – so how have the world’s sharks fared since the 1975 release?
The film made us afraid to go back in the water. It ultimately gave sharks more to fear from us.
tr.ee
June 20, 2025 at 9:02 AM
Reposted by Drug Discovery Unit, University of Dundee
rsc.org
If you’re studying chemistry & anything about graduating is making you anxious – whether that’s finding a job, managing finances, or feeling generally overwhelmed – we’re here for you. ➡️8am – 8pm, Mon–Fri: call 0800 084 3451 (UK Freephone) or +44 1223 853549 (Intl): buff.ly/tCWlE7s #ChemSky #EduSky
June 20, 2025 at 9:02 AM
Reposted by Drug Discovery Unit, University of Dundee
pdbeurope.bsky.social
🧪 We're beta testing - and we want your thoughts!
Try the redesigned PDBe entry pages & let us know:
🔸 What’s working?
🔸 What’s confusing?
🔸 What features do you miss?

💬 Feedback form: tinyurl.com/pdbe-beta-form

#PDBeBeta #Bioinformatics #Biochemistry #Science #UserVoice
June 19, 2025 at 3:16 PM
Reposted by Drug Discovery Unit, University of Dundee
plosbiology.org
Despite a century of use in #DrugDiscovery, specialized metabolism continues to amaze. Justin Nodwell explores a @plosbiology.org study that uses a novel computational approach to uncover unsuspected functions of a compound produced by #Streptomyces 🧪 Paper: plos.io/43UVUPB Primer: plos.io/4n25bOF
Proposed biosynthetic pathway for assembly of desferrioxamines E and B. Main biosynthetic enzymes presented in bold face. DesG and DesH balance intracellular N-hydroxy-N-succinylcadaverine (HSC) and N-hydroxy-N-acetylcadaverine (HAC) concentrations by converting HSC to HAC. In the absence of DesG and/or DesH, the cells likely fail to produce sufficient levels of HAC, thereby strongly attenuating the production of DFOB. Although DesC has been shown to be able to catalyze the acetylation of N-hydroxycadaverine in vitro, the enzyme can only modestly compensate for the loss of DesH in vivo, underlining the important role played by DesG and DesH in DFOB production.
June 16, 2025 at 8:01 AM
Reposted by Drug Discovery Unit, University of Dundee
cristinapujades.bsky.social
Do you want to join us to work in neurodevelopmental biology? Please apply 👇 #SEBD
June 4, 2025 at 4:33 AM
Reposted by Drug Discovery Unit, University of Dundee
cenmag.bsky.social
Nominate a chemist with disabilities for C&EN's Trailblazers 2025!

Please tell us about your chemistry heroes, mentors, mentees, and inspirations—or nominate yourself.
👉 cenm.ag/nominatetrai...

#chemsky 🧪 #phdsky #academicsky #STEM #phdchat #academicchatter
C&EN's Trailblazers
June 3, 2025 at 1:18 PM
Reposted by Drug Discovery Unit, University of Dundee
natrevdrugdiscov.nature.com
For readers interested in ion channels as drug targets, this Review in the May issue focuses on voltage-gated sodium channels, such as Nav1.8, the target of the first new non-opioid analgesic to be approved in decades
www.nature.com/articles/s41...
rdcu.be/enkq4
Voltage-gated sodium channels
May 23, 2025 at 2:33 PM
Reposted by Drug Discovery Unit, University of Dundee
imgprague.bsky.social
🧬 Passionate about primary cilia and cell signalling?
🧫 Curious about the actin role in growth and function?
🗣️ Skilled in communication and value flexibility in your work?
Join IMG now!
➡ www.img.cas.cz/2025/05/8654...
May 15, 2025 at 7:51 AM
Reposted by Drug Discovery Unit, University of Dundee
bpernaute.bsky.social
🚨🚨#Hiring!

3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG

📆 Apply by 23rd May 2023

🔗Details below

@sebioldev.bsky.social

Please RT!🙏
April 23, 2025 at 12:45 PM
ddu-dundee.bsky.social
Morning sky friends!

Check out this LinkedIn post from our friends @astrazeneca.bsky.social's Cambridge Discovery Centre!
Dr Luma Godoy Magalhaes is spending some time away from us in sunny Dundee to start work on the first #MRC funded #HTS project.
#collaboration
www.linkedin.com/posts/hannah...
Launching the first Medical Research Council (MRC) funded High Throughput… | Hannah Semple
Launching the first Medical Research Council (MRC) funded High Throughput Screen (HTS) in AstraZeneca's Cambridge Discovery Centre! As part of AstraZeneca Open Innovation, we offer access to our ...
www.linkedin.com
May 15, 2025 at 7:31 AM
Reposted by Drug Discovery Unit, University of Dundee
unaids.org
The cuts in US funding continue to impact countries.

Read how HIV services and communities in Angola, Lao PDR, Lesotho, and South Africa are being impacted, and how governments and partners are taking urgent action protect progress and ensure continuity of care. www.unaids.org/en/impact-US...
May 1, 2025 at 7:26 AM