#AlternativeSplicing
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plosbiology.org
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
Schematic model depicting the role of PRMT5-mediated symmetric arginine dimethylation in regulation of TCF3 alternative splicing under normoxia (left) and hypoxia (right). Created in BioRender. Shukla, S.
November 5, 2025 at 8:59 AM
jsantoyo.bsky.social
Predicting the structural impact of human alternative splicing. #AlternativeSplicing #GenomeBiology
genomebiology.biomedcentral.com/articles/10....
September 24, 2025 at 9:15 AM
jsantoyo.bsky.social
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing. #SingleCell #scRNAseq #AlternativeSplicing #LongReads #Sequencing @nanoporetech.com @natcomms.nature.com
www.nature.com/articles/s41...
July 29, 2025 at 5:51 PM
haoyin.bsky.social
Genome-wide #AlternativeSplicing variation in #SmoothMuscleCell phenotypic plasticity

#Nanopore long-read RNAseq

Cultured👤aortic SMC
TGFβ/PDGFBB/miR-221

When your targets don't vary at the gene level, take a look at their AS variants

#CommsBio 2023
www.nature.com/articles/s42...
December 22, 2023 at 7:54 PM
longtrec.bsky.social
Next Up in the #LongTREC Series 📽️ : Yalan Bi!
Yalan is a LongTREC Doctoral Candidate working with Ralf Herwig at @molgen.mpg.de Yalan shares insights into her research project and her experience as part of the LongTREC network. #LongReadsTranscriptomics #AlternativeSplicing #ProteinInteraction
July 12, 2025 at 2:21 PM
plosbiology.org
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
Schematic model depicting the role of PRMT5-mediated symmetric arginine dimethylation in regulation of TCF3 alternative splicing under normoxia (left) and hypoxia (right). Created in BioRender. Shukla, S.
November 5, 2025 at 5:30 PM
actaneuropsych.bsky.social
📌The TMEM18 gene exhibits distinct alternative splicing patterns in LBD: potentially disrupting protein stability
📌The MICB gene, crucial for immune signaling, also showed LBD-specific splicing
#LewyBodyDementia #Neurodegeneration #Transcriptomics #AlternativeSplicing #Biomarkers #Neuroscience
March 3, 2025 at 11:37 AM
cosybio-uhh.bsky.social
Presenting DIGGER 2.0: we extended our #AlternativeSplicing software DIGGER with new functionalities, including support of the mouse interactome and NEASE for #EnrichmentAnalysis! Check it out here: exbio.wzw.tum.de/digger/
August 21, 2025 at 11:32 AM
unleash-as.bsky.social
It's day 2 of the UNLEASH meeting! We are in beautiful Bernried and looking forward to hearing more about the progress our members have made unpicking the details of #AlternativeSplicing!
September 16, 2025 at 7:21 AM
cp-trendsbiochem.bsky.social
Online now - the Review "#RNAprocessing in innate immunity: regulation by RNA binding proteins" from Asmita Panthi and Kristen Lynch.

#AlternativeSplicing #3EndProcessing #AlternativePolyadenylation #RBP

Read it here 👉 authors.elsevier.com/a/1l5yN_M0e4...
May 22, 2025 at 3:41 PM
haoyin.bsky.social
Patho-DBiT
Spatial #RNAWorld on FFPE section👹
Now tissues can be mapped by RNA variants or non-coding RNAs

Whole transcriptome seq covers
mRNA
LincRNA
microRNA
sn/snoRNA
#AlternativeSplicing
#RNAEditing
RNA #SingleNucleotideVariation

In situ polyA

bioRxiv 2024
www.biorxiv.org/content/10.1...
February 9, 2024 at 1:06 PM
rnadoctor.bsky.social
📢 #PaperAlert

Review article in @WIREs_Reviews on #AlternativeSplicing, voltage-gated #calcium #channels, and #channelopathies. #IonChannels

Alternative Splicing and CaV‐Associated Channelopathies - Munyao - 2025 - WIREs RNA - Wiley Online Library wires.onlinelibrary.wiley.com/doi/10.1002/...
Alternative Splicing and CaV‐Associated Channelopathies
Voltage-gated calcium channels control vital cellular processes through complex alternative splicing mechanisms, and their dysfunction contributes to neurological, cardiac, endocrine, oncogenic, and ...
wires.onlinelibrary.wiley.com
June 11, 2025 at 8:16 PM
genomiqueens.bsky.social
🛠️ Resources

All code, datasets, and reproducible pipelines are openly available: github.com/alihamraoui/...

#bioinformatics #RNAseq #singlecell #alternativesplicing #benchmark #opensource #scRNAseq #MinION

cc @fr-genomics.bsky.social @mthomaschollier.bsky.social
GitHub - alihamraoui/scKenver
Contribute to alihamraoui/scKenver development by creating an account on GitHub.
github.com
July 30, 2025 at 12:00 PM
ddu-dundee.bsky.social
Good morning Sky-Friends!
Our own @biochemtrix.bsky.social (and occasional poster!) is in Germany at the #Unleash consortium meeting. They are joining us here in the sky @unleash-as.bsky.social so follow along to find out about #AlternativeSplicing!
September 16, 2025 at 7:54 AM
earlhaminst.bsky.social
Thanks to @alperakay.bsky.social from @uniofeastanglia.bsky.social who joined us this morning for our weekly seminar, sharing his research in #alternativesplicing regulation by snRNA modifications.

@norwichrnaclub.bsky.social @whaerty.bsky.social
Dr Alper Akay, UKRI Future Leaders Fellow at the University of East Anglia, standing behind the EI seminar lecturn, next to Dr Wilfried Haerty, Group Leader at EI.
February 11, 2025 at 2:04 PM
slefkopoulos.bsky.social
#NCB2024
In July, @tamraogilvie.bsky.social, Taylor, @olivier-saulnier.bsky.social & co reported a noncanonical role for OTX2 in regulating #AlternativeSplicing and a stem cell and pro-tumorigenic splicing program in group 3 #medulloblastoma.
www.nature.com/articles/s41...
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing - Nature Cell Biology
Werbowetski-Ogilvie, Taylor and colleagues report a noncanonical role for OTX2 in regulating alternative splicing and controlling a stem cell and pro-tumorigenic splicing program in group 3 medullobla...
www.nature.com
December 20, 2024 at 11:25 PM
haoyin.bsky.social
#AlternativeSplicing #SmoothMuscleCell

RBPMS, coordinating with RBFOX2, mediates splicing events of SMC contractile, focal adhesion & actin cytoskeleton genes

234 skipped exon events shared by high-level RBPMS overexpression in hESC adult aorta

#CardiovascRes 2024
academic.oup.com/cardiovascre...
October 17, 2024 at 6:56 PM
boblivion.bsky.social
#quotes #books #excerpts #citations #sapolsky #behave #molbio #genes #exons #alternativesplicing #splicing #dna #centraldogma
December 14, 2024 at 7:32 PM
rnadoctor.bsky.social
🚨 New paper alert! 🚨

Our paper entitled: "Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3" is out now on Journal of Biological Chemistry!

www.jbc.org/article/S002...

#AlternativeSplicing #RNAediting

🧵 👇
Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3
Alternative splicing and adenosine-to-inosine (A-to-I) RNA editing are post-transcriptional mechanisms that promote proteomic diversity in the brain. The impact of RNA editing on brain physiology is u...
www.jbc.org
October 14, 2025 at 2:34 PM
jimenagiudice.bsky.social
Our most recent paper is out! #alternativeSplicing #RNA #SNAP23 #heart #muscle

Full article: Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases www.tandfonline.com/doi/full/10....
Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is mis-spliced in striated muscle diseases
The reprogramming of alternative splicing networks during development is a hallmark of tissue maturation and identity. Alternative splicing of microexons (small, genomic regions ≤ 51 nucleotides) f...
www.tandfonline.com
April 24, 2025 at 4:40 PM
evbc.bsky.social
Discover a new tool: DIGGER 2.0 enables splice-aware functional annotation of interaction network changes using RNA seq analysis via NEASE.
#VirusBioinformatics #AlternativeSplicing #InteractomeTools

📄 doi.org/10.1093/nar/...
👤EVBC: Olga Kalinina
DIGGER 2.0: digging into the functional impact of differential splicing on human and mouse disorders
Abstract. Changes in alternative splicing between groups or conditions contribute to protein–protein interaction rewiring, a consequence often neglected in
doi.org
August 11, 2025 at 7:16 AM
jimenagiudice.bsky.social
Our new review about RNA processing and mechanotransduction is out in Cell Reports! Link: lnkd.in/edApA4ZT. Proud of our very talented graduate student Gabrielle Bais and thankful to our institution and funding sources: UNC-Chapel Hill, NIH, NSF.
#mechanotransduction #RNA #alternativesplicing
August 29, 2025 at 4:47 PM
sigtrans-sttt.bsky.social
Multiomics analyses of #SCLC #tumors reveals widespread #AlternativeSplicing and frequent #FocalAdhesionKinase splicing variants that drive aggressive disease, predict poor prognosis, & show marked sensitivity to FAK inhibitors. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...
September 19, 2025 at 2:53 PM
mirimiam.bsky.social
🚨🚨🚨

If you're a bioinformatician who loves:

🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling

Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com

Please RT! 🙏
December 23, 2024 at 3:54 PM
sigtrans-sttt.bsky.social
This study reveals that TPM3P9 promotes #tumor growth in #ClearCellRenalCellCarcinoma (ccRCC) by enhancing the #alternativesplicing of oncogenic RNAs and highlights it as a potential therapeutic target in ccRCC management. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...
August 23, 2025 at 8:30 AM