Barbara Pernaute
@bpernaute.bsky.social
Developmental biologist. Group Leader @cabd-upo-csic.bsky.social
Reposted by Barbara Pernaute
Last days to apply! Cool project, cool cities! :-)
(Please repost! 🙏)
(Please repost! 🙏)
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
September 22, 2025 at 7:04 AM
Last days to apply! Cool project, cool cities! :-)
(Please repost! 🙏)
(Please repost! 🙏)
Reposted by Barbara Pernaute
Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)
August 7, 2025 at 3:58 PM
Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)
Reposted by Barbara Pernaute
1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells".
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs
Hanna and colleagues show that signaling pathway modulation amplifies the inherent
flexibility of genetically unmodified mouse naive PSCs to adopt extra-embryonic cell
fate potential. This endows them...
www.cell.com
August 7, 2025 at 3:29 PM
1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells".
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reposted by Barbara Pernaute
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
www.nature.com
June 30, 2025 at 1:12 PM
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Barbara Pernaute
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
June 23, 2025 at 7:51 AM
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
Reposted by Barbara Pernaute
How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
June 18, 2025 at 5:11 PM
How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Barbara Pernaute
Los cursos de verano en #olavidecarmona son 🔝
Nuestras compañeras @anafminan.bsky.social , Sol Sotillos y @proteolaura.bsky.social organizan el curso ‘Modelos genéticos en investigación, de la bacteria al ratón’ dividido en dos partes!
Info ⤵️
www.upo.es/formacionper...
www.upo.es/formacionper...
Nuestras compañeras @anafminan.bsky.social , Sol Sotillos y @proteolaura.bsky.social organizan el curso ‘Modelos genéticos en investigación, de la bacteria al ratón’ dividido en dos partes!
Info ⤵️
www.upo.es/formacionper...
www.upo.es/formacionper...
May 13, 2025 at 8:12 AM
Los cursos de verano en #olavidecarmona son 🔝
Nuestras compañeras @anafminan.bsky.social , Sol Sotillos y @proteolaura.bsky.social organizan el curso ‘Modelos genéticos en investigación, de la bacteria al ratón’ dividido en dos partes!
Info ⤵️
www.upo.es/formacionper...
www.upo.es/formacionper...
Nuestras compañeras @anafminan.bsky.social , Sol Sotillos y @proteolaura.bsky.social organizan el curso ‘Modelos genéticos en investigación, de la bacteria al ratón’ dividido en dos partes!
Info ⤵️
www.upo.es/formacionper...
www.upo.es/formacionper...
🚨🚨#Hiring!
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
April 23, 2025 at 12:45 PM
🚨🚨#Hiring!
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
Reposted by Barbara Pernaute
🧐🧐🧐 Amazing course in Clinical Embryology
📍Santander
🗓️ July 28th-August 1st
💰4 scholarships available by @sebioldev.bsky.social
Counts with great line up of speakers including @bpernaute.bsky.social from #CABD
📍Santander
🗓️ July 28th-August 1st
💰4 scholarships available by @sebioldev.bsky.social
Counts with great line up of speakers including @bpernaute.bsky.social from #CABD
The #SEBD is offering 4 scholarships to cover the registration of this international course on clinical embryology taking place in Santander at the end of July and sponsored by @sebioldev.bsky.social @csic.es and @devdynamics.bsky.social sebd.es/otros-congre...
April 16, 2025 at 6:08 PM
🧐🧐🧐 Amazing course in Clinical Embryology
📍Santander
🗓️ July 28th-August 1st
💰4 scholarships available by @sebioldev.bsky.social
Counts with great line up of speakers including @bpernaute.bsky.social from #CABD
📍Santander
🗓️ July 28th-August 1st
💰4 scholarships available by @sebioldev.bsky.social
Counts with great line up of speakers including @bpernaute.bsky.social from #CABD
Reposted by Barbara Pernaute
First seen in Biorxiv and now published and updated with more data in @naturecomms.bsky.social. With this work we have further enhanced CRISPR-Cas RNA targeting in vivo using transient approaches such as RNP or mRNA-gRNA in zebrafish embryos as vertebrate model. www.nature.com/articles/s41...
Enhanced RNA-targeting CRISPR-Cas technology in zebrafish - Nature Communications
CRISPR-Cas13 RNA-targeting systems comprise an invaluable set of tools in the fields of basic and applied sciences. Here, Moreno-Sánchez, Hernández-Huertas, and Nahón-Cano et al. enhanced the use of t...
www.nature.com
March 16, 2025 at 6:27 PM
First seen in Biorxiv and now published and updated with more data in @naturecomms.bsky.social. With this work we have further enhanced CRISPR-Cas RNA targeting in vivo using transient approaches such as RNP or mRNA-gRNA in zebrafish embryos as vertebrate model. www.nature.com/articles/s41...
Reposted by Barbara Pernaute
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
February 21, 2025 at 3:50 PM
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Reposted by Barbara Pernaute
Happy to share our Slow cooked work together with @mcgregorlab.bsky.social, @posnienlab.bsky.social , @nuneslab.bsky.social sky.social and Saad Arif and the collaboration of @maikekittelmann.bsky.social, Fernando Casares & @laurensr.bsky.social and many other friends
rdcu.be/d8whP
rdcu.be/d8whP
Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species
rdcu.be
February 4, 2025 at 5:50 PM
Happy to share our Slow cooked work together with @mcgregorlab.bsky.social, @posnienlab.bsky.social , @nuneslab.bsky.social sky.social and Saad Arif and the collaboration of @maikekittelmann.bsky.social, Fernando Casares & @laurensr.bsky.social and many other friends
rdcu.be/d8whP
rdcu.be/d8whP
Reposted by Barbara Pernaute
Hello early researchers! Interesting in doing a PhD in senescence, ageing and cancer? We have an open position in our lab in Spain! Please retweet or reach out if interested!
February 4, 2025 at 11:06 AM
Hello early researchers! Interesting in doing a PhD in senescence, ageing and cancer? We have an open position in our lab in Spain! Please retweet or reach out if interested!
Reposted by Barbara Pernaute
🚨🚨🚨
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
December 23, 2024 at 3:54 PM
🚨🚨🚨
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
Reposted by Barbara Pernaute
Happy to share our latest review by @shifaant.bsky.social with @cwhanna.bsky.social. A detailed look at extraembryonic tissues – the 'other half' of the conceptus.
www.nature.com/articles/s41... @natrevmcb.bsky.social
www.nature.com/articles/s41... @natrevmcb.bsky.social
Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology
During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...
www.nature.com
December 6, 2024 at 12:41 PM
Happy to share our latest review by @shifaant.bsky.social with @cwhanna.bsky.social. A detailed look at extraembryonic tissues – the 'other half' of the conceptus.
www.nature.com/articles/s41... @natrevmcb.bsky.social
www.nature.com/articles/s41... @natrevmcb.bsky.social
Reposted by Barbara Pernaute
Please RT: In my lab we are looking for computational #postdoc researchers to apply to a #juandelacierva or #embo postdoctoral fellowships to work on projects on post-transcriptional regulation on single-cell data (method development and/or data analysis). Contact me if you are interested!
December 4, 2024 at 11:28 AM
Please RT: In my lab we are looking for computational #postdoc researchers to apply to a #juandelacierva or #embo postdoctoral fellowships to work on projects on post-transcriptional regulation on single-cell data (method development and/or data analysis). Contact me if you are interested!
Reposted by Barbara Pernaute
Honored and excited to receive an #ERCCoG grant. Big thanks to my colleagues, former mentors and, most importantly, my amazing lab members. Together, we will be exploring cell type evolution across timescales, from population variation (with @xgrau.bsky.social) to regulatory sequences across phyla.
December 3, 2024 at 12:35 PM
Honored and excited to receive an #ERCCoG grant. Big thanks to my colleagues, former mentors and, most importantly, my amazing lab members. Together, we will be exploring cell type evolution across timescales, from population variation (with @xgrau.bsky.social) to regulatory sequences across phyla.
Really excited to share that I got an #ERCCoG
The project EARLYFATE will explore the interplay between DNA damage responses and the very first events of mammalian embryo development. Huge thanks to all colleagues, former mentors and lab members for their help and support!
The project EARLYFATE will explore the interplay between DNA damage responses and the very first events of mammalian embryo development. Huge thanks to all colleagues, former mentors and lab members for their help and support!
December 3, 2024 at 9:54 PM
Really excited to share that I got an #ERCCoG
The project EARLYFATE will explore the interplay between DNA damage responses and the very first events of mammalian embryo development. Huge thanks to all colleagues, former mentors and lab members for their help and support!
The project EARLYFATE will explore the interplay between DNA damage responses and the very first events of mammalian embryo development. Huge thanks to all colleagues, former mentors and lab members for their help and support!
Reposted by Barbara Pernaute
Happy to share our latest work, together with the Casares lab, studying the outstanding regenerative capabilities of mayflies
royalsocietypublishing.org/doi/10.1098/...
@geneticsub.bsky.social @irbio-ub.bsky.social @cabd-upo-csic.bsky.social @sebioldev.bsky.social
royalsocietypublishing.org/doi/10.1098/...
@geneticsub.bsky.social @irbio-ub.bsky.social @cabd-upo-csic.bsky.social @sebioldev.bsky.social
Gill regeneration in the mayfly Cloeon uncovers new molecular pathways in insect regeneration | Open Biology
The capacity to regenerate lost organs is widespread among animals, and yet the number
of species in which regeneration has been experimentally probed using molecular and
functional assays is very sma...
royalsocietypublishing.org
November 27, 2024 at 7:55 AM
Happy to share our latest work, together with the Casares lab, studying the outstanding regenerative capabilities of mayflies
royalsocietypublishing.org/doi/10.1098/...
@geneticsub.bsky.social @irbio-ub.bsky.social @cabd-upo-csic.bsky.social @sebioldev.bsky.social
royalsocietypublishing.org/doi/10.1098/...
@geneticsub.bsky.social @irbio-ub.bsky.social @cabd-upo-csic.bsky.social @sebioldev.bsky.social
Reposted by Barbara Pernaute
2nd edition of the EMBO Workshop on Dev timing & evolution will take place in Paris.
6-9 May 2025. Save the date!!!
coming-soon.embo.org/w25-105
6-9 May 2025. Save the date!!!
coming-soon.embo.org/w25-105
November 14, 2024 at 8:32 PM
2nd edition of the EMBO Workshop on Dev timing & evolution will take place in Paris.
6-9 May 2025. Save the date!!!
coming-soon.embo.org/w25-105
6-9 May 2025. Save the date!!!
coming-soon.embo.org/w25-105
Reposted by Barbara Pernaute
Fascinating & unexpected from the Rodriguez lab on cell competition acting as a nutrient sensor
Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them
Explains old observations that starvation prevents competition
www.biorxiv.org/content/10.1...
Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them
Explains old observations that starvation prevents competition
www.biorxiv.org/content/10.1...
Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition.
Cell competition is a quality control acting from development to the adult that eliminates cells that are less-fit than their neighbours. How winner cells induce the elimination of losers during this ...
www.biorxiv.org
November 29, 2024 at 1:49 PM
Fascinating & unexpected from the Rodriguez lab on cell competition acting as a nutrient sensor
Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them
Explains old observations that starvation prevents competition
www.biorxiv.org/content/10.1...
Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them
Explains old observations that starvation prevents competition
www.biorxiv.org/content/10.1...
Reposted by Barbara Pernaute
Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)
November 26, 2024 at 1:45 PM
Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)