Institute of Molecular Genetics
@imgprague.bsky.social
Public scientific institution, part of the Czech Academy of Sciences. Research in molecular, structure and cell biology, immunology, genomics and bioinformatics.
🚀Open PhD position!
Combine bioinformatics, single-cell and spatial multi-omics, with machine learning to uncover how the vertebrate head evolved.
🧫Laboratory of Transcriptional Regulation is seeking a highly motivated PhD candidate.
Come and join us
🧡APPLY NOW img.cas.cz/phd
Combine bioinformatics, single-cell and spatial multi-omics, with machine learning to uncover how the vertebrate head evolved.
🧫Laboratory of Transcriptional Regulation is seeking a highly motivated PhD candidate.
Come and join us
🧡APPLY NOW img.cas.cz/phd
February 10, 2026 at 10:52 AM
🚀Open PhD position!
Combine bioinformatics, single-cell and spatial multi-omics, with machine learning to uncover how the vertebrate head evolved.
🧫Laboratory of Transcriptional Regulation is seeking a highly motivated PhD candidate.
Come and join us
🧡APPLY NOW img.cas.cz/phd
Combine bioinformatics, single-cell and spatial multi-omics, with machine learning to uncover how the vertebrate head evolved.
🧫Laboratory of Transcriptional Regulation is seeking a highly motivated PhD candidate.
Come and join us
🧡APPLY NOW img.cas.cz/phd
🚀Open PhD position!
Genome instability promotes cancer development. This project will examine metabolic signaling defects to reveal cell vulnerabilities and novel chemotherapeutics.
🧬Laboratory of Cancer Cell Biology is seeking a new team player.
Do you fit?
🧡APPLY NOW img.cas.cz/phd
Genome instability promotes cancer development. This project will examine metabolic signaling defects to reveal cell vulnerabilities and novel chemotherapeutics.
🧬Laboratory of Cancer Cell Biology is seeking a new team player.
Do you fit?
🧡APPLY NOW img.cas.cz/phd
February 9, 2026 at 9:51 AM
🚀Open PhD position!
Genome instability promotes cancer development. This project will examine metabolic signaling defects to reveal cell vulnerabilities and novel chemotherapeutics.
🧬Laboratory of Cancer Cell Biology is seeking a new team player.
Do you fit?
🧡APPLY NOW img.cas.cz/phd
Genome instability promotes cancer development. This project will examine metabolic signaling defects to reveal cell vulnerabilities and novel chemotherapeutics.
🧬Laboratory of Cancer Cell Biology is seeking a new team player.
Do you fit?
🧡APPLY NOW img.cas.cz/phd
🚀Open PhD position!
Join Nenad at IMG and share with us:
💛Experience
🧡Friendship
💙Professionalism
💜PhD community
APPLY NOW: img.cas.cz/phd
Join Nenad at IMG and share with us:
💛Experience
🧡Friendship
💙Professionalism
💜PhD community
APPLY NOW: img.cas.cz/phd
February 4, 2026 at 1:32 PM
🚀Open PhD position!
Join Nenad at IMG and share with us:
💛Experience
🧡Friendship
💙Professionalism
💜PhD community
APPLY NOW: img.cas.cz/phd
Join Nenad at IMG and share with us:
💛Experience
🧡Friendship
💙Professionalism
💜PhD community
APPLY NOW: img.cas.cz/phd
🚀Open PhD position!
Ever wondered how cells polarize during early development?
This PhD project dives into how mechanochemically-driven cell polarization evolves.
🧪 Genomics
🔬 Biophysics
📊 Fitness analysis
Hooked?
🧡APPLY NOW img.cas.cz/phd
Ever wondered how cells polarize during early development?
This PhD project dives into how mechanochemically-driven cell polarization evolves.
🧪 Genomics
🔬 Biophysics
📊 Fitness analysis
Hooked?
🧡APPLY NOW img.cas.cz/phd
February 3, 2026 at 10:42 AM
🚀Open PhD position!
Ever wondered how cells polarize during early development?
This PhD project dives into how mechanochemically-driven cell polarization evolves.
🧪 Genomics
🔬 Biophysics
📊 Fitness analysis
Hooked?
🧡APPLY NOW img.cas.cz/phd
Ever wondered how cells polarize during early development?
This PhD project dives into how mechanochemically-driven cell polarization evolves.
🧪 Genomics
🔬 Biophysics
📊 Fitness analysis
Hooked?
🧡APPLY NOW img.cas.cz/phd
🚀Open PhD position!
Join our newly established Lab of Immunophysiology.
🧪How do lymph nodes maintain immune tolerance? We‘ll study how fibroblastic reticular cells present self-antigens to support Treg maintenance and prevent autoimmunity.
👉Do you know lab work and coding?
🧡APPLY NOW img.cas.cz/phd
Join our newly established Lab of Immunophysiology.
🧪How do lymph nodes maintain immune tolerance? We‘ll study how fibroblastic reticular cells present self-antigens to support Treg maintenance and prevent autoimmunity.
👉Do you know lab work and coding?
🧡APPLY NOW img.cas.cz/phd
January 29, 2026 at 2:32 PM
🚀Open PhD position!
Join our newly established Lab of Immunophysiology.
🧪How do lymph nodes maintain immune tolerance? We‘ll study how fibroblastic reticular cells present self-antigens to support Treg maintenance and prevent autoimmunity.
👉Do you know lab work and coding?
🧡APPLY NOW img.cas.cz/phd
Join our newly established Lab of Immunophysiology.
🧪How do lymph nodes maintain immune tolerance? We‘ll study how fibroblastic reticular cells present self-antigens to support Treg maintenance and prevent autoimmunity.
👉Do you know lab work and coding?
🧡APPLY NOW img.cas.cz/phd
Joining IMG was the right choice 🎉
Read the full interview with our PhD student Kristína Jamrichová www.img.cas.cz/2025/02/8515...
Be like Kristína, join us now!
APPLY HERE img.cas.cz/phd
Read the full interview with our PhD student Kristína Jamrichová www.img.cas.cz/2025/02/8515...
Be like Kristína, join us now!
APPLY HERE img.cas.cz/phd
January 27, 2026 at 9:59 AM
Joining IMG was the right choice 🎉
Read the full interview with our PhD student Kristína Jamrichová www.img.cas.cz/2025/02/8515...
Be like Kristína, join us now!
APPLY HERE img.cas.cz/phd
Read the full interview with our PhD student Kristína Jamrichová www.img.cas.cz/2025/02/8515...
Be like Kristína, join us now!
APPLY HERE img.cas.cz/phd
🚀Open PhD position!
Lab of Cell and Developmental Biology is seeking a new team player.
🤝Join us to study stem cells, DNA repair, and how 💥cancer💥 really starts.
👉We seek independent thinker ready to learn both experimental and computational approaches.
🧡APPLY NOW img.cas.cz/phd
Lab of Cell and Developmental Biology is seeking a new team player.
🤝Join us to study stem cells, DNA repair, and how 💥cancer💥 really starts.
👉We seek independent thinker ready to learn both experimental and computational approaches.
🧡APPLY NOW img.cas.cz/phd
January 26, 2026 at 12:03 PM
🚀Open PhD position!
Lab of Cell and Developmental Biology is seeking a new team player.
🤝Join us to study stem cells, DNA repair, and how 💥cancer💥 really starts.
👉We seek independent thinker ready to learn both experimental and computational approaches.
🧡APPLY NOW img.cas.cz/phd
Lab of Cell and Developmental Biology is seeking a new team player.
🤝Join us to study stem cells, DNA repair, and how 💥cancer💥 really starts.
👉We seek independent thinker ready to learn both experimental and computational approaches.
🧡APPLY NOW img.cas.cz/phd
Join the Laboratory of Haematooncology and study chronic inflammation, aging and blood stem cells🩸
👩🔬👨🔬We seek a highly motivated, enthusiastic and hard-working PhD student with a strong team spirit
🤝We offer a friendly and supportive environment in a state-of-the-art institution
APPLY: img.cas.cz/phd
👩🔬👨🔬We seek a highly motivated, enthusiastic and hard-working PhD student with a strong team spirit
🤝We offer a friendly and supportive environment in a state-of-the-art institution
APPLY: img.cas.cz/phd
January 22, 2026 at 9:46 AM
Join the Laboratory of Haematooncology and study chronic inflammation, aging and blood stem cells🩸
👩🔬👨🔬We seek a highly motivated, enthusiastic and hard-working PhD student with a strong team spirit
🤝We offer a friendly and supportive environment in a state-of-the-art institution
APPLY: img.cas.cz/phd
👩🔬👨🔬We seek a highly motivated, enthusiastic and hard-working PhD student with a strong team spirit
🤝We offer a friendly and supportive environment in a state-of-the-art institution
APPLY: img.cas.cz/phd
Reposted by Institute of Molecular Genetics
Hope for rare anemia patients: Czech scientists create "perfect" mouse model
Researchers from @czphenogenomics.bsky.social @imgprague.bsky.social achieved a breakthrough in understanding Diamond-Blackfan anemia, a severe genetic disease causing anemia and birth defects in children.
bit.ly/4r4dg6I
Researchers from @czphenogenomics.bsky.social @imgprague.bsky.social achieved a breakthrough in understanding Diamond-Blackfan anemia, a severe genetic disease causing anemia and birth defects in children.
bit.ly/4r4dg6I
Rps19R67∆ mutation creates a model of Diamond–Blackfan anemia and reveals downstream mediators of p53 pathway
Diamond–Blackfan anemia (DBA) is a rare bone marrow failure syndrome accompanied by cardiovascular, skeletal, and urogenital abnormalities. Most of the affected individuals carry mutations in ribosom...
onlinelibrary.wiley.com
January 21, 2026 at 12:51 PM
Hope for rare anemia patients: Czech scientists create "perfect" mouse model
Researchers from @czphenogenomics.bsky.social @imgprague.bsky.social achieved a breakthrough in understanding Diamond-Blackfan anemia, a severe genetic disease causing anemia and birth defects in children.
bit.ly/4r4dg6I
Researchers from @czphenogenomics.bsky.social @imgprague.bsky.social achieved a breakthrough in understanding Diamond-Blackfan anemia, a severe genetic disease causing anemia and birth defects in children.
bit.ly/4r4dg6I
💪PhD at IMG is always a good choice.
Join @sindija.s, our student representative, and start enjoying what IMG offers.
🧡PhD Conference, Career Day, Green Swap and much more - come and see!
Wanna help Sindi organizing PhD events?
APPLY NOW ➡ img.cas.cz/phd
Join @sindija.s, our student representative, and start enjoying what IMG offers.
🧡PhD Conference, Career Day, Green Swap and much more - come and see!
Wanna help Sindi organizing PhD events?
APPLY NOW ➡ img.cas.cz/phd
January 21, 2026 at 9:24 AM
💪PhD at IMG is always a good choice.
Join @sindija.s, our student representative, and start enjoying what IMG offers.
🧡PhD Conference, Career Day, Green Swap and much more - come and see!
Wanna help Sindi organizing PhD events?
APPLY NOW ➡ img.cas.cz/phd
Join @sindija.s, our student representative, and start enjoying what IMG offers.
🧡PhD Conference, Career Day, Green Swap and much more - come and see!
Wanna help Sindi organizing PhD events?
APPLY NOW ➡ img.cas.cz/phd
🚀Open PhD position!
Lab of Integrative Biology @gregorlab.bsky.social is seeking a new talent.
💪Ultimate goal: Develop AAV-compatible mini-plectins to treat muscular dystrophy and cardiomyopathy
👉Profile: MSc, interest in biology, motivation, independence
🧡APPLY: img.cas.cz/phd
Lab of Integrative Biology @gregorlab.bsky.social is seeking a new talent.
💪Ultimate goal: Develop AAV-compatible mini-plectins to treat muscular dystrophy and cardiomyopathy
👉Profile: MSc, interest in biology, motivation, independence
🧡APPLY: img.cas.cz/phd
January 19, 2026 at 10:16 AM
🚀Open PhD position!
Lab of Integrative Biology @gregorlab.bsky.social is seeking a new talent.
💪Ultimate goal: Develop AAV-compatible mini-plectins to treat muscular dystrophy and cardiomyopathy
👉Profile: MSc, interest in biology, motivation, independence
🧡APPLY: img.cas.cz/phd
Lab of Integrative Biology @gregorlab.bsky.social is seeking a new talent.
💪Ultimate goal: Develop AAV-compatible mini-plectins to treat muscular dystrophy and cardiomyopathy
👉Profile: MSc, interest in biology, motivation, independence
🧡APPLY: img.cas.cz/phd
🤝Join us in Prague!
Browse our open PhD positions at www.img.cas.cz/phd
Join a global team and supportive environment, work with top-notch facilities, and enjoy our IMG community!
➡APPLY NOW!
Browse our open PhD positions at www.img.cas.cz/phd
Join a global team and supportive environment, work with top-notch facilities, and enjoy our IMG community!
➡APPLY NOW!
January 15, 2026 at 9:13 AM
🤝Join us in Prague!
Browse our open PhD positions at www.img.cas.cz/phd
Join a global team and supportive environment, work with top-notch facilities, and enjoy our IMG community!
➡APPLY NOW!
Browse our open PhD positions at www.img.cas.cz/phd
Join a global team and supportive environment, work with top-notch facilities, and enjoy our IMG community!
➡APPLY NOW!
🚀CALL for PhDs just launched🚀
We are accepting applications for the PhD program
🚨APPLY NOW!🚨
📅28. 2. 2026
➡www.img.cas.cz/phd
We are accepting applications for the PhD program
🚨APPLY NOW!🚨
📅28. 2. 2026
➡www.img.cas.cz/phd
January 13, 2026 at 5:46 PM
🚀CALL for PhDs just launched🚀
We are accepting applications for the PhD program
🚨APPLY NOW!🚨
📅28. 2. 2026
➡www.img.cas.cz/phd
We are accepting applications for the PhD program
🚨APPLY NOW!🚨
📅28. 2. 2026
➡www.img.cas.cz/phd
🎉Publication in Nature Communications!🎉
The immune system at diagnosis in type 1 diabetes in children isn’t overactive, it’s immature🧒
Veronika Niederlova @vercanie.bsky.social and her colleagues showed that key immune cells fail to fully develop, allowing autoimmunity to arise⚖️
The immune system at diagnosis in type 1 diabetes in children isn’t overactive, it’s immature🧒
Veronika Niederlova @vercanie.bsky.social and her colleagues showed that key immune cells fail to fully develop, allowing autoimmunity to arise⚖️
January 9, 2026 at 2:02 PM
🎉Publication in Nature Communications!🎉
The immune system at diagnosis in type 1 diabetes in children isn’t overactive, it’s immature🧒
Veronika Niederlova @vercanie.bsky.social and her colleagues showed that key immune cells fail to fully develop, allowing autoimmunity to arise⚖️
The immune system at diagnosis in type 1 diabetes in children isn’t overactive, it’s immature🧒
Veronika Niederlova @vercanie.bsky.social and her colleagues showed that key immune cells fail to fully develop, allowing autoimmunity to arise⚖️
Reposted by Institute of Molecular Genetics
Our paper on #tcells in Type 1 #Diabetes is now out in @natcomms.nature.com 👩🔬 rdcu.be/eXEH6
T cells in T1D show higher stem-like signatures and signs of Treg dysfunction. Thanks all the collaborators! @imgprague.bsky.social
T cells in T1D show higher stem-like signatures and signs of Treg dysfunction. Thanks all the collaborators! @imgprague.bsky.social
Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets
Nature Communications - Dysregulation of the T cell compartment is a driving factor in the development of Type 1 diabetes (T1D). Here, the authors present a single-cell gene expression analysis of...
rdcu.be
January 5, 2026 at 2:53 PM
Our paper on #tcells in Type 1 #Diabetes is now out in @natcomms.nature.com 👩🔬 rdcu.be/eXEH6
T cells in T1D show higher stem-like signatures and signs of Treg dysfunction. Thanks all the collaborators! @imgprague.bsky.social
T cells in T1D show higher stem-like signatures and signs of Treg dysfunction. Thanks all the collaborators! @imgprague.bsky.social
🎉New publication in NatCom!
@sumbalovakoledova.bsky.social and her colleagues identified specialized contractile fibroblasts that actively guide growth and branching of the mammary gland during puberty.
👉These cells are temporary – once their job is done, they transform into other cell types.
@sumbalovakoledova.bsky.social and her colleagues identified specialized contractile fibroblasts that actively guide growth and branching of the mammary gland during puberty.
👉These cells are temporary – once their job is done, they transform into other cell types.
January 6, 2026 at 12:59 PM
🎉New publication in NatCom!
@sumbalovakoledova.bsky.social and her colleagues identified specialized contractile fibroblasts that actively guide growth and branching of the mammary gland during puberty.
👉These cells are temporary – once their job is done, they transform into other cell types.
@sumbalovakoledova.bsky.social and her colleagues identified specialized contractile fibroblasts that actively guide growth and branching of the mammary gland during puberty.
👉These cells are temporary – once their job is done, they transform into other cell types.
PF 2026 🧡💙
December 31, 2025 at 8:22 AM
PF 2026 🧡💙
Merry and scientifically peaceful Christmas!
✨🧬We wish you lovely holidays, minimal cellular stress, stable DNA, functional RNA, well-tempered reactions, and lots of joy not only in the laboratory.
🧡💙Thank you for being with us. And we look forward to another year full of discoveries.
✨🧬We wish you lovely holidays, minimal cellular stress, stable DNA, functional RNA, well-tempered reactions, and lots of joy not only in the laboratory.
🧡💙Thank you for being with us. And we look forward to another year full of discoveries.
December 24, 2025 at 9:58 AM
Merry and scientifically peaceful Christmas!
✨🧬We wish you lovely holidays, minimal cellular stress, stable DNA, functional RNA, well-tempered reactions, and lots of joy not only in the laboratory.
🧡💙Thank you for being with us. And we look forward to another year full of discoveries.
✨🧬We wish you lovely holidays, minimal cellular stress, stable DNA, functional RNA, well-tempered reactions, and lots of joy not only in the laboratory.
🧡💙Thank you for being with us. And we look forward to another year full of discoveries.
📣We’re proud to announce the successful completion of our first Single-Cell RNA-seq course at the Institute of Molecular Genetics
📅 1–3 December 2025
🤝 In collaboration with ELIXIR CZ, @ibtcas.bsky.social and MetaCentrum
📅 1–3 December 2025
🤝 In collaboration with ELIXIR CZ, @ibtcas.bsky.social and MetaCentrum
December 16, 2025 at 4:46 PM
📣We’re proud to announce the successful completion of our first Single-Cell RNA-seq course at the Institute of Molecular Genetics
📅 1–3 December 2025
🤝 In collaboration with ELIXIR CZ, @ibtcas.bsky.social and MetaCentrum
📅 1–3 December 2025
🤝 In collaboration with ELIXIR CZ, @ibtcas.bsky.social and MetaCentrum
🔥 WE ARE HIRING!
🔬Join Filip Šenigl and dive into the world of somatic hypermutation, DNA repair, and transcriptional kinetics!
Work with cutting-edge methods (CRISPR/Cas9-degron, CUT&RUN, integration libraries) and contribute to high-impact immunology research.
www.img.cas.cz/group/jiri-h...
🔬Join Filip Šenigl and dive into the world of somatic hypermutation, DNA repair, and transcriptional kinetics!
Work with cutting-edge methods (CRISPR/Cas9-degron, CUT&RUN, integration libraries) and contribute to high-impact immunology research.
www.img.cas.cz/group/jiri-h...
December 15, 2025 at 12:05 PM
🔥 WE ARE HIRING!
🔬Join Filip Šenigl and dive into the world of somatic hypermutation, DNA repair, and transcriptional kinetics!
Work with cutting-edge methods (CRISPR/Cas9-degron, CUT&RUN, integration libraries) and contribute to high-impact immunology research.
www.img.cas.cz/group/jiri-h...
🔬Join Filip Šenigl and dive into the world of somatic hypermutation, DNA repair, and transcriptional kinetics!
Work with cutting-edge methods (CRISPR/Cas9-degron, CUT&RUN, integration libraries) and contribute to high-impact immunology research.
www.img.cas.cz/group/jiri-h...
🚨 New publication in Leukemia!
The germline JAK2-R1063H variant drives risk of thrombosis and accelerates leukemic transformation. Our data highlight its impact on stem cell aging and disease progression.
👏Great work by Veronika Zimolová, Lucie Láníková et al
The germline JAK2-R1063H variant drives risk of thrombosis and accelerates leukemic transformation. Our data highlight its impact on stem cell aging and disease progression.
👏Great work by Veronika Zimolová, Lucie Láníková et al
December 12, 2025 at 8:04 AM
🚨 New publication in Leukemia!
The germline JAK2-R1063H variant drives risk of thrombosis and accelerates leukemic transformation. Our data highlight its impact on stem cell aging and disease progression.
👏Great work by Veronika Zimolová, Lucie Láníková et al
The germline JAK2-R1063H variant drives risk of thrombosis and accelerates leukemic transformation. Our data highlight its impact on stem cell aging and disease progression.
👏Great work by Veronika Zimolová, Lucie Láníková et al
Reposted by Institute of Molecular Genetics
Our lab has two new members Hanka and Eashayan #cilia #fun #Xmas #photoshooting @imgprague.bsky.social
December 8, 2025 at 1:39 PM
Our lab has two new members Hanka and Eashayan #cilia #fun #Xmas #photoshooting @imgprague.bsky.social
🚨Welcoming António P. Baptista, who just launched the Laboratory of Immunophysiology at IMG.
His research dives into how immune cells develop and react during infection.
➡Read what he said about his experience, Prague and moving with family: www.img.cas.cz/2025/11/8874...
His research dives into how immune cells develop and react during infection.
➡Read what he said about his experience, Prague and moving with family: www.img.cas.cz/2025/11/8874...
November 25, 2025 at 2:03 PM
🚨Welcoming António P. Baptista, who just launched the Laboratory of Immunophysiology at IMG.
His research dives into how immune cells develop and react during infection.
➡Read what he said about his experience, Prague and moving with family: www.img.cas.cz/2025/11/8874...
His research dives into how immune cells develop and react during infection.
➡Read what he said about his experience, Prague and moving with family: www.img.cas.cz/2025/11/8874...
🎓 PhD Bootcamp:
A weekend full of learning, exploring, and networking!🌟
This traditional event brought together our new PhD students - and for the first time, also the advanced ones🤝
We didn’t forget to spend time outside 🏞️ and enjoy fun evenings together!✨
A weekend full of learning, exploring, and networking!🌟
This traditional event brought together our new PhD students - and for the first time, also the advanced ones🤝
We didn’t forget to spend time outside 🏞️ and enjoy fun evenings together!✨
November 7, 2025 at 1:56 PM
🎓 PhD Bootcamp:
A weekend full of learning, exploring, and networking!🌟
This traditional event brought together our new PhD students - and for the first time, also the advanced ones🤝
We didn’t forget to spend time outside 🏞️ and enjoy fun evenings together!✨
A weekend full of learning, exploring, and networking!🌟
This traditional event brought together our new PhD students - and for the first time, also the advanced ones🤝
We didn’t forget to spend time outside 🏞️ and enjoy fun evenings together!✨
New publication in Nature Communications from Lukáš Čermák lab
⚖️Cells need the right balance between old and new MCM proteins for error-free DNA copying
🧩We identified DCAF12 as a key factor that controls how new MCM complexes are assembled
www.nature.com/articles/s41...
⚖️Cells need the right balance between old and new MCM proteins for error-free DNA copying
🧩We identified DCAF12 as a key factor that controls how new MCM complexes are assembled
www.nature.com/articles/s41...
CRL4DCAF12 regulation of MCMBP ensures optimal licensing of DNA replication - Nature Communications
MCM2-7 complexes drive genome duplication, but their assembly in human cells is not fully understood. Here, the authors identify the CRL4-DCAF12 ubiquitin ligase as crucial for MCM2-7 maturation, safe...
www.nature.com
November 5, 2025 at 11:34 AM
New publication in Nature Communications from Lukáš Čermák lab
⚖️Cells need the right balance between old and new MCM proteins for error-free DNA copying
🧩We identified DCAF12 as a key factor that controls how new MCM complexes are assembled
www.nature.com/articles/s41...
⚖️Cells need the right balance between old and new MCM proteins for error-free DNA copying
🧩We identified DCAF12 as a key factor that controls how new MCM complexes are assembled
www.nature.com/articles/s41...