@dayyapparaja.bsky.social
Reposted
#KnowYourZDM: In 2019, a 10-year-old patient w/ a life-threatening lymphatic disorder was losing hope. Zebrafish to the rescue! Scientists created zebrafish with the same gene mutation and found a melanoma drug that fixed the fish. Then, doctors used the same drug on the patient to save his life! 🧪
November 20, 2025 at 6:51 PM
#KnowYourZDM: In 2019, a 10-year-old patient w/ a life-threatening lymphatic disorder was losing hope. Zebrafish to the rescue! Scientists created zebrafish with the same gene mutation and found a melanoma drug that fixed the fish. Then, doctors used the same drug on the patient to save his life! 🧪
Reposted
Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish https://www.biorxiv.org/content/10.1101/2025.11.14.688311v1
November 17, 2025 at 12:16 AM
Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish https://www.biorxiv.org/content/10.1101/2025.11.14.688311v1
Reposted
What cell states are possible when they are missing key factors - Nanog, Pou5f3 (Oct4), & Sox19b (Sox2) - that are required for the first embryonic reprogramming steps? Follow along with our latest publication, finally out at doi.org/10.1016/j.ce... #devbio #reprogramming #zebrafish #embryo (1/6)
November 3, 2025 at 6:09 PM
What cell states are possible when they are missing key factors - Nanog, Pou5f3 (Oct4), & Sox19b (Sox2) - that are required for the first embryonic reprogramming steps? Follow along with our latest publication, finally out at doi.org/10.1016/j.ce... #devbio #reprogramming #zebrafish #embryo (1/6)
Reposted
Compared to other publishers, The Company of Biologists is small fry with fewer than 70 staff supporting 5 journals from a single office. But, for over 100 years now, it’s punched above its weight in innovation, prestige and community support.
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
October 17, 2025 at 3:31 PM
Compared to other publishers, The Company of Biologists is small fry with fewer than 70 staff supporting 5 journals from a single office. But, for over 100 years now, it’s punched above its weight in innovation, prestige and community support.
Reposted
1/9 Thrilled to share that our paper, “Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm,” is now published in @cp-cellreports.bsky.social! @amatrudalab.bsky.social @crumplab.bsky.social www.cell.com/cell-reports...
Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm
Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence
for a neural crest origin of the disease. These findings offer new insight into how
a single oncogenic fusion can hij...
www.cell.com
October 9, 2025 at 9:06 PM
1/9 Thrilled to share that our paper, “Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm,” is now published in @cp-cellreports.bsky.social! @amatrudalab.bsky.social @crumplab.bsky.social www.cell.com/cell-reports...
Reposted
Wonderful collaboration of Claire Arata and co-first-author Elena Vasileva from Amatruda lab. Claire provided the neural crest driver and Elena the EWS oncofusion. Best combination since PB&J. Amazing that expression of a single oncofusion in crest produces ectopic fins.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm
Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence
for a neural crest origin of the disease. These findings offer new insight into how
a single oncogenic fusion can hij...
www.cell.com
October 10, 2025 at 12:31 AM
Wonderful collaboration of Claire Arata and co-first-author Elena Vasileva from Amatruda lab. Claire provided the neural crest driver and Elena the EWS oncofusion. Best combination since PB&J. Amazing that expression of a single oncofusion in crest produces ectopic fins.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted
We are looking for a new technician to join our lab and gain some hands on #zebrafish and molecular biology experience. Interested parties should apply here: jobs.rutgers.edu/postings/259... Happy to answer any and all questions about the lab! #STEMJobs
Laboratory/Technical Assistant
Rutgers, The State University of New Jersey is seeking a Laboratory/Technical Assistant for the Department of Cell Biology and Neuroscience within the School of Arts and Sciences. Our mission is to un...
jobs.rutgers.edu
October 3, 2025 at 12:24 AM
We are looking for a new technician to join our lab and gain some hands on #zebrafish and molecular biology experience. Interested parties should apply here: jobs.rutgers.edu/postings/259... Happy to answer any and all questions about the lab! #STEMJobs
Reposted
Out @natcomms.nature.com:
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀
Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).
Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀
Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).
Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5
September 30, 2025 at 5:55 PM
Out @natcomms.nature.com:
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀
Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).
Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀
Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).
Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5
Reposted
Nice work from Val Wilson & co on neuromesodermal progenitors
SOX2/TBXT co-expressing cells are self-propagating bipotent NMPs
Increasing TBXT levels (not SOX2/TBXT ratio) switch NMPs from neural- to mesoderm-biased
www.biorxiv.org/content/10.1...
SOX2/TBXT co-expressing cells are self-propagating bipotent NMPs
Increasing TBXT levels (not SOX2/TBXT ratio) switch NMPs from neural- to mesoderm-biased
www.biorxiv.org/content/10.1...
Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors
Neuromesodermal progenitors (NMPs) produce the spinal cord and musculoskeleton in the elongating anterior-posterior axis. In vivo, NMPs possess dual potency, coinciding with regions coexpressing SOX2 ...
www.biorxiv.org
September 29, 2025 at 8:33 AM
Nice work from Val Wilson & co on neuromesodermal progenitors
SOX2/TBXT co-expressing cells are self-propagating bipotent NMPs
Increasing TBXT levels (not SOX2/TBXT ratio) switch NMPs from neural- to mesoderm-biased
www.biorxiv.org/content/10.1...
SOX2/TBXT co-expressing cells are self-propagating bipotent NMPs
Increasing TBXT levels (not SOX2/TBXT ratio) switch NMPs from neural- to mesoderm-biased
www.biorxiv.org/content/10.1...
Reposted
According to news reports, NIH is on track to award nearly all of its FY25 budget. Program officers—working long hours despite staff losses—made it possible. Take a moment to thank your PO for their dedication.
September 29, 2025 at 2:32 PM
According to news reports, NIH is on track to award nearly all of its FY25 budget. Program officers—working long hours despite staff losses—made it possible. Take a moment to thank your PO for their dedication.
Reposted
Thank you @stemcellreports.bsky.social for featuring our work on the Neural Stem Cells Special Issue cover! www.cell.com/stem-cell-re... Kudos to lead author Sriivatsan G. Rajan for designing the image. Check out the wide array of interesting papers in this packed issue: www.cell.com/stem-cell-re...
September 9, 2025 at 5:25 PM
Thank you @stemcellreports.bsky.social for featuring our work on the Neural Stem Cells Special Issue cover! www.cell.com/stem-cell-re... Kudos to lead author Sriivatsan G. Rajan for designing the image. Check out the wide array of interesting papers in this packed issue: www.cell.com/stem-cell-re...
Reposted
Our next #DevPres webinar focusses on gut development with talks from Surojit Sural @surojitsural.bsky.social, Swarnabh Bhattacharya @iamzico.bsky.social and Brittany Edens, chaired by Alex Eve @amjeve.bsky.social.
📆 17 September, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
📆 17 September, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
September 4, 2025 at 10:37 AM
Our next #DevPres webinar focusses on gut development with talks from Surojit Sural @surojitsural.bsky.social, Swarnabh Bhattacharya @iamzico.bsky.social and Brittany Edens, chaired by Alex Eve @amjeve.bsky.social.
📆 17 September, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
📆 17 September, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
Reposted
Excited to announce that our new paper is now published in Science Advances 🚀🧠 ‘Acquisition of neural crest promoted thyroid evolution from chordate endostyle’ — check it out here: www.science.org/doi/10.1126/...
Acquisition of neural crest promoted thyroid evolution from chordate endostyle
Integration of neural crest cells into the endostyle developmental program promoted its evolution into the thyroid gland.
www.science.org
August 13, 2025 at 3:33 PM
Excited to announce that our new paper is now published in Science Advances 🚀🧠 ‘Acquisition of neural crest promoted thyroid evolution from chordate endostyle’ — check it out here: www.science.org/doi/10.1126/...
Reposted
Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines.
tryptyr.myalcon.com?gad_source=1...
tryptyr.myalcon.com?gad_source=1...
TRYPTYR (acoltremon ophthalmic solution) 0.003% eye drops | Alcon US
TRYPTYR is a prescription eye drop used for the treatment of the signs and symptoms of dry eye disease. See prescribing information, how to save, and more.
tryptyr.myalcon.com
August 13, 2025 at 9:17 PM
Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines.
tryptyr.myalcon.com?gad_source=1...
tryptyr.myalcon.com?gad_source=1...
Reposted
It’s been 25 years since the UCSC Genome Browser launched. Nature profiles how the website remains an essential tool for navigating the genome and understanding its structure, function, and clinical impact. #Academicsky 🧬 🧪
’We couldn’t live without it’: the UCSC Genome Browser turns 25
After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.
go.nature.com
July 9, 2025 at 1:26 AM
It’s been 25 years since the UCSC Genome Browser launched. Nature profiles how the website remains an essential tool for navigating the genome and understanding its structure, function, and clinical impact. #Academicsky 🧬 🧪
Reposted
Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...
TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation
Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based
transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and
offers an alignment-free...
www.cell.com
July 8, 2025 at 5:07 PM
Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...
Reposted
New study online today! We present a method to identify insertion sites of Tol2 transgenes in zebrafish #zebrafish #Tol2 #Transgene www.cell.com/cell-reports...
TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation
Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based
transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and
offers an alignment-free...
www.cell.com
July 8, 2025 at 8:40 PM
New study online today! We present a method to identify insertion sites of Tol2 transgenes in zebrafish #zebrafish #Tol2 #Transgene www.cell.com/cell-reports...
Reposted
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Reposted
🧬 New preprint!
We’ve identified core microRNAs that orchestrate neural crest delamination and condensation in chick embryos, key for trigeminal ganglion formation.
✨ Introducing cranial MET-miRNAs into trunk neural crest cells reprograms them to gain cranial-like differentiation potential
We’ve identified core microRNAs that orchestrate neural crest delamination and condensation in chick embryos, key for trigeminal ganglion formation.
✨ Introducing cranial MET-miRNAs into trunk neural crest cells reprograms them to gain cranial-like differentiation potential
June 28, 2025 at 11:45 PM
🧬 New preprint!
We’ve identified core microRNAs that orchestrate neural crest delamination and condensation in chick embryos, key for trigeminal ganglion formation.
✨ Introducing cranial MET-miRNAs into trunk neural crest cells reprograms them to gain cranial-like differentiation potential
We’ve identified core microRNAs that orchestrate neural crest delamination and condensation in chick embryos, key for trigeminal ganglion formation.
✨ Introducing cranial MET-miRNAs into trunk neural crest cells reprograms them to gain cranial-like differentiation potential
Reposted
New research from Caltech and UC Berkeley has identified the circuit of genes controlling Zebrafish’s ability to regrow and repair their hearts after damage.
www.caltech.edu/about/news/g...
www.caltech.edu/about/news/g...
Genetic Code Enables Zebrafish to Mend Damaged Organs
New research identifies the genes necessary for zebrafish to regenerate their hearts after damage—work that could ultimately impact the recovery of human patients after heart attacks.
www.caltech.edu
June 24, 2025 at 4:53 PM
New research from Caltech and UC Berkeley has identified the circuit of genes controlling Zebrafish’s ability to regrow and repair their hearts after damage.
www.caltech.edu/about/news/g...
www.caltech.edu/about/news/g...
Reposted
Website is now open for registration and abstract submission! See you in beautiful SLO! 😎🏖️ www.sdbonline.org/wcsdb2025
June 3, 2025 at 8:48 PM
Website is now open for registration and abstract submission! See you in beautiful SLO! 😎🏖️ www.sdbonline.org/wcsdb2025
Reposted
Delighted to share our latest work on the anterior lateral line. Congratulations to our fabulous team! www.sciencedirect.com/science/arti...
Development of the zebrafish anterior lateral line system is influenced by underlying cranial neural crest
The mechanosensory lateral line system of aquatic vertebrates comprises a superficial network of distributed sensory organs, the neuromasts, which are…
www.sciencedirect.com
June 4, 2025 at 1:49 AM
Delighted to share our latest work on the anterior lateral line. Congratulations to our fabulous team! www.sciencedirect.com/science/arti...
Reposted
“These findings support the use of zebrafish as a useful comparative model for studying the meninges, provide a foundational description for future zebrafish meningeal research”
New work from @biomarina-vg.bsky.social & Weinstein Lab at NIH 🐟
New work from @biomarina-vg.bsky.social & Weinstein Lab at NIH 🐟
Anatomical and Molecular Characterization of the Zebrafish Meninges https://www.biorxiv.org/content/10.1101/2025.04.09.646894v1
April 16, 2025 at 4:35 PM
“These findings support the use of zebrafish as a useful comparative model for studying the meninges, provide a foundational description for future zebrafish meningeal research”
New work from @biomarina-vg.bsky.social & Weinstein Lab at NIH 🐟
New work from @biomarina-vg.bsky.social & Weinstein Lab at NIH 🐟