Dimitrios Davalos & Lab
@davalos.bsky.social
Assistant Professor, Cleveland Clinic Research | Program Chair, Spring Brain Conference | Neuroscience, Neuroimmunology, Microglia, Blood-Brain Barrier, Multiphoton microscopy | MS, Stroke, AD, AUD, Epilepsy
https://www.lerner.ccf.org/neurosciences/davalos
https://www.lerner.ccf.org/neurosciences/davalos
Reposted by Dimitrios Davalos & Lab
Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
October 31, 2025 at 10:10 AM
Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Dimitrios Davalos & Lab
Very excited to be part of the organizing committee for the upcoming Neurobiology of Stress Workshop, that will happen here in Montreal next June.
All the details can be found on the website 👇
www.stress2026.com
All the details can be found on the website 👇
www.stress2026.com
October 16, 2025 at 5:10 PM
Very excited to be part of the organizing committee for the upcoming Neurobiology of Stress Workshop, that will happen here in Montreal next June.
All the details can be found on the website 👇
www.stress2026.com
All the details can be found on the website 👇
www.stress2026.com
Reposted by Dimitrios Davalos & Lab
The Journal of Neuroscience has updated its policy on supplemental material. https://www.jneurosci.org/content/information-authors#suppl
October 9, 2025 at 12:13 PM
The Journal of Neuroscience has updated its policy on supplemental material. https://www.jneurosci.org/content/information-authors#suppl
The brilliance of ants never seizes to amaze me!
Architectural immunity: Ants alter their nest networks to prevent epidemics | Science www.science.org/doi/10.1126/...
Architectural immunity: Ants alter their nest networks to prevent epidemics | Science www.science.org/doi/10.1126/...
Architectural immunity: Ants alter their nest networks to prevent epidemics
In animal groups, spatial structure shapes social interaction patterns, thereby influencing the transmission of infectious diseases. Active modifications to the spatial environment could therefore be ...
www.science.org
October 17, 2025 at 2:42 AM
The brilliance of ants never seizes to amaze me!
Architectural immunity: Ants alter their nest networks to prevent epidemics | Science www.science.org/doi/10.1126/...
Architectural immunity: Ants alter their nest networks to prevent epidemics | Science www.science.org/doi/10.1126/...
Reposted by Dimitrios Davalos & Lab
A “crisis” that rocked the island of Santorini may reveal a shared magma system between two volcanoes with explosive histories. https://scim.ag/428JVho
Thousands of quakes struck a major Greek volcano, mapping the plumbing beneath it
A “crisis” that rocked the island of Santorini may reveal a shared magma system between two volcanoes with explosive histories
scim.ag
September 29, 2025 at 1:16 PM
A “crisis” that rocked the island of Santorini may reveal a shared magma system between two volcanoes with explosive histories. https://scim.ag/428JVho
Reposted by Dimitrios Davalos & Lab
Finding the tick-borne encephalitis cellular gateway could transform prevention and treatment
go.nature.com/3Kqp5E9
go.nature.com/3Kqp5E9
How a tick-borne virus enters human cells
Tick-borne encephalitis virus can infect the nervous system and cause life-threatening illness. Finding the cellular gateway it uses could transform prevention and treatment.
go.nature.com
September 25, 2025 at 7:49 AM
Finding the tick-borne encephalitis cellular gateway could transform prevention and treatment
go.nature.com/3Kqp5E9
go.nature.com/3Kqp5E9
Reposted by Dimitrios Davalos & Lab
Beneficial impact of physical activity on multiple sclerosis disability progression jnnp.bmj.com/content/earl...
Beneficial impact of physical activity on multiple sclerosis disability progression
Background Physical activity has been associated with neuroprotective and immunomodulatory benefits, potentially influencing long-term disability outcomes in multiple sclerosis (MS). However, longitud...
jnnp.bmj.com
September 25, 2025 at 8:52 AM
Beneficial impact of physical activity on multiple sclerosis disability progression jnnp.bmj.com/content/earl...
Reposted by Dimitrios Davalos & Lab
We are hiring and looking for exceptional faculty! If you are interested in the fundamental mechanisms of human biology, biochemistry, metabolism, or genetics, please look here! 🧪 jobs.sciencecareers.org/job/675109/f...
Faculty – Assistant, Associate and Full Professor - Miami, Florida (US) job with Miami Miller School of Medicine - Desai Sethi Urology and Sylvester Comprehensive Cancer Center | 675109
The Desai Sethi Urology Institute seeks scientists to study genitourinary cancers, offering strong support, collaboration, and a new cancer facility.
jobs.sciencecareers.org
September 25, 2025 at 10:26 AM
We are hiring and looking for exceptional faculty! If you are interested in the fundamental mechanisms of human biology, biochemistry, metabolism, or genetics, please look here! 🧪 jobs.sciencecareers.org/job/675109/f...
Reposted by Dimitrios Davalos & Lab
#BloodBrainBarrier
"microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain"
Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure
@cprofaci.bsky.social #Neuron 2024
www.cell.com/neuron/fullt...
"microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain"
Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure
@cprofaci.bsky.social #Neuron 2024
www.cell.com/neuron/fullt...
September 20, 2025 at 11:02 AM
#BloodBrainBarrier
"microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain"
Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure
@cprofaci.bsky.social #Neuron 2024
www.cell.com/neuron/fullt...
"microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain"
Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure
@cprofaci.bsky.social #Neuron 2024
www.cell.com/neuron/fullt...
Reposted by Dimitrios Davalos & Lab
Reposted by Dimitrios Davalos & Lab
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."
September 7, 2025 at 8:04 PM
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."
Reposted by Dimitrios Davalos & Lab
We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:
September 3, 2025 at 3:52 PM
We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:
Reposted by Dimitrios Davalos & Lab
New research from the #StricklandLab suggests that amyloid-beta (Aβ) oligomers and the vascular protein fibrinogen may, when forming a complex, contribute to Alzheimer's disease. #RockefellerScience
How an Alzheimer's peptide and a blood protein may combine to drive early disease pathology - News
A new study by researchers from The Rockefeller University identifies one possible means for the drug's impact on patients.
www.rockefeller.edu
June 20, 2025 at 7:33 PM
New research from the #StricklandLab suggests that amyloid-beta (Aβ) oligomers and the vascular protein fibrinogen may, when forming a complex, contribute to Alzheimer's disease. #RockefellerScience
Reposted by Dimitrios Davalos & Lab
Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...
June 14, 2025 at 4:13 PM
Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...
Reposted by Dimitrios Davalos & Lab
Massive telescope will map the Universe and provide an evolving record of the Solar System and distant stars.
https://go.nature.com/3HvKM4r
https://go.nature.com/3HvKM4r
Major telescope hosts world's largest digital camera: how it will transform astronomy
Massive telescope will map the Universe and provide an evolving record of the Solar System and distant stars.
go.nature.com
June 11, 2025 at 2:33 PM
Massive telescope will map the Universe and provide an evolving record of the Solar System and distant stars.
https://go.nature.com/3HvKM4r
https://go.nature.com/3HvKM4r
Reposted by Dimitrios Davalos & Lab
A man with a severe speech disability is able to speak expressively and sing using a brain implant that translates his neural activity into words almost instantly.
https://go.nature.com/4dV6avS
https://go.nature.com/4dV6avS
World first: brain implant lets man speak with expression ― and sing
Device translates thought to speech in real time.
go.nature.com
June 11, 2025 at 3:45 PM
A man with a severe speech disability is able to speak expressively and sing using a brain implant that translates his neural activity into words almost instantly.
https://go.nature.com/4dV6avS
https://go.nature.com/4dV6avS
Microglia: A super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holding her back (LD weights) and lift the amyloid load (beams) that trapped the neurons, thereby rescuing them in the aged Brain (City sign)! #NotTheCover @cp-immunity.bsky.social
May 21, 2025 at 5:55 PM
Microglia: A super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holding her back (LD weights) and lift the amyloid load (beams) that trapped the neurons, thereby rescuing them in the aged Brain (City sign)! #NotTheCover @cp-immunity.bsky.social
Reposted by Dimitrios Davalos & Lab
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 6:14 PM
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 5:09 PM
Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Reposted by Dimitrios Davalos & Lab
Check out our special collection on #neuroimmunology that is online now! www.cell.com/immuni/newar... #AAI2025
May 5, 2025 at 9:42 PM
Check out our special collection on #neuroimmunology that is online now! www.cell.com/immuni/newar... #AAI2025
Beautiful work by @lukensjohnr.bsky.social and team out @cp-immunity.bsky.social! Congratulations to all!
Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...
Inflammasome signaling in astrocytes modulates hippocampal plasticity
The function of immune pathways in homeostatic neurobiology remains underexplored.
Zengeler et al. find that the inflammasome complex, typically associated with immune
responses, is involved in memory...
www.cell.com
May 3, 2025 at 12:15 PM
Beautiful work by @lukensjohnr.bsky.social and team out @cp-immunity.bsky.social! Congratulations to all!
Reposted by Dimitrios Davalos & Lab
Also announcing our upcoming ISFP joint congress with IFRS and the Plasminogen Activation Workshop in Corfu, Sep 28, 2025! Abstract deadline has been extended! Please join the ISFP membership to ensure your registration (includes room & board) discount! ifrs-isfpcongress2025.org
IFRS-ISFP Congress 2025 in Corfu – Register Now!
Join top researchers in fibrinolysis and proteolysis. Register now for Corfu, Sept 28–Oct 2, 2025!
ifrs-isfpcongress2025.org
April 17, 2025 at 7:25 AM
Also announcing our upcoming ISFP joint congress with IFRS and the Plasminogen Activation Workshop in Corfu, Sep 28, 2025! Abstract deadline has been extended! Please join the ISFP membership to ensure your registration (includes room & board) discount! ifrs-isfpcongress2025.org
Reposted by Dimitrios Davalos & Lab
p-Tau217 is a breakthrough blood test that can predict and may help prevent Alzheimer's disease.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.
The Breakthrough Blood Test for Alzheimer's Disease
The p-Tau217 Biomarker for Prediction and Prevention
erictopol.substack.com
April 13, 2025 at 2:27 PM
p-Tau217 is a breakthrough blood test that can predict and may help prevent Alzheimer's disease.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.
Reposted by Dimitrios Davalos & Lab
Zebrafish Community Cre/lox Resource website (ZebrafishCCR) will be online soon!
March 29, 2025 at 6:21 PM
Zebrafish Community Cre/lox Resource website (ZebrafishCCR) will be online soon!
Reposted by Dimitrios Davalos & Lab
How does exercise and fitness promote healthy brain aging?
An outstanding, comprehensive review @thelancet.bsky.social
reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more
www.thelancet.com/journals/lan...
An outstanding, comprehensive review @thelancet.bsky.social
reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more
www.thelancet.com/journals/lan...
March 28, 2025 at 12:00 AM
How does exercise and fitness promote healthy brain aging?
An outstanding, comprehensive review @thelancet.bsky.social
reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more
www.thelancet.com/journals/lan...
An outstanding, comprehensive review @thelancet.bsky.social
reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more
www.thelancet.com/journals/lan...