That is the hope, but it remains to be seen. We share some thoughts about that in the discussion of the paper if you would like to take a look.

Thanks Kelsey! Teamwork makes the dream work! And having spent a few years thinking about the science, makes you “see” things in your head… 🤓

Emma Vidal brought our concept to life.
For more info about the science produced in the @chopralab.bsky.social and ours, that inspired our geeky idea, please read the paper here: www.cell.com/immunity/abs...

But blocking or reducing DGAT2 (using a cool new drug developed by @chopralab.bsky.social ) restores microglial phagocytosis of Aβ and thereby reduces plaque load and neuronal damage in a preclinical model of #Alzheimer’sDisease

Microglia are the brain’s resident immune cells & natural phagocytes, but they stop reducing amyloid deposits from Alzheimer’s disease brains for unknown reasons. We found that microglia increase their lipid droplets and lose their phagocytic capacity with increasing Aβ exposure from amyloid plaques

It was fantastic to work with you, Palak and the rest of the Chopra group @pryprk.bsky.social !

Tremendously grateful to an amazing team of lab members and collaborators including @pryprk.bsky.social , @evipaouri.bsky.social , Palak Manchanda and Gaurav Chopra and pretty much all Chopra and Davalos Lab members for the smooth teamwork @clevelandclinic.bsky.social @purdueuniversity.bsky.social