Nima Sharifi MD
@nimasharifimd.bsky.social
Scientific Director
Desai Sethi Urology Institute
Sylvester Comprehensive Cancer Center
University of Miami Miller School of Medicine
https://www.nimasharifilab.com
Desai Sethi Urology Institute
Sylvester Comprehensive Cancer Center
University of Miami Miller School of Medicine
https://www.nimasharifilab.com
Are you a postdoc or PhD student? Working on #metabolism?
Escape the snow, apply for a travel award & submit an abstract for the 3rd #Miami Symposium on Human Metabolism on February 14, 2026! 🧪
The deadline is 12/31!
Submit here: med.miami.edu/elp/miamimet...
Escape the snow, apply for a travel award & submit an abstract for the 3rd #Miami Symposium on Human Metabolism on February 14, 2026! 🧪
The deadline is 12/31!
Submit here: med.miami.edu/elp/miamimet...
Poster Session & Reception
Official website for the University of Miami Leonard M. Miller School of Medicine
med.miami.edu
December 19, 2025 at 1:25 PM
Are you a postdoc or PhD student? Working on #metabolism?
Escape the snow, apply for a travel award & submit an abstract for the 3rd #Miami Symposium on Human Metabolism on February 14, 2026! 🧪
The deadline is 12/31!
Submit here: med.miami.edu/elp/miamimet...
Escape the snow, apply for a travel award & submit an abstract for the 3rd #Miami Symposium on Human Metabolism on February 14, 2026! 🧪
The deadline is 12/31!
Submit here: med.miami.edu/elp/miamimet...
Very excited our story on a CYP17A1-independent androgen biosynthesis pathway is out! Could explain why androgens are left when we use abiraterone to block CYP17A1 clinically in prostate cancer. Need to look more closely at oxidized forms of cholesterol! Please read the whole paper. 🧪 rdcu.be/eS7kU
December 4, 2025 at 12:23 PM
Very excited our story on a CYP17A1-independent androgen biosynthesis pathway is out! Could explain why androgens are left when we use abiraterone to block CYP17A1 clinically in prostate cancer. Need to look more closely at oxidized forms of cholesterol! Please read the whole paper. 🧪 rdcu.be/eS7kU
Reposted by Nima Sharifi MD
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 7:01 PM
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
True words!
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
October 31, 2025 at 11:59 PM
True words!
Big and well deserved congratulations to @zhipengawang.bsky.social for his new Prostate Cancer Foundation Young Investigator Award! So well deserved! He is doing incredible work discovering new mechanisms of ketones in metabolism. And congrats to all the other PCF young investigator awardees! 🧪
October 25, 2025 at 11:56 AM
Big and well deserved congratulations to @zhipengawang.bsky.social for his new Prostate Cancer Foundation Young Investigator Award! So well deserved! He is doing incredible work discovering new mechanisms of ketones in metabolism. And congrats to all the other PCF young investigator awardees! 🧪
Reposted by Nima Sharifi MD
Evidence that even when LLMs produce similar results to humans, they “rely on lexical associations and statistical priors rather than contextual reasoning or normative criteria. We term this divergence epistemia: the illusion of knowledge emerging when surface plausibility replaces verification”
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 17, 2025 at 7:40 AM
Evidence that even when LLMs produce similar results to humans, they “rely on lexical associations and statistical priors rather than contextual reasoning or normative criteria. We term this divergence epistemia: the illusion of knowledge emerging when surface plausibility replaces verification”
Latest clinical data on HSD3B1 presented at ASTRO www.urotoday.com/conference-h...
ASTRO 2025: Influence of HSD3B1 Genotype on Prostate Cancer Outcomes Following Definitive Radiation Therapy with ADT: A Retrospective Analysis of the Million Veterans Program
prostate cancer, HSD3B1 Genotype, Influence of HSD3B1 Genotype on Prostate Cancer Outcomes Following Definitive Radiation Therapy with ADT.
www.urotoday.com
October 7, 2025 at 10:32 AM
Latest clinical data on HSD3B1 presented at ASTRO www.urotoday.com/conference-h...
"Rockets, computers and lifesaving medicines all come from decades of effort by scientists hunkered over pages of calculation or the laboratory bench. They required the same tireless, single-minded effort every elite athlete understands." 🧪 @adamfrank4.bsky.social www.nytimes.com/2025/10/03/o...
Opinion | How the Manosphere Hijacks Young Men’s Interest in Science
www.nytimes.com
October 3, 2025 at 10:20 AM
"Rockets, computers and lifesaving medicines all come from decades of effort by scientists hunkered over pages of calculation or the laboratory bench. They required the same tireless, single-minded effort every elite athlete understands." 🧪 @adamfrank4.bsky.social www.nytimes.com/2025/10/03/o...
We are hiring and looking for exceptional faculty! If you are interested in the fundamental mechanisms of human biology, biochemistry, metabolism, or genetics, please look here! 🧪 jobs.sciencecareers.org/job/675109/f...
Faculty – Assistant, Associate and Full Professor - Miami, Florida (US) job with Miami Miller School of Medicine - Desai Sethi Urology and Sylvester Comprehensive Cancer Center | 675109
The Desai Sethi Urology Institute seeks scientists to study genitourinary cancers, offering strong support, collaboration, and a new cancer facility.
jobs.sciencecareers.org
September 25, 2025 at 10:26 AM
We are hiring and looking for exceptional faculty! If you are interested in the fundamental mechanisms of human biology, biochemistry, metabolism, or genetics, please look here! 🧪 jobs.sciencecareers.org/job/675109/f...
Reposted by Nima Sharifi MD
Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.
A Trailblazing Geneticist Reflects On Her Life And Work
Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.
buff.ly
September 19, 2025 at 6:12 PM
Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.
These pelicans out this morning are just magnificent and mesmerizing to watch
September 20, 2025 at 1:51 PM
These pelicans out this morning are just magnificent and mesmerizing to watch
Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses www.nytimes.com/2025/09/02/s...
Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses
www.nytimes.com
September 3, 2025 at 8:04 AM
Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses www.nytimes.com/2025/09/02/s...
Congratulations @marinaparry.bsky.social! Wonderful work!
REALLY thrilled to share findings from my postdoc work in the Attard lab, which form part of this www.sciencedirect.com/science/arti....
Thanks to Emily and Gert for seeing it over the line, all the funders, the Veracyte, MRC CTU & STAMPEDE teams, and patients who contributed samples. Pls share!
Thanks to Emily and Gert for seeing it over the line, all the funders, the Veracyte, MRC CTU & STAMPEDE teams, and patients who contributed samples. Pls share!
Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers
Advanced prostate cancers respond to hormone therapy but outcomes vary and no predictive tests exist for informed treatment selection. To identify nov…
www.sciencedirect.com
August 27, 2025 at 8:52 AM
Congratulations @marinaparry.bsky.social! Wonderful work!
Enjoyed working with Masoud Bitaraf and Elena Castro on this review on prostate cancer germline variants with therapeutic implications for Trends in Molecular Medicine! 🧪 #UroSky #MedSky @cp-trendsmolecmed.bsky.social authors.elsevier.com/a/1lWYz5Eb1B...
authors.elsevier.com
July 30, 2025 at 2:40 PM
Enjoyed working with Masoud Bitaraf and Elena Castro on this review on prostate cancer germline variants with therapeutic implications for Trends in Molecular Medicine! 🧪 #UroSky #MedSky @cp-trendsmolecmed.bsky.social authors.elsevier.com/a/1lWYz5Eb1B...
Reposted by Nima Sharifi MD
Such an honor and so much fun to join the Cancer Clear and Simple @uwhealth.bsky.social Carbone Cancer Center Podcast to discuss liquid biopsies in cancer!
cancer.wisc.edu/community-ou...
cancer.wisc.edu/community-ou...
Cancer Clear and Simple Podcast
Welcome to ‘Cancer Clear and Simple,’ the podcast dedicated to simplifying cancer. Join us as we discuss the world of cancer, breaking down complex concepts for our listening audience. One of our goal...
cancer.wisc.edu
July 25, 2025 at 1:11 PM
Such an honor and so much fun to join the Cancer Clear and Simple @uwhealth.bsky.social Carbone Cancer Center Podcast to discuss liquid biopsies in cancer!
cancer.wisc.edu/community-ou...
cancer.wisc.edu/community-ou...
I consider myself fortunate for every day I can continue to do science
July 25, 2025 at 11:06 AM
I consider myself fortunate for every day I can continue to do science
An Editor's Pick paper at J Biol Chem @asbmb.bsky.social! Don't forget to read the profile about the first author Xiuxiu Li at the end of our paper on HSD3B1 and breast cancer! Dr. Li recently moved from University of Miami to the University of Alabama! 🧪 www.sciencedirect.com/science/arti...
July 15, 2025 at 11:49 AM
An Editor's Pick paper at J Biol Chem @asbmb.bsky.social! Don't forget to read the profile about the first author Xiuxiu Li at the end of our paper on HSD3B1 and breast cancer! Dr. Li recently moved from University of Miami to the University of Alabama! 🧪 www.sciencedirect.com/science/arti...
Reposted by Nima Sharifi MD
...a long way to go...
July 11, 2025 at 7:38 AM
...a long way to go...
Sage advice as always from @rjdlab.bsky.social 🧪
Thanks Nature Cancer for the chance to reflect on some factors that led me to study cancer metabolism. For the trainees and other young scientists: the critical events that shape your career might not be obvious while they are happening. Keep an open mind and trust your instincts.
rdcu.be/evi4I
rdcu.be/evi4I
An unexpected career in cancer metabolism
Nature Cancer - Ralph DeBerardinis obtained an MD and PhD from the University of Pennsylvania, then trained in Pediatrics and Medical Genetics at Children’s Hospital of Philadelphia. He moved...
rdcu.be
July 8, 2025 at 10:41 PM
Sage advice as always from @rjdlab.bsky.social 🧪