Josh Lang
@joshlangmd.bsky.social
Professor and Associate Director of Translational Research, GU Medical Oncologist at the University of Wisconsin Carbone Cancer Center.
https://langlab.labs.wisc.edu/
#prostatecancer #cancerbiology #biomarkers
https://langlab.labs.wisc.edu/
#prostatecancer #cancerbiology #biomarkers
Reposted by Josh Lang
Restaging w/ #PSMA Imaging in #mCRPC #ProstateCancer: When Seeing More Is Detrimental to Care
Sadly a year later this remains true & the frequency of this is 📈
@ascocancer.bsky.social @ascopost.bsky.social
ascopubs.org/doi/pdf/10.1...
Sadly a year later this remains true & the frequency of this is 📈
@ascocancer.bsky.social @ascopost.bsky.social
ascopubs.org/doi/pdf/10.1...
August 4, 2025 at 8:05 PM
Restaging w/ #PSMA Imaging in #mCRPC #ProstateCancer: When Seeing More Is Detrimental to Care
Sadly a year later this remains true & the frequency of this is 📈
@ascocancer.bsky.social @ascopost.bsky.social
ascopubs.org/doi/pdf/10.1...
Sadly a year later this remains true & the frequency of this is 📈
@ascocancer.bsky.social @ascopost.bsky.social
ascopubs.org/doi/pdf/10.1...
Reposted by Josh Lang
🗣️"The system is horribly broken & it hurts patients unnecessarily”
🗣️"They wrote me off as a dead man”
Navigating #priorauth requires tech savvy, an understanding of insurance processes, knowledge of personal rights, & time to engage in the process.
@ascocancer.bsky.social @astro-org.bsky.social
🗣️"They wrote me off as a dead man”
Navigating #priorauth requires tech savvy, an understanding of insurance processes, knowledge of personal rights, & time to engage in the process.
@ascocancer.bsky.social @astro-org.bsky.social
Patient Perspectives on Prior Authorization for Cancer Care
This qualitative study characterizes the perspectives of patients with cancer regarding their experience with prior authorization for cancer care.
jamanetwork.com
July 31, 2025 at 3:44 PM
🗣️"The system is horribly broken & it hurts patients unnecessarily”
🗣️"They wrote me off as a dead man”
Navigating #priorauth requires tech savvy, an understanding of insurance processes, knowledge of personal rights, & time to engage in the process.
@ascocancer.bsky.social @astro-org.bsky.social
🗣️"They wrote me off as a dead man”
Navigating #priorauth requires tech savvy, an understanding of insurance processes, knowledge of personal rights, & time to engage in the process.
@ascocancer.bsky.social @astro-org.bsky.social
Reposted by Josh Lang
Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!
UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
www.wsj.com
July 30, 2025 at 4:00 AM
Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!
Such an honor and so much fun to join the Cancer Clear and Simple @uwhealth.bsky.social Carbone Cancer Center Podcast to discuss liquid biopsies in cancer!
cancer.wisc.edu/community-ou...
cancer.wisc.edu/community-ou...
Cancer Clear and Simple Podcast
Welcome to ‘Cancer Clear and Simple,’ the podcast dedicated to simplifying cancer. Join us as we discuss the world of cancer, breaking down complex concepts for our listening audience. One of our goal...
cancer.wisc.edu
July 25, 2025 at 1:11 PM
Such an honor and so much fun to join the Cancer Clear and Simple @uwhealth.bsky.social Carbone Cancer Center Podcast to discuss liquid biopsies in cancer!
cancer.wisc.edu/community-ou...
cancer.wisc.edu/community-ou...
Reposted by Josh Lang
"We cure a lot of diseases, & we create a lot of medical debt. It’s a push/pull; right?
The advances that we have within science & medicine are profound. We have people living longer & better. Yet, the cost of treatment is a side effect like any other."
#financialToxicity @cancerletter.com
The advances that we have within science & medicine are profound. We have people living longer & better. Yet, the cost of treatment is a side effect like any other."
#financialToxicity @cancerletter.com
First-ever financial toxicity tumor board aims to change the standard of care Researchers focus on debt as a side effect of cancer, treatment amid cuts to Medicaid, NCI - The Cancer Letter
Nearly half of cancer patients and survivors in the United States face medical debt so crushing that it has sparked a relatively new focus within oncology: financial toxicity. To access this subscribe...
cancerletter.com
July 15, 2025 at 6:57 PM
"We cure a lot of diseases, & we create a lot of medical debt. It’s a push/pull; right?
The advances that we have within science & medicine are profound. We have people living longer & better. Yet, the cost of treatment is a side effect like any other."
#financialToxicity @cancerletter.com
The advances that we have within science & medicine are profound. We have people living longer & better. Yet, the cost of treatment is a side effect like any other."
#financialToxicity @cancerletter.com
Reposted by Josh Lang
"It is a nightmare waking up every day wondering if some people halfway across the country will approve what my doctors have said is my only chance."
📄 New #PriorAuth in cancer report shows the scope of the problem & the need to #fixpriorAuth @cancercare.bsky.social
www.cancercare.org/redtape
📄 New #PriorAuth in cancer report shows the scope of the problem & the need to #fixpriorAuth @cancercare.bsky.social
www.cancercare.org/redtape
June 18, 2025 at 5:48 PM
"It is a nightmare waking up every day wondering if some people halfway across the country will approve what my doctors have said is my only chance."
📄 New #PriorAuth in cancer report shows the scope of the problem & the need to #fixpriorAuth @cancercare.bsky.social
www.cancercare.org/redtape
📄 New #PriorAuth in cancer report shows the scope of the problem & the need to #fixpriorAuth @cancercare.bsky.social
www.cancercare.org/redtape
Reposted by Josh Lang
Better late than never I guess! Every year I try to write a review of the year just past, primarily for my grandkids to read when I’m no longer around and here is 2024 finally! runningintocancer.co.uk/2025/05/29/r...
Review of 2024 – Palaces and Parliament
It’s great to start by celebrating still being alive at the end of another year given that, in May 2017, I was told I might only live 2 years! 2024 saw me enter my 8th year post diagnosis having su…
runningintocancer.co.uk
May 29, 2025 at 1:27 PM
Better late than never I guess! Every year I try to write a review of the year just past, primarily for my grandkids to read when I’m no longer around and here is 2024 finally! runningintocancer.co.uk/2025/05/29/r...
Reposted by Josh Lang
Grateful to @ascocancer.bsky.social Ed Book 📗@n8pennell.bsky.social for this #MedEd publication
🛣️ How to move forward in #EarlyCareer
🚧 Overcoming barriers
⚙️ Switching gears
⏰ Making time and space
🔗: ascopubs.org/doi/10.1200/...
@ericroeland.bsky.social
@ryannipp.bsky.social
🛣️ How to move forward in #EarlyCareer
🚧 Overcoming barriers
⚙️ Switching gears
⏰ Making time and space
🔗: ascopubs.org/doi/10.1200/...
@ericroeland.bsky.social
@ryannipp.bsky.social
May 8, 2025 at 8:43 AM
Grateful to @ascocancer.bsky.social Ed Book 📗@n8pennell.bsky.social for this #MedEd publication
🛣️ How to move forward in #EarlyCareer
🚧 Overcoming barriers
⚙️ Switching gears
⏰ Making time and space
🔗: ascopubs.org/doi/10.1200/...
@ericroeland.bsky.social
@ryannipp.bsky.social
🛣️ How to move forward in #EarlyCareer
🚧 Overcoming barriers
⚙️ Switching gears
⏰ Making time and space
🔗: ascopubs.org/doi/10.1200/...
@ericroeland.bsky.social
@ryannipp.bsky.social
Reposted by Josh Lang
Special episode of GU Cast from Guy’s Hospital focused on #RadiationCystitis. Unique clinic dedicated to these unfortunate patients learn from Yasmin and Ramesh and team. Some great insights youtu.be/d4A2_swZOHw?...
Radiation cystitis!!! Help!!
YouTube video by GU Cast
youtu.be
April 23, 2025 at 8:59 AM
Special episode of GU Cast from Guy’s Hospital focused on #RadiationCystitis. Unique clinic dedicated to these unfortunate patients learn from Yasmin and Ramesh and team. Some great insights youtu.be/d4A2_swZOHw?...
Reposted by Josh Lang
Latest data on measles in the US. The total number of cases has already reached 800 in the first 4 months of 2025 with 85 hospitalizations and 3 deaths. There were 285 total cases last year. 🧪
www.cidrap.umn.edu/measles/us-m...
www.cidrap.umn.edu/measles/us-m...
US measles total climbs to 800 cases, 10 outbreaks
www.cidrap.umn.edu
April 21, 2025 at 2:01 AM
Latest data on measles in the US. The total number of cases has already reached 800 in the first 4 months of 2025 with 85 hospitalizations and 3 deaths. There were 285 total cases last year. 🧪
www.cidrap.umn.edu/measles/us-m...
www.cidrap.umn.edu/measles/us-m...
Reposted by Josh Lang
Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M ohiocapitaljournal.com/2025/04/17/o...
Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M • Ohio Capital Journal
The Ohio Department of Medicaid department in 2022 gave powerful prescription drug middlemen the boot and created a new system. The result: Fees paid to pharmacies were boosted more than 1,200% while ...
ohiocapitaljournal.com
April 17, 2025 at 1:29 PM
Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M ohiocapitaljournal.com/2025/04/17/o...
Reposted by Josh Lang
What if we screened smarter, not just more?
In BARCODE1, men with high polygenic risk (top 10%) had MRI + biopsy—
40% had prostate cancer.
Over half needed treatment.
Most would’ve been missed by PSA alone.
Genetics is rewriting the rules.
@nejm.org @myesmo.bsky.social @oncoalert.bsky.social
In BARCODE1, men with high polygenic risk (top 10%) had MRI + biopsy—
40% had prostate cancer.
Over half needed treatment.
Most would’ve been missed by PSA alone.
Genetics is rewriting the rules.
@nejm.org @myesmo.bsky.social @oncoalert.bsky.social
April 10, 2025 at 5:30 AM
What if we screened smarter, not just more?
In BARCODE1, men with high polygenic risk (top 10%) had MRI + biopsy—
40% had prostate cancer.
Over half needed treatment.
Most would’ve been missed by PSA alone.
Genetics is rewriting the rules.
@nejm.org @myesmo.bsky.social @oncoalert.bsky.social
In BARCODE1, men with high polygenic risk (top 10%) had MRI + biopsy—
40% had prostate cancer.
Over half needed treatment.
Most would’ve been missed by PSA alone.
Genetics is rewriting the rules.
@nejm.org @myesmo.bsky.social @oncoalert.bsky.social
Reposted by Josh Lang
The act will disenfranchise vets/active/overseas military from voting as well (who often have less access to reams of documents)
LDF Denounces House Passage of SAVE Act, Urges Senate to Reject Bill that Will Disenfranchise Millions of Americans - naacpldf.org/press-release/…#HellNoN#VotesForVetsts
LDF Denounces House Passage of SAVE Act, Urges Senate to Reject Bill that Will Disenfranchise Millions of Americans - naacpldf.org/press-release/…#HellNoN#VotesForVetsts
April 10, 2025 at 6:33 PM
The act will disenfranchise vets/active/overseas military from voting as well (who often have less access to reams of documents)
LDF Denounces House Passage of SAVE Act, Urges Senate to Reject Bill that Will Disenfranchise Millions of Americans - naacpldf.org/press-release/…#HellNoN#VotesForVetsts
LDF Denounces House Passage of SAVE Act, Urges Senate to Reject Bill that Will Disenfranchise Millions of Americans - naacpldf.org/press-release/…#HellNoN#VotesForVetsts
Reposted by Josh Lang
Whatever fraud there is in Medicaid is largely on the provider side, not beneficiaries. It's health insurance, its not cash.
"Fraud" here means going to a doctor if you are unemployed.
"Fraud" here means going to a doctor if you are unemployed.
Mike Johnson on Medicaid: "What we've talked about is returning work requirements ... you return the dignity of work to young men who need to be out working instead of playing video games all day. We have a lot of fraud, waste, and abuse in Medicaid."
April 10, 2025 at 5:04 PM
Whatever fraud there is in Medicaid is largely on the provider side, not beneficiaries. It's health insurance, its not cash.
"Fraud" here means going to a doctor if you are unemployed.
"Fraud" here means going to a doctor if you are unemployed.
Reposted by Josh Lang
🚨 Hot off the press! 🚨 The @myesmo.bsky.social ESMO Precision Oncology Working Group, has unveiled key "Recommendations for structuring Molecular Tumour Boards (MTBs) in clinical practice", now published in ESMO's flagship journal Annals of Oncology 🧬🏥
www.annalsofoncology.org/article/S092...
www.annalsofoncology.org/article/S092...
April 8, 2025 at 2:16 AM
🚨 Hot off the press! 🚨 The @myesmo.bsky.social ESMO Precision Oncology Working Group, has unveiled key "Recommendations for structuring Molecular Tumour Boards (MTBs) in clinical practice", now published in ESMO's flagship journal Annals of Oncology 🧬🏥
www.annalsofoncology.org/article/S092...
www.annalsofoncology.org/article/S092...
Reposted by Josh Lang
Low-dose CT for lung cancer screening in a high-risk population (SUMMIT): a prospective, longitudinal cohort study out on LANCET Oncology
www.thelancet.com/journals/lan...
These findings support the feasibility and effectiveness of large-scale lung cancer screening in a diverse population.
www.thelancet.com/journals/lan...
These findings support the feasibility and effectiveness of large-scale lung cancer screening in a diverse population.
April 2, 2025 at 4:18 PM
Low-dose CT for lung cancer screening in a high-risk population (SUMMIT): a prospective, longitudinal cohort study out on LANCET Oncology
www.thelancet.com/journals/lan...
These findings support the feasibility and effectiveness of large-scale lung cancer screening in a diverse population.
www.thelancet.com/journals/lan...
These findings support the feasibility and effectiveness of large-scale lung cancer screening in a diverse population.
Reposted by Josh Lang
I understand this concern, but the anti-vaxx arguments are already everywhere on social media. We have to have people refuting this stuff. Can’t let it go completely unchecked.
Do you worry that he’s giving them credibility by “debating” them?
March 31, 2025 at 4:51 PM
I understand this concern, but the anti-vaxx arguments are already everywhere on social media. We have to have people refuting this stuff. Can’t let it go completely unchecked.
Reposted by Josh Lang
Just in NIH grants, It looks like beautiful Iowa City, home of the U of Iowa, will lose $71m in funding. That's almost $1k per resident. And that's before all the other cuts to SSA, FDA, etc.
Anyone in Iowa City that can offer more insight?
scienceimpacts.org
H/T to Prathima !
Anyone in Iowa City that can offer more insight?
scienceimpacts.org
H/T to Prathima !
SCiMaP
scienceimpacts.org
March 29, 2025 at 6:29 PM
Just in NIH grants, It looks like beautiful Iowa City, home of the U of Iowa, will lose $71m in funding. That's almost $1k per resident. And that's before all the other cuts to SSA, FDA, etc.
Anyone in Iowa City that can offer more insight?
scienceimpacts.org
H/T to Prathima !
Anyone in Iowa City that can offer more insight?
scienceimpacts.org
H/T to Prathima !
Reposted by Josh Lang
This is not efficiency, this is abandonment.
Americans deserve health care that works for them — and instead, the Trump administration is wreaking havoc on seniors, people with disabilities, and our most vulnerable.
In Illinois, we will stand up against these attacks.
Americans deserve health care that works for them — and instead, the Trump administration is wreaking havoc on seniors, people with disabilities, and our most vulnerable.
In Illinois, we will stand up against these attacks.
The Trump administration restructures federal health agencies, cuts 20,000 jobs
The reduction in force comes along with a reorganization of the Department of Health and Human Services, consolidating 28 divisions to 15.
www.npr.org
March 27, 2025 at 6:31 PM
This is not efficiency, this is abandonment.
Americans deserve health care that works for them — and instead, the Trump administration is wreaking havoc on seniors, people with disabilities, and our most vulnerable.
In Illinois, we will stand up against these attacks.
Americans deserve health care that works for them — and instead, the Trump administration is wreaking havoc on seniors, people with disabilities, and our most vulnerable.
In Illinois, we will stand up against these attacks.
Reposted by Josh Lang
The NIH is set to lose ~1,200 ppl as part of the HHS restructuring.
An NIH researcher had not yet received news internally about plans to restructure the agency as of Thursday morning, less than an hour after Kennedy's statement published. cen.acs.org/policy/US-De... @cenmag.bsky.social #chemsky
An NIH researcher had not yet received news internally about plans to restructure the agency as of Thursday morning, less than an hour after Kennedy's statement published. cen.acs.org/policy/US-De... @cenmag.bsky.social #chemsky
US Department of Health and Human Services to lay off 10,000 employees
Cuts will affect the Food and Drug Administration, Centers for Disease Control and Prevention, and the National Institutes of Health
cen.acs.org
March 27, 2025 at 5:37 PM
The NIH is set to lose ~1,200 ppl as part of the HHS restructuring.
An NIH researcher had not yet received news internally about plans to restructure the agency as of Thursday morning, less than an hour after Kennedy's statement published. cen.acs.org/policy/US-De... @cenmag.bsky.social #chemsky
An NIH researcher had not yet received news internally about plans to restructure the agency as of Thursday morning, less than an hour after Kennedy's statement published. cen.acs.org/policy/US-De... @cenmag.bsky.social #chemsky
Reposted by Josh Lang
Happy to share our new work with @haognguyen on targeting mRNA translation of oncogenes by RNA structure remodeling with a small molecule zotatifin. Congrats to @DuyguKuzuoglu an amazing postdoc and all the authors and collaborators!
cell.com/cancer-cell/fu…
cell.com/cancer-cell/fu…
Small-molecule RNA therapeutics to target prostate cancer
Kuzuoglu-Ozturk et al. showcase a therapeutic approach, “translatome therapy,” to combat lethal prostate cancer. Zotatifin, a clinical molecule, targets the RNA-helicase eIF4A. Zotatifin decreases the select translation of key oncogenes, androgen receptor (AR), and HIF1α through remodeling their 5′ UTR RNA structure. Zotatifin enhances anti-androgen and radiotherapy sensitivity, highlighting a promising anti-cancer treatment.
www.cell.com
March 24, 2025 at 1:01 AM
Happy to share our new work with @haognguyen on targeting mRNA translation of oncogenes by RNA structure remodeling with a small molecule zotatifin. Congrats to @DuyguKuzuoglu an amazing postdoc and all the authors and collaborators!
cell.com/cancer-cell/fu…
cell.com/cancer-cell/fu…
Reposted by Josh Lang
A friend drove two hours today for her breast cancer chemotherapy only to learn it was canceled due to NIH cuts. Clinical trial ended midstream. No treatment, no restart, no plan, no information. Her bro-in-law's chemo was also canceled.
March 20, 2025 at 8:24 PM
A friend drove two hours today for her breast cancer chemotherapy only to learn it was canceled due to NIH cuts. Clinical trial ended midstream. No treatment, no restart, no plan, no information. Her bro-in-law's chemo was also canceled.
Reposted by Josh Lang
"more transparency throughout [the #priorAuth] process is great, I remain concerned that relying on patients & physicians to recognize & initiate appeals places disproportionate burden on our patients who can least afford it."
@michaelannica.bsky.social
@ascocancer.bsky.social
@michaelannica.bsky.social
@ascocancer.bsky.social
March 20, 2025 at 3:41 PM
"more transparency throughout [the #priorAuth] process is great, I remain concerned that relying on patients & physicians to recognize & initiate appeals places disproportionate burden on our patients who can least afford it."
@michaelannica.bsky.social
@ascocancer.bsky.social
@michaelannica.bsky.social
@ascocancer.bsky.social
Do these clinical trial failures demonstrate a failure of traditional pre-clinical models to reflect the human disease?
In addition to the complete avoidance of biomarker-driven clinical trials to find the subset of patients that would benefit.? @asharpmedonc.bsky.social @pcf-science.bsky.social
In addition to the complete avoidance of biomarker-driven clinical trials to find the subset of patients that would benefit.? @asharpmedonc.bsky.social @pcf-science.bsky.social
Dr. Susan Slovin from MSK asks some key questions regarding #ProstateCancer #Immunotherapy
@ascocancer.bsky.social
ascopubs.org/doi/10.1200/...
@ascocancer.bsky.social
ascopubs.org/doi/10.1200/...
Immune Checkpoint Combos in Metastatic Castration-Resistant Prostate Cancer: Where Are We Going, What Are We Doing, and Why?
ascopubs.org
March 17, 2025 at 1:48 PM
Do these clinical trial failures demonstrate a failure of traditional pre-clinical models to reflect the human disease?
In addition to the complete avoidance of biomarker-driven clinical trials to find the subset of patients that would benefit.? @asharpmedonc.bsky.social @pcf-science.bsky.social
In addition to the complete avoidance of biomarker-driven clinical trials to find the subset of patients that would benefit.? @asharpmedonc.bsky.social @pcf-science.bsky.social