Alexi Nott 🏳️🌈
@nottalexi.bsky.social
Group Leader at UK Dementia Research Institute at Imperial @ukdri | Lecturer @imperialbrains.bsky.social | Epigenetics in brain disorders | LGBTQ+ champion | He/him
https://nottgroup.com/
https://nottgroup.com/
Pinned
Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Alexi Nott 🏳️🌈
🔬 New research 🔬
A study led by Dr Alexi Nott at UK DRI at Imperial finds that different brain-cell types are linked to genetic risk for dementia in distinct ways.
Read more here 👉 tinyurl.com/3f9rnurz
A study led by Dr Alexi Nott at UK DRI at Imperial finds that different brain-cell types are linked to genetic risk for dementia in distinct ways.
Read more here 👉 tinyurl.com/3f9rnurz
October 31, 2025 at 9:49 AM
🔬 New research 🔬
A study led by Dr Alexi Nott at UK DRI at Imperial finds that different brain-cell types are linked to genetic risk for dementia in distinct ways.
Read more here 👉 tinyurl.com/3f9rnurz
A study led by Dr Alexi Nott at UK DRI at Imperial finds that different brain-cell types are linked to genetic risk for dementia in distinct ways.
Read more here 👉 tinyurl.com/3f9rnurz
Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
October 31, 2025 at 10:10 AM
Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Alexi Nott 🏳️🌈
Extremely proud of Dr Janis Transfeld, who defended her PhD. Janis' project was a heroic undertaking to profile the epigenome of in vivo human dopaminergic neurons, which she then leveraged to interpret Parkinson's risk variants. @jaenice.bsky.social @ukdri.ac.uk @imperialbrains.bsky.social 🎉🎓🍾
September 15, 2025 at 1:05 PM
Extremely proud of Dr Janis Transfeld, who defended her PhD. Janis' project was a heroic undertaking to profile the epigenome of in vivo human dopaminergic neurons, which she then leveraged to interpret Parkinson's risk variants. @jaenice.bsky.social @ukdri.ac.uk @imperialbrains.bsky.social 🎉🎓🍾
Reposted by Alexi Nott 🏳️🌈
Really nice work from the @nottalexi.bsky.social lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, @mangiruben.bsky.social and Alexi 👏🏻✨
A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾
journals.plos.org/plosgenetics... More to come from Aydan soon!
journals.plos.org/plosgenetics... More to come from Aydan soon!
May 1, 2025 at 12:29 PM
Really nice work from the @nottalexi.bsky.social lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, @mangiruben.bsky.social and Alexi 👏🏻✨
A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾
journals.plos.org/plosgenetics... More to come from Aydan soon!
journals.plos.org/plosgenetics... More to come from Aydan soon!
May 1, 2025 at 12:19 PM
A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾
journals.plos.org/plosgenetics... More to come from Aydan soon!
journals.plos.org/plosgenetics... More to come from Aydan soon!
Reposted by Alexi Nott 🏳️🌈
Many thanks to the excellent team on this, including @kittybmurphy.bsky.social , Yuqian Ye, Maria Tsalenchuk and @nottalexi.bsky.social 🙏🏻🙏🏻
April 28, 2025 at 3:20 PM
Many thanks to the excellent team on this, including @kittybmurphy.bsky.social , Yuqian Ye, Maria Tsalenchuk and @nottalexi.bsky.social 🙏🏻🙏🏻
Reposted by Alexi Nott 🏳️🌈
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 1:31 AM
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Wonderful evening with @liddelowsa.bsky.social following his visit to @imperialbrains.bsky.social @ukdri.ac.uk 🧠
April 14, 2025 at 7:46 PM
Wonderful evening with @liddelowsa.bsky.social following his visit to @imperialbrains.bsky.social @ukdri.ac.uk 🧠
Reposted by Alexi Nott 🏳️🌈
@nottalexi.bsky.social we are looking forward to your presentation at #Neuroepi25 in Malta.🌞
Please share with your followers to let them know early bird registration & talk submission closes on 24 April 2025!
Find out more: bit.ly/42ls1an
#FusionNeuro
Please share with your followers to let them know early bird registration & talk submission closes on 24 April 2025!
Find out more: bit.ly/42ls1an
#FusionNeuro
April 10, 2025 at 9:54 AM
@nottalexi.bsky.social we are looking forward to your presentation at #Neuroepi25 in Malta.🌞
Please share with your followers to let them know early bird registration & talk submission closes on 24 April 2025!
Find out more: bit.ly/42ls1an
#FusionNeuro
Please share with your followers to let them know early bird registration & talk submission closes on 24 April 2025!
Find out more: bit.ly/42ls1an
#FusionNeuro
Reposted by Alexi Nott 🏳️🌈
Massive congrats and gratitude to lead authors Leyla Abbasova, Paulina Urbanaviciute, Di Hu and Joy Ismail, as well as collaborators Brian Schilder, @nottalexi.bsky.social and Nathan Skene 🙏🏻🥰 It's been a long journey, but I'm so glad I got to share it with these excellent colleagues!
March 27, 2025 at 11:16 AM
Massive congrats and gratitude to lead authors Leyla Abbasova, Paulina Urbanaviciute, Di Hu and Joy Ismail, as well as collaborators Brian Schilder, @nottalexi.bsky.social and Nathan Skene 🙏🏻🥰 It's been a long journey, but I'm so glad I got to share it with these excellent colleagues!
Reposted by Alexi Nott 🏳️🌈
Thank you for the invite, it was great to hear about the amazing science being done in the centre during my visit!
Thank you to @ukdri.ac.uk Group Leader @nottalexi.bsky.social for joining us today & for his great talk on ‘The Epigenome of brain cell types and associations with disease’ @kavlioxford.bsky.social @oxforddpag.bsky.social @sophielfarrow.bsky.social @wademartinslab.bsky.social
Bluesky
forddpag.bsky.social
March 4, 2025 at 12:29 AM
Thank you for the invite, it was great to hear about the amazing science being done in the centre during my visit!
Reposted by Alexi Nott 🏳️🌈
Last day @ukdri.ac.uk @imperialbrains.bsky.social before starting my maternity leave 🍼 I will only briefly come back before heading to Turin for a new adventure 🇮🇹 Millions thanks to this bunch of people who supported me through these last 4 intense years! 💙🙏
February 14, 2025 at 6:14 PM
Last day @ukdri.ac.uk @imperialbrains.bsky.social before starting my maternity leave 🍼 I will only briefly come back before heading to Turin for a new adventure 🇮🇹 Millions thanks to this bunch of people who supported me through these last 4 intense years! 💙🙏
Reposted by Alexi Nott 🏳️🌈
Very excited to share our latest publication in @NatureGenet! Our manuscript shows how Mendelian Randomization (MR) isolates putatively causal links between cell-type specific gene expression & brain phenotypes.
www.nature.com/articles/s41...
Tweetorial below 👇
www.nature.com/articles/s41...
Tweetorial below 👇
January 14, 2025 at 8:22 AM
Very excited to share our latest publication in @NatureGenet! Our manuscript shows how Mendelian Randomization (MR) isolates putatively causal links between cell-type specific gene expression & brain phenotypes.
www.nature.com/articles/s41...
Tweetorial below 👇
www.nature.com/articles/s41...
Tweetorial below 👇
Happy holidays from the Neurogenomics groups at Imperial with the @sj-marzi.bsky.social and Skene labs ☃️. We had a wonderful evening of Nepalese food, quizzes and an epigenetics-inspired sip and paint 🎨🍷🧬
December 13, 2024 at 12:40 PM
Happy holidays from the Neurogenomics groups at Imperial with the @sj-marzi.bsky.social and Skene labs ☃️. We had a wonderful evening of Nepalese food, quizzes and an epigenetics-inspired sip and paint 🎨🍷🧬
Reposted by Alexi Nott 🏳️🌈
So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Predicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular states
Abstract. To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based o
academic.oup.com
December 11, 2024 at 5:02 PM
So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Looking forward to another amazing Neuroepigenomics meeting, held in Malta this coming year!
🌟 SAVE THE DATE! 🌟
The 4th Neuroepigenetics & Neuroepitranscriptomics Conference is back! 🎉
Join us in sunny St Julians, Malta, with chairs Hongjun Song (University of Pennsylvania) and Li-Huei Tsai (MIT)! ☀️
💥 Stay updated—sign up here: bit.ly/41ibKUS
The 4th Neuroepigenetics & Neuroepitranscriptomics Conference is back! 🎉
Join us in sunny St Julians, Malta, with chairs Hongjun Song (University of Pennsylvania) and Li-Huei Tsai (MIT)! ☀️
💥 Stay updated—sign up here: bit.ly/41ibKUS
December 8, 2024 at 11:49 PM
Looking forward to another amazing Neuroepigenomics meeting, held in Malta this coming year!
Reposted by Alexi Nott 🏳️🌈
OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr
go.bsky.app/6LWE4dr
November 25, 2024 at 6:37 PM
OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr
go.bsky.app/6LWE4dr
News & Views with @irholtman.bsky.social on spatial and single-cell gene expression analyses of Alzheimer's and Down's Sydrome www.nature.com/articles/s41.... This is a commentary on the work by the Swarup lab: www.nature.com/articles/s41....
Spatial mapping of Alzheimer’s disease across genetic subtypes - Nature Genetics
Alzheimer’s disease is a complex, heterogeneous disorder with multiple genetic subtypes. Spatial and single-cell gene expression analyses of these subtypes have provided new insights into general and ...
www.nature.com
November 25, 2024 at 1:55 PM
News & Views with @irholtman.bsky.social on spatial and single-cell gene expression analyses of Alzheimer's and Down's Sydrome www.nature.com/articles/s41.... This is a commentary on the work by the Swarup lab: www.nature.com/articles/s41....
Reposted by Alexi Nott 🏳️🌈
Professor Valentina Escott-Price in the UK Dementia Research Institute at Cardiff University is looking for a Research Associate in Bioinformatics and Machine Learning. Closing date: 1st December.
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Associate: Bioinformatics and Machine Learning
Prof Valentina Escott-Price in the UK Dementia Research Institute at Cardiff University is looking for a Research Associate in Bioinformatics & Machine Learning
www.dementiaresearcher.nihr.ac.uk
November 17, 2024 at 10:54 AM
Professor Valentina Escott-Price in the UK Dementia Research Institute at Cardiff University is looking for a Research Associate in Bioinformatics and Machine Learning. Closing date: 1st December.
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Reposted by Alexi Nott 🏳️🌈
Excited that my work bestie @nottalexi.bsky.social has joined the blue site. Anyone interested in epigenomics, brains and neurodegeneration, give him a follow 🧠🧬👇
Making the transition over to bluesky 👋 I'm a group leader with the UK Dementia Research Institute at Imperial working on epigenetics and dementia 🧬🧠
November 16, 2024 at 2:01 PM
Excited that my work bestie @nottalexi.bsky.social has joined the blue site. Anyone interested in epigenomics, brains and neurodegeneration, give him a follow 🧠🧬👇
Making the transition over to bluesky 👋 I'm a group leader with the UK Dementia Research Institute at Imperial working on epigenetics and dementia 🧬🧠
November 16, 2024 at 1:54 PM
Making the transition over to bluesky 👋 I'm a group leader with the UK Dementia Research Institute at Imperial working on epigenetics and dementia 🧬🧠