Yehuda M. Danino
@daninoyehuda.bsky.social
Molecular and cellular biologist. Post-Doc at Weizmann. Interested in HTP levels and biochemistry of RNAs, non-canonical RNA structures, and proteins in cancers and neurodegeneration
A paper from the JUMP Cell Painting Consortium presents image-based phenotypic profiles for 75% of the protein coding genome of human U-2 OS cells, offering a valuable resource for exploring gene relationships. @shantanu-singh.cc @drannecarpenter.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 8, 2025 at 6:30 AM
Reposted by Yehuda M. Danino
Excited to share my postdoctoral research on how neuronal #aging contributes to RNA dysfunction is now online at Nature Neuroscience! Here we find that aged neurons suffer from chronic cellular stress that compromises resiliency to new stressors🧪 www.nature.com/articles/s41...
Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress - Nature Neuroscience
Rhine et al. find that neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress and reduced resiliency.
www.nature.com
June 2, 2025 at 1:35 PM
Excited to share my postdoctoral research on how neuronal #aging contributes to RNA dysfunction is now online at Nature Neuroscience! Here we find that aged neurons suffer from chronic cellular stress that compromises resiliency to new stressors🧪 www.nature.com/articles/s41...
Reposted by Yehuda M. Danino
Don’t miss the Early Career Showcase in Lisbon!
With 16 inspiring talks, interactive networking, and a relaxed, collaborative vibe, it’s a unique chance to explore cutting-edge cancer research and connect with peers.
Learn more: 2025.eacr.org/cancer-resea...
With 16 inspiring talks, interactive networking, and a relaxed, collaborative vibe, it’s a unique chance to explore cutting-edge cancer research and connect with peers.
Learn more: 2025.eacr.org/cancer-resea...
April 25, 2025 at 12:02 PM
Don’t miss the Early Career Showcase in Lisbon!
With 16 inspiring talks, interactive networking, and a relaxed, collaborative vibe, it’s a unique chance to explore cutting-edge cancer research and connect with peers.
Learn more: 2025.eacr.org/cancer-resea...
With 16 inspiring talks, interactive networking, and a relaxed, collaborative vibe, it’s a unique chance to explore cutting-edge cancer research and connect with peers.
Learn more: 2025.eacr.org/cancer-resea...
Great new field.
“Cell surface RNA biology: new roles for RNA binding proteins” Jennifer Porat and I discuss this new cellular topology on which to study RNA–RBP interactions and consider how changes in the csRBPs may drive autoimmune responses. @cp-trendsbiochem.bsky.social www.sciencedirect.com/science/arti...
Cell surface RNA biology: new roles for RNA binding proteins
Much of our understanding of RNA–protein interactions, and how these interactions shape gene expression and cell state, have come from studies looking…
www.sciencedirect.com
April 25, 2025 at 12:56 PM
Great new field.
Reposted by Yehuda M. Danino
Welcome to BlueSky @jamchemsoc.bsky.social !
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
March 11, 2025 at 10:36 AM
Welcome to BlueSky @jamchemsoc.bsky.social !
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
Reposted by Yehuda M. Danino
Have a look at our newest commentary in @pnas.org :
"G-quadruplexes and their unexpected ability to fold proteins"
Full text: www.pnas.org/doi/10.1073/...
#G4 #quadruplex #proteins #folding
"G-quadruplexes and their unexpected ability to fold proteins"
Full text: www.pnas.org/doi/10.1073/...
#G4 #quadruplex #proteins #folding
G-quadruplexes and their unexpected ability to fold proteins | PNAS
G-quadruplexes and their unexpected ability to fold proteins
www.pnas.org
March 11, 2025 at 9:18 AM
Have a look at our newest commentary in @pnas.org :
"G-quadruplexes and their unexpected ability to fold proteins"
Full text: www.pnas.org/doi/10.1073/...
#G4 #quadruplex #proteins #folding
"G-quadruplexes and their unexpected ability to fold proteins"
Full text: www.pnas.org/doi/10.1073/...
#G4 #quadruplex #proteins #folding
Reposted by Yehuda M. Danino
How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
www.science.org
March 6, 2025 at 9:30 PM
How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!
Reposted by Yehuda M. Danino
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 5:47 PM
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Reposted by Yehuda M. Danino
Who made the mRNA vaccine? Measuring division of labor in therapeutic innovation go.nature.com/4eS8YJj
November 19, 2024 at 2:50 PM
Who made the mRNA vaccine? Measuring division of labor in therapeutic innovation go.nature.com/4eS8YJj
Reposted by Yehuda M. Danino
Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...
Single-molecule states link transcription factor binding to gene expression - Nature
A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...
www.nature.com
November 20, 2024 at 8:34 PM
Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...
Reposted by Yehuda M. Danino
New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: cell.com/cell-reports... #ALS
ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes
Alirzayeva et al. find that ALS-related mutant FUS gains interaction with PARP1 and
histone H1.2. Reducing either PARP1 activity or H1.2 levels prevents pathological
changes in human motor neurons and...
cell.com
August 21, 2024 at 3:37 PM
New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: cell.com/cell-reports... #ALS
Reposted by Yehuda M. Danino
🧬 🖥️ Thrilled to share our recent work on TME heterogeneity, published on iScience:
t.co/whajXd0SjU
A joint effort with Federica Eduati's lab
Follow the thread for more🧵👇
1/
t.co/whajXd0SjU
A joint effort with Federica Eduati's lab
Follow the thread for more🧵👇
1/
November 12, 2024 at 2:32 PM
🧬 🖥️ Thrilled to share our recent work on TME heterogeneity, published on iScience:
t.co/whajXd0SjU
A joint effort with Federica Eduati's lab
Follow the thread for more🧵👇
1/
t.co/whajXd0SjU
A joint effort with Federica Eduati's lab
Follow the thread for more🧵👇
1/
Reposted by Yehuda M. Danino
That's a really interesting system from Georgia Tech. Immune Organoids! The research team used synthetic hydrogels which can make a microenvironment for B cells, isolated from human tonsils and blood, to mature and produce antibodies.
Published in Nature Materials.
news.gatech.edu/news/2024/11...
Published in Nature Materials.
news.gatech.edu/news/2024/11...
Lab-Grown Human Immune System Model Uncovers Weakened Response in Cancer Patients
To better understand why some cancer patients struggle to fight off infections, Georgia Tech researchers have created tiny lab-grown models of human immune systems.
news.gatech.edu
November 15, 2024 at 5:57 PM
That's a really interesting system from Georgia Tech. Immune Organoids! The research team used synthetic hydrogels which can make a microenvironment for B cells, isolated from human tonsils and blood, to mature and produce antibodies.
Published in Nature Materials.
news.gatech.edu/news/2024/11...
Published in Nature Materials.
news.gatech.edu/news/2024/11...
Reposted by Yehuda M. Danino
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
November 16, 2024 at 7:05 PM
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
Reposted by Yehuda M. Danino
Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705
https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000B06P
t.co
November 15, 2024 at 9:13 PM
Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705
Reposted by Yehuda M. Danino
November 16, 2024 at 9:53 AM
Reposted by Yehuda M. Danino
November 15, 2024 at 7:44 AM
Reposted by Yehuda M. Danino
.. by the way, I also created starter pack focused on DNA and RNA G-quadruplexes #G4 and included some buddies @sebastien-britton.bsky.social @granzhan.bsky.social @drzoewaller.bsky.social @paeschkelab.bsky.social @jschneek.bsky.social
Contact me if interested!
go.bsky.app/4VgiGa4
Contact me if interested!
go.bsky.app/4VgiGa4
November 13, 2024 at 9:50 PM
.. by the way, I also created starter pack focused on DNA and RNA G-quadruplexes #G4 and included some buddies @sebastien-britton.bsky.social @granzhan.bsky.social @drzoewaller.bsky.social @paeschkelab.bsky.social @jschneek.bsky.social
Contact me if interested!
go.bsky.app/4VgiGa4
Contact me if interested!
go.bsky.app/4VgiGa4